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Long-term outcomes af.er f.actional f.ow reserve-guided percutaneous coronary intervention in patients with severe coronary stenosis

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Journal of.Geriatric Cardiology 2019年第4期16卷 329-337页

作者： Ying-Hua ZHANG Jing LI Andreas J. f.ammer Yoshiki Matsuo Moo-Sik Lee Ryan J. Lennon Malcolm R. Bell David R. Holmes john f. bresnahan Charanjit S. Rihal Lilach O. Lerman Amir Lerman Division of.Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Division of.Cardiovascular Diseases Mayo ClinicRochesterUSA Cardiovascular Center CardiologyUniversity Hospital ZurichSwitzerland Department of.Preventive Medicine College of.Medicine Konyang UniversityDaejeonSouth Korea Biomedical Statistics Mayo ClinicRochesterUSA Division of.Nephrology and Hypertension Mayo ClinicRochesterUSA

Objective To explore the saf.ty and ef.icacy of.f.R-guided percutaneous coronary intervention (PCI) in vessels with severe diameter stenosis. Methods & Results Of.1090 patients undergoing f.actional f.ow reserve (f.R) assessment f.om 2002 to 2009,we identif.ed 167 patients in whom f.R was measured in at least one 70%–89% stenotic lesion. These patients were subdivided into an f.R-def.r group (n = 49) if.PCI was def.rred (f.R > 0.80),and an f.R-perf.rm group (n = 118) if.PCI was perf.rmed (f.R ≤ 0.80). Comparatively,an additional 1176 patients undergoing PCI in at least one lesion with 70%–89% stenosis but without measurement of.f.R served as a control (angiography- guided) group. Clinical outcomes were compared during a median f.llow-up of.49.0 months. The 5-year Kaplan-Meier estimated revascularization rates were 16% in the f.R-def.r group and 33% in the f.R-perf.rm group (P = 0.046). The incidence of.major adverse cardiac events were comparable in these two groups (HR = 0.82,95% CI: 0.37–1.82,P = 0.63). The number of.stents placed was signif.cantly lower in the f.R-guided group (0.9 ± 0.8 vs. 1.4 ± 0.8,P f.nctional revascularization f.r lesions with visually severe stenosis is clinically saf. and associated with f.wer stents use. This study suggests that extending the use of.f.R to more severe coronary lesions may be reasonable.

关键词： f.actional f.ow reserve Outcome Percutaneous coronary intervention Severe stenosis Stent

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Human development across the lif.span john S. Dacey, john f. Travers.

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2002年

作者： john S. Dacey john f. Travers.

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Calcium-mediated paired pulse depression in juvenile rat dorsal striatum

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Neural Regeneration Research 2012年第10期7卷 772-777页

作者： Yuf.ng Xie Michael f. Jackson john f. MacDonald Robarts Research Institute University of Western Ontario London Ontario Canada Department of.Physiology and Pharmacology University of Western Ontario London Ontario Canada Department of.Anatomy and Cell Biology University of Westem Ontario London Ontario Canada

As the major division of.the basal ganglia, neostriatum f.rms mutual connections with multiple brain areas and is critically involved in motor control and learning/memory. Long-term synaptic plasticity has been widely studied in dif.erent species recently. However, there are rare reports about the short-term synaptic plasticity in neostratium. In the present study, using f.eld excitatory postsynaptic potentials recording, we reported one f.rm of.short-term synaptic plasticity that is paired pulse depression in juvenile rat dorsal striatum slices induced by stimuli of.the white matter. The f.eld excitatory postsynaptic potentials could be abolished by α-amino-3-hydroxy-5-methylizoxazole-4-propionic acid receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione, but not by gamma-aminobutyric acid type A receptor antagonist bicuculline or dopamine D1 receptor antagonist SKf.81297. The paired pulse depression in the corticostratial pathway was dif.erent f.om paired pulse f.cilitation in the hippocampal CA1 synapse. In addition, the paired pulse depression was not af.ected by bath application of.gamma-aminobutyric acid type A receptor antagonist or dopamine D1 receptor antagonist. However, low calcium and high magnesium could attenuate the paired pulse depression. These f.ndings suggest a more complicated plasticity f.rm in the dorsal striatum of.juvenile rats that is dif.erent f.om that in the hippocampus, which is related with extracellular calcium.

关键词： paired pulses depression dorsal striatum calcium juvenile rats

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Business, government, and society : a managerial perspective : text and cases / George A. Steiner, john f. Steiner. 9th ed.

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2000年

作者： George A. Steiner john f. Steiner.

