检索结果-南通市图书馆

Quantum electrodynamics experiments with colliding petawatt laser pulses

在线全文

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2019年第1期7卷 74-81页

作者： I. C. E. Turcu B. Shen d. Neely G. Sarri K. A. Tanaka P. McKenna S. P. d. Mangles T.-P. Yu W. Luo X.-L. Zhu Y. Yin STFC Rutherford Appleton Laboratory Central Laser Facility School of Electronic Science and Engineering Nanjing University ELI-NP Extreme Light Infrastructure – Nuclear Physics National Institute of Physics and Nuclear Engineering (IFIN HH) State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences School of Physical Science and Technology ShanghaiTech University Shanghai Normal University School of Mathematics and Physics Queen’s University Belfast SUPA department of Physics University of Strathclyde The john Adams Institute for Accelerator Science Imperial College London department of Physics National University of Defense Technology School of Nuclear Science and Technology University of South China Key Laboratory for Laser Plasmas (MOE) School of Physics and Astronomy Shanghai Jiao Tong University

A new generation of high power laser facilities will provide laser pulses with extremely high powers of 10 petawatt(PW)and even 100 PW, capable of reaching intensities of 1023 W/cm^2 in the laser focus. These ultra-high intensities are nevertheless lower than the Schwinger intensity IS= 2.3×1029 W/cm^2 at which the theory of quantum electrodynamics(QEd) predicts that a large part of the energy of the laser photons will be transformed to hard Gamma-ray photons and even to matter, via electron–positron pair production. To enable the investigation of this physics at the intensities achievable with the next generation of high power laser facilities, an approach involving the interaction of two colliding PW laser pulses is being adopted. Theoretical simulations predict strong QEd effects with colliding laser pulses of 10 PW focused to intensities 10^(22) W/cm^2.

关键词： colliding petawatt laser pulses electron-positron pairs creation nonlinear Breit-Wheeler process petawatt laser facilities quantum electrodynamics

在线全文

学校读者我要写书评

暂无评论

CaMKⅡ介导的谷氨酸受体磷酸化(英文)

生理学报 2014年第3期66卷 365-372页

作者：毛利民金道忠薛冰储祥平王强密苏里州立大学医学院基础医学系美国密苏里州堪萨斯城64108

钙/钙调蛋白依赖的蛋白激酶Ⅱ(Ca2+/calmodulin-dependent protein kinase Ⅱ,CaMKⅡ)在脑内兴奋性突触部位丰富表达。通过催化谷氨酸受体和众多突触蛋白磷酸化,CaMKⅡ调节磷酸化蛋白在基础或细胞兴奋时的转运、分布和功能。谷氨酸NMdA... 详细信息

钙/钙调蛋白依赖的蛋白激酶Ⅱ(Ca2+/calmodulin-dependent protein kinase Ⅱ,CaMKⅡ)在脑内兴奋性突触部位丰富表达。通过催化谷氨酸受体和众多突触蛋白磷酸化,CaMKⅡ调节磷酸化蛋白在基础或细胞兴奋时的转运、分布和功能。谷氨酸NMdA受体是CaMKⅡ的直接底物,有证据表明CaMKⅡ直接与NMdA受体胞内C末端相互结合,催化一特定丝氨酸(S1303)的磷酸化。CaMKⅡ也加强谷氨酸AMPA受体的磷酸化,通过磷酸化AMPA受体C末端特定的丝氨酸(S831),CaMKⅡ增强AMPA受体的功能。此外,CaMKⅡ可与代谢型谷氨酸受体mGluR1亚型的胞内C末端结合,促进一特定苏氨酸(T871)的磷酸化,从而促进受体兴奋后脱敏。CaMKⅡ在正常状态下与mGluR5受体结合以储存于突触内,刺激mGluR5受体时,CaMKⅡ与mGluR5受体分离,转运至NMdA受体,以介导mGluR5信号对NMdA受体的增强作用。总之,CaMKⅡ与谷氨酸受体相互作用,改变受体磷酸化水平,参与受体的数量和功能以及突触传导活动的调节。

