检索结果-南通市图书馆

Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance

World Journal of Stem Cells 2015年第2期7卷 281-299页

作者： john d West Natalie J dorà J Martin Collinson Genes and development Group Centre for Integrative PhysiologyCollege of Medicine and Veterinary MedicineUniversity of Edinburgh Institute of Medical Sciences School of Medical SciencesCollege of Life Sciences and MedicineForesterhillUniversity of Aberdeen

In this review we evaluate evidence for three different hypotheses that explain how the corneal epithelium is maintained. The limbal epithelial stem cell(LESC)hypothesis is most widely accepted. This proposes that stem cells in the basal layer of the limbal epithelium, at the periphery of the cornea, maintain themselves and also produce transient(or transit) amplifying cells(TACs). TACs then move centripetally to the centre of the cornea in the basal layer of the corneal epithelium and also replenish cells in the overlying suprabasal layers. The LESCs maintain the corneal epithelium during normal homeostasis and become more active to repair significant wounds. Second, the corneal epithelial stem cell(CESC) hypothesis postulates that, during normal homeostasis, stem cells distributed throughout the basal corneal epithelium, maintain the tissue. According to this hypothesis, LESCs are present in the limbus but are only active during wound healing. We also consider a third possibility, that the corneal epithelium is maintained during normal homeostasis by proliferation of basal corneal epithelial cells without any input from stem cells. After reviewing the published evidence, we conclude that the LESC and CESC hypotheses are consistent with more of the evidence than the third hypothesis, so we do not consider this further. The LESC and CESC hypotheses each have difficulty accounting for one main type of evidence so we evaluate the two key lines of evidence that discriminate between them. Finally, we discuss how lineage-tracing experiments have begun to resolve the debate in favour of the LESC hypothesis. Nevertheless, it also seems likely that some basal corneal epithelial cells can act as long-term progenitors if limbal stem cell function is compromised. Thus, this aspect of the CESC hypothesis may have a lasting impact on our understanding of corneal epithelial maintenance, even if it is eventually shown that stem cells are restricted to the limbus as proposed by the

关键词： Eye Cornea Corneal epithelium Limbalepithelium Stem cell Lineage tracing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

differential response of tomato genotypes to Xanthomonas-specific pathogen-associated molecular patterns and correlation with bacterial spot (Xanthomonas perforans) resistance

引用

Horticulture Research 2016年第1期3卷 142-147页

作者： Krishna Bhattarai Frank J Louws john d Williamson dilip R Panthee department of Horticultural Science North Carolina State UniversityMountain Horticultural Crops Research and Extension CenterMills RiverMills RiverNC 28759USA department of Plant Pathology North Carolina State UniversityRaleighNC 27695USA department of Horticultural Science North Carolina State UniversityRaleighNC 27695USA

Plants depend on innate immune responses to retard the initial spread of pathogens entering through stomata,hydathodes or *** responses are triggered by conserved patterns in pathogen-encoded molecules known as pathogen-associated molecular patterns(PAMPs).Production of reactive oxygen species(ROS)is one of the first responses,and the resulting‘oxidative burst’is considered to be a first line of *** this study,we conducted association analyses between ROS production and bacterial spot(BS;Xanthomonas spp.)resistance in 63 genotypes of tomato(Solanum lycopersicum L.).A luminol-based assay was performed on leaf tissues that had been treated with a flagellin 22(flg22),flagellin 28 and a Xanthomonas-specific flg22(flg22-Xac)peptide,to measure PAMP-induced ROS production in each *** genotypes were also assessed for BS disease response by inoculation with Xanthomonas perforans,race *** there was no consistent relationship between peptides used and host response to the BS,there was a significant negative correlation(r=−0.25,Pdisease severity and ROS production,when flg22-Xac was *** response could potentially be used to identify the Xanthomonas-specific PRR allele in tomato,and eventually PAMP-triggered immunity loci could be mapped in a segregating *** has potential significance in tomato improvement.

