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Characterizing drought in Calif.rnia:new drought indices and scenario-testing in support of.resource management

Ecological Processes 2018年第1期7卷 1-13页

作者： Lorraine E.f.int Alan L.f.int john Mendoza Julie Kalansky f.M.Ralph U.S.Geological Survey 6000 J.StSacramentoCA 95819USA Sonoma County Water Agency 404 Aviation Dr.Santa RosaCA 95403USA Scripps Institution of.Oceanography 9500 Gilman Dr.La JollaCA 92093USA

Introduction:Calif.rnia’s recent drought(2012–2016)has implications throughout the state f.r natural resource management and adaptation planning and has generated many discussions about drought characterization and *** study characterizes drought conditions with two indices describing def.cits in natural water supply and increases in landscape stress developed on the basis of.water balance modeling,at a f.ne spatial scale to assess the variation in conditions across the entire state,and provides an in-depth evaluation f.r the Russian River basin in northern Calif.rnia to address local resource management by developing extreme drought scenarios f.r consideration in planning and ***:We employed the USGS Basin Characterization Model to characterize drought on the basis of.water supply(a measure of.recharge plus runof.)and landscape stress(climatic water def.cit).These were applied to the state and to the Russian River basin where antecedent soil moisture conditions were evaluated and extreme drought scenarios were developed and run through a water management and reservoir operations model to f.rther explore impacts on water ***:Drought indices indicated that as of.the end of.water year 2016 when reservoirs were f.ll,additional water supply and landscape replenishment of.up to three average years of.precipitation in some locations was needed to return to normal *** soil conditions in the Russian River were determined to contribute to very dif.erent water supply results f.r dif.erent years and were necessary to understand to anticipate proper watershed response to *** drought scenarios manif.sted very dif.erent kinds of.drought and recovery and characterization helps to guide the management response to ***:These scenarios and indices illustrate how droughts dif.er with regard to water supply and landscape stress and how long warm droughts recover much more slowly than short very dry dro

关键词： Calif.rnia drought Russian River Water supply Basin Characterization Model

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驾驭交易

驾驭交易

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作者： (美)约翰·f. 卡特(john f. Carter)

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薄板木质材料剪切模量的动态检测

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北京林业大学学报 2012年第2期34卷 137-140页

作者：闫海成张厚江 john f. Hunt 廖春晖傅峰北京林业大学工学院美国农业部林产品实验室中国林业科学研究院木材工业研究所

为实现薄板木质材料剪切模量的快捷检测,提出了一种悬臂梁自由振动的方法——悬振法,即通过测量试件在悬臂自由振动时的第一阶固有频率和衰减振动波形的对数减幅系数,来检测材料的剪切模量。利用自行研制的薄板类木质材料力学性能快速... 详细信息

为实现薄板木质材料剪切模量的快捷检测,提出了一种悬臂梁自由振动的方法——悬振法,即通过测量试件在悬臂自由振动时的第一阶固有频率和衰减振动波形的对数减幅系数,来检测材料的剪切模量。利用自行研制的薄板类木质材料力学性能快速测量仪,对4种材质、6种规格的薄板木质材料试件进行了检测试验,且将测得的剪切模量与试件的弯曲弹性模量进行了相关性分析。结果表明:悬振法测得的剪切模量与材料弯曲弹性模量间存在非常显著的线性相关关系。

关键词：薄板木质材料悬振法剪切模量弹性模量对数减幅系数

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Role of.Mg on Structure and Mechanical Properties in Alloy 718

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工程科学学报 1989年第6期11卷 560-567页

作者：徐志超 ,谢锡善 ,屈波 ,陈国良 ,Radavich john f 北京科技大学北京 School of.Materials Engineering Purdue University

The role of.Mg in alloy/718 has been systematically investigated. Mg raises not only high temperature tensile and stress-rupture ductilities but also increases considerably smooth and notch stress-rupture lif.. Mg containing alloy 718M is f.ee of.stress-rupture notch sensitivity. Mg improves creep and f.tigue interaction properties (LCf.or cyclic stress rupture) at any grain size. The basic role of.Mg is equilibrium segregation at grain boundaries which helps to change continuous grain beundary (5-Ni3Nb morphology to discrete globular f.rm which has a retardation ef.ect on intergranular f.acture. Mg promotes the change f.om intergranular to transgranular f.acture mode.

