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武汉大学学报（信息科学版） 2006年第5期31卷 448-450页

作者：赵建虎张红梅 john e hughes clarke 武汉大学测绘学院武汉市珞喻路129号430079 武汉大学动力与机械学院武汉市东湖南路8号430072 新伯伦瑞克大学图形组

为在局域建立一个无缝垂直参考基准面,提出了两步转换的思想和方法,即从大地高到正高然后到海图高。利用该方法,构造了Saint john河高程转换模型,并在该河段建立了无缝垂直参考基准面,且得到了实际验证。

关键词：大地高正常高海图基准海图基准高程

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测船处瞬时潮位的GPS精密确定

武汉大学学报（信息科学版） 2006年第12期31卷 1067-1070页

作者：赵建虎张红梅 john e.hughes clarke 武汉大学测绘学院武汉市珞喻路129号430079 武汉大学动力与机械学院武汉市东湖南路8号430072 海洋图形研究组新布伦兹维克大学

利用GPS载波相位差分测量技术,借助时间偏差改正、姿态改正、高程转换、信号处理和吃水改正,获得了测船处精密在航潮位。该方法已在几个GPS在航潮位测量实验中得到了验证,并取得了理想的结果。

关键词： GPS潮位时间偏差改正姿态改正高程转换信号处理

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多波束测量中换能器瞬时精密高程的确定

武汉大学学报（信息科学版） 2006年第11期31卷 983-986页

作者：赵建虎张红梅 john e hughes clarke 王胜平武汉大学测绘学院武汉市珞喻路129号430079 武汉大学动力与机械学院新布伦兹维克大学海洋图形研究组

分析了GPS高程信号和Heave信号的频段特征,利用数字信号处理技术,提取了GPS高程和Heave中的有效频段信号,合成了一个全新的信号。该合成信号能够全面反映多波束换能器的实际垂直运动,并能够克服传统多波束测量和数据处理方法的缺陷,大... 详细信息

分析了GPS高程信号和Heave信号的频段特征,利用数字信号处理技术,提取了GPS高程和Heave中的有效频段信号,合成了一个全新的信号。该合成信号能够全面反映多波束换能器的实际垂直运动,并能够克服传统多波束测量和数据处理方法的缺陷,大大提高了多波束在垂直方向的成果精度。实验证明了该方法的正确性和可行性。

关键词：多波束数字信号处理 GPS 涌浪

Determination of Precise Instantaneous Height at Multibeam Transducer

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Geo-Spatial Information Science 2007年第4期10卷 250-254页

作者： ZHAO Jianhu ZHANG Hongmei john e. hughes clarke School of Geodesy and Geomatics Wuhan University 129 Luoyu Road Wuhan 430079 China

To overcome the shortcomings of the traditional multibeam survey and data processing, a new method is presented for the precise determination of the instantaneous height at the multibeam transducer by the blend of GPS height and heave signals. Before signal blend, GPS height and heave signals need to be corrected first to the transducer center by attitude correction. Second, the GPS height needs to be checked and modified by heave check and modification itself. Butterworth and FFT （fast Fourier transformation） were used in the signal blend. Finally, FFT is thought to be appropriate in signal processing. The new method efficiently overcomes the shortcomings of the traditional method, and this is proven well by the MBS （multibeam bathymetric system） experiment.

关键词： multibeam digital signal processing GPS heave

establishing a seamless vertical reference along the tidal segment of the Saint john River

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Establishing a seamless vertical reference along the tidal s...

Host-environment mismatches associated with subalpine fir decline in Colorado

The 2nd International Conference on environmental and engineering Geophysics

作者： john e. hughes clarke Ocean Mapping Group Department of Geodesy and Geomatics engineering University of New Brunswick