关键词： eventually injuries specific

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Leading Approaches to Vascularize Kidney Constructs in Tissue Engineering

引用

Engineering 2022年第12期19卷 117-127页

作者： diana S.Lim john d.Jackson Anthony Atala James J.Yoo Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineMedical Center BoulevardNC 27157USA

There is an unprecedented need for new treatments for renal failure,as the incidence of this disease is increasing disproportionately to advancements in *** treatments are limited by the availability of viable organs,for which there is a worldwide *** treatment modalities also require a substantial amount of infrastructure,significantly limiting the access to care in most *** tissue engineering approaches promise to develop alternative solutions that address many of the inadequacies in current *** many advancements have been made—primarily in the past decade—in biofabrication and whole-organ tissue engineering,many challenges *** major hindrance to the progress of current tissue engineering approaches is establishing successful vascularization of developed engineered tissue *** review focuses on the recent advancements that address the vascular challenge,including the biofabrication of vasculature,whole-organ engineering through decellularization and recellularization approaches,microscale organogenesis,and vascularization using organoids in the context of kidney tissue *** also highlight the specific challenges that remain in developing successful strategies capable of clinical translation.

关键词： Kidney Vascularization Tissue engineering Biofabrication Organoids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

引用

Frontiers of Medicine 2021年第3期15卷 416-437页

作者： Xu Yu Jin Mario Petrou Jiang Ting Hu Ed d Nicol john R Pepper Surgical Echo-Cardiology Services Oxford Heart CentreJohn Radcliffe HospitalOxford University Hospitals NHS Foundation TrustOxford OX39DUUK Cardiac Surgical Physiology and Genomics Group Nuffield Division of Clinical Laboratory SciencesRadcliffe Department of MedicineUniversity of OxfordOxford OX39DUUK department of Cardiac Surgery Royal Brompton HospitalLondon SW36NPUK National Heart and Lung Institute Imperial College LondonLondon SW36LYUK NIHR Imperial Biomedical Research Centre London W21NYUK department of Cardiology Royal Brompton HospitalLondon SW36NPUK

Over the last half century,surgical aortic valve replacement(SAVR)has evolved to offer a durable and efficient valve haemodynamically,with low procedural complications that allows favourable remodelling of left ventricular(LV)structure and *** latter has become more challenging among elderly patients,particularly following trans-catheter aortic valve implantation(TAVI).Precise understanding of myocardial adaptation to pressure and volume overloading and its responses to valve surgery requires comprehensive assessments from aortic valve energy loss,valvular-vascular impedance to myocardial activation,force-velocity relationship,and myocardial *** hypertrophy and myocardial fibrosis remains as the structural and morphological focus in this *** intervention in asymptomatic aortic stenosis or regurgitation along with individualised management of hypertension and atrial fibrillation is likely to improve patient *** pacing via the His-Purkinje system for conduction abnormalities,further reduction in para-valvular aortic regurgitation along with therapy of angiotensin receptor blockade will improve patient outcome by facilitating hypertrophy regression,LV coordinate contraction,and global vascular *** leaflet thromboses require anticoagulation while impaired access to coronary ostia risks future TAVI-in-TAVI or coronary *** comparable long-term durability and the resolution of TAVI related complications become available,SAVR remains the first choice for lower risk younger patients.

关键词： surgical aortic valve replacement trans-catheter aortic valve implantation left ventricular hypertrophy and fibrosis myocardial force-velocity relationship His-Purkinje pacing renin-angiotensin system inhibitors coronary access impairment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

design and simulation of self-powered radio frequency identification (RFId) tags for mobile temperature monitoring

引用

Science China(Technological Sciences) 2013年第1期56卷 1-7页

作者： CHU HeQun WU GuangMin CHEN JianMing FEI Fei MAI john d LI Wen J MEMS Laboratory Department of Physics Faculty of Science Kunming University of Science and Technology department of Mechanical and Biomedical Engineering City University of Hong Kong

This paper presents a design for a self-powered radio frequency identification (RFId) tag with a thin film bulk acoustic reso- nating piezoelectric power supply (PPS), which can be used for portable remote temperature monitoring. We call this system a PPS-RFId for short. The RFId systems have been found to have many applications in the internet of things (IOT) in the past decade. But semi-active RFId tags require an onboard battery which limits their applications in many fields. For these reasons, our research focuses on power sources for the RFId tags. This paper emphasizes the circuit design and simulation of PPS. In our tests, 0.283 mW was generated by PPS at 1 Hz vibration by a 650 N impact force. The results showed that the integrated PPS could supply sufficient power for the designed PPS-RFId tag. The PPS-RFId tag can be widely used for temperature monitoring during mobile transport of perishable items such as medicines or food.