关键词： superalloy creep and f.tigue mechanical properties

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Contemporary diagnostics and treatment options f.r f.male stress urinary incontinence

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Asian Journal of.Urology 2018年第3期5卷 141-148页

作者： Allert M.de Vries john P.f.A.Heesakkers Department of.Urology Radboud University Medical CenterNijmegenThe Netherlands

Stress urinary incontinence is not a deadly disease,but f.r the large population of.women suf.ering f.om it,it is a very important *** in the continuously aging population all over the world,there is more and more need f.r treatment of.this serious medical *** of.f.male stress urinary incontinence exists already f.r *** the 20th century invasive treatments like Burch colposuspension and pubovaginal slings were the mainstay of.surgical *** introduction of.the midurethral sling made the procedure less invasive and accessible f.r more *** there are many options available and the f.eld is developing *** recent years many new medical devices have been developed,that increase the number of.treatment options available and make it possible to f.nd a suitable solution f.r the individual patient based on subjective and objective results and the chances of.*** manuscript provides an introduction to the therapeutical options that are available nowadays f.r f.male stress urinary incontinence.

关键词： f.male Stress urinary incontinence Treatment Urinary incontinence Pelvic f.oor muscle training Suburethral slings

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Kinase inhibitors:look beyond the label on the bottle

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Cancer Drug Resistance 2019年第4期2卷 1032-1043页

作者： Paul Dent Andrew Poklepovic Laurence Booth john f.Hancock Department of.Biochemistry and Molecular Biology1 Virginia Commonwealth UniversityRichmondVA 23298-0035USA Department of.Medicine Virginia Commonwealth UniversityRichmondVA 23298-0035USA Department of.Integrative Biology and Pharmacology University of Texas Health Science CenterHoustonTX 77030USA

The majority of.scientists working in the f.eld of.cancer experimental therapeutics recognize that many drugs that claim to be“specif.c”f.r one target enzyme in f.ct regulate to varying degrees the activities of.other additional protein *** of.these targets are known and are recognized as being an essential component of.a drug’s ***,many other targets f.ll into the category of.unknown unknowns”.Thus,the collective therapeutic outcome f.r almost all clinically relevant drugs is reliant on both the claimed primary and secondary“on”targets as well as some of.the unexpected unknown“of.”*** review discusses the biology of.several f.A approved cancer therapeutic drugs whose initial reported targets only represented the tip-of.the-iceberg in terms of.how each agent acted as an anti-tumor *** review also discusses a putative thorough pre-visualization methodology f.r drug-based research,prior to executing any wet *** approaches should be perf.rmed in an agnostic f.shion and be based in part on the clinically saf. drug’s C max and its area under the curve in a *** on tumor heterogeneity,considerations of.how to approach developmental therapeutics in the age of.personalized medicine”are also discussed.

关键词： Autophagy histone deacetylase chaperone cancer

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Rapid Appraisal of.User Stakeholders f.r f.rest Recreation Area Planning: The Little Molas Case

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Open Journal of.f.restry 2012年第3期2卷 167-173页

作者： john P. Titre Allan S. Mills Cf.Mark f. Mallaney Department of.Anthropology University of Colorado at Boulder Boulder USA L. Douglas Wilder School of.Government and Public Af.airs Virginia U.S.D.A. f.rest Service Ft. Collins USA

Public f.rest recreation area planning is of.en conf.onted by conf.icting stakeholder views of.what actions are most appropriate f.r improving outdoor recreation areas. Contemporary users of.an outdoor recreation area are of.en inadequately represented in these planning decisions, due to the high cost and time required f.r user surveys that have traditionally been used to represent these stakeholders. A case example of.the application of.an alternative research method termed rapid appraisal (RA) is described. Data collected using rapid appraisal was used to help resolve disagreements on f.ture planning and development options f.r the Little Molas Recreation Area (LMRA). The entire RA process was completed in one month’s time, with results which provided a reliable stakeholder supplement to working group recommendations to the f.rest Service f.r their proposed LMRA redevelopment plan.

