检索结果-南通市图书馆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

证据学的现代趋势:一切都生机盎然?

证据学论坛

证据学论坛 2010年 15卷 253-262页

作者： john d.jackson 王进喜爱尔兰Belfast女王大学中国政法大学证据科学研究院

一、导言当证据学思想史的老前辈William Twining处于其探索的较早阶段时,他得出了这样的结论,即尽管正统的证据文献有诸多优点,仍可以对其提出许多指摘。第一,它过于狭隘,关注的几乎完全是可采性规则。第二,它是非理论性的,因为许多讨...

一、导言当证据学思想史的老前辈William Twining处于其探索的较早阶段时,他得出了这样的结论,即尽管正统的证据文献有诸多优点,仍可以对其提出许多指摘。第一,它过于狭隘,关注的几乎完全是可采性规则。第二,它是非理论性的,因为许多讨论都是在假定的常识性的经验主义范围内进行的。第三,它是非连贯性的,因为法律理论的概念框架没有为建立与其他论域的联系提供足够的基础。第四,它导

关键词：

组织工程中肾脏血管化构建的领先方法（英文）

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Engineering 2022年第12期 117-127+6页

作者： diana S.Lim john d.jackson Anthony Atala James J.Yoo Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineMedical Center Boulevard

由于肾衰竭发病率升高的速度远超治疗方法的进展速度,因而对这种疾病新的治疗方法的需求也是以前所未有的速度不断增加。目前的治疗受制于可供应的活器官,而世界范围内均缺乏这种器官。这些治疗模式还需要大量的基础结构,这也极大地限...

由于肾衰竭发病率升高的速度远超治疗方法的进展速度,因而对这种疾病新的治疗方法的需求也是以前所未有的速度不断增加。目前的治疗受制于可供应的活器官,而世界范围内均缺乏这种器官。这些治疗模式还需要大量的基础结构,这也极大地限制了大多数国家的患者获得医疗服务的机会。通过肾脏组织工程方法有望开发出替代的解决方案,解决目前治疗中仍存在的许多不足之处。尽管在生物制造和全器官组织工程方面已经取得了许多进展——主要是在过去的十年中取得的,但仍然存在许多挑战。当前组织工程方法进展中的一个主要障碍是如何对已形成的工程化组织构建体实施成功的血管化。本文主要涉及近年来解决血管问题取得的进展,包括脉管系统的生物制造、通过脱细胞和再细胞化方法实施全器官工程、微尺度器官形成,以及在肾脏组织工程背景下以类器官取得血管化。我们还着重探讨了在制定成功的临床转化策略中仍然存在的具体问题。

关键词：

Theoretical study and optimization of a high power mid-infrared erbium-doped ZBLAN fibre laser

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2011年第3期20卷 239-246页

作者：李剑峰 Stuart d.jackson School of Optoelectronic Information University of Electronic Science and Technology of China Institute of Photonics and Optical Science School of PhysicsUniversity of Sydney

Based on the rate equations describing the erbium-doped fluoride glass （ZBLAN） fibre lasers with different pumping configurations being taken into account, this paper presents theoretical calculations related to the dynamic population density and the operation performance of a high power mid-infrared all-fibre erbium-doped ZBLAN fibre laser. It shows that the ground-state absorption, excited-state absorption and energy-transfer-upconversion processes co-exist and produce a population balance, causing the laser to operate stably at a continuous wave state. A good agreement between the theoretical results and recent experimental measurement is obtained. Furthermore, the laser structure parameters including fibre length, reflectance of output fibre Bragg grating and pumping configurations are quantitatively optimised to achieve the best performance. The results show, as expected, that the slope efficiency of the fibre laser can be improved significantly through optimisation, which then provides an important guide for the design of high-performance mid-infrared erbium-doped ZBLAN fibre lasers.

关键词： Lerbium-doped fibre laser mid-infrared fibre laser ZBLAN fibre rate equations

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in drosophila

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 475-476页

作者： jackson Powell Tobias Steinschaden Rose Horowitz Yuanquan Song Raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

Targeting TrkB–PSd-95 coupling to mitigate neurological disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Postpartum meloxicam administration alters plasma haptoglobin, polyunsaturated fatty acid, and oxylipid concentrations in postpartum ewes

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2020年第4期11卷 1047-1060页

作者： Katie EOlagaray Barry J.Bradford Lorraine M.Sordillo Jeffery C.Gandy Laman K.Mamedova Turner H.Swartz Trey d.jackson Emma K.Persoon Caitlin S.Shugart Curtis R.Youngs department of Animal Sciences and Industry Kansas State UniversityManhattan 66506USA College of Veterinary Medicine Michigan State University2265K Anthony HallEast LansingMI 48824-1225USA department of Animal Science Iowa State UniversityAmesIAUSA.

Background: Postpartum inflammation is a natural and necessary response;however, a dysfunctional inflammatory response can be detrimental to animal productivity. The objective of this study was to determine the effects of a non-steroidal anti-inflammatory drug(meloxicam) on ewe postpartum inflammatory response, ewe plasma polyunsaturated fatty acid and oxylipid concentrations, and lamb ***: After lambing, 36 Hampshire and Hampshire × Suffolk ewes were sequentially assigned within type of birth to control(n = 17) or meloxicam orally administered on d 1 and 4 of lactation(MEL;90 mg, n = 19). Milk and blood samples were collected on d 1(prior to treatment) and d 4. Milk glucose-6-phosphate was not affected by MEL. Plasma haptoglobin(Hp) concentrations were less for MEL ewes;control ewes with greater d 1 Hp concentrations had elevated Hp on d 4, but this was not the case for MEL-treated ewes. Treatment with MEL increased plasma arachidonic acid concentration by more than 4-fold in ewes rearing singles but decreased concentrations of 9,10-dihydroxyoctadecenoic acid, prostaglandin F2α, 8-iso-prostaglandin E2, and 8,9-dihydroxyeicosatetraenoic acid. Nine oxylipids in plasma had interactions of treatment with d 1 Hp concentration,all of which revealed positive associations between d 1 Hp and d 4 oxylipid concentrations for CON, but neutral or negative relationships for MEL. MEL decreased 13-hydroxyoctadecadienoic acid:13-oxooctadecadienoic acid ratio and tended to increase 9-hydroxyoctadecadienoic acid:9-oxooctadecadienoic acid ratio(both dependent on d 1 values), indicating progressive metabolism of linoleic acid-derived oxylipids occurred by enzymatic oxidation after MEL treatment. Meloxicam reduced oxylipids generated across oxygenation pathways, potentially due to an improved redox ***: Postpartum MEL treatment of ewes decreased plasma concentrations of Hp and several oxylipids,with the greatest impact in ewes with biomarkers reflecting a greate

关键词： Eicosanoid Inflammation Lactation Nonsteroidal anti-inflammatory drug Sheep

在线全文

学校读者我要写书评

暂无评论

南加州概率性地震危险性分析

世界地震译丛 1996年第6期27卷 74-79页

作者： M.Mahdyiar A.Cornell d.jackson K.Aki 赵军河北省地震局

引言概率性地震危险性分析(PSHA)是一种涉及多学科的工作,它需要诸如区域地震构造学、地震特征和重复性、地震动形成、地震波传播以及局部场地效应的多种知识。这些资料组成概率模型,可提供任一场地的地震动参数的年超越概率。

关键词：地震危险性概率性分析南加州

Calcium-mediated paired pulse depression in juvenile rat dorsal striatum

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2012年第10期7卷 772-777页

作者： Yufeng Xie Michael F. jackson john F. Macdonald Robarts Research Institute University of Western Ontario London Ontario Canada department of Physiology and Pharmacology University of Western Ontario London Ontario Canada department of Anatomy and Cell Biology University of Westem Ontario London Ontario Canada

As the major division of the basal ganglia, neostriatum forms mutual connections with multiple brain areas and is critically involved in motor control and learning/memory. Long-term synaptic plasticity has been widely studied in different species recently. However, there are rare reports about the short-term synaptic plasticity in neostratium. In the present study, using field excitatory postsynaptic potentials recording, we reported one form of short-term synaptic plasticity that is paired pulse depression in juvenile rat dorsal striatum slices induced by stimuli of the white matter. The field excitatory postsynaptic potentials could be abolished by α-amino-3-hydroxy-5-methylizoxazole-4-propionic acid receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione, but not by gamma-aminobutyric acid type A receptor antagonist bicuculline or dopamine d1 receptor antagonist SKF-81297. The paired pulse depression in the corticostratial pathway was different from paired pulse facilitation in the hippocampal CA1 synapse. In addition, the paired pulse depression was not affected by bath application of gamma-aminobutyric acid type A receptor antagonist or dopamine d1 receptor antagonist. However, low calcium and high magnesium could attenuate the paired pulse depression. These findings suggest a more complicated plasticity form in the dorsal striatum of juvenile rats that is different from that in the hippocampus, which is related with extracellular calcium.

关键词： paired pulses depression dorsal striatum calcium juvenile rats

A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： john Mitrofanis Jonathan Stone Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress