检索结果-南通市图书馆

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

科学资源对公众科学兴趣的贡献(下)

自然科学博物馆研究 2019年第4期 74-81,96页

作者：约翰·H·福尔克科特·帕蒂森大卫·麦耶大卫·毕贝斯凯瑟琳·利文斯顿杨玉娟(译) 美国俄勒冈州科瓦利斯市创新学习研究所美国加利福利亚州洛杉矶市加州科学中心美国密西根州底特律市曝光博物馆广东科学中心广州市510006

学校、科学中心、广播媒体、纸质媒体及互联网是五种主要的公共科学教育资源。本研究以美国三座大城市的3000名成人为样本,调查了以上资源对公众科学兴趣的价值及认知倾向的作用。下篇展示了如下调查结果:有五种经历对预测成年后的科学... 详细信息

学校、科学中心、广播媒体、纸质媒体及互联网是五种主要的公共科学教育资源。本研究以美国三座大城市的3000名成人为样本,调查了以上资源对公众科学兴趣的价值及认知倾向的作用。下篇展示了如下调查结果:有五种经历对预测成年后的科学兴趣、价值及认知倾向具有特殊重要性,即青少年早期参观科学中心;青少年早期观看科学类电视节目;成年后参观科学中心;成年后阅读科学类书籍杂志;成年后使用互联网学习科学。本文同时讨论了自我选择、经历的质量以及科学学习生态系统的复杂性和协同性。

关键词：科学教育资源科学兴趣学习生态系统相关性调查

维普期刊数据库

一项对比从富马酸替诺福韦二吡呋酯(TdF)转换为丙酚替诺福韦(TAF)和继续TdF治疗用于病毒学抑制的慢性乙型肝炎(CHB)患者的3期研究:第48周时的疗效和安全性结果

在线全文

学校读者我要写书评

暂无评论

一项对比从富马酸替诺福韦二吡呋酯(TDF)转换为丙酚替诺福韦(TAF)...

Tubular-Cell Secrets Osteoblast Growth Factor and Kaempferol from drynaria fortunei Promotes the Secretion

第十届全国疑难及重症肝病大会

作者： Pietro Lampertico Maria Buti Scott Fung Sang Hoon Ahn Wan-Long Chuang Won Young Tak Alnoor Ramji Chi-Yi Chen Edward Tam Ho Bae Xiaoli Ma john F.Flaherty Anuj Gaggar Audrey Lau Becket Feierbach George Wu Vithika Suri Mani Subramanian Cong Cheng Huy N.Trinh Seung Kew Yoon Kosh Agarwal Young-Suk Lim Henry Chan Università degli Studi di Milano Division of Gastroenterology and Hepatology University Hospital Vall d'Hebron University Health Network Yonsei University Kaohsiung Medical University

背景和目的TAF是替诺福韦(TFV)的一种新型前体药物,近期获批用于治疗慢性乙型肝炎。与TdF相比,TAF的血浆稳定性更高,能够更有针对性地将TFV递送至肝脏且降低了TFV的循环水平。第48周和第96周时,TAF表现出不劣于TdF的疗效且改善肾脏和骨...

背景和目的TAF是替诺福韦(TFV)的一种新型前体药物,近期获批用于治疗慢性乙型肝炎。与TdF相比,TAF的血浆稳定性更高,能够更有针对性地将TFV递送至肝脏且降低了TFV的循环水平。第48周和第96周时,TAF表现出不劣于TdF的疗效且改善肾脏和骨骼安全性。本研究评估了从TdF转换为TAF vs.继续接受1年TdF治疗用于病情稳定的病毒学抑制患者时的疗效和安全性。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Tubular-Cell Secrets Osteoblast Growth Factor and Kaempferol...

丙酚替诺福韦(TAF)和富马酸替诺福韦二吡呋酯(TdF)治疗用于HBeAg阴性和HBeAg阳性的慢性乙型肝炎患者三年疗效和安全性对比

2010年中国药学大会暨第十届中国药师周

作者： LI Shunxiang1,2,YUE Chunhua1,HUANG dan1,johnson Francis3,LONG Mian1,4?,ZHANG Zhiguang5 (1. Pharmacy school,Hunan University of Chinese Medicine,Changsha 410218,China 2. Hunan Provincial Key Laboratory of drug Research,Hunan Academy of Traditional Chinese Medicine,Changsha 410013,China 3. departments of Pharmacology and Chemistry,Stony Brook University,Stony Brook,NY 11794-3400 USA 4. department of Complementary and Alternative Medicine,john A. Burns School of Medicine. University of Hawaii at Maona,96813 USA 5. Hunan Normal University,Changsha 410081,China.)

