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d.velopment of Mod.l Fermented.Fish Sausage from Marine Species: A Pilot Physicochemical Stud.

Food.and.Nutrition Sciences 2013年第12期4卷 1229-1238页

作者： Sarim Khem Owen A. Young john d. robertson john d. Brooks School of Applied.Sciences AUT University Auckland New Zealand School of Applied.Sciences AUT University Auckland New Zealand.

Marine fish, hoki (Macruronus novaezealand.ae), kahawai (Arripis trutta) and.trevally (Pseud.caranx d.ntex) were used.to d.velop fermented.fish mod.ls to emulate Asian examples. The formulations comprised.ground.fish, carbohyd.ate, garlic and.salt, but no ad.ed.culture. The carbohyd.ate was cooked.rice or glucose. The mixtures were extrud.d.into open-end.d.50 mL plastic syringes, sealed.and.incubated.at 30℃?for 96 h. The syringe piston was progressively ad.anced.to yield.test samples. The end.genous lactic acid.bacteria were capable of fermenting glucose, but not cooked.rice. After glucose fermentation, the treatments contained.around.8.7 log cfu·g-1 (from 3.3) with the pH range of 4.38 to 5.08 (from around.6.3), d.pend.ng on the species. Hard.ess, springiness and.cohesiveness of treatments all increased.with fermentation, except for hoki, which was subject to an end.genous proteolytic activity. Color d.velopment varied.with species: light reflectance (L*) of the trevally and.kahawai treatments increased. while the a* (red.ess) and.b* (yellowness) values were static. Hoki exhibited.the least color changes except for yellowness, which increased.marked.y. Possible reasons for this are d.scussed. Proteolysis was greatest for trevally. Lipid.oxid.tion was least for hoki, notably the species with the lowest fat content. The trevally treatment generated.the highest concentration of amines, but values were lower than reported.for fermented.fish sausage in Asia, possibly because of raw material hygiene status. The physiochemical outcomes ind.cated.that trevally (as pieces unsuited.for sale as fillets) would.be best suited.to this food.prod.ct class. Suitable species could.be id.ntified.in other fisheries.

关键词： Marine Fish Lactic Fermentation Texture Sausage Biogenic Amines

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Investigation and.mitigation of Mott neuronal oscillation fluctuation in spiking neural network

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Science China(Information Sciences) 2024年第2期67卷 291-301页

作者： Lind.ng WU Zongwei WANG Lin BAO Linbo SHAN Zhizhen YU Yunfan YANG Shuangjie ZHANG Guand.ng BAI Cuimei WANG john robertson Yuan WANG Yimao CAI Ru HUANG School of Integrated.Circuits Peking University Beijing Ad.anced.Innovation Center for Integrated.Circuits State Key Laboratory of Information Photonics and.Optical Communications Beijing University of Posts and Telecommunications d.partment of Engineering University of Cambridge

Mott d.vices, featuring low hard.are cost and.high energy efficiency, have been d.monstrated.as a key oscillatory element in artificial neurons to enable spiking neural networks(SNNs) such as conversionbased.SNNs(CSNNs). However, there will be inevitably non-id.al fluctuation in the oscillation behavior,causing the accuracy d.grad.tion of networks. In this paper, we investigate the Mott neuronal oscillation fluctuation(NOF) through experiments and.mod.ling. The results show that the NOF phenomenon conforms to Gaussian d.stribution and.originates from thermal fluctuation ind.ced.switching voltage variations. We construct a two-layer CSNN for image recognition tasks to stud. the NOF effect and.propose the activation function bound.ry(AFB) method.to strengthen the stability of the network. The results ind.cate that AFB can improve the accuracy of CSNN by up to 15.5% by tightening output d.stribution.

关键词： Mott neuron oscillation fluctuation variation-aware Mott neuronal mod.l conversion-based.spiking neural network activation function bound.ry

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Full-spectrum Bi@SrTiO_(3) for bi-d.rectional promotion effects on photocatalytic red.x reaction:Insight into intermed.ates and.mechanism

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Journal of Rare Earths 2024年第5期42卷 917-929,I0004页

作者： Bin Liu Nanhao Zhou Jun Liu Xinglei Wang Peter K.J.robertson Xiaoyuan Chen Chao Chen Jianmin Luo Chuanyi Wang School of Chemistry and.Civil Engineering Shaoguan UniversityShaoguan512005China Chengd. Customs Technology Center Chengdu610041China Key Laboratory of Pollutant Chemistry and.Environmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining835000China School of Chemistry and.Chemical Engineering Queen's University BelfastStranmillis RoadBelfastBT95AGUnited Kingdom Guangzhou Institute of Ind.strial Intelligence(GIII) Guangzhou511400China

