检索结果-南通市图书馆

Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere damage repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of.Molecular Cell Biology 2024年第3期16卷 46-60页

作者： Katrina N.Estep john W.Tobias Raf.el J.f.rnandez Brinley M.Beveridge f.Brad johnson Department of.Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPA 19104USA Quantiative Biosciences Merck&Co.Inc.West PointPA 19486USA Penn Genomic Analysis Core University of PennsylvaniaPhiladelphiaPA 19104USA

Although mechanisms of.telomere protection are well-def.ned in dif.erentiated cells,how stem cells sense and respond to telomere dysf.nction,in particular telomeric double-strand breaks(DSBs),is poorly ***,we report the DNA damage signaling,cell cycle,and transcriptome changes in human induced pluripotent stem cells(iPSCs)in response to telomere-internal *** engineer human iPSCs with an inducible TRf.-f.kI f.sion protein to acutely induce DSBs at *** this model,we demonstrate that TRf.-f.kI DSBs activate an ATR-dependent DNA damage response,which leads to p53-independent cell cycle arrest in *** CRISPR–Cas9 to cripple the catalytic domain of.telomerase reverse transcriptase,we show that telomerase is largely dispensable f.r survival and lengthening of.TRf.-f.kI-cleaved telomeres,which instead are ef.ectively repaired by robust homologous recombination(HR).In contrast to HR-based telomere maintenance in mouse embryonic stem cells,where HR causes ZSCAN4-dependent extension of.telomeres beyond their initial lengths,HR-based repair of.telomeric breaks is suf.icient to maintain iPSC telomeres at a normal length,which is compatible with sustained survival of.the cells over several days of.TRf.-f.kI *** f.ndings suggest a previously unappreciated role f.r HR in telomere maintenance in telomerase-positive iPSCs and reveal distinct iPSC-specif.c responses to targeted telomeric DNA damage.

关键词： telomeres telomerase alternative lengthening of.telomeres pluripotent stem cells DNA damage double-strand breaks

Boron neutron capture therapy of.cancer:where do we stand now?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第8期44卷 889-892页

作者： Rolf.f.Barth Gong Wu Maria da Graca H.Vicente john C Grecula Nilendu Gupta Department of.Pathology The Ohio State UniversityColumbusOhioUSA Mass Spectrometry and Proteomics f.cility The Ohio State UniversityColumbusOhioUSA Department of.Chemistry Louisiana State UniversityBaton RougeLouisianaUSA Department of.Radiation Oncology The Ohio State UniversityColumbusOhioUSA

1 INTRODUCTION,This is the third Editorial/Commentary that one of.us(***)has written relating to boron neutron capture therapy(BNCT)[1,2].f.r those readers who are unf.miliar with BNCT we would ref.r them to several recent comprehensive reviews[3–5].The second Editorial ended on a hopef.l note that with the introduction of.acceleratorbased neutron sources(ABNSs),BNCT would enter into the mainstream of.radiation therapy[2].

关键词： boron 1,2 neutron

Optimization of.Stealthwatch Network Security System f.r the Detection and Mitigation of.Distributed Denial of.Service (DDoS) Attack: Application to Smart Grid System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications and Network 2024年第3期16卷 108-134页

作者： Emmanuel S. Kolawole Penrose S. Cof.e john H. f.ller Cajetan M. Akujuobi Emmanuel A. Dada Justin f. f.reman Pamela H. Obiomon Electrical and Computer Engineering Department Prairie View A&M University Prairie View TX USA

The Smart Grid is an enhancement of.the traditional grid system and employs new technologies and sophisticated communication techniques f.r electrical power transmission and distribution. The Smart Grid’s communication network shares inf.rmation about status of.its several integrated IEDs (Intelligent Electronic Devices). However, the IEDs connected throughout the Smart Grid, open opportunities f.r attackers to interf.re with the communications and utilities resources or take clients’ private data. This development has introduced new cyber-security challenges f.r the Smart Grid and is a very concerning issue because of.emerging cyber-threats and security incidents that have occurred recently all over the world. The purpose of.this research is to detect and mitigate Distributed Denial of.Service [DDoS] with application to the Electrical Smart Grid System by deploying an optimized Stealthwatch Secure Network analytics tool. In this paper, the DDoS attack in the Smart Grid communication networks was modeled using Stealthwatch tool. The simulated network consisted of.Secure Network Analytic tools virtual machines (VMs), electrical Grid network communication topology, attackers and Target VMs. f.nally, the experiments and simulations were perf.rmed, and the research results showed that Stealthwatch analytic tool is very ef.ective in detecting and mitigating DDoS attacks in the Smart Grid System without causing any blackout or shutdown of.any internal systems as compared to other tools such as GNS3, NeSSi2, NISST f.amework, OMNeT++, INET f.amework, ReaSE, NS2, NS3, M5 Simulator, OPNET, PLC & TIA Portal management Sof.ware which do not have the capability to do so. Also, using Stealthwatch tool to create a security baseline f.r Smart Grid environment, contributes to risk mitigation and sound security hygiene.

