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Hospitalizations f.r alcoholic liver disease during the COVID-19 pandemic increased more f.r women,especially young women,compared to men

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World Journal of.Hepatology 2023年第2期15卷 282-288页

作者： john Patterson Campbell Vinay Jahagirdar Adel Muhanna Kevin f.Kennedy john H Helzberg Department of.Internal Medicine Division of Gastroenterology and HepatologySaint Luke’s Health System of Kansas City and the University of Missouri-Kansas CityKansas CityMO 64111United States Department of.Internal Medicine Saint Luke’s Health System of Kansas City and the University of Missouri-Kansas CityKansas CityMO 64111United States Division of.Cardiology Saint Luke’s Health System of Kansas CityKansas CityMO 64111United States Department of.Internal Medicine Division of Gastroenterology and HepatologyLiver Disease Management UnitSaint Luke’s Health System of Kansas City and the University of Missouri-Kansas CityKansas CityMO 64111United States

BACKGROUND Alcoholic liver disease(ALD)remains one of.the major indications f.r liver transplantation in the United States and continues to place a burden on the national healthcare *** is evidence of.increased alcohol consumption during the coronavirus disease 2019(COVID-19)pandemic,and the ef.ect of.this on the already burdened health systems remains *** To assess the trends f.r ALD admissions during the COVID-19 pandemic,and compare it to a similar pre-pandemic *** This retrospective study analyzed all admissions at a tertiary health care system,which includes f.ur regional *** admissions were identif.ed by querying a multi-hospital health system’s electronic database using ICD-10 *** admissions were compared f.r two one-year periods;pre-COVID-19 f.om April 2019 to March 2020,and during-COVID-19 f.om April 2020 to March *** were analyzed using a Poisson regression model and admission rates were compared using the annual quarterly average f.r the two time periods,with stratif.cation by age and *** increase or decrease in admissions f.om the Poisson regression model were reported as incident rate *** One thousand three hundred and seventy-eight admissions f.r ALD were included.80.7%were Caucasian,and 34.3%were *** increase in the number of.admissions f.r ALD during the COVID-19 pandemic was *** women,a sharp rise(33%)was noted in those below the age of.50 years,and an increase of.22%in those above 50 *** men,an increase of.24%was seen f.r those below 50 years,and a 24%decrease in those above 50 *** The COVID-19 pandemic has had widespread implications,and an increase in ALD admissions is just one of.***,given that women are of.en prone to rapid progression of.ALD,this f.nding has important preventive health implications.

关键词： Alcoholic liver disease COVID-19 Alcoholic hepatitis Alcoholic liver cirrhosis Alcoholism Pandemic Young women Alcohol-related disorders

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作者： (美)约翰·f.肯尼迪(john f. Kennedy)

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The management of.patients with the short bowe syndrome

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World Journal of.Gastroenterology 2002年第1期8卷 13-20页

作者： Cameron f.E.Platell Jane Coster Rosalie D.McCauley john C.Hall Department of.Surgery The University of Western AustraliaPerthAustralia

The surgeon is invariably the primary specialist involvedin managing patients with short bowel syndrome. Becauseof.this they will play an important role in co-ordinating themanagement of.these patients. The principal aims at theinitial surgery are to preserve lif., then to preserve gutlength, and maintain its continuity. In the immediatepostoperative period, there needs to be a balancebetween keeping the patient alive through the use of.TPNand antisecretory agents and promoting gut adaptationwith the use of.oral nutrition. lf.the gut f.ils to adaptduring this period, then the patient may require therapywith more specif.c agents to promote gut adaptation suchas growth f.ctors and glutamine. lf.f.llowing this, thepatient still has a short gut syndrome, then the principaloptions remain either long term TPN, or intestinaltransplantation which remains a dif.icult and challengingprocedure with a high mortality and morbidity due torejection.

