检索结果-南通市图书馆

Versatile tape-drive target for high-repetition-rate laser-driven proton acceleration

在线全文

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2023年第4期11卷 59-69页

作者： N.Xu M.J.V.Streeter O.C.Ettlinger H.Ahmed S.Astbury M.Borghesi N.Bourgeois C.B.Curry S.J.d.dann N.P.dover T.dzelzainis V.Istokskaia M.Gauthier L.Giuffrida G.d.Glenn S.H.Glenzer R.J.Gray J.S.Green G.S.Hicks C.Hyland M.King B.Loughran d.Margarone O.McCusker P.McKenna C.Parisuaña P.Parsons C.Spindloe d.R.Symes F.Treffert C.A.J.Palmer Z.Najmudin john Adams Institute for Accelerator Science Blackett LaboratoryImperial College LondonLondonUK School of Maths and Physics Queen’s University BelfastBelfastUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK SLAC National Accelerator Laboratory Menlo ParkUSA ELI Beamlines Centre Institute of PhysicsCASDolni BrezanyCzech Republic Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in PraguePragueCzech Republic department of Physics SUPAUniversity of StrathclydeGlasgowUK department of Mechanical Engineering Stanford UniversityStanfordUSA department of Applied Physics Stanford UniversityStanfordUSA department of Electrical and Computer Engineering University of AlbertaEdmontonCanada Institut für Kernphysik Technische Universität DarmstadtDarmstadtGermany

We present the development and characterization of a high-stability,multi-material,multi-thickness tape-drive target for laser-driven acceleration at repetition rates of up to 100 *** tape surface position was measured to be stable on the sub-micrometre scale,compatible with the high-numerical aperture focusing geometries required to achieve relativistic intensity interactions with the pulse energy available in current multi-Hz and near-future higher repetition-rate lasers(>kHz).Long-term drift was characterized at 100 Hz demonstrating suitability for operation over extended *** target was continuously operated at up to 5 Hz in a recent experiment for 70,000 shots without intervention by the experimental team,with the exception of tape replacement,producing the largest data-set of relativistically intense laser–solid foil measurements to *** tape drive provides robust targetry for the generation and study of high-repetitionrate ion beams using next-generation high-power laser systems,also enabling wider applications of laser-driven proton sources.

关键词： high-repetition-rate laser target laser-plasma acceleration proton generation tape-drive target

结直肠癌肝转移切除术:危险评分系统的价值?

在线全文

学校读者我要写书评

暂无评论

医学信息（手术学分册） 2008年第3期21卷 201-201页

作者： Zakaria Shaheen donohue john H. Que Florencia G. Farnell Michael B. Schleck Cathy d. Ilstrup duane M. Nagorney david M.

在线全文

学校读者我要写书评

暂无评论

最小侵入性眼眶减压术局部麻醉和人造骨

美国医学会眼科杂志（中文版） 2006年第4期18卷 252-252页

作者： Guy J. Ben Simon Robert M. Schwarcz Ahmad M. Mansury Lillian Wang john d. McCann Robert A. Goldberg 刘亮（译）

目的：探讨用刮匙进行骨性减压和经结膜切口圆锥内脂肪切除的保守的眼眶减压术对甲状腺相关性眼病和轻中度突眼患者的安全性和有效性。

关键词：眼眶减压术最小侵入性局部麻醉人造骨甲状腺相关性眼病经结膜切口脂肪切除有效性

UV Sensing Properties of Single 2d ZnO Nanostructure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

材料科学与工程（中英文A版） 2014年第7期4卷 197-201页

作者： Mohammad R. Alenezi Talal H. Alzanki Abdullah S. Alshammari Simon john Henley S. Ravi P. Silva Collage of Technological Studies PAAET Shuwaikh P.O. Box 42325 Kuwait department of Physics College of Science University of Hail P.O. Box 2440 Hail KSA Nanoelectronics Center Advanced Technology Institute University of Surrey Guildford GU2 7XH UK

The performance of nanostructured devices depend significantly on the morphology and structure of the used nanostructures. We report the hydrothermal synthesis of high quality 2d ZnO nanostructures and the fabrication of ultraviolet (UV) sensors based on single 2d ZnO nanostructures. The grown nanostructures are characterized using SEM, STEM, SAEd, and XRd. The single 2d ZnO nanostructure UV sensor demonstrates high photosensitivity of 980 and speed of response and recovery of 19 and 25 s, respectively. The high performance is attributed to the high quality of the ZnO 2d crystals and its high surface to volume ratio.

关键词：纳米结构氧化锌传感特性 UV 二维 ZnO 水热合成 STEM

Rhenium-osmium(Re-Os)geochronology of crude oil from lacustrine source rocks of the Hailar Basin,NE China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2021年第1期18卷 1-9页

作者： Qi-An Meng Xue Wang Qiu-Li Huo Zhong-Liang dong Zhen Li Svetlana GTessalina Bryant dWare Brent IAMcInnes Xiao-Lin Wang Ting Liu Li Zhang Exploration and development Research Institute Daqing Oilfield Co.Ltd.Daqing 163712HeilongjiangChina Heilongjiang Provincial Key Laboratory for the Study of Tight Oil and Shale Oil Accumulation Daqing 163712HeilongjiangChina john de Laeter Centre Faculty of Science and EngineeringCurtin UniversityGPO Box U1987PerthWA 6485Australia State Key Laboratory for Mineral deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing 210023JiangsuChina

Re-Os radiometric dating of crude oil can be used to constrain the timing of hydrocarbon generation,migration or *** approach has been successfully applied to marine petroleum systems;however,this study reports on its application to lacustrine-sourced natural crude *** s amples from multiple wells producing from the Cretaceous Nantun Formation in the Wuerxun-Beier depression of the Hailar Basin in NE China were *** of the Re-Os data are compatible with a Cretaceous hydrocarbon generation event(131.1±8.4 Ma)occurring within 10 Myr of deposition of the Nantun Formation source *** addition,two younger age trends of 54±12 Ma and 1.28±0.69 Ma can be regressed from the Re-Os data,which may reflect the timing of subsequent hydrocarbon generation *** Re-Os geochronometer,when combined with complementary age dating techniques,can provide direct temporal constraints on the evolution of petroleum system in a terrestrial basin.

关键词： Re-Os dating Lacustrine crude oils Hailar basin Petroleum system evolution

Oral creatine supplementation:A potential adjunct therapy for rheumatoid arthritis patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Rheumatology 2014年第3期4卷 22-34页

作者： Thomas J Wilkinson Thomas d O’Brien Andrew B Lemmey School of Sport Health and Exercise SciencesBangor UniversityWales LL57 2PZUnited Kingdom Research Institute for Sport and Exercise Sciences Liverpool John Moores UniversityEngland L3 3AFUnited Kingdom

Creatine is one of the most popular forms of protein supplements and is known to improve performance in healthy athletic populations via enhanced muscle mass and adenosine triphosphate energy *** use of creatine may similarly benefit patients with rheumatoid arthritis(RA), an inflammatory condition characterised by generalised muscle loss termed"rheumatoid cachexia". The adverse consequences of rheumatoid cachexia include reduced strength, physical function and, as a consequence, quality of *** regular high-intensity exercise training has been shown to increase muscle mass and restore function in RA patients, this form of therapy has very low uptake amongst RA patients. Thus, acceptable alternatives are required. The aim of this review is to consider the potential efficacy of creatine as an anabolic and ergonomic therapy for RA patients. To date, only one study has supplemented RA patients with creatine, and the findings from this investigation were inconclusive. However, trials in populations with similar losses of muscle mass and function as RA, including older adults andthose with other muscle wasting conditions, indicate that creatine is an efficacious way of improving muscle mass, strength and physical function, and may offer an easy, safe and cheap means of treating rheumatoid cachexia and its consequences.

关键词： Creatine supplementation Nutritional supplement Rheumatoid arthritis Rheumatoid cachexia Physical function

Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2016年第1期6卷 206-214页

作者： Adrian d Hibberd david A Clark Paul R Trevillian Patrick Mcelduff Newcastle Transplant Unit Division of Surgery John Hunter Hospital Hunter Region Mail Centre Hunter Transplant Research Foundation Hunter Medical Research Institute School of Medicine and Public Health University of Newcastle

AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for ***: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and dA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte ***: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P d(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P ddition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction n

关键词： Cardiac transplantation Castanospermine Cyclosporin A Positive interaction Mixed lymphocyte reaction

Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第21期28卷 2334-2349页

作者： Sabrina Berens Yuanjun dong Nikola Fritz Jutta Walstab Mauro d'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler department of General Internal Medicine and Psychosomatics University Hospital HeidelbergHeidelberg 69120Germany department of Human Molecular Genetics Institute of Human GeneticsUniversity of HeidelbergHeidelberg 69120Germany department of General Internal Medicine and Psychosomatics Internal Medicine IIUniversity Hospital HeidelbergHeidelberg 69120Germany department of Human Molecular Genetics University of HeidelbergHeidelberg 69120Germany Gastrointestinal Genetics Lab CIC bioGUNE-BRTADerio 48160Spain IKERBASQUE Basque Foundation for ScienceBilbao 48001Spain Unit of Clinical Epidemiology Department of Medicine SolnaKarolinska InstitutetStockholm 17177Sweden Institute of Medical Biometry and Informatics Heidelberg UniversityHeidelberg 69120Germany Lleida Institute for Biomedical Research dr.PifarréFoundation(IRBLleida) Av.Alcalde Rovira RoureLleida 25198Spain department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersKU LeuvenLeuven 3000Belgium department of Gastroenterology Infectious Diseases and IntoxicationsUniversity of HeidelbergHeidelberg 69120Germany department of General Internal Medicine and Psychosomatics Heidelberg UniversityHeidelberg 69120Germany Nottingham digestive diseases Centre University of NottinghamNottingham NG72QLUnited Kingdom Helios Klinikum Rottweil Rottweil 78628Germany department of Medicine Institute of Neurogastroenterology(H.M.)Martin-Luther-HospitalBelin 14193Germany Israelitisches Krankenhaus in Hamburg Hamburg 22297Germany Internal Medicine II Helios Klinikum KrefeldKrefeld 47805Germany Israelitisches Krankenhaus Hamburg Hamburg 22297Ghana Krankenhaus Vilsbiburg Vilsbiburg 84137Germany division of Microbiome and Cancer German Cancer Research Center(DKFZ)Heidelberg 69120Germany department of Psychiatry and Neurobehavioral Science University College CorkCork T23Ireland Medicine in digestive disorders Department of MedicineLynda K.and David M.Underwood Center for Digestive DisordersHou

BACKGROUNd Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with *** In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and ***,anxiety,and somatization symptoms and sociodemographic characteristics were *** functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive *** also performed separate analyses for sex and IBS *** scores were calculated as the number of minor alleles of the SNPs *** impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx *** depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in *** potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant *** We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with *** SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.

关键词： Irritable bowel syndrome 5-HT3 receptor subunit gene polymorphisms Single-nucleotide polymorphism score depression Anxiety Somatization

Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 213-222页

作者： Kunwar Shailubhai Vaseem Palejwala Krishna Priya Arjunan Sayali Saykhedkar Bradley Nefsky john A Foss Stephen Comiskey Gary S Jacob Scott E Plevy R and d Center Synergy Pharmaceuticals Inc. Baruch Blumberg Institute PA Biotechnology Center Synergy Pharmaceuticals Inc. departments of Medicine Microbiology and Immunology University of North Carolina School of Medicine

AIM: To evaluate the effect of orally administeredplecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine ***: The cyclic guanosine monophosphate(cG MP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma T84 cellbased assay. For animal studies all test agents were formulated in phosphate buffered saline. Sulfasalazine or 5-amino salicylic acid(5-ASA) served as positive controls. Effect of oral treatment with test agents on amelioration of acute colitis induced either by dextran sulfate sodium(dSS) in drinking water or by rectal instillation of trinitrobenzene sulfonic(TNBS) acid, was examined in BALB/c and/or BdF1 mice. Additionally, the effect of orally administered plecanatide on the spontaneous colitis in T-cell receptor alpha knockout(TCRα-/-) mice was also examined. Amelioration of colitis was assessed by monitoring severity of colitis, disease activity index and by histopathology. Frozen colon tissues were used to measure myeloperoxidase ***: Plecanatide and dolcanatide are structurally related analogs of uroguanylin, which is an endogenous ligand of guanylate cyclase-C(GC-C). As expected from the agonists of GC-C, both plecanatide and dolcanatide exhibited potent cG MP-stimulatory activity in T84 cells. Once-daily treatment by oral gavage with either of these analogs(0.05-0.5 mg/kg) ameliorated colitis in both dSS and TNBS-induced models of acute colitis, as assessed by body weight, reduction in colitis severity(P d disease activity index(P drug candidates was comparable to that achieved by orally administered sulfasalazine or 5-ASA. Plecanatide also effectively ameliorated colitis in TCRα-/- mice, a model of spontaneous colitis. As dolcanatide exhibited higher resistance to proteolysis in simulated gastric and intestinal juices, it was selected for further studies. CONCLUSION: This is the first-ever s

关键词： Guanylate cyclase-C Inflammatory bowel disease Uro