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Chemoembolization Combined with RFA for HCC:Survival Benefits and Tumor Treatment Response

Journal of Cancer Therapy 2013年第2期4卷 493-499页

作者： Renumathy dhanasekaran Vinit Khanna david A. Kooby john S. Kauh john d. Carew Hyun S. Kim Biostatistics Winship Cancer Institute Emory University School of Medicine Atlanta USA Hematology and Medical Oncology Emory University School of Medicine Atlanta USA Interventional Radiology and Image Guided Medicine Emory University School of Medicine Atlanta USA Surgery Emory University School of Medicine Atlanta USA

Purpose: To investigate survival benefits and tumor treatment response among patients who received treatment with transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) and TACE alone. Materials and Methods: A total of 108 HCC patients were treated with TACE between the period of 1998 and 2008. 51 (47.2%) received TACE followed by planned RFA and 57 (52.8%) received TACE alone. 57 patients received Precision TACE with doxorubicin drug eluting beads and 51 received conventional TACE. Survival analysis was performed using Kaplan Meier Estimator with a log rank test, Fischer exact test was performed for categorical variables and the t test for continuous variables. Results: Mean MELd (Model for End Stage Liver disease) score among the TACE-RFA and TACE-only groups were 12.87 and 12.33 respectively (p = 0.64). The number of patients in Child’s Class A, B, C in the two groups were 28/15/8 and 23/23/11 (p = 0.30);in Okuda Class I, ii and iiI in the two groups were 22/23/6 and 14/30/9 (p = 0.2). Median survival among patients who received TACE-RFA and TACE alone were 566 days and 209 days (p = 0.01). Median survival of patients treated with Precision-TACE + RFA was 566 days and that of patients treated with conventional TACE + RFA was 336 days (p = 0.510). Mean progression-free duration by RECIST criteria among the TACE + RFA group was 210 days vs. TACE only group 97 days (p = 0.04). Conclusion: Combination therapies of TACE and RFA were associated with improved overall survival than TACE alone. Patients with single tumors cm appeared to have a survival advantage with combination therapy when compared to larger tumors. TACE-RFA was associated with improved tumor response and progression-free duration than TACE alone.

关键词： TACE RFA Survival RECIST

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A two-dimensional microporous metal–organic framework for highly selective adsorption of carbon dioxide and acetylene

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Chinese Chemical Letters 2017年第8期28卷 1653-1658页

作者： Osamah Alduhaish Bin Li Hadi Arman Rui-Biao Lin john Cong-Gui Zhao Banglin Chen deportment of Chemistry University of Texas at San AntonioSon AntonioTX 78249-0698USA

Solvothermal reaction of 3-aminoisonicotinic acid（Haina） and Cu（NO_3）_2·2.5H_2O gave a novel twodimensional（2d） microporous metal–organic framework, [Cu（aina）_2（dMF）]·dMF（1, dMF = N,N-dimethylformamide）. Single-crystal X-ray crystallographic study of compound 1 revealed that Cu（ii）ions are linked by ainaàligands forming square grid-like layers, which stack together via multiple hydrogen bonding interactions. The solvent-free framework of 1a displayed considerable porosity（void = 46.5%） with one-dimensional（1d） open channels（4.7 ？？ 4.8 ？） functionalized by amino *** sorption measurements of 1 revealed selective carbon dioxide（CO_2） and acetylene（C_2H_2） adsorption over methane（CH_4） and nitrogen（N_2） at ambient temperature.