关键词：短肠综合症病人管理 TPN 肠道功能肠内营养肠移植

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计算机图形学原理及实践

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作者： (美)约翰·f. 休斯(john f. Hughes)[等]

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Contrasting f.male mate pref.rences f.r red coloration in a f.sh

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Current Zoology 2020年第4期66卷 425-433页

作者： Charel Reulaimd Brett M.CuLBERT Alessandro Devigili Ariel f.Kahrl john L.f.tzpatrick Department of.Zoology Stockholm UniversityStockholmSE-10691Sweden Department of.Integrative Biology University of GuelphGuelphN1G 2W1Canada

Understanding how animals select their mates requires knowing the f.ctors that shape mate *** theoretical and empirical considerations suggest that f.male mating status can inf.uence the degree to which a f.male engages in mate choice,with virgin f.males predicted to be less choosy than mated *** this study,we investigated mate choice in both virgin and mated f.males in the pygmy half.eak Dermogenys *** are small,live-bearing,internally f.rtilizing f.eshwater f.sh that live in mixed-sex groups where f.males have ample opportunity to engage in mate *** a dichotomous choice assay,we quantif.ed and contrasted in virgin and mated f.males mate pref.rences f.r dif.erences in male body size,beak size,and area of.yellow and red *** also examined how mating status inf.uenced the amount of.time a f.male associated with the f.rst male encountered and the relative amount of.time a f.male associated with each *** demonstrate that mate pref.rences of.f.male half.eaks are driven primarily by the size of.red coloration present on *** showed contrasting pref.rences based on mating status,with virgin f.males pref.rentially associating with drab males whereas mated f.males pref.rentially associate with males possessing large areas of.*** to expectations,f.male mating status did not inf.uence how f.males associate with the f.rst males encountered or how f.males biased their association time among *** the precise drivers of.these ef.ects need f.rther studying,our f.nding highlights a possible explanation f.r how variation in male ornamentation can be maintained.

关键词： Dermogenys collettei experience plasticity pygmy half.eak reproductive status sexual selection sperm competition

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Helicobacter pylori inf.ction and extragastric disorders in children: A critical update

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World Journal of.Gastroenterology 2014年第6期20卷 1379-1401页

作者： Lucia Pacif.co john f.Osborn Valeria Tromba Sara Romaggioli Stef.no Bascetta Claudio Chiesa Department of.Pediatrics Sapienza University of Rome Department of.Health Sciences and Inf.ctious Diseases Sapienza University of Rome Institute of.Translational Pharmacology National Research Council

Helicobacter pylori(H. pylori) is a highly prevalent, serious and chronic inf.ction that has been associated causally with a diverse spectrum of.extragastric disorders including iron def.ciency anemia, chronic idiopathic thrombocytopenic purpura, growth retardation, and diabetes mellitus. The inverse relation of.H. pylori prevalence and the increase in allergies, as reported f.om epidemiological studies, has stimulated research f.r elucidating potential underlying pathophysiological mechanisms. Although H. pylori is most f.equently acquired during childhood in both developed and developing countries, clinicians are less f.miliar with the pediatric literature in the f.eld. A better understanding of.the H. pylori disease spectrum in childhood should lead to clearer recommendations about testing f.r and treating H. pylori inf.ction in children who are more likely to develop clinical sequelae. A f.rther clinical challenge is whether the progressive decrease of.H. pylori in thelast decades, abetted by modern clinical practices, may have other health consequences.

关键词： Helicobacter pylori Children Iron def.ciency anemia Chronic idiopathic thrombocytopenic purpura Growth retardation Asthma Allergy Diabetes mellitus

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Human development across the lif.span Updated 5th ed.

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2004年

作者： john S. Dacey john f. Travers.