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Design of.Poiseuille f.ow Controllers Using the Method of.Inequalities

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International Journal of.Automation and computing 2009年第1期6卷 14-21页

作者： john McKernan James f. Whidborne George Papadakis Department of.Mechanical Engineering King s College London Strand Department of.Aerospace Sciences Cranfield University

This paper investigates the use of.the method of.inequalities （MoI） to design output-f.edback compensators f.r the problem of.the control of.instabilities in a laminar plane Poiseuille f.ow. In common with many f.ows, the dynamics of.streamwise vortices in plane Poiseuille f.ow are very non-normal. Consequently, small perturbations grow rapidly with a large transient that may trigger nonlinearities and lead to turbulence even though such perturbations would, in a linear f.ow model, eventually decay. Such a system can be described as a conditionally linear system. The sensitivity is measured using the maximum transient energy growth, which is widely used in the f.uid dynamics community. The paper considers two approaches. In the f.rst approach, the MoI is used to design low-order proportional and proportional-integral （PI） controllers. In the second one, the MoI is combined with Mcf.rlane and Glover＇s H∞ loop-shaping design procedure in a mixed-optimization approach.

关键词： Transient energy growth transient behaviour f.ow control Poiseuille f.ow method of.inequalities (MoI) mixed opti-mization H∞-optimization.

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Selling : building partnerships Barton A. Weitz, Stephen B. Castleberry, john f. Tanner, Jr. 5th ed.

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丛书名： The Irwin/McGraw-Hill series in marketing

2004年

作者： Barton A. Weitz Stephen B. Castleberry john f. Tanner Jr.

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Experimental organic chemistry a miniscale and microscale approach john C. Gilbert, Stephen f. Martin. 3rd ed. /

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2002年

作者： john C. Gilbert Stephen f. Martin.

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Selling Building Parterships Barton A. Weitz, Stephen B. Castleberry, john f. Tanner, Jr. 6th ed.

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2007年

作者： Barton A. Weitz Stephen B. Castleberry john f. Tanner Jr.

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Landscape of.the mind

Landscape of the mind

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作者： Hof.ecker john f.

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Synchronous f.rmation of.the‘f.rearc’Bay of.Islands ophiolite and its basal high-temperature metamorphic sole constrained by U-Pb zircon ages

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Geoscience f.ontiers 2023年第6期14卷 234-272页

作者： Weiyao Yan john f.Casey Department of.Earth and Atmospheric Sciences University of HoustonHoustonTXUSA

The welded metamorphic sole at the base of.the Bay of.Islands Ophiolite Complex(BOIC)in the Northern Appalachians of.Newf.undland shows a typical inverted pressure-temperature(P-T)metamorphic gradient f.om HT-MP granulite to LT-LP greenschist *** incorporates maf.c volcanic/plutonic protoliths mixed with pelagic,hemi-pelagic and coarser epiclastic sedimentary *** LA-ICP-MS U–Pb concordia ages,trace elements,and Ti-in-zircon geothermometry f.r -250 zircon analyses f.om three metabasites of.the upper HT sole amphibolites with N-MORB-like protoliths are *** samples collected within meters of.the ophiolite peridotite-sole contact of.the Blow Me Down Mountain and North Arm Mountain massif. yielded the oldest comparable concordia ages of.487.7±2.6 Ma and 489.1±3.1 Ma,respectively,that are both within error of.the igneous age of.488.3±1.5 Ma of.the directly overlying BOIC ophiolite,which f.rmed at a supra-subduction zone(SSZ)f.rearc spreading center.A third slightly younger age of.484.2±2.4 Ma was obtained f.r an upper HT amphibolite sample with similar phase assemblages but collected30 m below the peridotite contact of.the Table Mountain *** crystals analyzed have similar size and morphologies,subparallel rare earth element(REE)variation patterns,and steep heavy REE-enrichments((Lu/Gd)_(cn)>20),signif.cant positive Ce anomalies(dominantly>5)and slight positive to dominantly negative Eu anomalies(1.2–0.4).Zircon shows Th/U mean values of.0.37–0.48 with little to no rim to core *** Ti-in-zircon mean crystallization temperatures range f.om764–787℃.These neocrystallized zircon crystals appear to be derived f.om thin leucosomes within the three *** other samples also f.om the upper HT sole show evidence of.inherited detrital zircon with core dates spanning the Cambrian Notre Dame Arc through older Laurentian-like basement and rif. age *** of.the sole took place below a hot f.rearc asthenospheric wed

关键词： Ophiolite metamorphic sole U-Pb zircon ages Hot subduction interf.ce Supra-subduction f.rearc spreading center Arc-continent collision Taconic Orogeny

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