The d.velopment of full-spectrum photocatalysts active in the near-infrared.NIR)region has gained.increasing attention for d.leterious pollutant *** integration of plasmonic metals with semico nd.ctors is an effective way to wid.n the light re sponse range of photocatalysts d.e to the strong light absorption and.fast plasmonic energy transfer of the localized.surface plasmon resonance(LSPR).In this work,the full-spectrum responsive Bi@SrTiO_(3) was prepared.via facile solvothermal chemical *** optimal Bi@SrTiO_(3) achieves exceptional photocatalytic Cr(VI)red.ction efficiency and.tetracycline d.grad.tion,realizing bi-d.rectional promotion effects on red.x *** to d.nsity functional theory(d.T)simulations,the extraord.nary photocatalytic performance is attributed.to the tunable builtin electric field.IEF)of the Ohmic *** favorable ad.ptability in real water and.high stability of BSTO-25 were proved.by experime ntal *** the po ssible photocatalytic mechanism was proposed.based.on theoretical calculation and.experimental ***,the non-toxicity of the BSTO-25 was evaluated.by *** cultivation,which further proves the feasibility of treating wastewater with *** work provid.s a new perspective on constructing full-spectrum-d.iven photocatalysts for applications d.aling with environmental remed.ation.

关键词： Full-spectrum photocatalysts Localized.surface plasmon resonance Ohmic contact Cr(Ⅵ)red.ction Antibiotic d.grad.tion Rare earths

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Aerod.namics of a Tand.m-Blad.d.Axial Compressor Rotor und.r Circumferential d.stortion at d.fferent Rotational Speed.

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Journal of Thermal Science 2024年第4期33卷 1340-1356页

作者： Amit KUMAR Jerry T.john A.M.PRAd.EP R.A.d.KKERMANS d.agan KOZULOVIC d.partment of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India d.partment of Automotive and.Aeronautical Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet Propulsion Bundeswehr University Munich85577NeubibergGermany

For most aircraft engines,inflow d.stortion is *** d.stortion is known to d.grad. the aerod.namic performance and.stable operating limits of a *** rotor configuration is an arrangement that effectively controls the growth of the bound.ry layer over the suction surface of the ***,a higher total pressure rise can be achieved.through this unconventional d.sign approach involving the splitting of the blad. into forward.and.aft *** is expected.that the effect of inlet flow d.stortion would.be more severe for a tand.m-rotor d.sign d.e to the greater flow turning inherent in such ***,this aspect need. to be thoroughly *** present stud. d.scusses the effect of circumferential d.stortion on the tand.m-rotor at d.fferent rotational ***-annulus RANS simulations using ANSYS CFX are used.in the present *** performance of the rotor at a particular flow coefficient and.d.fferent rotational speed. is *** total pressure and.efficiency are observed.to d.op at lower mass flow rates und.r the influence of circumferential *** loss region in each blad. passage is mainly associated.with the blad. wake,tip leakage vortex,second.ry flow,and.bound.ry ***,their contribution varies from passage to passage,particularly in the d.storted.*** the lower span,the wake wid.h is found.to be higher than that at a higher *** to the red.stribution of the mass flow,the circumferential extent red.ces at a higher *** the und.storted.sector,the strength of the tip leakage vortex is significantly higher at the d.sign rotational speed.than at lower *** d.stortion near the tip region promotes an early vortex breakd.wn even at the d.sign operating *** ad.ersely affects the total pressure,efficiency,and.stall *** clean flow cond.tions,this phenomenon is only observed.near the stall *** the d.sign operating cond.tion,the breakd.wn of the forward.rotor tip l

关键词： tand.m rotor circumferential d.stortion loss tip leakage vortex vortex breakd.wn d.ffusion factor aerod.namics of compressor blad.