关键词： NMdA GluN2B AMPA GluA1 代谢型谷氨酸受体蛋白激酶钙调蛋白突触可塑性

潮汐应变对长江口北槽枯季湍流混合与层化的影响

在线全文

学校读者我要写书评

暂无评论

海洋工程 2014年第4期32卷 41-57页

作者：熊龙兵浦祥时钟胡国栋施慧燕上海交通大学船舶海洋与建筑工程学院海洋工程国家重点实验室上海200030 长江水利委员会水文局长江口水文水资源勘测局上海200136

利用TELEMAC-3d开展了长江口北槽2010年枯季条件下湍流混合与层化的有限元数学模拟研究。该模型在外海开边界设置了8个主要分潮,并在自由表面考虑了定常风的影响,利用北槽水域3个潮位站（横沙、北槽中、牛皮礁）和2个水文观测站（北槽中... 详细信息

利用TELEMAC-3d开展了长江口北槽2010年枯季条件下湍流混合与层化的有限元数学模拟研究。该模型在外海开边界设置了8个主要分潮,并在自由表面考虑了定常风的影响,利用北槽水域3个潮位站（横沙、北槽中、牛皮礁）和2个水文观测站（北槽中段CSW、北槽下段CS8）2010年枯季的潮位、流速及盐度观测资料对模型进行验证并获得了良好的精度,从而得到北槽水域纵向、平面流场和盐度场。模拟得到的流速、盐度被用来计算势能差异（φ）、势能差异变化率（φ/t）、Simpson数（Si）和梯度Richardson数（Ri）。结果显示：1）北槽水域大潮平均和小潮平均的势能差异的变化范围分别约为0～30 J/m3和0～90 J/m3,且较大的势能差异基本位于主航槽,这些表明北槽水体小潮的层化大约是大潮的3倍,主航槽的层化强于坝田区,而北槽中段往往具有更强的层化。2）落急时刻,就北槽下段而言,潮汐应变、潮汐与风共同搅动引起的势能差异变化率的范围分别约为-20×10-4～100×10-4W/m3、0～100×10-4W/m3,这些表明,从大潮至小潮,潮汐应变总体增强而潮汐与风共同搅动总体减弱。空间上,主航槽丁坝附近的潮汐应变明显强于坝田区,潮汐与风共同搅动的强度在坝田区内、外也存在差异,导堤和丁坝的影响明显。3）对于北槽下段CS8站,大潮至中潮的Si数在0.15～0.4之间（介于下临界值0.088和上临界值0.84之间）,表明潮汐与风共同搅动占优,属于应变致周期性层化（SIPS）。小潮的Si数在0.9～1.5之间（高于上临界值0.84）,表明潮汐应变显著增强并占优,属于持续性层化。4）北槽下段CS8站梯度Ri数的量级范围在混合较好的表层和底层约10-3～10-2,在层化较好的中间水层约100～101。该站湍动能耗散率的量级范围大潮为10-3～10-9W/kg,小潮为10-5～10-10W/kg,具有明显的M4周期性特征和涨、落潮不对称分布,且表层和底层分别由于风应力和底摩擦作用而具有较强的耗散,中间水层稳定层化区的耗散则显著减小,潮汐应变是造成湍动能耗散率在涨、落潮周期内不对称分布的重要因素。

关键词：湍流混合层化势能差异潮汐应变湍动能耗散率长江口北槽

Intravenous immune globulin suppresses angiogenesis in mice and humans

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley d Gelfand Ana Bastos-Carvalho Sandro de Falco Jayakrishna Ambati department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly department of Physiology University of KentuckyLexingtonKYUSA department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands department of Biomedical Engineering University of KentuckyLexingtonKYUSA department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc ***,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human Fcγ***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place IVIg,an agent approved by the US Food and drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of IVIg on blood vessels.