A method is developed to use GPS ellipsoid height observations as a means of applying a seamless vertical reference to hydrographic surveys along a 110 km tidal segment of the Saint john River. In order to be able to use the GPS ellipsoid heights, the Canada national geoid model HTv2.0 is firstly modified using a GPS/levelling geometric method to achieve a locally more accurate transformation from NAD83 ellipsoid height to CGVD28 orthometric height. In the modification, integrating the river shape with the distribution of these GPS/levelling points along the river, few geometric models are tested, and an optimal model, which has about 3 centimetres standard bias in the model interior test and 1 centimetres standard bias in the model exterior test, is chose for the modification of HTv2.0. After the modification of geoid model, the purified HTv2.0 can fulfill the precise transformation from NAD83 ellipsoid heights to CGVD28 orthometric height. The second step is to develop a cross-section linear interpolation method to define an equivalent, continuously varying chart datum reference from which the transformation from CGVD28 height to CD2000 height can be derived. Integrating the definition of chart datum and the linear varying ruler of tide, a new interpolation method is developed. The method can ensure the chart datum definitions of each of points along a cross section are equal, and also guarantee the riverbed topographic continuation and consistency in hydrographic survey after the transformation from CGVD28 height to CD2000 height with the interpolation model. Using this approach to a seamless vertical reference, two on-the-fly GPS tidal measurement experiments are implemented along the tidal segments of Saint john River where the seamless datum reference is constructed. The tidal data processing result with 2 centimeters standard bias and 5 centimeters maximum bias proves that the seamless vertical reference model is credible and can meet with the reauirement of

关键词： ellipsoidal height orthometric height chart datum seamless vertical reference datum

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Journal of Forestry Research 2016年第5期27卷 1177-1189页

作者： Robin M. Reich john e. Lundquist Kristina hughes Colorado State University Fort Collins CO USA U.S. Forest Service Anchorage Anchorage AK 99501 USA

Subalpine fir decline （SFD） has killed more trees in Colorado＇s high elevation forests than any other insect or disease problem. The widespread nature of this disorder suggests that the cause involves climatic factors. We examined the influence of varying combinations of average annual temperature and precipitation on the incidence and distribution of SFD. Climatic transition matrices generated in this study indicate that most healthy trees are found in climatic zones with moderate to low temperatures and high precipitation; whereas, SFD occurs mostly in zones of moderate temperatures and moderate precipitation. The contrasting distributions define an environmental mismatch. Forests matched with favorable climatic conditions thrive; those that are mismatched can become vulnerable to decline disease.

关键词： Abiotic disorder Climate stress High elevation forests Forest disease - Subalpine fir

Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer

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World Journal of Gastrointestinal Surgery 2017年第4期9卷 103-108页

作者： Kathryn e Hitchcock R Charles Nichols Christopher G Morris Debashish Bose Steven J hughes john A Stauffer Scott A Celinski elizabeth A johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg Department of Radiation Oncology University of Florida Department of Surgical Oncology UF Health Cancer Center-Orlando Health Department of Surgery University of Florida Department of Surgery Mayo Clinic Department of Surgery Baylor University Medical Center at Dallas Department of Hematology/Oncology Mayo Clinic Department of Hematology/Oncology Baptist Health

AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic *** From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBe) to the gross disease and 1 patient received 50.40 Gy(RBe) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRe) of a pancreatic head mass(n = 1). ReSULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRe followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after

关键词： Pancreatic cancer Pancreatectomy Pancreas Proton therapy Radiotherapy

Genome-wide studies of time of day in the brain: Design and analysis

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Brain Science Advances 2020年第2期6卷 92-107页

作者： Gang Wu Marc D.Ruben Yinyeng Lee Jiajia Li Michael e.hughes john B.Hogenesch Divisions of Human Genetics and Immunobiology Center for ChronobiologyDepartment of PediatricsCincinnati Childrenʹs Hospital Medical Center240 Albert Sabin WayCincinnatiOH 45229U.S.A. Division of Pulmonary and Critical Care Medicine Washington University School of MedicineSt.LouisMO 63310U.S.A.

Transcriptome profiling at different times of day is powerful for studying circadian regulation in model organisms and *** date,24 h profiles from many tissue types suggest that about half of all genes are circadian-expressed somewhere in the ***,few of these studies focused on the ***,despite known links between circadian disruption and neurological disease,we have virtually no mechanistic *** the coming decade,we expect more genome-wide studies of time of day in different brain diseases,regions,and cell *** expect just as many different approaches to the design and analysis of these *** review considers key principles of circadian tran scriptomics,with the goal of maximizing utility and reproducibility of future studies in the nervous system.