关键词： Smart Grid System Distributed Denial of.Service (DDoS) Attack Intrusion Detection and Prevention Systems Detection Mitigation and Stealthwatch

Artif.cial light at night(ALAN) pollution alters bat lunar chronobiology:insights f.om broad-scale long-term acoustic monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2024年第1期13卷 176-187页

作者： Han Li Pauline Allen Saige Boris Samantha Lagrama Jade Lyons Christina Mills Pauline Moussi Casey Nichols Carter Tacosik Mc Kenzie Tsaousis Nyzaya Livingston Wilson john f.Grider Kevin A.Parker Matina C.Kalcounis-Rueppell Department of.Biology University of Nebraska Omaha Department of.Biology University of North Carolina Greensboro Colorado Parks and Wild-lif. Parker Ecology LLC Department of.Biological Sciences University of Alberta

Background The timing of.behavior and habitat use of.nocturnal animals can be inf.uenced by the lunar cycle in nature. The prevalence of.artif.cial light at night(ALAN) has been recognized as a source of.environmental pol-lution. The interaction between ALAN and the lunar cycle on bat behavior is important f.r understanding anthro-pogenic ef.ects on bats. We utilized a decade(2012–2022) of.acoustic monitoring data collected in North Carolina, United States, to investigate the relationship between bat activity, lunar cycle, and light pollution. We examined whether the amount of.lunar illumination af.ected species-specif.c nightly activity and whether hourly bat activity patterns varied between nights with dif.erent moon phases. We f.rther investigated if.the relationship between bat activity and the lunar cycle might be altered by light *** We f.und that seven bat species showed activity variation across nights in relation to the amount of.moon illumination when ALAN was absent. In general, bats were less active on f.ll moon nights compared to new moon nights. Light pollution interacted with the bat–lunar relationship in f.ve of.the seven species, masking the ef.ect of.the lunar cycle. We identif.ed delayed bat activity patterns on nights with a f.ll or waxing moon in seven species, and light pollution altered that pattern in f.ur species. Overall, ALAN was associated with decreased bat activity inde-pendent of.lunar cycle *** Our study demonstrated that at a broad spatial scale, ALAN negatively af.ected many North American temperate bat species and altered their lunar chronobiology. As light pollution is spreading to historically dark areas and habitats, ALAN might couple with other threats, such as the white-nose syndrome or climate change, to cause cascading damage in the environment that depends on ecosystem services such as pest control provided by bats. We argue that f.rther research and conservation actions are needed to mitigate

关键词： Artif.cial light at night ALAN Bats Chiroptera Chronobiology Light pollution Lunar cycle Moonlight

The Making of.a Health Prof.ssion:How Chinese Medicine Became a Nationally Registered Allied Health Prof.ssion in Australia

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medicine and Culture 2024年第1期7卷 51-62页

作者： john L McDonald Judy B James School of.Chinese Medicine Endeavour College of Natural HealthSouthport 4215Australia Acupuncture now Australia Brisbane 4120Australia