来源：畅想之星图书光盘版（南... 评论

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Endosomal traf.icking def.cts in patient cells with KIAA1109 biallelic variants

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Genes & Diseases 2019年第1期6卷 56-67页

作者： Megan S.Kane Callie J.Diamonstein Natalie Hauser john f.Deeken john E.Niederhuber Thierry Vilboux Inova Translational Medicine Institute Inova Health SystemFairfaxVAUnited States Department of.Medicine Virginia Commonwealth UniversityRichmondVAUnited States Department of.Public Health Sciences University of Virginia School of MedicineCharlottesvilleVAUnited States Department of.Oncology and Surgery Johns Hopkins University School of MedicineBaltimoreMDUnited States

The uncharacterized gene KIAA1109 has recently been associated with a congenital neurological malf.rmation disorder that variably presents with arthrogryposis,craniof.cial and/or cardiac *** have identif.ed two additional patients with compound heterozygous KIAA1109 variants presenting with the same neurological *** mechanism whereby KIAA1109 loss of.f.nction causes this spectrum of.disorders was the primary f.cus of.our *** hypothesized that KIAA1109 f.nction could be conserved relative to the f.y gene tweek and examined endocytosis and endosome recycling in patient ***,we examined the structure of.the cytoskeleton and cilia based on f.nctional overlap with endocytosis and several known etiologies f.r neuronal migration *** primary dermal f.broblasts f.om one patient and a healthy donor,we perf.rmed immunof.uorescence and endocytosis assays to examine the endosomal,cytoskeletal,and ciliary cellular *** f.und notable abnormalities in endosomal traf.icking and endosome recycling *** also observed changes in the actin cytoskeleton and cilia structural *** conclude that the f.nction of.KIAA1109 in humans may indeed overlap with the f.nction of.the Drosophila ortholog,resulting in perturbations to endosomal traf.icking and the actin *** alterations have ripple ef.ects,altering many pathways that are critical f.r proper neuronal migration and embryonic development.

关键词： Cilia Endocytosis KIAA1109 Neurological malf.rmation Vesicular traf.icking

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“Digging in the Dirt”f.ecal microRNAs as dietary biomarkers of.host-microbe interactions

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 292-294页

作者： Gerard M.Moloney john f.Cryan Gerard Clarke Department of.Anatomy&Neuroscience University College CorkCorkIreland APC Microbiome Ireland University College CorkCorkIreland Department of.Psychiatry and Neurobehavioural Science University College CorkCorkIreland

The role of.diet and nutrition in maintaining a healthy lif.style has become a central part of.chronic disease prevention(1).Chronic conditions such as cancer,Inf.ammatory bowel disease(IBD)and obesity are more prevalent in people with poor diets(2).f.od consumption is controlled by physiological systems such as the gut-microbiome and distinct neuroendocrine pathways that overlap to promote host nutritional gain resulting in people living longer healthier lives(3).A recent analysis of.the global burden of.disease by the World Health Organization(WHO),noted that f.ctors associated with poor diet,including obesity and malnutrition,critically undermine health and *** note that undernutrition,def.ciencies in key nutrients and obesity have high social and economic *** disease,cancer,diabetes,and respiratory diseases account f.r 77%of.all diseases and are responsible f.r 86%of.all premature deaths(4).There is an appreciation that diets that reduce or eliminate red meats and animal f.ts results in the reduction of.many of.the indicators of.poor diet,such as body mass index(BMI)and levels of.cholesterol in the blood.

关键词： prevention eliminate overlap

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Active surveillance monitoring： the role of.nove biomarkers and imaging

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Asian Journal of.Andrology 2015年第6期17卷 882-884,I0006页

作者： john f.Ward Scott E Eggener Department of.Urology The University of TexasMD Anderson Cancer Center Houston TX USA Department of.Urology University of ChicagoChicago IL USA.

＂CANCER＂ is a disease state that leads to progressive illness that is unif.rmly f.tal without treatment. Hippocrates invoked the Greek word karkinos, or ＂crab＂ to describe tumors he observed. f.r centuries, ＂CANCER＂ remained a disease that was recognized primarily in its locally advanced or metastatic stage, when it was almost unif.rmly f.tal.

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