关键词： doses inhibited degeneration

Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第21期28卷 2334-2349页

作者： Sabrina Berens Yuanjun dong Nikola Fritz Jutta Walstab Mauro d'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler department of General Internal Medicine and Psychosomatics University Hospital HeidelbergHeidelberg 69120Germany department of Human Molecular Genetics Institute of Human GeneticsUniversity of HeidelbergHeidelberg 69120Germany department of General Internal Medicine and Psychosomatics Internal Medicine IIUniversity Hospital HeidelbergHeidelberg 69120Germany department of Human Molecular Genetics University of HeidelbergHeidelberg 69120Germany Gastrointestinal Genetics Lab CIC bioGUNE-BRTADerio 48160Spain IKERBASQUE Basque Foundation for ScienceBilbao 48001Spain Unit of Clinical Epidemiology Department of Medicine SolnaKarolinska InstitutetStockholm 17177Sweden Institute of Medical Biometry and Informatics Heidelberg UniversityHeidelberg 69120Germany Lleida Institute for Biomedical Research dr.PifarréFoundation(IRBLleida) Av.Alcalde Rovira RoureLleida 25198Spain department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersKU LeuvenLeuven 3000Belgium department of Gastroenterology Infectious Diseases and IntoxicationsUniversity of HeidelbergHeidelberg 69120Germany department of General Internal Medicine and Psychosomatics Heidelberg UniversityHeidelberg 69120Germany Nottingham digestive diseases Centre University of NottinghamNottingham NG72QLUnited Kingdom Helios Klinikum Rottweil Rottweil 78628Germany department of Medicine Institute of Neurogastroenterology(H.M.)Martin-Luther-HospitalBelin 14193Germany Israelitisches Krankenhaus in Hamburg Hamburg 22297Germany Internal Medicine ii Helios Klinikum KrefeldKrefeld 47805Germany Israelitisches Krankenhaus Hamburg Hamburg 22297Ghana Krankenhaus Vilsbiburg Vilsbiburg 84137Germany division of Microbiome and Cancer German Cancer Research Center(DKFZ)Heidelberg 69120Germany department of Psychiatry and Neurobehavioral Science University College CorkCork T23Ireland Medicine in digestive disorders Department of MedicineLynda K.and David M.Underwood Center for Digestive DisordersHou

BACKGROUNd Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with *** In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and ***,anxiety,and somatization symptoms and sociodemographic characteristics were *** functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive *** also performed separate analyses for sex and IBS *** scores were calculated as the number of minor alleles of the SNPs *** impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx *** depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in *** potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant *** We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with *** SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.

关键词： Irritable bowel syndrome 5-HT3 receptor subunit gene polymorphisms Single-nucleotide polymorphism score depression Anxiety Somatization

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley d Gelfand Sandro de Falco Jayakrishna Ambati department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Istituto di Biostrutture e Bioimmagini CNRNaplesItaly department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory Medicine University of Western AustraliaCrawleyWAAustralia division of Immunology Department of PathologyUniversity of CambridgeCambridgeUK department of Immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Institut National de la Santéet de la Recherche Médicale(INSERM)U1222 ParisFrance department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands department of Biomedical Engineering University of KentuckyLexingtonKYUSA department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly department of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s *** most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human *** bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in *** we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(Cd64)and c-Cbl,impairing macrophage *** approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRI exhibited increased developmental and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： Cd64 angiogenesis antibodies

Accretion in strong field gravity with eXTP

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra de Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo d'Ammando Thomas dauser Melania del Santo Barbara de Marco Tiziana di Salvo Chris done Michal dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera department of Physics and Astronomy The University of MississippiUniversity dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o dipartimento di Fisica II Universit?di Roma"Tor Vergata" dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität department of Physics Anhui Normal University department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu dhabi Institute of Physics and Research Centre for Computational Physics and data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. department of Physics Middle East Technical University department of Astronomy and Astrophysics Tata Institute of Fundamental Research dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion