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Short Review of Ischemia- and Hypoxia-Protective Roles of “Big Potassium” (BK) Channels

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Journal of Biosciences and Medicines 2021年第6期9卷 150-160页

作者： john F. Peppin Joseph V. Pergolizzi Alexander kraus Robert B. Raffa Marian University College of Osteopathic Medicine Indianapolis USA Pikeville University College of Osteopathic Medicine Pikeville Kentucky USA Enalare Therapeutics Inc. Princeton USA NEMA Research Inc. Naples USA Neumentum Inc. Morristown USA University of Arizona College of Pharmacy Tucson USA Temple University School of Pharmacy Philadelphia USA

There is accumulating evidence that the subfamily of large-conductance potassium (“big”, “BK”) channels are involved in diverse, and perhaps coordinated, protective or counteractive responses to local or generalized ischemia and hypoxia. Although widely distributed, the physiological differences among BK channels which results from posttranslational modification (alternative splicing) and co-assembly with auxiliary modulatory subunits (β1-4 and γ1-4), bestows localized differences in subunit composition, distribution, 2nd-messenger coupling, and pharmacologic properties. Due to the ubiquitous nature of BK channels and the multiplicity of subtypes, they have many potential therapeutic applications in the maintenance of oxygen homeostasis, cerebro- and cardio-protection, and stimulation of respiration in response to drug-induced respiratory depression. BK channels may also offer other potentially broad and underrecognized promising targets for novel pharmaceutical development.

关键词： Big potassium Channels BKCa Ischemia Hypoxia Respiratory Stimulation ENA-001

改进高校IT服务支持混合工作模式——EDUCAUSE 2023年度十大IT议题(五)

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中国教育网络 2023年第4期 42-44页

作者： Brian Basgen Adrian Ellison Curt Hillegas Pekka Kahkipuro Leah kraus john Stroud David Ayersman Barron Koralesky Emma Woodcock 杨望(译) 不详东南大学

EDUCAUSE日前发布了《2023年度十大IT议题:基础模型》报告,描述了高校未来将如何发展的基础模型(FoundationModels),这些模型由领导力、数据、工作和学习三个主题构建而成。与人工智能的基础模型一样,高等教育的基础模型会带来巨大好处... 详细信息

EDUCAUSE日前发布了《2023年度十大IT议题:基础模型》报告,描述了高校未来将如何发展的基础模型(FoundationModels),这些模型由领导力、数据、工作和学习三个主题构建而成。与人工智能的基础模型一样,高等教育的基础模型会带来巨大好处,可能代表着学校前进的最佳路线。本刊将逐期刊载该报告。

关键词：人工智能 EDUCAUSE IT服务最佳路线基础模型高等教育领导力主题构建

系统评价类综述与普通综述:标准及复杂性探究

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中华耳鼻咽喉头颈外科杂志 2021年第7期56卷 687-690页

作者： Robert T.Sataloff Matthew L.Bush Rakesh Chandra Douglas Chepeha Brian Rotenberg Edward W.Fisher David Goldenberg Ehab Y.Hanna Joseph E.Kerschner Dennis H.kraus john H.Krouse Daqing Li Michael Link Lawrence R.Lustig Samuel H.Selesnick Raj Sindwani Richard J.Smith James R.Tysome Peter C.Weber D.Bradley Welling 张心浩(译) 刘争(译) Department of Otolaryngology-Head and Neck Surgery Drexel University College of MedicinePhiladelphiaPennsylvaniaUSA Department of Otolaryngology University of KentuckyLexingtonKentuckyUSA Department of Otolaryngology Vanderbilt University Medical CenterNashvilleTennesseeUSA Faculty of Medicine Department of Otolaryngology-Head and Neck SurgeryUniversity of TorontoTorontoOntarioCanada Department of Otolaryngology-Head and Neck Surgery Western UniversityTorontoOntarioCanada Department of Otolaryngology Cambridge University PressCambridgeUK Department of Otolaryngology-Head and Neck Surgery Pennsylvania State University College of MedicineHersheyPennsylvaniaUSA Department of Head and Neck Surgery The University of Texas M D.Anderson Cancer CenterHoustonTexasUSA Department:of Otolaryngology Medical College of WisconsinMilwaukeeWisconsinUSA Department of Otolaryngology-Head and Neck Surgery Northwell HealthNew YorkNew YorkUSA Department of Otolaryngology University of Texas Rio Grande Valley School of MedicineBrownsvilleTexasUSA Department of Otorhinolaryngology-Head and Neck Surgery Hospital of the University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department:of Radiation Oncology Mayo CinicRochesterMinnesotaUSA Department of Otolaryngology Columbia University Medical CenterNew YorkNew YorkUSA Department of Otolaryngology Weill Cornell Medical College of Cornell UniversityNew YorkNew YorkUSA Cleveland Clinic Head and Neck InstituteClevelandOhioUSA Department of Otolaryngology-Head and Neck Surgery The University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Otolaryngology Cambridge University Hospitals NHS Foundation TrustCambridgeUK Mount Sinai Health System New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery Harvard UniversityCambridgeMassachusettsUSA 华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科