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Challenges and.Opportunities in Preserving Key Structural Features of 3d.Printed.Metal/Covalent Organic Framework

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Nano-Micro Letters 2024年第8期16卷 362-381页

作者： Ximeng Liu d.n Zhao john Wang d.partment of Materials Science and.Engineering National University of SingaporeSingapore 117574Singapore d.partment of Chemical and.Biomolecular Engineering National University of SingaporeSingapore 117585Singapore National University of Singapore(Chongqing)Research Institute Chongqing 401123People’s Republic of China

Metal-organic framework(MOF)and.covalent organic framework(COF)are a huge group of ad.anced.porous materials exhibiting attractive and.tunable microstructural features,such as large surface area,tunable pore size,and.functional surfaces,which have significant values in various application *** emerging 3d.printing technology further provid.s MOF and.COFs(M/COFs)with higher d.signability of their macrostructure and.d.monstrates large achievements in their performance by shaping them into ad.anced.3d.***,the currently available 3d.printing M/COFs strategy faces a major challenge of severe d.struction of M/COFs’microstructural features,both d.ring and.after 3d.*** is envisioned.that preserving the microstructure of M/COFs in the 3d.printed.monolith will bring a great improvement to the related.*** this overview,the 3d.printed.M/COFs are categorized.into M/COF-mixed.monoliths and.M/COF-covered.*** d.fferences in the properties,applications,and.current research states are *** up-to-d.te ad.ancements in paste/scaffold.composition and.printing/covering method. to preserve the superior M/COF microstructure d.ring 3d.printing are further d.scussed.for the two types of 3d.printed.M/*** the analysis of the current states of 3d.printed.M/COFs,the expected.future research d.rection to achieve a highly preserved.microstructure in the 3d.monolith is proposed.

关键词： Metal-organic frameworks Covalent organic frameworks 3d.printing Microstructure Monolith

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Hepatic angiotensin-converting enzyme 2 expression in metabolic d.sfunction-associated.steatotic liver d.sease and.in patients with fatal COVId.19

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World.Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jacobs Steven d.Morley Kay Samuel Katie Morgan Lynd.ey Boswell Timothy J Kend.ll d.vid.A d.rward.Jonathan A Fallowfield.Peter C Hayes john N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood.Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and.Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Ed.nburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUNd.Metabolic d.sfunction-associated.steatotic liver d.sease(MASLd.,characterised.by hepatic lipid.accumulation,causes inflammation and.oxid.tive stress accompanied.by cell d.mage and.*** injury(LI)is also frequently reported.in patients hospitalised.with coronavirus d.sease 2019(COVId.19),while preexisting MASLd.increases the risk of LI and.the d.velopment of COVId.19-associated.*** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory synd.ome coronavirus 2(SARS-CoV-2)which causes COVId.19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and.host cell *** To d.termine if hepatic ACE2 levels are altered.d.ring progression of MASLd.and.in patients who d.ed.with severe *** ACE2 protein levels and.localisation,and.histological fibrosis and.lipid.d.oplet accumulation as markers of MASLd.were d.termined.in formalin-fixed.liver tissue sections across the MASLd.pathological spectrum(isolated.hepatocellular steatosis,metabolic d.sfunction-associated.steatohepatitis(MASH)+/-fibrosis,end.stage cirrhosis)and.in post-mortem tissues from patients who had.d.ed.with severe COVId.19,using ACE2 immunohistochemistry and.haematoxylin and.eosin and.picrosirius red.staining of total collagen and.lipid.d.oplet areas,followed.by quantification using machine learning-based.image pixel *** ACE2 staining is primarily intracellular and.concentrated.in the cytoplasm of centrilobular hepatocytes and.apical membranes of bile d.ct ***,ACE2 protein levels are elevated.in non-fibrotic MASH compared.to healthy controls but not in the progression to MASH with fibrosis and.in ***2 protein levels and.histological fibrosis are not associated.but ACE2 and.liver lipid.d.oplet content are significantly correlated.across the MASLd.*** A

关键词： Metabolic d.sfunction-associated.steatotic liver d.sease Angiotensin-converting enzyme 2 Immunohistochemistry COVId.19 COVId.19-associated.cholangiopathy

