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Search for a natural scientific measure of economy

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Frontiers of environmental Science & engineering 2011年第1期5卷 111-118页

作者： john e COULTeR Xiwangzhuang Shuangqing RdHaidianBeijing 100084China

Through human history,wealth has been measured in grain,gold,and,now,*** counterfeiting of coins and notes goes back a long way,it is only with electronic financial accounting in a global economy tainted by toxic loans and imaginary funds that there is an urgency to search for a realistic objective way to monitor and regulate what we are doing to our earth and *** schemes using analysis of utility functions,oil equivalents,entropy,energy,and other units have been tried and,while helping to understand some basic processes and flows,have always been swamped by the machinations of financiers and the attention big sums of money ***,the concept of exergy,pioneered in eastern europe in the 1950s,is being researched,developed,and applied,especially in China,driven by the desperation to measure the reality beyond the twin specters of global financial and environmental crises.A rough inventory of the matter in the biosphere at the coordinate details of an angstrom and an appreciation of how humans harness and manipulate electromagnetic forces can be enlightening as to what is and is not *** that understanding,any financial estimate and proposed stimulus packages or IMF reform will be wildly wrong and may even be headed in the wrong direction.

关键词： climate change financial crisis energy exergy environment

Tyrosine metabolic enzymes from insects and mammals：A comparative perspective

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Insect Science 2014年第1期21卷 13-19页

作者： Christopher john Vavricka Qian Han Prajwalini Mehere Haizhen Ding Bruce M. christensen and Jianyong Li Research Network of Immunity and Health (RNIH) Beijing Institutes of Life Science Chinese Academy of Sciences BeUing China Department of Biochemistry Virginia Polytechnic and State University Blacksburg VA 24061 USA Department of Tuberculosis The Foundation for Medical Research Mumbai India and Department of Pathobiology University of Wisconsin-Madison Madison Wl 53706 USA

Differences in the metabolism of tyrosine between insects and mammals present an interesting example of molecular evolution. Both insects and mammals possess finetuned systems of enzymes to meet their specific demands for tyrosine metabolites; however, more homologous enzymes involved in tyrosine metabolism have emerged in many insect species. Without knowledge of modem genomics, one might suppose that mammals, which are generally more complex than insects and require tyrosine as a precur sor for important catecholamine neurotransmitters and for melanin, should possess more enzymes to control tyrosine metabolism. Therefore, the question of why insects actually possess more tyrosine metabolic enzymes is quite interesting. It has long been known that insects rely heavily on tyrosine metabolism for cuticle hardening and for innate immune responses, and these evolutionary constraints are likely the key answers to this question. In terms of melanogenesis, mammals also possess a high level of regulation; yet mam malian systems possess more mechanisms for detoxification whereas insects accelerate pathways like melanogenesis and therefore must bear increased oxidative pressure. Our research group has had the opportunity to characterize the structure and function of many key proteins involved in tyrosine metabolism from both insects and mammals. In this mini review we will give a brief overview of our research on tyrosine metabolic enzymes in the scope of an evolutionary perspective of mammals in comparison to insects.

关键词： arylalkylamine N-acetyltransferase (aaNAT) enzymology L-DOPAdecarboxylase (DDC) melanogenesis tyrosine metabolism

Development of Light Weight Structures to Provide Blast-Resistant Designs

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Transactions of Tianjin University 2006年第B09期12卷 16-21页

作者： CRAWFORD john e Karagozian & Case 2550 N.Hollywood Way #500BurbankCA 91505USA

In the past, blast-resistant designs for structures were often constructed with massive type structural systems, which relied more on brute strength than on finesse to achieve the required blast resistance. However, structures composed of COLD-FORMeD steel components, such as sheet metal and metal studs, have shown great promise in providing blast resistance with the added benefits of low cost and ease of construction. Some examples of using such structures to provide containment for package handling facilities (PHF) are described in the paper for situations where blast containment is needed, such as a potential package bomb being discovered during the package vetting process. Results from tests and analytic data are used to illustrate aspects of design peculiar to such types of applications. Designs for specific capacities of PHF are described.