本文是由Robert ***,Ehab ***,李大庆教授等20余位耳鼻咽喉头颈外科领域知名期刊主编共同撰写的一篇针对系统评价等不同类型综述文章标准及复杂性分析的述评类文章。该文章将于2021年7月在包括《世界耳鼻咽喉头颈外科杂志(英文)》,Journ... 详细信息

本文是由Robert ***,Ehab ***,李大庆教授等20余位耳鼻咽喉头颈外科领域知名期刊主编共同撰写的一篇针对系统评价等不同类型综述文章标准及复杂性分析的述评类文章。该文章将于2021年7月在包括《世界耳鼻咽喉头颈外科杂志(英文)》,Journal of Voice,Head&Neck,American Journal of Rhinology&Allergy,The Laryngoscope等20余本国际知名耳鼻咽喉头颈外科期刊同时以英文版本刊出,为了便于中国读者对该内容进行深入了解,在获得相应授权后,本刊特别邀请刘争教授团队对该文章进行翻译,同期在本刊以中文版本刊登。希望本文对广大读者在撰写综述类文章时有所裨益。

关键词：耳鼻咽喉头颈外科中文版本复杂性分析期刊主编英文版本李大庆综述类文章评价类

Systematic and other reviews: Criteria and complexities

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第3期7卷 236-239页

作者： Robert T.Sataloff Matthew L.Bush Rakesh Chandra Douglas Chepeha Brian Rotenberg Edward W.Fisher David Goldenberg Ehab Y.Hanna Joseph E.Kerschner Dennis H.kraus john H.Krouse Daqing Li Michael Link Lawrence R.Lustig Samuel H.Selesnick Raj Sindwani Richard J.Smith James R.Tysome Peter C.Weber D.Bradley Welling Department of Otolaryngology-Head and Neck Surgery Drexel University College of MedicinePhiladelphiaPennsylvaniaUSA Department of Otolaryngology University of KentuckyLexingtonKentuckyUSA Department of Otolaryngolosy Vanderbilt University Medical CenterNashvilleTennesseeUSA Faculty of Medicine Deportment of Otolaryngology-Head and Neck SurseryUniversity of TorontoTorontoOntarioCanada Department of Otolaryngology·Head and Neck Surgery Western UniversityTorontoOntarioCanada Department of Otolaryngology Cambridge University PressCambridgeUK Department of Otolaryngology-Head and Neck Surgery Pennsylvania State University College of MedicineHersheyPennsylvaniaUSA Department of Head and Neck Surgery The University of Texas M.D.Anderson Cancer CenterHoustonTexasUSA Department of Otolaryngology Medical College of WisconsinMilwaukeeWisconsinUSA Department of Otolaryngology-Head and Neck Surgery Northwell HealthNew YorkNew YorkUSA Department of Otolaryngology University of Texas Rio Grande Valley School of MedicineBrownsvilleTexasUSA Department of Otorhinolaryngology·Head and Neck Surgery Hospital of the University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Radiation Oncology Mayo ClinicRochesterMinnesotaUSA Department of Otolaryngology Columbia University Medical CenterNew YorkNew YorkUSA Department of Otolarynsology Weill Cornell Medical College of Cornell UniversityNew YorkNew YorkUSA Cleveland Clinic Head and Neck InstituteClevelandOhioUSA Department of Otolaryngology·Head and Neck Surgery The University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Otolarynsolosy Cambridge University Hospitals NHS Foundation TrustCambridgeUK Mount Sinai Health System New YorkNew YorkUSA Department of Otolaryngology·Head and Neck Surgery Harvard UniversityCambridgeMassachusettsUSA

Review articles can be extremely *** synthesize information for readers,often provide clarity and valuable insights into a topic;and good review articles tend to be cited *** articles do not require Institutional Review Board(IRB)approval if the data reviewed are public(including private and government databases)and if the articles reviewed have received IRB approval previously.

关键词： approval insight valuable

文献快报(7):电子产品使用可影响学龄前儿童脑发育

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中国学校卫生 2020年第8期41卷 I0001-I0001页

作者： HUTTON J S DUDLEY J HOROWITZ-kraus T 孙莹(译) 不详安徽医科大学公共卫生学院儿少卫生与妇幼保健学系

美国儿科学会(AAP)认为,视屏时间过多可影响儿童语言、睡眠、执行功能和认知功能的发育及干扰亲子联结的建立等,2~5岁儿童高质量节目的屏幕使用时间限制为每天1 h。辛辛那提儿童医院医学中心的john Hutton博士领导的研究团队招募了47名... 详细信息

美国儿科学会(AAP)认为,视屏时间过多可影响儿童语言、睡眠、执行功能和认知功能的发育及干扰亲子联结的建立等,2~5岁儿童高质量节目的屏幕使用时间限制为每天1 h。辛辛那提儿童医院医学中心的john Hutton博士领导的研究团队招募了47名3~5岁健康儿童及其父母(幼儿完成标准认知测试并进行弥散张量成像检查,评估脑白质的完整性;幼儿父母填写包含15项的筛查工具Screen Q,反映幼儿电子产品使用情况)。

关键词：弥散张量成像美国儿科学会电子产品儿童语言儿童医院脑发育认知功能脑白质