关键词： self-powered radio frequency identification (RFId) piezoelectric temperature monitoring energy harvesting internet of things

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Qidong: a crucible for studies on liver cancer etiology and prevention

引用

Cancer Biology & Medicine 2019年第1期16卷 24-37页

作者： Jianguo Chen Jian Zhu Gaoren Wang john d.Groopman Thomas W.Kensler department of Epidemiology Qidong Liver Cancer Institute department of Epidemiology Tumor Hospital Nantong University department of Environmental Health and Engineering Johns Hopkins Bloomberg School of Public Health Public Health Sciences division Fred Hutchinson Cancer Research Center

Qidong(Jiangsu, China) has been of interest to cancer epidemiologists and biologists because, until recently, it was an endemic area for liver cancer, having amongst the highest incidence rates in the world. The establishment of the Qidong Cancer Registry together with the Qidong Liver Cancer Institute in 1972 has charted the patterns of liver cancer incidence and mortality in a stable population throughout a period of enormous economic, social, and environmental changes as well as of improvements in health care delivery. Updated incidence trends in Qidong are described. Notably, the China age-standardized incidence rate for liver cancer has dropped by over 50% in the past several decades. Molecular epidemiologic and genomic deep sequencing studies have affirmed that infection with hepatitis B virus as well as dietary exposure to aflatoxins through contamination of dietary staples such as corn, and to microcystins–blue-green algal toxins found in ditch and pond water – were likely important etiologic factors that account for the high incidence of liver cancer in this region. Public health initiatives to facilitate universal vaccination of newborns against HBV and to improve drinking water sources in this rural area, as well as economic and social mandates serendipitously facilitating dietary diversity, have led to precipitous declines in exposures to these etiologic factors, concomitantly driving substantive declines in the liver cancer incidence seen now in Qidong. In this regard, Qidong serves as a template for the global impact that a package of intervention strategies may exert on cancer burden.

关键词： Liver cancer incidence hepatitis B virus aflatoxin microcystin screening chemoprevention mutational signature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of introducing weather parameters on the accuracy of milk production forecast models

引用

Information Processing in Agriculture 2020年第1期7卷 120-138页

作者： Fan Zhang john Upton Laurence Shalloo Philip Shine Michael d.Murphy department of Process Energy and Transport EngineeringCork Institute of TechnologyCo.CorkIreland Animal and Grassland Research Innovation Centre Teagasc MooreparkCo.CorkIreland

The objective of this study was to analyze the effect of adding meteorological data to the training process of two milk production forecast *** two models chosen were the nonlinear auto-regressive model with exogenous input(NARX)and the multiple linear regression(MLR)*** accuracy of these models were assessed using seven different combinations of precipitation,sunshine hours and soil temperature as additional model training *** data(daily milk yield and days in milk)from 39 pasture-based Holstein-Friesian Irish dairy cows were selected to compare to the model outputs from a central *** models were trained using historical milk production data from three lactation cycles and were employed to predict the total daily milk yield of a fourth lactation cycle for each individual cow over short(10-day),medium(30-day)and long-term(305-day)forecast *** NARX model was found to provide a greater prediction accuracy when compared to the MLR model when predicting annual individual cow milk yield(kg),with R2 values greater than 0.7 for 95.5%and 14.7%of total predictions,*** results showed that the introduction of sunshine hours,precipitation and soil temperature data improved the prediction accuracy of individual cow milk prediction for the NARX model in the short,medium and long-term forecast *** hours was shown to have the largest impact on milk production with an improvement of forecast accuracy observed in 60%and 70%of all predictions(for all 39 test cows from both groups).However,the overall improvement in accuracy was small with a maximum forecast error reduction of 4.3%.Thus,the utilization of meteorological parameters in milk production forecasting did not have a substantial impact on forecast accuracy.