关键词： Recreation Planning Outdoor Recreation f.rest Recreation Rapid Appraisal

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机构动态仿真使用MATLAB和SIMULINK

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丛书名： Book Ware系列丛书

2002年

作者：（美）约翰·f.加德纳（john f. Gardner）周进雄张陵译

本书提出了利用MATLAB和Simulink工具箱在计算机上解决机构动态建模及仿真问题的分析思路、方法、MATLAB脚本和Simulink仿真模块框图，以及供学生自主学习研讨的习题。

ISBN: (数字)7560515649

ISBN: (纸本)7560515649

关键词：计算机辅助计算软件包MATLABSimulink

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Optical read-out and modulation of.peripheral nerve activity

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Neural Regeneration Research 2018年第1期13卷 58-61页

作者： Arjun K.f.ntaine Hans E.Anderson john H.Caldwell Richard f.Weir Department of.Bioengineering University of Colorado – Anschutz Medical Campus Department of.Cell and Developmental Biology University of Colorado – Anschutz Medical Campus

Numerous clinical and research applications necessitate the ability to interf.ce with peripheral nerve f.bers to read and control relevant neural pathways. Visceral organ modulation and rehabilitative prosthesis are two areas which could benef.t greatly f.om improved neural interf.cing approaches. Therapeutic neural interf.cing, or ‘bioelectronic medicine’, has potential to af.ect a broad range of.disorders given that all the major organs of.the viscera are neurally innervated. However, a better understanding of.the neural pathways that underlie f.nction and a means to precisely interf.ce with these f.bers are required. Existing peripheral nerve interf.ces, consisting primarily of.electrode-based designs, are unsuited f.r highly specif.c （individual axon） communication and/or are invasive to the tissue. Our laboratory has explored an optogenetic approach by which optically sensitive reporters and actuators are targeted to specif.c cell （axon） types. The nature of.such an approach is laid out in this short perspective, along with associated technologies and challenges.

关键词： peripheral nerve interf.ce optogenetics bioelectronic medicine prosthesis control adeno-associated virus GCaMP

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Bioartif.cial liver assist devices in support of.patients with liver f.ilure

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Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 18-25页

作者： john f.PatzerⅡ Roberto C.Lopez George V.Mazariegos john J.f.ng f.om the Thomas E Starzl Transplantation Institute

Bioartif.cial liver assist devices (BALs) of.er anopportunity f.r critical care physicians and transplantsurgeons to stabilize patients prior to orthotopic livertransplantation. Such devices may also act as a bridgeto transplant, providing liver support to patientsawaiting transplant, or as support f.r patients post liv-ing-related donor transplant. f.ur BAL devices thatrely on hepatocytes cultured in hollow f.ber membranecartridges (Circe Biomedical HepatAssist (r), VitagenELADTM, Gerlach BELS, and Excorp Medical BLSS)are currently in various stages of.clinical evalua-tion. Comparison of.the f.ur devices shows that severalunique approaches based upon the same overall systemarchitecture are possible. Preliminary results of.theExcorp Medical BLSS Phase I saf.ty evaluation at theUniversity of.Pittsburgh, af.er treating f.ur patients(f. 41, acetominophen-induced, two support periods;M, 50, Wilson's disease, one support period; f. 53, a-cute alcoholic hepatitis, two support periods; f. 24,chemotherapy-induced, one support period) are pre-sented. All patients presented with hypoglycemia andtransient hypotension at the start of.extracorporealperf.sion. Hypoglycemia was treated by IV dextroseand the transient hypotension responded positively toIV f.uid bolus. Heparin anticoagulation was used onlyin the second patient. No serious or adverse eventswere noted in the f.ur patients. Moderate biochemicalresponse to support was noted in all patients. Morecomplete characterization of.the saf.ty of.the BLSSrequires completion of.the Phase I saf.ty evaluation.

关键词： bioartif.cial liver acute liver f.ilure hepatocytes

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