关键词： blast containment package handling facility hardened design light weight structures COLD-FORMeD steel structures

Simulation of Fragment Impact on Multi-Layer Targets Using Contact Method

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Transactions of Tianjin University 2006年第B09期12卷 152-157页

作者： CRAWFORD john e Karagozian & Case 2550 N.Hollywood WaySuite 500BurbankCA 91505USA

Cased explosives generate highly energetic fragments as their casing breaks up. Due to the complexity of casing fragment related behavior such as embedment, perforation and ricochet, it may be insufficient to use equivalent triangular pressure loading in fragment impact simulations. This simplified method may over- or under-predict the target response. Recently, a procedure using contact techniques has been proposed to overcome such difficulties. It has been shown that the new method has the inherent capability in modeling the multi-piece and multi-hit fragment impact problems in a more realistic way. To investigate the applicability of the proposed method to simulations involving multi-layer penetration, the selected problems of fragment impact on multi-layer targets are described in this paper. It is demonstrated that this method is capable of predicting the complicated multi-layer structural response caused by fragment impact and penetration. Modeling procedures and some technical issues are also discussed.

关键词： contact finite element fragment impact multi-layer penetration simulation

SWITCHING AND SeQUeNCING AVAILABLe THeRAPIeS SO AS TO MAXIMIZe A PATIeNT＇S eXPeCTeD TOTAL LIFeTIMe

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International Journal of Biomathematics 2012年第4期5卷 113-125页

作者： john e. GOULIONIS Department of Statistics and Insurance Science University of Piraeus 80 Karaoli a Dimitriou Street 18534 Piraeus Greece

This paper has focused on applying mathematical techniques to address fundamental question in therapy planning when to switch, and how to sequence therapies. We consider switching and sequencing available therapies so as to maximize a patient＇s expected total lifetime. We assume knowledge only about the lifetime distributions induced by the therapies. We discuss a specialization of this model that is tailored to a frequently reoccurring type of management problem, where our goal is to determine the best timing for testing and treatment decisions for patients with ischemic heart disease. Typically, decisions are made with an overall, goal of maximizing the patient＇s expected lifetime or quality-adjusted lifetime.

关键词： expected total lifetime maintenance ischemic heart disease stochasticordering relationships statistical distributions.

A FAST LAGRANGIAN SIMULATION MeTHOD FOR FLOW ANALYSIS AND RUNNeR DeSIGN IN PeLTON TURBINeS

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Journal of Hydrodynamics 2012年第6期24卷 930-941页

作者： ANAGNOSTOPOULOS john S. PAPANTONIS Dimitris e. School of Mechanical engineering National Technical University of Athens

In the present work, an alternative numerical methodology is developed for a fast and effective simulation and analysis of the complex flow and energy conversion in Pelton impulse hydro turbines. The algorithm is based on the Lagrangian approach and the unsteady free-surface flow during the jet-bucket interaction is simulated by tracking the trajectories of representative fluid particles at very low computer cost. Modern regression tools are implemented in a new parameterization technique of the inner bucket surface. Key-feature of the model is the introduction of additional terms into the particle motion equations to account for various hydraulic losses and the flow spreading, which are regulated and evaluated with the aid of experimental data in a Laboratory Pelton turbine. The model is applied to study the jet-runner interaction in various operation conditions and then to perform numerical design optimization of the bucket shape, using a stochastic optimizer based on evolutionary algorithms. The obtained optimum runner attains remarkably higher hydraulic efficiency in the entire load range. Finally, a new small Pelton turbine （150 kW） is designed, manufactured and tested in the Laboratory, and its performance and efficiency verify the model predictions.

关键词： Pelton turbine hydraulic efficiency Lagrangian simulation bucket shape parameterization numerical design optimization

Knowledge and attitudes towards the use of histological assessments in ulcerative colitis by gastroenterologists vs pathologists

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World Journal of Gastroenterology 2023年第2期29卷 378-389页

作者： Aviv Pudipeddi Caroline Fung Britt christensen Robert V Bryant Kavitha Subramaniam john Chetwood Sudarshan Paramsothy Rupert W Leong Gastroenterology and Liver Services Concord Repatriation General HospitalSydney 2139Australia Faculty of Medicine and Health Concord Clinical SchoolUniversity of SydneySydney 2138Australia Department of Anatomical Pathology Concord Repatriation General HospitalSydney 2139Australia Department of Gastroenterology Royal Melbourne HospitalMelbourne 3050Australia Department of Medicine University of MelbourneMelbourne 3052Australia Department of Gastroenterology and Hepatology The Queen Elizabeth HospitalAdelaide 5011Australia Gastroenterology and Hepatology Unit Canberra HospitalCanberra 2605Australia Australian National University Medical School Australian National UniversityCanberra 2601Australia Faculty of Medicine and Health Sciences Macquarie University HospitalSydney 2109Australia

