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Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(cUMS) in mice

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Food Science and Human Wellness 2024年

作者： Qi-Ming Yu Yan Zhu Tao Jiang Ying Gao Nan Ling Na Wang john Shi Wei-chun Pan Qi-Zhen Du Jun-Feng Yin Tea Research Institute chinese Academy of Agricultural Sciences， Key Laboratory of Tea Biology and Resources Utilization， Ministry of Agriculture college of Food and Health Sciences， Zhejiang A & F University Zhejiang Gongshang University Guelph Food Research center， Agriculture and Agri-Food canada college of Public Health， Guilin Medical University

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored L-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (cUMS) mouse model. Male c57BL/6J mice were divided into control， cUMS model， and cUMS+TG groups with varying doses. The cUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the cUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that cUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting L-theanine and geniposide’s potential as a novel depression therapy.

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Materials-oriented integrated design and construction of structures in civil engineering—A review

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Frontiers of Structural and civil Engineering 2022年第1期16卷 24-44页

作者： Xing MING john c.HUANG Zongjin LI Institute of Applied Physics and Materials Engineering University of MacaoMacao SAR 999078China cHc Engineering LLCFairfaxVA 20030USA

Design is a goal-oriented planning activity for creating products,processes,and systems with desired functions through *** is a decision-making exploration:the design outcome may vary greatly depending on the designer’s knowledge and *** design is one type of design philosophy that takes an interdisciplinary and holistic *** civil engineering,structural design is such an activity for creating buildings and ***,structural design in many countries has emphasized a performance-based philosophy that simultaneously considers a structure’s safety,durability,serviceability,and ***,integrated design in civil engineering has become more popular,useful,and ***-oriented integrated design and construction of structures(MIDcS)combine materials engineering and structural engineering in the design stage:it fully utilizes the strengths of materials by selecting the most suitable structural forms and construction *** paper will explore real-world examples of MIDcS,including the realization of MIDcS in timber seismic-resistant structures,masonry arch structures,long-span steel bridges,prefabricated/on-site extruded light-weight steel structures,fiber-reinforced cementitious composites structures,and fiber-reinforced polymer bridge ***,advanced material design methods such as bioinspired design and structure construction technology of additive manufacturing are briefly reviewed and discussed to demonstrate how MIDcS can combine materials and structures.A unified strengthdurability design theory is also introduced,which is a human-centric,interdisciplinary,and holistic approach to the description and development of any civil infrastructure and includes all processes directly involved in the life cycle of the ***,this paper lays out future research directions for further development in the field.

关键词： integrated design and construction fiber-reinforced concrete fiber-reinforced polymer light-weight steel structures digital fabrication composites

An Improved Evolvable Oscillator and Basis Function Set for control of an Insect-Scale Flapping-Wing Micro Air Vehicle

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Journal of computer Science & Technology 2012年第5期27卷 966-978页

作者： john c.Gallagher Michael W.Oppenheimer Department of computer Science and Engineering Wright State University control Sciences Branch Air Force Research Laboratory

This paper introduces an improved evolvable and adaptive hardware oscillator design capable of supporting adaptation intended to restore control precision in damaged or imperfectly manufactured insect-scale flapping-wing micro air vehicles. It will also present preliminary experimental results demonstrating that previously used basis function sets may have been too large and that significantly improved learning times may be achieved by judiciously culling the oscillator search space. The paper will conclude with a discussion of the application of this adaptive, evolvable oscillator to full vehicle control as well as the consideration of longer term goals and requirements.

关键词： evolvable and adaptive hardware micro air vehicle evolutionary algorithm

识别液态和固态水的四波段水指数及其在咸海流域的应用

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中国科学：地球科学 2024年第3期54卷 788-807页

作者：岳兵陈曦李赛博杜正平 john WILSON 杨筠慧焦毅蒙黄双燕周成虎中国科学院新疆生态与地理研究所乌鲁木齐830011 中国科学院大学资源与环境学院北京100049 中国科学院地理科学与资源研究所北京100101 Spatial Sciences Institute University of Southern CaliforniaLos AngelesCA 90089-0374USA

虽然已有许多水指数被运用于咸海和咸海流域的水域面积分析,然而已有研究尚存在很大的不确定性.由于所使用水指数存在水体误识别的问题,导致不同研究得出的结论差异很大.此外,各种研究采用的咸海流域面积也差异很大,流域面积从约1百万km... 详细信息