关键词： Metal–organic frameworks Two-dimensional structure 3-Aminoisonicotinic acid Hydrogen bonding Gas separation Acetylene

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Optimizing beam transport in rapidly compressing beams on the neutralized drift compression experiment-ii

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Matter and Radiation at Extremes 2018年第2期3卷 78-84页

作者： Anton d.Stepanov john J.Barnard Alex Friedman Erik P.Gilson david P.Grote Qing Ji Igor d.Kaganovich Arun Persaud Peter A.Seidl Thomas Schenkel University of Washington SeattleWAUSA Lawrence Livermore National Laboratory LivermoreCAUSA Princeton Plasma Physics Laboratory PrincetonNJUSA Lawrence Berkeley National Laboratory BerkeleyCAUSA

The Neutralized drift Compression Experiment-ii(NdCX-ii)is an induction linac that generates intense pulses of 1.2 MeV helium ions for heating matter to extreme ***,we present recent results on optimizing beam *** NdCX-ii beamline includes a 1-m-long drift section downstream of the last transport solenoid,which is filled with charge-neutralizing plasma that enables rapid longitudinal compression of an intense ion beam against space-charge *** transport section on NdCX-ii consists of 28 *** optimal field settings for a group of solenoids requires knowledge of the envelope parameters of the *** the beam on the scintillator gives the radius of the beam,but the envelope angle is not measured *** demonstrate how the parameters of the beam envelope(radius,envelop angle,and emittance)can be reconstructed from a series of images taken by varying the B-field strengths of a solenoid upstream of the *** use this technique to evaluate emittance at several points in the NdCX-ii beamline and for optimizing the trajectory of the beam at the entry of the plasma-filled drift section.

关键词： Charged-particle beams Induction accelerators Beam dynamics Beam emittance Ion beam diagnostics

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The molecular conformation of silk fibroin regulates osteogenic cell behavior by modulating the stability of the adsorbed protein-material interface

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Bone Research 2021年第2期9卷 188-199页

作者： Yanlin Long Xian Cheng john A.Jansen Sander G.C.Leeuwenburgh Jing Mao Fang Yang Lili Chen department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial development and Regeneration Wuhan 430022China department of dentistry–Biomaterials Radboud University Medical CenterPhilips van Leydenlaan 256525 EX NijmegenThe Netherlands Center of Stomatology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Silk fibroin(SF)can be used to construct various stiff material interfaces to support bone *** essential preparatory step is to partially transform SF molecules from random coils toβ-sheets to render the material water ***,the influence of the SF conformation on osteogenic cell behavior at the material interface remains ***,three stiff SF substrates were prepared by varying theβ-sheet content(high,medium,and low).The substrates had a comparable chemical composition,surface topography,and *** adsorbed fibronectin was used as a model cellular adhesive protein,the stability of the adsorbed protein-material interface,in terms of the surface stability of the SF substrates and the accompanying fibronectin detachment resistance,increased with the increasingβ-sheet content of the SF ***,(i)larger areas of cytoskeleton-associated focal adhesions,(ii)higher orders of cytoskeletal organization and(iii)more elongated cell spreading were observed for bone marrow-derived mesenchymal stromal cells(BMSCs)cultured on SF substrates with high ***β-sheet contents,along with enhanced nuclear translocation and activation of YAP/TAZ and ***,osteogenic differentiation of BMSCs was stimulated on highβ-sheet *** results indicated that theβ-sheet content influences osteogenic differentiation of BMSCs on SF materials in vitro by modulating the stability of the adsorbed protein-material interface,which proceeds via protein-focal adhesion-cytoskeleton links and subsequent intracellular *** findings emphasize the role of the stability of the adsorbed protein-material interface in cellular mechanotransduction and the perception of stiff SF substrates with differentβ-sheet contents,which should not be overlooked when engineering stiff biomaterials.