BACKGROUND Histological remission is increasingly accepted as a treatment endpoint in the management of ulcerative colitis(UC).However,the knowledge of histology guidelines and the attitudes towards their use in clinical practice by gastroenterologists and pathologists is *** To evaluate the knowledge of histology guidelines and attitudes towards the use of histology in UC by gastroenterologists and *** A prospective,cross-sectional nationwide survey of gastroenterologists and pathologists who analyse UC specimens was *** survey consisted of 34 questions to assess gastroenterologists’and pathologists’knowledge(score out of 19)and attitudes towards histological assessment in *** questions were formulated using the european Crohn’s and Colitis position paper on histopathology and the British Society of Gastroenterology biopsy reporting *** included knowledge of histological assessment of disease activity and dysplasia,knowledge of histological scoring systems for ulcerative colitis,uptake of histology scoring systems in routine practice,attitudes towards the role of histological activity,and the use of histological activity in clinical *** Of 89 responders(77 gastroenterologists,12 pathologists),there was almost universal acceptance that histological assessment should form part of UC evaluation[95%gastroenterologists,92%pathologists].However,gastroenterologists reported that 92%of their pathologists do not use a histological scoring *** of a formal histological scoring system was preferred by 77%of gastroenterologists and 58%of *** groups lacked awareness of the Geboes Score,Nancy Index and Robarts Histopathological Index scoring systems with 91%,87%,and 92%of gastroenterologists respectively;and 83%,83%,and 92%pathologists respectively,being uncertain of scoring systems’remission *** knowledge score was not significantly different between gastroenterologist

关键词： Histology Scoring system Ulcerative colitis Survey

25 Years of sensory drive： the evidence and its watery bias

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Current Zoology 2018年第4期64卷 471-484页

作者： Molly e. CUMMINGS john A. eNDLeR Department of Integrative Biology University of Texas Austin TX 78712 USA School of Life and environmental Sciences Deakin University Waurn Ponds VIC 3216 Australia

It has been 25years since the formalization of the Sensory Drive hypothesis was published in the American Naturalist （1992）. Since then, there has been an explosion of research identifying its utility in contributing to our understanding of inter- and intra-specific variation in sensory systems and signaling properties. The main tenet of Sensory Drive is that environmental characteristics will influence the evolutionary trajectory of both sensory （detecting capabilities） and signaling （detectable features and behaviors） traits in predictable directions. We review the accumulating evidence in 154 studies addressing these questions and categorized their approach in terms of testing for environmental influence on sensory tuning, signal characteristics, or both. For the subset of studies that examined sensory tuning, there was greater support for Sensory Drive processes shaping visual than auditory tuning, and it was more prevalent in aquatic than terrestrial habitats. Terrestrial habitats and visual traits were the prevalent habitat and sensory modality in the 104 studies showing support for environmental influence on signaling properties. An additional 19 studies that found no supporting evidence for environmental influence on signaling traits were all based in terrestrial ecosystems and almost exclusively involved auditory signals. Only 29 studies examined the complete coevolutionary process between sensory and signaling traits and were dominated by fish visual communication. We discuss biophysical factors that may contribute to the visual and aquatic bias for Sensory Drive evidence, as well as biotic factors that may contribute to the lack of Sensory Drive processes in terrestrial acoustic signaling systems.

关键词： animal communication sensory drive sensory ecology sexual selection

Is Takotsubo syndrome in patients receiving chemotherapy drug-specific?

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World Journal of Clinical Cases 2015年第2期3卷 204-205页

作者： john e Madias Icahn School of Medicine at Mount Sinai Division of Cardiology Elmhurst Hospital Center

In commenting on a case report of a 55-year-old man who suffered Takotsubo syndrome(TTS), in the setting of receiving chemotherapy with cytarabine and daunorubicin for acute myeloid leukemia, the author expresses his views that TTS in the setting of chemotherapy for malignancies may not be chemotherapeutic drug-specific(like in the chemotherapeutic drug induced-cardiomyopathy), but may be due to the emotional and physical stresses resulting from the realization of having diagnosed with a malignancy, and the diagnostic testing, and therapeutic management which follows.

关键词： Daunorubicin Radiotherapy Cardiotoxicity Takotsubo syndrome Malignancies Chemotherapy Cytarabine Anthracyclines Cardiomyopathy Autonomic sympathetic Nervous system