虽然已有许多水指数被运用于咸海和咸海流域的水域面积分析,然而已有研究尚存在很大的不确定性.由于所使用水指数存在水体误识别的问题,导致不同研究得出的结论差异很大.此外,各种研究采用的咸海流域面积也差异很大,流域面积从约1百万km^(2)到2百万km^(2)不等.因此,我们首先界定咸海流域、锡尔河和阿姆河流域以及它们的上、中、下游的边界,然后提出可识别液态水和固态水的四波段指数(ILSW),以解决传统水指数的误别偏差问题.ILSW基于绿色、红色、近红外和热红外波段反射值,是归一化差异水指数(NDWI)和地表温度(LST)的合成.验证结果显示,ILSW水指数在咸海流域的准确性远远超过其他指数.研究结果表明,南咸海的水域面积平均每年缩小963km^(2),而北咸海几乎没有变化;由于气候变暖,咸海流域上游常年冰雪面积有大幅度退缩趋势,阿姆河上游和锡尔河上游常年冰雪的退缩速率分别为年均6233和384km^(2)/a.气候变化和人类活动引起了严重的水亏问题.自20世纪90年代以来,水亏呈增长趋势,平均每年增长3.778亿m^(3).2011~2020年期间,整个咸海流域平均总水亏量为76.967亿m^(3),而锡尔河流域上游(咸海流域的一个组成部分)水盈余量为25.461亿m^(3).研究结果对制定咸海流域可持续发展战略具有重要意义.

关键词：咸海流域锡尔河流域阿姆河流域水指数水面积覆盖水亏缺气候变化

Human thrombin for the treatment of gastric and ectopic varices

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World Journal of Gastroenterology 2012年第41期18卷 5912-5917页

作者： Norma c McAvoy john N Plevris Peter c Hayes Department of Hepatology University of EdinburghRoyal Infirmary of EdinburghEdinburgh EH16 4SAUnited Kingdom

AIM:To evaluate the efficacy of human thrombin in the treatment of bleeding gastric and ectopic ***:Retrospective observational study in a Tertiary Referral *** January 1999-October 2005,we identified 37 patients who were endoscopically treated with human thrombin injection therapy for bleeding gastric and ectopic *** details including age,gender and aetiology of liver disease/segmental portal hypertension were *** thrombin was obtained from the Scottish National Blood Transfusion Service and prepared to give a solution of 250 IU/mL which was injected via a standard injection *** patient case notes were reviewed and the total dose of thrombin given along with the number of endoscopy sessions was *** haemostasis rates,rebleeding rates and mortality were catalogued along with the incidence of any immediate complications which could be attributable to the thrombin *** duration of follow up was also *** study was conducted according to the United Kingdom research ethics ***:Thirty-seven patients were included.33 patients(89%) had thrombin(250 U/mL) for gastric varices,2(5.4%) for duodenal varices,1 for rectal varices and 1 for gastric and rectal varices.(1) Gastric varices,an average of 15.2 mL of thrombin was used per ***-bleeding occurred in 4 patients(10.8%),managed in 2 by a transjugular intrahepatic portosystemic shunt(TIPSS)(one unsuccessfully who died) and in other 2 by a distal splenorenal shunt;(2) Duodenal varices(or type 2 isolated gastric varices),an average of 12.5 mL was used per patient over 2-3 endoscopy ***-bleeding occurred in one patient,which was treated by TIPSS;and(3) Rectal varices,an average of 18.3 mL was used per patient over 3 endoscopy *** re-bleeding occurred in this ***:Human thrombin is a safe,easy to use and effective therapeutic option to control haemorrhage from gastric and ectopic varices.

关键词： Variceal haemorrhage Ectopic Varices Gastric varices, Portal hypertension Thrombin

Glaciology and Global climate change

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Engineering 2018年第1期4卷 6-8页

作者： john c. Moore college of Global change and Earth System Science Beijing Normal University Beijing 100875 China Arctic center University of Lapland Rovaniemi 96100 Finland

If it had been suggested prior to the 1980s that the study of ice- that is, glaciology-would be the key to initiating international action on global climate change, most climate scientists would probably have laughed. However, that is exactly what occurred. The kick-start came from the Vostok ice core, a project that had been underway at the Soviet station at the Pole of Inaccessibility in East Antarctica since the 1970s. By the mid-1980s, the French were in close partnership with the Soviets.

关键词： Glaciology Global climate change

An electrochemical process that uses an Fe^0/TiO2 cathode to degrade typical dyes and antibiotics and a bio-anode that produces electricity

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Frontiers of Environmental Science & Engineering 2016年第4期10卷 25-32页

作者： chaojie Jiang Lifen Liu john c. crittenden Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education) School of Environmental Science and Technology Dalian University of Technology Dalian 116024 China School of civil and Environmental Engineering Georgia Institute of Technology Atlanta GA 30332 USA

In this study a new water treatment system that couples （photo-） electrochemical catalysis （PEc or Ec） in a microbial fuel cell （MFc） was configured using a stainless-steel （SS） cathode coated w th Fe / TiO2. We examined the destruction of methylene blue （MB） and tetracycline. Fe^0/TiO2 was prepared using a chemical reduction-deposition method and coated onto an SS wire mesh （500 mesh） using a sol technique. The anode generates electricity using microbes （bio-anode）. connected via wire and ohmic resistance, the system requires a short reaction time and operates at a low cost by effectively remowng 94% MB （initial concentration 20 mg·L^-1） and 83% TOc/TOco under visible light illumination （50 W; 1.99 mW·cm^-2 for 120 rain, MFc-PEc）. The removal was similar even without light irradiation （MFc-Ec）. The EEo of the MFc-PEc system was approximately 0.675 kWh·m^-3. order-l whereas that of the MFc-Ec system was zero. The system was able to remove 70% cOD in tetracycline solution （initial tetracycline concentration 100 mg·L^-1） after 120 min of visible light illumination; without light, the removal was 15% lower. The destruction of MB and tetracycline in both traditional photocatalysis and photoelectrocatalysis systems was notably low. The electron spinresonance spectroscopy （ESR） study demonstrated that. OH was formed under visible light, and. 02 was formed without light. The bio-electricity-activated O2 and ROS （reactive oxidizing species） generation by Fe^0/TiO2 effectively degraded the pollutants. This cathodic degradation improved the electricity generation by accepting and consuming more electrons from the bio-anode.

关键词： Bio-anodePhotocatalytic cathode Fe^0/TiO2 ESRDye and antibioticsAdvanced oxidation

Gastroesophageal reflux disease and severe obesity:Fundoplication or bariatric surgery?

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World Journal of Gastroenterology 2010年第30期16卷 3757-3761页

作者： Vivek N Prachand john c Alverdy center for the Surgical Treatment of Obesity Department of SurgeryUniversity of Chicago Pritzker School of MedicineChicagoIL 60637United States

Increases in the prevalence of obesity and gastroesophageal reflux disease (GERD) have paralleled one another over the past decade, which suggests the possibility of a linkage between these two processes. In both instances, surgical therapy is recognized as the most effective treatment for severe, refractory disease. current surgical therapies for severe obesity include (in descending frequency) Roux-en-Y gastric bypass, adjustable gastric banding, sleeve gastrectomy, and biliopancreatic diversion with duodenal switch, while fundoplication remains the mainstay for the treatment of severe GERD. In several large series, however, the outcomes and durability of fundoplication in the setting of severe obesity are not as good as those in patients who are not severely obese. As such, bariatric surgery has been suggested as a potential alternative treatment for these patients. This article reviews current concepts in the putative pathophysiological mechanisms by which obesity contributes to gastroesophageal reflux and their implications with regards to surgical therapy for GERD in the setting of severe obesity.

关键词： Morbid obesity Gastroesophageal reflux disease Fundoplication Bariatric surgery Gastric bypass Sleeve gastrectomy

Impact of past and on-going changes on climate and weather on vector-borne diseases transmission:a look at the evidence

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Infectious Diseases of Poverty 2019年第3期8卷 1-9页

作者： Florence Fouque john c.Reeder UNIcEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases(TDR) 20 Avenue Appia1211 Geneva 27Switzerland

Background:The climate variables that directly influence vector-borne diseases'ecosystems are mainly temperature and *** is not only because the vectors bionomics are strongly dependent upon these variables,but also because most of the elements of the systems are impacted,such as the host behavior and development and the pathogen *** impact of the climate changes on the transmission patterns of these diseases is not easily understood,since many confounding faaors are acting ***,knowledge of these impacts is often based on hypothesis derived from mathematical ***,some direct evidences can be found for several vector-borne *** body:Evidences of the impact of climate change are available for malaria,arbovirus diseases such as dengue,and many other parasitic and viral diseases such as Rift Valley Fever,Japanese encephalitis,human African trypanosomiasis and *** effect of temperature and rainfall change as well as extreme events,were found to be the main cause for outbreaks and are alarming the global *** the main driving factors,climate strongly influences the geographical distribution of insect veaors,which is rapidly changing due to climate ***,in both models and direct evidences,climate change is seen to be affecting veaor-borne diseases more strikingly in fringe of different climatic areas often in the border of transmission zones,which were once free of these diseases with human populations less immune and more *** impact of climate change is also more devastating because of the unpreparedness of Public Health systems to provide adequate response to the events,even when climatic warning is *** evidences are strong at the regional and local levels,the studies on impact of climate change on vector-borne diseases and health are producing contradictory results at the global ***:In this paper we discuss the current state of the

关键词： climate change Veaor-borne diseases Mosquitoes veaors Malaria Arboviruses