In 2012, traditional Chinese medicine(TCM) practitioners in Australia became nationally-registered allied health prof.ssionals in three categories: acupuncturist, Chinese herbal medicine practitioner, and Chinese herbal medicine dispenser. Australia was the f.rst Western country to introduce national registration f.r Chinese medicine, f.llowed by Portugal and, recently, New Zealand. The practice of.TCM in Australia can be traced back to the beginning of.Chinese immigration to Australia during the Victorian Gold Rush which began in the 1850s. The process which led to national registration commenced in the early 1970s with the establishment of.the f.rst acupuncture courses. Decades of.gradual development of.courses f.om unaccredited part-time diplomas to accredited bachelor degrees, and the development, by the prof.ssion, of.national consensus on educational standards were essential elements in the process which led to registration. Prof.ssional associations, such as the Australian Acupuncture and Chinese Medicine Association Ltd.(AACMA), also developed a f.amework of.prof.ssional self.egulation, including Codes of.Ethics, Codes of.Conduct, ongoing prof.ssional development requirements and Inf.ction Control Guidelines, and provided leadership in the development of.the prof.ssion. Af.er decades of.tribalism and division within the TCM prof.ssion, the National Academic Standards Committee brought almost all stakeholders together to reach a consensus on the Australian Guidelines f.r Traditional Chinese Medicine Education which were published by AACMA in 2001. Prof.ssional associations also collaborated on joint submissions to the government in support of.registration, which was introduced f.rst in the state of.Victoria in 2000, and subsequently became national in 2012. Despite national registration, some barriers still remain, and prof.ssional associations continue to lobby the f.deral government f.r inclusion in Medicare, chronic disease management scheme, and Veterans

关键词： Acupuncture Chinese medicine Registration Regulation Education Standards Australia TCM

Impact of.COVID-19 pandemic on cardiovascular health in sedentary and athletes:Consensus,uncertainties,and ways f.r mitigation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sports Medicine and Health Science 2024年第3期6卷 205-208页

作者： john C.Quindry Lei Xi School of.Integrative Physiology and Athletic Training University of MontanaMissoulaMT59812USA Pauley Heart Center Department of Internal MedicineSchool of MedicineVirginia Commonwealth UniversityRichmondVA23298-0204USA

More than 4 years has elapsed since the World Health Organization(WHO)of.cially announced the coronavirus disease 2019(COVID-19)as a pandemic outbreak in March 11,*** the ongoing investigations and political debates upon the origin,exacerbation,resurgence,andﬁnal control of.COVID-19,medical and scientiﬁc consensus indicates that the now endemic COVID-19 virus is one of.the worst public health crises in our *** every person on earth has been directly or indirectly impacted by the adverse ef.ects of.the highly contagious viral pathogen-SARS-CoV-2(severe acute respiratory syndrome coronavirus 2).Indeed,the population reach of.the COVID-19 inf.ction includes governmental response measures(e.g.,lockdowns and social distancing,mandates f.r masks and f.ce coverings,vaccines,etc.)that have restricted entrenched societal routines,personal mobility,and ***,the host of.health problems linked to this viral inf.ction linger to this day,with selective groups of.people experiencing a higher risk f.r untoward medical outcomes and/or elevated levels of.vulnerability to the post-acute sequelae of.COVID-19(***-COVID).f.r example,a 2021 study by Logue et *** initial evidence that 10%–30%of.individuals in United States may experience prolonged symptoms f.llowing SARS-CoV-2 inf.ction,including cardiovascular abnormalities.1 Similarly,a 2021 retrospective cohort study in England suggest that the incidence of.major adverse cardiovascular events(*** f.ilure,myocardial inf.rction,ischemic stroke.

关键词： cardiovascular routine Impact

Managerial perspectives of.scaling up robotic-assisted surgery in healthcare systems:A systematic literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 113-122页

作者： Ravichandran Anitha Komattu Chacko john Gnanadhas Jabarethina Sri Ramachandra f.culty of.Management Sciences Sri Ramachandra Institute of Higher Education and Research(Category-I Deemed to be University)ChennaiIndia

Objectives Robotic-assisted surgery(RAS)is a minimally invasive technique practiced in multiple *** training is essential f.r the acquisition of.RAS *** cost of.RAS is considered to be high,which makes it a burden f.r institutes and unaf.ordable f.r *** systematic literature review(SLR)f.cused on the various RAS training methods applied in dif.erent surgical specialties,as well as the cost elements of.RAS,and was to summarize the opportunities and challenges associated with scaling up *** An SLR was carried out based on the Pref.rred Reporting Items f.r Systematic reviews and Meta-Analyses reporting *** PubMed,EBSCO,and Scopus databases were searched f.r reports f.om January 2018 through January ***-text reviews and research articles in the English language f.om Asia-Pacif.c countries were *** that outlined training and costs associated with RAS were *** The most common training system is the da Vinci *** simulation technique,which includes dry-lab,wet-lab,and virtual reality training,was f.und to be a common and important *** cost of.RAS encompasses the installation and maintenance costs of.the robotic system,the operation theatre rent,personnel cost,surgical instrument and material cost,and other miscellaneous *** synthesis of.SLR revealed the challenges and opportunities regarding RAS training and *** The results of.this SLR will help stakeholders such as decision-makers,inf.uencers,and end users of.RAS to understand the signif.cance of.training and cost in scaling up RAS f.om a managerial *** any healthcare innovation to reach a vast population,cost-ef.ectiveness and standard training are crucial.