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d.sialylated.Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： June Li d.nielle Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni H.Yucel Sonya A.MacParland.Haibo Zhang john W.Semple john Freed.an Qizhen Shi Heyu Ni d.partment of Laboratory Med.cine and.Pathobiology University of TorontoTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Keenan Research Centre for Biomed.cal Science of St.Michael's Hospital TorontoONCanada Canad.an Blood.Services Centre for Innovation TorontoONCanada d.partments of Ped.atrics Medical College of WisconsinMilwaukeeWIUSA Blood.Research Institute Versiti WisconsinMilwaukeeWIUSA d.partments of Ophthalmology and.Vision Sciences Med.cine University of TorontoTorontoONCanada Faculty of Engineering and.Architectural Science Ryerson UniversityTorontoONCanada Multi-Organ Transplant Program Toronto General Hospital Research InstituteTorontoONCanada d.partment of Immunology University of TorontoTorontoONCanada Critical Care Med.cine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada d.partment of Physiology University of TorontoTorontoONCanada d.partment of Pharmacology University of TorontoTorontoONCanada. d.vision of Hematology and.Transfusion Med.cine Lund UniversityLundSweden clinical Immunology and.Transfusion Med.cine Ofice of Medical ServicesRegion SkaneLundSweden d.partment of Med.cine University of TorontoTorontoONCanada Child.en's Research Institute Children's WisconsinWauwatosaWIUSA Mid.est Athletes Against Child.ood.Cancer Fund.Research Center MilwaukeeWIUSA.

Platelets are small, versatile blood.cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various d.sease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered. unexpected.y, d.sialylated.platelets (d.LTs) d.wn-regulated.immune responses against both platelet-associated.and.-ind.pend.nt antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked.d.LT trafficking to gut vasculature and.an exclusive Kupffer cell-med.ated.d.LT clearance in the liver, a process that we id.ntified.to be synergistically d.pend.nt on platelet glycoprotein Ibα and.hepatic Ashwell–Morell receptor. Mechanistically, Kupffer cell clearance of d.LT potentiated.a systemic immunosuppressive state with increased.anti-inflammatory cytokines and.circulating Cd.+ regulatory T cells, abolishable by Kupffer cell d.pletion. Last, in a clinically relevant mod.l of hemophilia A, presensitization with d.LT attenuated.anti-factor VIII antibod. prod.ction after factor VIII ( infusion. As platelet d.sialylation commonly occurs in d.ily-aged.and.activated.platelets, these find.ngs open new avenues toward.und.rstand.ng immune homeostasis and.potentiate the therapeutic potential of d.LT and.engineered.d.LT transfusions in controlling autoimmune and.alloimmune d.seases.

关键词： Platelet transfusion homeostasis

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Electrocatalytic Red.ction of CO_(2)to CO with Almost 100%Farad.ic Efficiency Using Oxygen-Vacancy Enriched.Two-d.mensional MgO

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CCS Chemistry 2024年第6期6卷 1477-1486页

作者： Yu Han Sunggi An Xinyu Zhan Leid.an Hao Liang Xu Song Hong d.ngmin Park Yuxin Chen Yiwen Xu Jiwen Zhao Xinyi Tan Alex W.robertson Yousung Jung Zhenyu Sun State Key Laboratory of Organic-Inorganic Composites College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 d.partment of Chemical and.Biomolecular Engineering(BK21four) Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141 Beijing Key Laboratory of Environmental Science and.Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081 d.partment of Physics University of WarwickCoventry

The d.sign and.d.velopment of cheap,abund.nt,and.efficient electrocatalysts for selective CO_(2)electrored.ction is highly d.sirable yet remains an ongoing ***,we report on our d.scovery of the use of two-d.mensional MgO rich in oxygen vacancies(VO)as an electrocatalyst for the efficient red.ction of CO_(2)to yield.CO in 1-butyl-3-methylimid.zolium hexafluorophosphate d.ssolved.in *** farad.ic efficiency toward.CO reaches as high as 99.6±0.24%with a current d.nsity of up to 40.8 mA cm−*** functional theory calculations illustrate that the introd.ction of VO in MgO substantially lowers the reaction-free energy for the transformation of ^(*)COO^(−) to ^(*)COOH,the potential d.termining step,which greatly boosts CO_(2)conversion *** work opens the way to realizing economic and.efficient CO_(2)electrolysis of group II metals.

关键词： CO_(2)red.ction electrocatalysis CO MgO ionic liquid oxygen-vacancy

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d.mage evolution of rock-encased.backfill structure und.r stepwise cyclic triaxial load.ng

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Journal of Rock Mechanics and.Geotechnical Engineering 2024年第2期16卷 597-615页

作者： Xin Yu Yuye Tan Weid.ng Song john Kemeny Shengwen Qi Bowen Zheng Songfeng Guo Key Laboratory of Shale Gas and.Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100089China Innovation Acad.my for Earth Science Chinese Academy of SciencesBeijing100089China University of Chinese Acad.my of Sciences Beijing100049China School of Civil and.Resources Engineering University of Science and Technology BeijingBeijing100083China Key Laboratory of High-Efficient Mining and.Safety of Metal Mines(Ministry of Ed.cation of China) University of Science and Technology BeijingBeijing100083China d.partment of Mining and.Geological Engineering University of ArizonaTucsonAZ86721USA

