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Combining GlP-1 receptor agonists and SGlT-2 inhibitors for cardiovascular disease prevention in type 2 diabetes:A systematic review with multiple network meta-regressions

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World Journal of Diabetes 2024年第10期15卷 2135-2146页

作者： Jing-Jing Zhu john P H Wilding Xiao-Song Gu Department of Endocrinology and Metabolic Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Cardiovascular and Metabolic Medicine University of LiverpoolLiverpool L697ZXUnited Kingdom Clinical Sciences Centre Liverpool University Hospitals NHS Foundation TrustLiverpool L97ALUnited Kingdom Department of Cardiovascular Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina

BACKGROUND Glucagon-like peptide-1 receptor agonists(GlP-1RA)and sodium-glucose co-transporter-2 inhibitors(SGlT-2I)are associated with significant cardiovascular benefit in type 2 diabetes(T2D).However,GlP-1RA or SGlT-2I alone may not improve some cardiovascular outcomes in patients with prior cardiovascular *** To explore whether combining GlP-1RA and SGlT-2I can achieve additional benefit in preventing cardiovascular diseases in *** The systematic review was conducted according to PRISMA *** protocol was registered on PROSPERO(ID:42022385007).A total of 107049 participants from eligible cardiovascular outcomes trials of GlP-1RA and SGlT-2I were included in network meta-regressions to estimate cardiovascular benefit of the combination *** modification of prior myocardial infarction(MI)and heart failure(HF)was also explored to provide clinical insight as to when the INTRODUCTION The macro-and micro-vascular benefits of glucagon-like peptide-1 receptor agonists(GlP-1RA)and sodium-glucose co-transporter-2 inhibitors(SGlT-2I)are independent of their glucose-lowering effects[1].In patients with type 2 diabetes(T2D),the major cardiovascular outcome trials(CVOT)showed that dipeptidyl peptidase-4 inhibitors(DPP-4I)did not improve cardiovascular outcomes[2],whereas cardiovascular benefit of GlP-1RA or SGlT-2I was significant[3,4].Further subgroup analyses indicated that the background cardiovascular risk should be considered when examining the cardiovascular outcomes of these newer glucose-lowering *** instance,prevention of major adverse cardiovascular events(MACE)was only seen in those patients with baseline atherosclerotic cardiovascular disease[3,4].Moreover,a series of CVOT conducted in patients with heart failure(HF)have demonstrated that(compared with placebo)SGlT-2I significantly reduced risk of hospitalization for HF or cardiovascular death,irrespective of their history of T2D[5-8].However,similar car

关键词： Type 2 diabetes Glucagon-like peptide-1 receptor agonist Sodium-glucose co-transporter-2 inhibitor Combination treatment Cardiovascular outcome Systematic review Network meta-regression

Geochemistry and mineralogy of beach sediments in the northern Gulf of Mexico,Tamaulipas state,Mexico:implication for provenance

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Journal of Palaeogeography 2024年第3期13卷 375-400页

作者： Mayank Shukla Sanjeet K.Verma Mayla A.Ramos-Vázquez john S.Armstrong-Altrin Karla R.Hernández-Martínez Sumit Mishra Vivek P.Malviya Héctor Hernández-Mendoza Posgrado de la Division de Geociencias Aplicadas Instituto Potosino de Investigacion Científica y Tecnologica(IPICYT)Camino a la Presa San José2055San Luis Potosí78216Mexico Division de Geociencias Aplicadas Instituto Potosino de Investigación Científica y Tecnologica(IPICYT)Camino a la Presa San Jose 2055San Luis Potosí78216Mexico Universidad Nacional Autonoma de México Instituto de Ciencias del Mar y LimnologíaUnidad de ProcesosOceanicos y CosterosCiudad UniversitariaCiudad de México 04510Mexico Department of Marine Sciences Bharathidasan UniversityTiruchirappalli620024Tamil NaduIndia Instituto de Geociencias Universidad Nacional Autonoma de MéxicoBoulevard Juriquilla 300176230JuriquillaQueretaroMexico Department of Applied Geology Dr.Harisingh Gour Central UniversitySagar470002Madhya PradeshIndia Instituto de Investigacion de Zonas Desérticas Universidad Autònoma de San Luis PotosíAltair 200CP 78377San LuisS.L.P.Mexico Universidad del Centro de Mexico Capitán Caldera 75CP 78250San LuisS.L.P.Mexico

Geochemical and mineralogical studies were performed in the la Pesca(lP)and Tesoro Altamira(TA)beach sediments,located in the Tamaulipas state,northern Gulf of *** main aim of this study is to infer the weathering history and provenance and to discriminate the tectonic environment of the beach *** sediments are composed of quartz with small amounts of accessory minerals such as plagioclase,calcite,orthoclase,microcline,and *** beach sediments are classified as fine-grained and very well sorted,however lP has coarse skewed and leptokurtic sediments,whereas TA has fine-skewed and very leptokurtic *** chemical index of weathering(CIW’)indicates intense weathering in the source *** quartz grain microtextures in the lP and TA are classified into mechanical,chemical,and mechanical/chemical *** features such as fractures,pits,percussion marks,abrasion fatigue,and V-shaped marks favor high-energy littoral,fluvial,subaqueous-marine,and aeolian *** chemical features indicate solution pits and crystalline overgrowth,which suggests a silica saturated marine *** mechanical/chemical features display adhering particles and elongated depressions suggest formation in a sub-aqueous nearshore marine *** and trace elements-based provenance discrimination diagrams indicate a felsic source derived from the Mesa Central(MC),Sierra Madre Oriental(SMOr)and Oaxaquia *** major and trace element concentrations imply a passive margin setting for the northern Gulf of Mexico,which is consistent with the general geology.

关键词： Beach sediments Geochemistry Mineralogy Provenance Tamaulipas Tectonic setting

Optimization of specific cell-peptide interactions at the bio-material interface via regulation of nonspecific biofouling interactions

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Science China Chemistry 2020年第2期63卷 143-144页

作者： john l.Brash Department of Chemical Engineering School of Biomedical EngineeringMcMaster University

Materials that interact with biological systems in a wellcontrolled,predictable manner are highly sought after for numerous biomedical and biotechnological *** example,it is essential that devices such as stents or heart valves in the blood stream of patients do not cause thrombosis or infection,or that biosensors do not lose their function due to adverse interactions with the bio environment.A general approach to the design of biointerfaces that addresses this need has been pursued over a number of years[1].It has two elements:(1)prevention of non-specific interfacial interactions,and(2)promotion of specific biointeractions required for the intended functioning of the *** practice this means preventing all interactions except for the desired one(s).With respect to the first point it should be appreciated that biological species such as proteins and cells have a natural affinity for the interfacial ***,the realization of a surface that eliminates the adsorption/adhesion of these species is extremely *** of PEO/PEG,other hydrophilic polymers(PVP,PHEMA),and zwitterionic polymers[2]to the surface is the most common strategy to achieve“bio-resistance”.Regarding the second point,the surface must be designed so that it interacts selectively and exclusively with the component(s)(proteins,cells)that will give the desired *** this purpose,“ligands”that bind these specific components are incorporated into the surface[3].

关键词： desired interfacial realization

Ionic conductivity anomaly in soil cover——Exploration of blind mineralization beneath regolith cover

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Science China Earth Sciences 2010年第5期53卷 649-656页

作者： KEElING john l. Primary Industries and Resources South Australia (PIRSA)

This paper briefly describes the formation of ionic conductivity anomalies in soil cover, and the characteristics of ionic composition that forms conductivity anomalies, based on the theory of geoelectrochemical halo. Based on some practical results of soluble ions in soil cover and soil conductivity derived from a number of mining areas of both China and overseas, here we present the correlation of a conductivity anomaly with the ionic composition and establish a model for the formation of conductivity anomalies in soil cover. The results indicate that the formation of a conductivity anomaly is not a simple transformation of a secondary geochemical anomaly. A conductivity anomaly is formed as the result of electrochemical and chemical processes, by transformation of orebody into various ionic haloes through four physicochemical processes: 1) dissolution of the orebody, 2) migration of dissolved matter, 3) conversion of matter near the surface, and 4) the formation of ionic conductivity anomalies. The conductivity anomaly, as a physical parameter, essentially represents the integration of various geochemical compositions and is controlled by a set of particular ionic groups.

关键词： ionic conductivity regolith mineralisation exploration

Synthesis of liSm_(0.01)Mn_(1.99)O_4 by molten salt technique

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Journal of Rare Earths 2010年第2期28卷 255-259页

作者： M Helan l john Berchmans Department of Chemistry Jamal Mohamed College (Autonomous) Electropyrometallurgy Division Central Electrochemical Research Institute

Samarium substituted lithium manganese oxide powders were successfully prepared by molten-salt synthesis(MSS) using eutectic mixture of liCl,SmCl3.6H2O and MnO2 salt at 700 °*** synthesis was carried out in open *** crystalline powders were characterized for their phase identification using X-ray diffraction(XRD) *** physico-chemical properties of the samarium substituted lithium manganese oxide powders were investigated by thermal analysis(TGA/DTA),FT-IR spectroscopy,EDAX,electron par...

关键词： liSm0.01Mn1.99O4 molten salt synthesis cathode materials rare earth ion

Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen lin Wen-Feng Fang Jui-Ning Yeh john Y Chiang Hsin-Ju Chiang Pei-lin Shao Pei-Hsun Sung Hon-Kan Yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including l2 cells treated with lipopolysaccharide(lPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-l2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(Plevels of inflammation[interleukin(Il)-1β/tumor necrosis factor(TNF)-α/nuclear factor-κB/toll-like receptor(TlR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(lPS)-treated l2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all Pls were euthanized by 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all Pl oxygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

Configuration-Sensitive Molecular Sensing on Doped Graphene Sheets

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Nano Research 2010年第7期3卷 472-480页

作者： john Russell Petr Král Department of Chemistry University of Illinois at ChicagoChicagoIL 60607USA

We show by molecular dynamics simulations that configuration-sensitive molecular spectroscopy can be realized on optimally doped graphene sheets vibrated by an oscillatory electric *** selectivity of the spectroscopy is achieved by maximizing Coulombic binding between the detected molecule and a specific nest,formed for this molecule on the graphene sheet by substituting selected carbon atoms with boron and nitrogen *** can detect binding of different isomers to the nest from the frequency shifts of selected vibrational modes of the combined *** an illustrative example,we simulate detection of hexanitrostilbene enantiomers in chiral nests formed on graphene.

关键词： Molecular sensing enantiomer graphene functionalization molecular dynamics

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang liu Junya Fujimoto lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina McDowell luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning le Natalie I Vokes Chao Cheng john V.Heymach Don l.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSClC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

Integration of the Coupled Orbit-Attitude Dynamics Using Modified Chebyshev-Picard Iteration Methods

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Computer Modeling in Engineering & Sciences 2016年第2期111卷 129-146页

作者： Xiaoli Bai john l.Junkins Rutgers The State University of New JerseyPiscatawayNJU.S.A Texas A&M College StationTXU.S.A

This paper presents Modified Chebyshev-Picard Iteration(MCPI)methods for long-term integration of the coupled orbit and attitude *** most orbit predictions for operational satellites have assumed that the attitude dynamics is decoupled from the orbit dynamics,the fully coupled dynamics is required for the solutions of uncontrolled space debris and space objects with high area-to-mass ratio,for which cross sectional area is constantly changing leading to significant change on the solar radiation pressure and atmospheric *** is a set of methods for solution of initial value problems and boundary value *** methods refine an orthogonal function approximation of long-time-interval segments of state trajectories iteratively by fusing Chebyshev polynomials with the classical Picard iteration and have been applied to multiple challenging aerospace *** the studies on integrating a torque-free rigid body rotation and a long-term integration of the coupled orbit-attitude dynamics through the effect of solar radiation pressure,MCPI methods are shown to achieve several times speedup over the Runge-Kutta 7(8)methods with several orders of magnitudes of better *** methods are further optimized by integrating the decoupled dynamics at the beginning of the iteration and coupling the full dynamics when the attitude solutions and orbit solutions are converging during the *** approach of decoupling and then coupling during iterations provides a unique and promising perspective on the way to warm start the solution process for the longterm integration of the coupled orbit-attitude ***,an attractive feature of MCPI in maintaining the unity constraint for the integration of quaternions within machine accuracy is illustrated to be very appealing.

关键词： Orbit propagation orbit-attitude dynamics Modified Chebyshev-Picard Iteration(MCPI)Methods