关键词： da Vinci system Healthcare Robotic-assisted surgery Robotic surgery Robotic training Robotic surgery cost

What diameter?What height?Inf.uence of.measures of.average tree size on area-based allometric volume relationships

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

f.rest Ecosystems 2024年第1期11卷 100-109页

作者： Yilin Wang john A.Kershaw Mark J.Ducey Yuan Sun James B.McCarter Integrated f.rest Mensuration and Systems Analysis Laboratory Faculty of Forestry and Environmental ManagementUniversity of New BrunswickFrederictonNBCanada Department of.Natural Resources and the Environment University of New HampshireDurhamNHUSA College of.f.restry Nanjing Forestry UniversityNanjing210037China Scientif.c Programmer RayonierYuleeFLUSA

Volume is an important attribute used in many f.rest management *** f.om 83 f.xed-area plots located in central New Brunswick,Canada,are used to examine how dif.erent measures of.stand-level diameter and height inf.uence volume prediction using a stand-level variant of.Honer's(1967)volume *** density was included in the models(Volume=f.Diameter,Height,Density))choice of.diameter measure was more important than choice of.height *** density was not included(Volume=f.Diameter,Height)),the opposite was *** models with density included,moment-based estimators of.stand diameter and height perf.rmed better than all other *** models without density,largest tree estimators of.stand diameter and height perf.rmed better than other *** overall best equation used quadratic mean diameter,Lorey's height,and density(root mean square error=5.26 m^3·ha^(-1);1.9%relative error).The best equation without density used mean diameter of.the largest trees needed to calculate a stand density index of.400 and the mean height of.the tallest 400 trees per ha(root mean square error=32.08 m^(3)·ha^(-1);11.8%relative error).The results of.this study have some important implications f.r height subsampling and LiDAR-derived f.rest inventory analyses.

关键词： Allometric relationships Stand structure Volume estimation Stand-level attributes

Rodent management in Aotearoa New Zealand: approaches and challenges to landscape-scale control

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第1期19卷 8-26页

作者： john G.INNES Grant NORBURY Araceli SAMANIEGO Susan WALKER Deborah J.WILSON Manaaki Whenua-Landcare Research HamiltonNew Zealand Manaaki Whenua-Landcare Research AlexandraNew Zealand Manaaki Whenua-Landcare Research AucklandNew Zealand Manaaki Whenua-Landcare Research DunedinNew Zealand

Aotearoa—New Zealand has only f.ur rodent species,all *** order of.arrival,they are Pacif.c rat Rattus exulans,brown rat ***,house mouse Mus musculus,and black rat *** management in New Zealand aims mainly to conserve indigenous biodiversity rather than to protect crops or manage diseases,as is usual *** describe f.ur major“regimes”and one major vision f.r rodent control in New Zealand to meet ecological restoration *** challenges f.r island eradications are f.r large islands that are remote or populated by *** 1080 is the only large-scale(tens of.thousands of.hectares)option f.r black rat control,but its application requires adjustment to counter subsequent rapid black rat ***“ecosanctuaries”(mean 720 ha)use ground-based traps and poisons to target mainly black rats and f.ce constant *** with mammal-resistant f.nces(up to 3500 ha)limit reinvasion and target more pest species and have enabled the return of.previously extirpated taxa to the main *** f.ee 2050 aims to eradicate the rat species(but not mice)plus some other introduced mammals f.om New Zealand by *** vision is not attainable with current tools,but research and experimental management is exploring techniques and *** large scale(to 100000 ha)at which black rats are now targeted f.r control to extremely low abundance seems to be unique to New Zealand.

关键词： black rat brown rat eradication house mouse rodent control