关键词： Milk production forecasting dairy modelling Model optimization Meteorological data

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Upper range limit establishment after wildfire of an obligateseeding montane forest tree fails to keep pace with 20th century warming

引用

Journal of Plant Ecology 2018年第2期11卷 200-207页

作者： john W.Morgan James d.Vincent James S.Camac Research Centre for Applied Alpine Ecology Department of EcologyEnvironment and EvolutionLa Trobe UniversityKingsbury DriveBundooraVIC 3086Australia department of Biological Sciences Macquarie UniversityBalaclava RoadNorth RydeNew South Wales 2109Australia

Aims How species respond to climate change at local scales will depend on how edaphic and biological characteristics interact with species physiological limits and traits such as *** seeders,those species that depend on fire for recruitment,have few and epi-sodic opportunities to track a changing climate *** such cases,long-distance seed dispersal will be necessary to take advan-tage of rare recruitment *** examine recruitment patterns and seedling growth below,at and above the timberline of an obligate-seeding Australian montane forest tree(Eucalyptus delegatensis)after stand-replacing fire,and place these changes in the context of regional *** We use two methods to detect whether *** can estab-lish and persist above the timberline after stand-replacing wildfire in montane forests in south-east ***,we examine estab-lishment patterns by using belt transects at six sites to quantify how changes in post-fire recruit density with increasing distance above the timberline seven years ***,to determine whether dispersal or physiological constraints determine post-fire establish-ment patterns,we transplanted seedlings and saplings into bare ground above(100 m elevation),at,and below(50 m elevation)timberline 18-months after *** monitored seedling growth and survival for one growing *** Findings There was minimal upslope migration of the species after fire with most saplings observed near seed-bearing timberline trees,with only occasional outpost *** seedlings and saplings sur-vived equally well across one growing season when planted above existing timberlines,relative to saplings at or below the *** and sapling growth rates also did not differ across these location,although seedlings grew at much faster rates than *** findings suggest that upslope growing season conditions are unlikely to limit initial range expansion of trees aft

关键词： climate change dispersal limitation growth rates regeneration niche timberline

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

diagnosis and management of ureteral complications following renal transplantation

引用

Asian Journal of Urology 2015年第4期2卷 202-207页

作者： Brian d.duty john M.Barry department of Urology Oregon Health&Science UniversityPortlandORUSA department of Surgery Division of Abdominal Organ TransplantationOregon Health&Science UniversityPortlandORUSA

When compared with maintenance dialysis,renal transplantation affords patients with end-stage renal disease better long-term survival and a better quality of *** 9% of patients will develop a major urologic complication following kidney *** complications are most common and include obstruction(intrinsic and extrinsic),urine leak and vesicoureteral *** anastomotic strictures result from technical error or ureteral *** dilation or endoureterotomy may be considered for short,low-grade strictures,but open reconstruction is associated with higher success *** leak usually occurs in the early postoperative *** 60% of patients can be successfully managed with a pelvic drain and urinary decompression(nephrostomy tube,ureteral stent,and indwelling bladder catheter).Proximal,large-volume,or leaks that persist despite urinary diversion,require open *** reflux is common following *** with recurrent pyelonephritis despite antimicrobial prophylaxis require surgical *** injection may be considered in recipients with low-grade *** IV and V reflux are best managed with open reconstruction.

关键词： Renal transplantation Ureteral stricture Ureteral obstruction Urine leak Vesicoureteral reflux

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A review of organotin contamination in arctic and subarctic regions

引用

Emerging Contaminants 2019年第1期5卷 150-156页

作者： john R.Kucklick Michael d.Ellisor National Institute of Standards and Technology Chemical Sciences DivisionCharlestonSouth Carolina 29412USA Current Address:O2SI Smart Solutions an LGC Standards Company CharlestonSouth CarolinaUSA

Organotin(OT)compounds are of continued Arctic concern as they are still widely used despite the most well-studied OT,tributyl tin(TBT),being restricted from use on marine vessels to prevent fouling by marine *** highest OT concentrations found in Arctic fauna are in regions associated with human activity especially *** is an overall trend of declining butyl tin(BT)concentrations in Arctic fauna especially molluscs which are the subject of a limited number of long-term monitoring *** incidence of imposex has likewise generally declined in molluscs in response to declining TBT *** are a number of knowledge gaps in OT occurrence and transport in the Arctic that warrant continued ***,in particular octyl tins,are heavily used in the production of plastic,hence leaching from plastic may be an unrecognized source to Arctic *** review also found several studies reporting volatile tin species in the atmosphere suggesting atmospheric transport of volatile tins to the Arctic is *** to other more well know persistent organic pollutants,there are few reports of OTs in marine mammals and temporal tend studies are needed to define trends in BTs and search for the occurrence of other tin species.

关键词： continued Arctic volatile

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：