关键词： circadian transcriptome rhythmic analysis brain

Spatial and Temporal Patterns of In Situ Sea Surface Temperatures within the Gulf of Mexico from 1901-2010

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American Journal of Climate Change 2016年第3期5卷 314-343页

作者： Jason Allard john V. clarke III Barry D. Keim Department of Physics Astronomy & Geosciences Valdosta State University Valdosta GA USA Department of Geography and Anthropology Louisiana State University Baton Rouge LA USA

This work examines the spatial and temporal patterns of seasonal sea surface temperatures (SSTs) across the Gulf of Mexico (GoM) for the period 1901-2010. The extended Reconstructed Sea Surface Temperature, version 4 (eRSST.v4), dataset was selected for this study over other reconstructions because of its 2° × 2° grid cell spatial resolution, its recent update to adjust for known biases in SST observations, and its ability to be compared to other in situ studies of GoM SSTs. The monthly eRSST.v4 data were averaged seasonally for each year and grid cell in the GoM. Seasonal SST trends were then calculated for each grid cell with varying start dates (e.g., 1901-2010, 1911- 2010) to account for nonlinear SST changes over the study period. Results indicate that the GoM SSTs closely resemble those of global annual temperature trends: SSTs warmed from 1901 to ~1940, followed by a period with little trend or a slight cooling until the mid-1970s, and then a warming afterwards through 2010. The spatial patterns and magnitudes of SST changes, however, varied by season and location within the GoM. The spatial patterns involved gradients with latitudinal and/or longitudinal components: a southwest-northeast (warmer-cooler) gradient in winter, an east-west (warmer-cooler) gradient in spring and fall, and a northwest-southeast (warmer-cooler) gradient in summer. The magnitude of SST changes tended to be largest in summer, followed by spring, fall, and winter. The long-term (1901-2010) SST trends were significant throughout the GoM in summer and fall, but only significant towards the southwestern GoM in winter and spring. These results have implications in discussion of climate change and its impacts on tropical activity in the GoM Basin.

关键词： Sea Surface Temperature Gulf of Mexico Temperature Reconstructions Temperature Variability

effect of mucin 4 allele on susceptibility to experimental infection with enterotoxigenic F4 escherichia coli in pigs fed experimental diets

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Journal of Animal Science and Biotechnology 2019年第4期10卷 981-989页

作者： Samantha O.Sterndale Danica J.evans Josephine P.Mansfield Julie clarke Shafi Sahibzada Sam Abraham Mark O’Dea David W.Miller Jae Cheol Kim john R.Pluske Agriculture Sciences College of ScienceHealthEngineering and Education Murdoch UniversityMurdochWA 6150Australia CSIRO Health and Biosecurity PO BOX 10041AdelaideBC 5000Australia Antimicrobial Resistance and Infectious Disease Laboratory Murdoch UniversityMurdochWA 6150Australia AB Vista Asia Pte.Ltd The MezzoWhampoa 329682Singapore

Background: This study investigated the validity of the DNA-marker based test to determine susceptibility to eTeCF4 diarrhoea by comparing the results of two DNA sequencing techniques in weaner pigs following experimental infection with F4 enterotoxigenic escherichia coli(eTeC-F4). The effects of diet and genetic susceptibility were assessed by measuring the incidence of piglet post-weaning diarrhoea(PWD), faecal e. coli shedding and the diarrhoea ***: A DNA marker-based test targeting the mucin 4 gene(MUC4) that encodes F4 fimbria receptor identified pigs as either fully susceptible(SS), partially or mildly susceptible(SR), and resistant(RR) to developing eTeC-F4 diarrhoea. To further analyse this, DNA sequencing was undertaken, and a significantly higher proportion of C nucleotides was observed for RR and SR at the Xba I cleavage site genotypes when compared to SS. However, no significant difference was found between SR and RR genotypes. Therefore, results obtained from Sanger sequencing retrospectively allocated pigs into a resistant genotype(MUC4–), in the case of a C nucleotide, and a susceptible genotype(MUC4+), in the case of a G nucleotide, at the single nucleotide polymorphism site. A total of 72 weaner pigs(age ~ 21 days), weighing 6.1 ± 1.2 kg(mean ± SeM), were fed 3 different diets:(i) positive control(PC) group supplemented with 3 g/kg zinc oxide(Zn O),(ii) negative control(NC) group(no Zn O or HAMSA),and(iii) a diet containing a 50 g/kg high-amylose maize starch product(HAMSA) esterified with acetate. At days five and six after weaning, all pigs were orally infected with eTeC(serotype O149:F4;toxins LT1, ST1, ST2 and eAST). The percentage of pigs that developed diarrhoea following infection was higher(P = 0.05) in MUC4+ pigs compared to MUC4– pigs(50% vs. 26.8%, respectively). Furthermore, pigs fed Zn O had less eTeC-F4 diarrhoea(P = 0.009) than pigs fed other diets, however faecal shedding of eTeC was similar(P > 0.05) between ***

关键词： Diarrhoea escherichia coli F4 MUC4 Weaner pigs Zinc oxide