关键词： interface stability adsorbed

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Coping with extremes:convergences of habitat use,territoriality,and diet in summer but divergences in winter between two sympatric snow finches on the Qinghai-Tibet Plateau

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Integrative Zoology 2020年第6期15卷 533-543页

作者： dongming LI Jason E.dAVIS Yanfeng SUN Gang WANG Ghulam NABI john C.WINGFIELd Fumin LEI Key Laboratory of Animal Physiology Biochemistry and Molecular Biology of Hebei ProvinceCollege of Life SciencesHebei Normal UniversityShijiazhuangHebei ProvinceChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina department of Neurobiology Physiology and BehaviorUniversity of CaliforniaDavisCaliforniaUSA department of Biology Radford UniversityRadfordVirginiaUSA Ocean College Hebei Agricultural UniversityQinhuangdaoHebei ProvinceChina University of Chinese Academy of Sciences BeijingChina Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingChina

On the Qinghai-Tibet Plateau,extreme environmental conditions have imposed intense selective pressure on the evolution of phenotypic traits of wild *** date,limited information is available on behavioral and ecological traits concerning niche differentiation among sympatric animals on the Qinghai-Tibet Plateau,especially during winter when the environments are most ***,we studied the seasonal variations in habitat occurrence,territorial behavior,and diet in two sympatric snow finches(the white-rumped snow finch,Onychostruthus taczanowskii,WRSF;and the rufous-necked snow finch,Pyrgilauda ruficollis,RNSF)to determine convergence and divergence of ecological traits in such severe climatic *** results showed that:(i)WRSF occupied rural areas as a dominant species throughout the annual cycle while RNSF occupied the rural areas in summer and then shifted to human-occupied areas in winter and spring;(ii)WRSFs exhibited robust aggressive behavior and territoriality during winter relative to RNSFs;(iii)the diets of both species varied with the season but did not vary between species except that WRSF ate significantly more seeds but RNSF consumed more starchy material derived from human food waste during ***,the separations in the spatial niche and territoriality between WRSF and RNSF,especially in winter,may contribute to alleviating the pressure of interspecific competition,and promoting the coexistence of the two sympatric snow finches in the extreme environments on the Qinghai-Tibet Plateau.

关键词： diet habitat use Qinghai-Tibet Plateau snow finch territorial behavior

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福利国家与经济发展:比较视野中的美国

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社会保障评论 2018年第1期2卷 141-152页

作者：约翰.史蒂芬斯杨无意北卡罗来纳大学中国人民大学中国社会保障研究中心中国社会保障学会秘书处

在本文中,笔者考察了美国福利国家的发展与经济发展之间的关系。笔者结合了两种方法,即同其他国家进行对比和对美国进行历史分析。该比较分析有部分是统计性的,考察了经济发展水平不同的国家以揭示经济增长的决定因素,并进一步在高度发... 详细信息

在本文中,笔者考察了美国福利国家的发展与经济发展之间的关系。笔者结合了两种方法,即同其他国家进行对比和对美国进行历史分析。该比较分析有部分是统计性的,考察了经济发展水平不同的国家以揭示经济增长的决定因素,并进一步在高度发达国家的样本中分析了这一问题。笔者认为,在直到20世纪70年代的一个半世纪里,美国在教育社会权发展方面一直是领先者,但在收入转移与医疗保健社会权的发展方面却处于落后地位,仅在大萧条和20世纪60年代出现过跨越式发展,却仍落后于其它工业民主国家。这种社会发展模式解释了为什么美国在19世纪和20世纪初是经济发展的领先者,并在20世纪20年代成为最富有的国家,但在二战后与其他工业和后工业民主国家相比增长水平有所滞后。到2010年,在人均收入方面,这些国家中有许多几乎赶上了美国,少数超过了美国。此外,由于收入差距的急剧扩大,收入前1%的人攫取了自上世纪80年代以来美国经济增长的大部分成果,而中位家庭的收入几乎没有改善。鉴于笔者对发展的人类能力定义,这种模式无异于退步而非发展。

关键词：福利国家经济发展美国

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Review of primary sclerosing cholangitis with increased IgG4 levels

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World Journal of Gastroenterology 2020年第23期26卷 3126-3144页

作者： Charis d Manganis Roger W Chapman Emma L Culver Translational Gastroenterology Unit and Oxford NIHR Biomedical Research Centre John Radcliffe HospitalOxford OX39DUUnited Kingdom

Primary sclerosing cholangitis(PSC) is a chronic progressive liver disease. Subtypes of PSC have been described, most recently PSC with elevated serum and/or tissue IgG4 subclass. We aim to summarise the clinical phenotype,disease associations, differential diagnosis, response to therapy and pathogenic mechanisms underlying PSC-high IgG4 subtype. We reviewed Pub Med,MEdLINE and Embase with the search terms "primary sclerosing cholangitis","IgG4", and "IgG4-related sclerosing cholangitis(IgG4-SC)". Elevated serum IgG4 are found in up-to one-quarter, and abundant IgG4-plasma cell infiltrates in the liver and bile ducts are found in up-to one-fifth of PSC patients. This group have a distinct clinical phenotype, with some studies reporting a more aggressive course of liver and associated inflammatory bowel disease, compared to PSCnormal IgG4 and the disease mimic IgG4-SC. distinguishing PSC-high IgG4 from IgG4-SC remains challenging, requiring careful assessment of clinical features,organ involvement and tissue morphology. Calculation of serum IgG4:IgG1 ratios and use of a novel IgG4:IgG RNA ratio have been reported to have excellent specificity to distinguish IgG4-SC and PSC-high IgG4 but require validation in larger cohorts. A role for corticosteroid therapy in PSC-high IgG4 remains unanswered, with concerns of increased toxicity and lack of outcome data. The immunological drivers underlying prominent IgG4 antibodies in PSC are incompletely defined. An association with PSC-high IgG4 and HLA class-ii haplotypes(B*07, dRB1*15), T-helper2 and T-regulatory cytokines(IL4, IL10,IL13) and chemokines(CCL1, CCR8) have been described. PSC-high IgG4 have a distinct clinical phenotype and need careful discrimination from IgG4-SC,although response to immunosuppressive treatments and long-term outcome remains unresolved. The presence of IgG4 likely represents chronic activation to persistent antigenic exposure in genetically predisposed individuals.

关键词： Primary sclerosing cholangitis IgG4 IgG4-related disease IgG4-related sclerosing cholangitis

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青少年安氏Ⅱ类1分类非拥挤错（牙合）的正畸治疗双期连续矫治

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丛书名：口腔开业医师临床指导丛书

2008年

作者： john C. Bennett 丁云

全书主要内容包括：双期矫治的时机、病例选择、功能性矫治器的选择、固定矫治器的选择、功能矫治阶段的治疗、固定矫治阶段的治疗、矫治后的注意事项以及保持等。

ISBN: (纸本)9787509120903

关键词：医药、卫生口腔科学

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developments,bottlenecks,and opportunities in seed markets for improved forages in East Africa:The case of Kenya

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Grassland Research 2024年第1期3卷 79-96页

作者： Jesús F.Florez Peggy Karimi john J.J.Paredes Natalia T.Ángel Stefan Burkart International Center for Tropical Agriculture(CIAT) Tropical Forages ProgramCaliColombia International Center for Tropical Agriculture(CIAT) Tropical Forages ProgramNairobiKenya

Background:Cattle farming plays a pivotal role in Africa's agricultural and livestock sector,poised for growth due to population expansion and rising per capita consumption of animal-sourced *** are a primary source of feed for dairy cattle,signiﬁcantly impacting production *** local forage varieties are preferred by dairy farmers,there has been an increase in the adoption of improved forages in recent ***,the overall adoption rate is still low,for example,due to underdeveloped forage seed ***:This study describes the dynamics,challenges,and potential of these markets in Kenya and selected East African countries,focusing on(i)market evolution over the past decade,(ii)forthcoming market prospects,and(iii)bottlenecks and opportunities for *** were gathered in 2022 through qualitative interviews with stakeholders representing six segments of the forage seed sector across six ***:We found a sustained growth of the improved forage seed market in recent *** main challenges for further growth are high seed prices,regulatory difﬁculties,and limited producer ***:Theﬁndings unveil positive dynamics in the region's forage seed market,fueled by the engagement and determination of stakeholders who recognize the manifold beneﬁts that it holds for both the dairy industry and economic *** realization of this market's potential requires addressing prevailing challenges,including elevated seed costs,intricate variety registration processes,and a pervasive lack of awareness among farmers.K E Y W O R d S animal productivity,dairy,improved forages,market development,sustainability,tropical forages adoption *** need to involve governmental entities and seed companies is recognized since both actors have so far mostly worked ***-theless,the strong partnership between the Alliance of Bioversity and CIAT and Grupo Papalotla is highlighted as an example of coordinated work

关键词： animal productivity dairy improved forages market development sustainability tropical forages

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学校领导技能对教师教学效果的影响——以坦桑尼亚姆万扎地区为例

学校领导技能对教师教学效果的影响——以坦桑尼亚姆万扎地区为例

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作者： john J. Malagira 华东师范大学

学位级别：硕士

尽管学校的领导技能水平符合区、县及学校层面对学生学业成绩所设目标的落实要求,但教育领导者同时还影响着学校教师的教学效果。本研究以领导技能对教师教学效果的影响为研究课题。在姆万扎区,教师的教学效果不容乐观,其前景也并不明... 详细信息

尽管学校的领导技能水平符合区、县及学校层面对学生学业成绩所设目标的落实要求,但教育领导者同时还影响着学校教师的教学效果。本研究以领导技能对教师教学效果的影响为研究课题。在姆万扎区,教师的教学效果不容乐观,其前景也并不明朗。本研究采用定性研究的方法,以揭示领导技能在提升教师教学效果方面的应用现状。同时,本研究采用归纳和探索性研究设计,采用随机抽样方法确定研究对象。本研究从1326名教师和校长为母体的研究对象中抽取了其中的9.8%来分析。本研究涉及32名学校校长和98名中学教师,共计130名受访者。本研究涉及32所随机抽选的中学,每所中学有10%的教师参与了此次研究。本研究采用定性研究方法,通过访谈、焦点小组讨论和问卷调查的形式收集所需信息。研究数据的呈现、分析、阐释及讨论以两个章节进行分述。第四章主要分析了学校校长和坦桑尼亚国家考试委员会(NECTA)的统计数据以及有关学生学业成绩的各方数据,而这些成绩是对教师教学效果的反映;第五章则主要讨论了收集自焦点小组讨论和访谈对话的信息。此外,本研究采用描述性和探索性的内容分析方法进行数据分析,数据内容以表格形式呈现。本研究认为,在提高中学教师的教学效果方面,人事、概念、技术和专业领导技能没有得到合适有效的应用。在提高教学效果方面,中学教师高度依赖概念、人事、技术和专业领导技能,而不是经验和过往背景。这并不意味着除了受到学校领导的关注以外,领导技能就无益于提高姆万扎地区教师的教学效果,而是领导技能未能有效地用于改善教师的教学效果。因此,本研究建议对人事,技术,专业和概念领导技能进行有效应用。通过问卷调查、访谈和焦点小组讨论,受访者主要提出了四种针对学校校长和教师的领导技能培养方法,分别是在职培训、向教学效果有所提升的教师提供激励性补偿、制定领导技能政策和为教师创造有利的工作环境。上述技能将用于提高教师的教学效果,而提高教学效果的途径便是使学生取得优异成绩。教师的优异教学效果体现于学生的I、ii、iiI级得分,教师的不佳教学效果则体现于学生的IV和0级得分。本研究以Ketz(1995)的技能理论和Mumford的领导技能模型(2000)为理论基础。这两种理论与本研究所提出的四种学校领导技能(人事、概念、技术和专业)直接相关。学校校长及教育领导者需共同运用这四种领导技能,以使教师的教学效果提高至最佳水平。但是,由于所管教师的背景和秉性不同,在运用领导技能时,教育领导者若取其一而舍其他,则可能无法实现预期效果。

关键词：领导力技能教师教学效果

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