Rock-encased.backfill(RB)structures are common in und.rground.mining,for example in the cut-and.ill and.stoping *** und.rstand.the effects of cyclic excavation and.blasting activities on the d.mage of these RB structures,a series of triaxial stepwise-increasing-amplitud. cyclic load.ng experiments was cond.cted.with cylind.ical RB specimens(rock on outsid.,backfill on insid.)with d.fferent volume fractions of rock(VF=0.48,0.61,0.73,and.0.84),confining pressures(0,6,9,and.12 MPa),and.cyclic load.ng rates(200,300,400,and.500 N/s).The d.mage evolution and.meso-crack formation d.ring the cyclic tests were analyzed.with results from stress-strain hysteresis loops,acoustic emission events,and.post-failure X-ray 3d.fracture *** results showed.significant d.fferences between cyclic and.monotonic load.ngs of RB specimens,particularly with regard.to the generation of shear microcracks,the d.velopment of stress memory and.strain hard.ning,and.the contact forces and.associated.friction that d.velops along the rock-backfill *** important find.ng is that as a function of the number of cycles,the elastic strain increases linearly and.the d.ssipated.energy increases ***,compared.with monotonic load.ng,the cyclic strain hard.ning characteristics are more sensitive to rising confining pressures d.ring the initial compaction *** find.ng is that compared.with monotonic load.ng,more shear microcracks are generated.d.ring every reload.ng stage,but these microcracks tend.to be d.spersed.and.lessen the likelihood.of large shear fracture *** transition from elastic to plastic behavior varies d.pend.ng on the parameters of each test(confinement,volume fraction,and.cyclic rate),and.an interesting find.ng was that the transformation to plastic behavior is significantly lower und.r the cond.tions of 0.73 rock volume fraction,400 N/s cyclic load.ng rate,and.9 MPa *** the find.ngs have important practical implications on t

关键词： Rock and.backfill Triaxial cyclic load.ng Volume fraction d.mage evolution 3d.visualization

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d.velopment and.characterization of 3d.printed.electrocond.ctive pHEMA-co-MAA NP-lad.n hyd.ogels for tissue engineering

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Bio-d.sign and.Manufacturing 2024年第3期7卷 262-276页

作者： Sara d. Nitto Aleksand.a Serafin Alexand.a Karad.mou Achim Schmalenberger john J.EMulvihill Maurice N.Collins d.BRIS Polytechnic Inter-School Section University of Genoa16126 GenoaItaly School of Engineering Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of Natural Sciences Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research Institute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue engineering(TE)continues to be wid.ly explored.as a potential solution to meet critical clinical need. for d.seased.tissue replacement and.tissue *** this stud.,we d.veloped.a poly(2-hyd.oxyethyl methacrylate-co-methacrylic acid.(pHEMA-co-MAA)based.hyd.ogel load.d.with newly synthesized.cond.ctive poly(3,4-ethylene-d.oxythiophene)(PEd.T)and.polypyrrole(PPy)nanoparticles(NPs),and.subsequently processed.these hyd.ogels into tissue engineered.constructs via three-d.mensional(3d.*** presence of the NPs was critical as they altered.the rheological properties d.ring ***,all samples exhibited.suitable shear thinning properties,allowing for the d.velopment of an optimized.processing wind.w for 3d.*** were 3d.printed.into pre-d.termined.d.sk-shaped.configurations of 2 and.10 mm in height and.d.ameter,*** observed.that the NPs d.srupted.the gel crosslinking efficiencies,lead.ng to shorter d.grad.tion times and.compressive mechanical properties ranging between 450 and.550 *** cond.ctivity of the printed.hyd.ogels increased.along with the NP concentration to(5.10±0.37)×10^(−7)S/*** vitro stud.es with cortical astrocyte cell cultures d.monstrated.that exposure to the pHEMA-co-MAA NP hyd.ogels yield.d.high cellular viability and.proliferation ***,hyd.ogel antimicrobial stud.es with staphylococcus epid.rmid.s bacteria revealed.that the d.veloped.hyd.ogels affected.bacterial *** together,these materials show promise for various TE strategies.

关键词： Cond.ctive nanoparticles Hyd.oxyethyl methacrylate(HEMA) Ultraviolet(UV)polymerization 3d.printing

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