Patients with Chronic kidney disease （CKd） associated with bone deficiency are observed in clinical practice. This article reports the finding that kidney cells secrete a bone growth factor that is stimulated by kaempferol found in the flavones fraction （FF） of Rhizoma drynariae （Gu Sui Bu, GSB）. The FF was extracted from GSB by 50% ethanol, and isolated by macroporous resin, silica gel and Sephadex LH-20 column chromatography. Four components were isolated and identified to be naringin （1）, neoeriocitrin （2） , kaempferol （3） and naringenin-7-O-β-d-glucoside （4）. The activity of the components was examined by studying the proliferation and bio-function of Opossum Kidney （OK）, osteoblast （MC3T3 E1） and human fibroblast （HF） cells. Kaempferol was found to be active in promoting OK cell growth, which increased by 16-30% and 11.6% respectively in the absence or presence of gentamicin. Kaempferol promoted neither MC3T3 E1 nor HF cell proliferation. OK cell-conditioned culture medium （OKM） increased MC3T3 E1 growth by 198%. At 70 nmol·L-1 kaempferol- conditioned OKM, MC3T3E1 cell growth additionally increased by 127% in comparison to control OKM. Both OKMs failed to show any significant effect on HF cell growth. The results of OKM promoted osteoblast proliferation indicate that the kidney cell secretes a bone-growth factor （BGF）. Kaempferol stimulates kidney cells proliferation and increases secretion of BGF. The data suggest that patients with CKd associated with bone deficiency, may have a lower level of BGF. Kaempferol may serve to stimulate kidney repair and up-regulate bone formation and may be useful in treating CKd and osteoporosis. [

关键词： kaempferol renal tubular cell osteoblast bone growth factor (BGF) Rhizoma drynariae Gusuibu

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

丙酚替诺福韦(TAF)和富马酸替诺福韦二吡呋酯(TDF)治疗用于HBeAg...

异丁子香酚及其衍生物接触致敏:过敏原置换问题

第十届全国疑难及重症肝病大会

作者： Henry Lik Yuen Chan Young-Suk LIM Wai Kay Walter Seto Kosh Agarwal Maurizia R.Brunetto Harry L.A.Janssen Florin Caruntu Tatjana Stepanova Owen Tsang Hiroshi Yatsuhashi Won Young Tak Chi-Yi Chen Mustafa Celen Vithika Suri john F.Flaherty Lanjia Lin Andrea Cathcart Anuj Gaggar Cong Cheng Calvin Q.Pan Shalimar Maria Buti Institute of digestive disease Department of Medicine and Therapeuticsand State Key Laboratory of Digestive DiseaseThe Chinese University of Hong Kong Gastroenterology Asan Medical CenterUniversity of Ulsan College of Medicine Queen Mary Hospital Institute of Liver Studies King’s College Hospital NHS Trust Hepatology Unit University Hospital of Pisa Toronto Centre for Liver disease University Health Network Infectious diseases National Institute for Infectious Diseases Matei Bals Modern Medicine Clinic Princess Margaret Hospital National Hospital Organization Nagasaki Medical Center Kyungpook National University Hospital Chia-Yi Christian Hospital Gilead Sciences Inc NYU Langone Medical Center Gastroenterology All India Institute of Medical Sciences Hospital Universitari Vall d’Hebron dicle University Hospital Infectious diseases

背景在2项设计相同的双盲、随机(2:1)、3期研究中,第48周和第96周时,TAF的疗效不劣于TdF,而且具有良好的肾脏和骨骼安全性。方案修订后,50%的入组患者的双盲(dB)治疗期再延长1年,而其余受试者在第96周(第2年)时更换为开放标签(OL)TAF。...

背景在2项设计相同的双盲、随机(2:1)、3期研究中,第48周和第96周时,TAF的疗效不劣于TdF,而且具有良好的肾脏和骨骼安全性。方案修订后,50%的入组患者的双盲(dB)治疗期再延长1年,而其余受试者在第96周(第2年)时更换为开放标签(OL)TAF。本研究评估了3年TAF和TdF治疗在接受相应药物的患者中的安全性和疗效对比结果。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 25-25页

作者： Tanaka S. Royds C. Buckley d. J.P. McFadden 崔荣 St. john's Institute of dermatology St. Thomas'Hospital London SE17EH United Kingdom

A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed i n the EUInventory of Fragrance Ingredients. Positive reactions were found to iso eugenol in 40, transisoeugenol in 40, isoeugenyl acetate in 19, isoeugenyl benzo ate in 4, isoeugenyl phenylacetate in 16, isoeugenyl methyl ether in 6 and benzy l isoeugenyl ether in 2 patients. There was a concomitant reaction to isoeugenol in 36/40 of those positive to transisoeugenol, 13/19 of those to isoeugenyl ace tate, 3/4 of those to isoeugenyl benzoate and 15/16 of those to isoeugenyl pheny lacetate but in none of those 6 positive to isoeugenyl methyl ether and in neith er of those 2 positive to benzylisoeugenyl ether. Concomitant contact allergy be tween isoeugenol and its derivatives may occur through chemical cross-reactivit y or local skin metabolism of the derivatives. It is more commonly observed with the esters rather than the ethers. Isoeugenyl acetate has been proposed as an a lternative to isoeugenol, but there is a high degree of concomit an treactivity with isoeugenol.

关键词：异丁子香酚丁子香斑贴试验致敏安息香酸乙酸苯酯反应者阳性反应皮肤代谢醚类

维普期刊数据库

左半球损伤后的不同右额叶激活在语言处理中的作用

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(神经病学分册) 2006年第8期 45-45页

作者： Voets N.L. Adcock J.E. Flitney d.E. 赵天智 FMRIB Centre John Radcliffe Hospital Headington Oxford OX3 9DU United Kingdom

Right hemisphere activation during functional imaging studies of language has frequently been reported following left hemisphere injury. Few studies have anatomically characterized the specific right hemisphere structures engaged. We used functional MRI (fMRI) with verbal fluency tasks in 12 right- handed patients with left temporal lobe epilepsy (LTLE)and 12 right- handed healthy controls to localize language- related activity in the right inferior frontal gyrus (RIFG). during the phonemic task, LTLE patients activated a significantly more posterior region of the right anterior insula/frontal operculum than healthy controls (P = 0.02). Activation of the left inferior frontal gyrus (LIFG) did not differ significantly between the two groups. This suggests that, following left hemisphere injury, language- related processing in the right hemisphere differs from that with a functionally normal left hemisphere. The localization of activation in the left and right inferior frontal gyri was determined with respect to the anatomical sub- regions pars opercularis (Pop), pars triangularis (Ptr) and pars orbitalis (Por). In the LIFG, both healthy controls (8 out of 12) and LTLE patients (9 out of 12) engaged primarily Pop during phonemic fluency. Activations in the RIFG, however, were located mostly in the anterior insula/frontal operculum in both healthy controls (8 out of 12) and LTLE patients (8 out of 12), albeit in distinct regions. Mapping the locations of peak voxels in relation to previously obtained cytoarchitectonic maps of Broca’s area confirmed lack of homology between activation regions in the left and right IFG. Verbal fluency- related activation in the RIFG was not anatomically homologous to LIFG activation in either patients or controls. To test more directly whether RIFG activation shifts in a potentially adaptive manner after left hemisphere injury, fMRI studies were performed in a patient prior to and following anatomical left hemispherectomy for the treatme

关键词：大脑半球切除术损伤后左半球额叶大脑皮质

五羟色胺2C受体结构揭示GPCR多重药理学特性的结构基础

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

科学新闻 2019年第2期 48-48页

作者：彭瑶 john d.McCorvy Kasper Harps?e Katherine Lansu Shuguang Yuan Petr Popov Lu Qu Mengchen Pu Tao Che Louise F.Nikolajsen Xi-Ping Huang Yiran Wu Ling Shen Walden E.Bj?rn-Yoshimoto Kang ding daniel Wacker Gye Won Han Jianjun Cheng Vsevolod Katritch Anders A.Jensen Michael A.Hanson Suwen Zhao david E.Gloriam Bryan L.Roth Raymond C.Stevens 刘志杰上海科技大学iHuman研究所中国科学院生物物理研究所上海科技大学

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2C受体选择性的配体或设计具有明确的多重药理学特... 详细信息

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2C受体选择性的配体或设计具有明确的多重药理学特征的药物仍然是极其困

关键词：五羟色胺

扩张型心肌病:7T31P-MR波谱成像的应用

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2017年第1期 82-82页

作者： V.M.Stoll W.T.Clarke E.Levelt A.Liu S.G.Myerson M.d.Robson 赵玉娇 division of Cardiovascular Medicine Radcliffe Department of Medicine University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR)Level 0 John Radcliffe Hospital

摘要目的与3 T心脏代谢产物定量分析相比,探讨7 T31P-MR波谱成像中信噪比增加能否提高诊断扩张型心肌病的精确性。材料与方法本研究已通过伦理委员会批准,

关键词：心肌病心肌疾病波谱成像 P-MR 扩张型

CEPC Technical design Report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Radiation detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili deng Binglin denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella d'Anzi Ling-Yun dai Xinchen dai Xuwen dai Antonio de Maria Nicola de Filippis Christophe de La Taille Francesca de Mori Chiara de Sio Elisa del Core Shuangxue deng Wei-Tian deng Zhi deng Ziyan deng Bhupal dev Tang dewen Biagio di Micco Ran ding Siqin dingl Yadong ding Haiyi dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTd Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille dalian Minzu University DalianLiaoning dalian University of Technology Department of PhysicsDalian deutsches Elektronen-Synchrotron dESY Hamburg dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(dLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical design Report(TdR)follows the Preliminary Conceptual design Report(Pre-CdR,2015)and the Conceptual design Report(CdR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&d and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise