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Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management

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World Journal of Gastroenterology 2014年第46期20卷 17352-17359页

作者： Roberta Elisa Rossi Ioanna Parisi Edward john Despott andrew Kenneth Burroughs James O'Beirne Dario Conte Mark Ian Hamilton Charles Daniel Murray Centre for Gastroenterology Royal Free HospitalLondon NW3 2QGUnited Kingdom Department of Pathophysiology and Organ Transplant Universita’ degli Studi di Milano20122 MilanoItaly Division of Gastroenterology and Endoscopy Fondazione IRCCS Ca' GrandaOspedale Maggiore Policlinico20122 MilanoItaly Sheila Sherlock Liver Centre Royal Free Hospital and Institute of Liver and Digestive HealthLondon NW3 2PFUnited Kingdom

Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)*** optimal management of liver injury related to antiTNF therapy is still a matter of *** some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver *** searches were performed in Pub Med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;*** to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual ***-TNF agents seem to be safe with a low risk of causing severe drugrelated liver *** to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate *** algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of ***,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception.

关键词： Inflammatory bowel disease Tumour necrosis factor inhibitors Hypertransaminasemia Drug-related liver injury Infliximab

Some Insights in Novel Risk Modeling of Liquefied Natural Gas Carrier Maintenance Operations

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Journal of Marine Science and Application 2016年第2期15卷 144-156页

作者： T. C. Nwaoha andrew john Marine Engineering Department College of Technology Federal University of Petroleum Resources Effurun P.M.B. 1221 Nigeria Welding and Offshore Engineering Department Petroleum Training Institute Effurun P.M.B. 20 Nigeria

This study discusses the analysis of various modeling approaches such as genetic algorithms, fuzzy logic and evidential reasoning, and maintenance techniques applicable to the liquefied natural gas （LNG） carrier operations in the maritime environment. The usefulness of these algorithms in the LNG carrier industry in the areas of risk assessment and maintenance modeling as a standalone or hybrid algorithm are identified. This is evidenced with illustrative case studies.

关键词： safety risk modeling maintenance LNG carrier fuzzylogic genetic algorithm evidential reasoning

New Partnerships for Co-delivery of the 2030 Agenda for Sustainable Development

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International Journal of Disaster Risk Science 2020年第5期11卷 680-685页

作者： Adrian Bucher andrew Collins Ben Heaven Taylor David Pan Emma Visman James Norris Joel CGill john Rees Mark Felling Marta Tufet Bayona Sonia Cassidy Virginia Murray UK Collaborative on Development Research London NW12BEUK Disaster and Development Network(DDN) Department of Geography and Environmental SciencesNorthumbria UniversityNewcastle-upon-Tyne NE18STUK Evidence Aid AbingdonOxfordshire OX135DBUK Global Health Medical Research Council SwindonSwindon SN21FLUK Department of Geography King's College LondonLondon WC2B 4BGUK VNG Consulting Limited Kent TN248DHUK Ordnance Survey Southampton SO16 OASUK Global Geoscience British Geological SurveyKeyworth NG125GGUK Earth Hazards and Observatories British Geological SurveyNottingham NG123ENUK ALLFED LondonUK Global Disaster Risk Reduction Public Health EnglandLondon SE18UGUK

Partnerships have become a comer stone of contemporary research that recognizes working across disciplines and co-production with intended users as essential to enabling sustainable ***,research that addresses sustainable development challenges brings an urgent need to reflect on the ways that partnerships are supported,and for the disaster risk management and resilience communities,efforts to support realization of the wider 2030 Agenda for sustainable development bring particular *** November 2019,the UK Disasters Research Group(DRG)brought together a number of key stakeholders focused on disaster risk,resilience,and sustainability research relevant to Official DevelopmeAssistance to consider how fit for purpose existing partnership models are for the pace of change required to deliver the priorities of the wider 2030 *** were invited to discuss how research partnerships across three levels(individual and project-based;national and institutional;and international)could be improved based on elements that facilitate robust partnerships and learning from aspects that hinder *** the discussions,participanls emphasized the importance of effective communication mechanisms in building partnerships,co-designing projects,and establishing shared *** approaches to addressing equitable partnerships and funding more substantive timelines will be key to responding to the challenges of the 2030 Agenda.

关键词： 2030 Agenda for sustainable development Disaster risk reduction DRG Inter national development Partnerships Research fun ding

COVID-19 and the heart

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World Journal of Clinical Cases 2022年第28期10卷 9970-9984页

作者： andrew Xanthopoulos Angeliki Bourazana Grigorios Giamouzis Evangelia Skoularigki Apostolos Dimos Alexandros Zagouras Michail Papamichalis Ioannis Leventis Dimitrios E Magouliotis Filippos Triposkiadis john Skoularigis Department of Cardiology University Hospital of LarissaLarissa 41110Greece Department of Cardiothoracic Surgery University of ThessalyLarissa BiopolisLarissa 41110Greece

An outbreak of coronavirus disease 2019(COVID-19) occurred in December 2019 due to severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which is a strain of SARS-Co *** infected with the virus present a wide spectrum of manifestations ranging from mild flu-like symptoms,cough,fever and fatigue to severe lung injury,appearing as bilateral interstitial pneumonia or acute respiratory *** SARS-Co V-2 infection predominantly offends the respiratory system,it has been associated with several cardiovascular complications as *** example,patients with COVID-19 may either develop type 2 myocardial infarction due to myocardial oxygen demand and supply imbalance or acute coronary syndrome resulting from excessive inflammatory response to the primary *** incidence of COVID-19 related myocarditis is estimated to be accountable for an average of 7% of all COVID-19 related fatal cases,whereas heart failure(HF) may develop due to infiltration of the heart by inflammatory cells,destructive action of pro-inflammatory cytokines,micro-thrombosis and new onset or aggravated endothelial and respiratory ***,SARSCo V-2 can engender arrhythmias through direct myocardial damage causing acute myocarditis or through HF decompensation or secondary,through respiratory failure or severe res-piratory distress *** this comprehensive review we summarize the COVID-19 related cardiovascular complications(acute coronary syndromes,myocarditis,HF,arrhythmias) and discuss the main underlying pathophysiological mechanisms.

关键词： COVID-19 Virus Complications Cardiac Acute coronary syndromes Heart failure Myocarditis Arrhythmias

Patent hemostasis of radial artery:Comparison of two methods

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World Journal of Cardiology 2021年第10期13卷 574-584页

作者： Vassileios Kyriakopoulos andrew Xanthopoulos Michail Papamichalis Spyridon Skoularigkis Chara Tzavara Emmanouil Papadakis Sotirios Patsilinakos Filippos Triposkiadis john Skoularigis Department of Cardiology Konstantopoulio General HospitalAthens 14233Greece Department of Cardiology University Hospital of LarissaLarissa 41110Greece Department of Health Medical SchoolUniversity of AthensAthens 11527Greece

BACKGROUND Radial artery obstruction is the most common complication of coronary angiography performed via transradial *** hemostasis can significantly reduce the risk of radial artery *** studies utilized sophisticated methods to evaluate radial artery *** and easily applicable methods for successful patent hemostasis are currently *** To determine which method(pulse oximeter vs the traditional radial artery palpation)is better to achieve patent *** This prospective,single center study included 299 consecutive patients who underwent coronary angiography or percutaneous coronary intervention between November 2017 and July *** less than 18 years old,with a history of radial artery disease,or no palpable artery pulse were excluded from the *** were randomly assigned to two *** the first group,radial artery flow was assessed by palpation of the artery during hemostasis(traditional method).In the second group,radial artery patency was estimated with the use of a pulse *** different compression devices were used for hemostasis(air chamber and pressure valve).The primary study endpoint was the achievement of successful patent *** The two groups(pulse oximeter vs artery palpation)had no significant differences in age,sex,body mass index,risk factors,or comorbidities except for supraventricular *** percentage of patients with successful patent hemostasis was significantly higher in the pulse oximeter group(82.2%vs 68.1%,P=0.005).A lower percentage of patients with spasm was recorded in the pulse oximeter group(9.9%vs 19.0%,P=0.024).The incidence of local complications,edema,bleeding,hematoma,vagotonia,or pain did not differ between the two *** the multivariate analysis,the use of a pulse oximeter(OR:2.35,95%CI:1.34-4.13,P=0.003)and advanced age(OR:1.04,95%CI:1.01-1.07,P=0.006),were independently associated with an increased probability of succe

关键词： Radial access Patent hemostasis Palpation Oximeter Coronary angiography Radial artery occlusion

Laser requirements for a laser fusion energy power plant

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High Power Laser Science and Engineering 2013年第1期1卷 2-10页

作者： Stephen E.Bodner andrew J.Schmitt john D.Sethian 550 Carolina Meadows Villas Chapel Hill NC 27517United States Plasma Physics Division Naval Research LaboratoryWashington DC 20375United States

We will review some of the requirements for a laser that would be used with a laser fusion energy power plant, including frequency, spatial beam smoothing, bandwidth, temporal pulse shaping, efficiency, repetition rate, and reliability. The lowest risk and optimum approach uses a krypton fluoride gas laser. A diode-pumped solid-state laser is a possible contender.

关键词： laser fusion energy

Selection and quality assessment of Landsat data for the North American forest dynamics forest history maps of the US

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International Journal of Digital Earth 2016年第10期9卷 963-980页

作者： Karen Schleeweis Samuel N.Goward Chengquan Huang john L.Dwyer Jennifer L.Dungan Mary A.Lindsey andrew Michaelis Khaldoun Rishmawi Jeffery G.Masek Forest Inventory and Analysis US Forest ServiceRocky Mountain Research StationOgdenUTUSA Department of Geographical Sciences University of MarylandCollege ParkMDUSA U.S.Geological Survey Earth Resources Observation and Science(EROS)Center Sioux FallsSDUSA NASA Ames Research Center Moffett FieldCAUSA Climate Program Office NOAAWashingtonDCUSA NASA Ames Research Center University Corporation Monterey BayMoffett FieldCAUSA NASA Goddard Space Flight Center GreenbeltMDUSA

Using the NASA Earth Exchange platform,the North American Forest Dynamics(NAFD)project mapped forest history wall-to-wall,annually for the contiguous US(1986–2010)using the Vegetation Change Tracker *** with any effort to identify real changes in remotely sensed time-series,data gaps,shifts in seasonality,misregistration,inconsistent radiometry and cloud contamination can be sources of *** discuss the NAFD image selection and processing stream(NISPS)that was designed to minimize these sources of *** NISPS image quality assessments highlighted issues with the Landsat archive and metadata including inadequate georegistration,unreliability of the pre-2009 L5 cloud cover assessments algorithm,missing growing-season imagery and paucity of clear *** maps of Landsat 5–7 image quantities and qualities are presented that offer novel perspectives on the growing-season archive considered for this *** 150,000+Landsat images were considered for the NAFD ***,one high quality cloud-free image in each year or a total of 12,152 images would be ***,to accommodate data gaps and cloud/shadow contamination 23,338 images were *** 220 specific path-row image years no acceptable images were found resulting in data gaps in the annual national map products.

关键词： Landsat forest cover change time-series mapping forest disturbance North American forest dynamics nasa earth exchange

Floating production storage and offloading systems＇ cost and motion performance： A systems thinking application

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Frontiers of Engineering Management 2018年第3期5卷 357-368页

作者： Rini NISHANTH andrew WHYTE V.john KURIAN Civil & Environmental Engineering University Tech. PETRONASBandar Seri Iskandar Malaysia Civil Engineering Curtin University Perth Australia

Floating production storage and offloading （FPSO） units increasingly represent a practical and economic means for deep-water oil extraction and production. Systems thinking gives a unique opporamity to seek a balance between FPSO technical performance（s）, with whole-cost; stakeholder decision-making is charged to align different fit-for-use design specification options＇ that address technical-motion（s）, with respective life-cycle cost analyses （LCCA）. Soft system methodology allows situation based analyses over set periods-of-time by diagnosing the problem-at-hand; namely, assessing the antecedents of life-cycle cost relative to FPSO sub- component design alternatives. Alternative mooring- component comparisons for either new-build hulls or refurbished hulls represent an initial necessary considera- tion to facilitate extraction, production and storage of deep- water oil reserves. Coupled dynamic analysis has been performed to generate FPSO motion in six degrees of freedom using SESAM DeepC, while life-cycle cost analysis （LCAA） studies give net-present-value comparsons reflective of market conditions. A parametric study has been conducted by varying wave heights from 4 - 8 m to understand FPSO motion behavior in the presence of wind and current, as well as comparing the motions of turreted versus spread mooring design alternatives. LCCA data has been generated to compare the cost of such different mooring options/hull conditions over 10 and 25- year periods. Systems thinking has been used to explain the interaction of problem variables; resultantly this paper is able to identify explicit factors affecting the choice of FPSO configurations in terms of motion and whole-cost, toward assisting significantly with the front-end engineering design （FEED） phase of fit-for-purpose configured FPSOs, in waters off Malaysia and Australia.

关键词： FPSO LCCA spread/turret-mooring DeepC cost motion soft-systems

Moment transfer factors for column-supported cast-in-situ hollow core slabs

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第3期13卷 165-173页

作者： Hai-tao LI andrew john DEEKS Li-xin LIU Dong—shengHUANG Xiao-zu SU Department of Building Engineering Nanj ing Forestry University Nanj ing 210037 China Faculty of Science Durham University Durham DH1 3LE England Department of Civil Engineering Zhengzhou University Zhengzhou 450002 China Department of Building Engineering Tongji University Shanghai 200092 China

Hollow core slabs are becoming of increasing interest as the construction industry attempts to minimise the impact of its activities on the environment. By forming voids in the interior of a concrete slab, the amount of concrete used can be reduced without significantly altering the capacity of the structure. In this study, we examined the inner force transfer mechanism of a column-supported cast-in-situ hollow core slab using finite element analysis. Both a hollow core slab and the corresponding solid slab were analysed using ANSYS and the results were compared. The orientation of the tube fillers causes the stiffness of the hollow slab to be orthotropic, potentially changing the distribution of load carried in the two orthogonal directions. Both the cross-section’s moments in the column strip and near the columns in the hollow core slab become larger than that in the solid floor. As well, the cross-section’s stiffness along the tube arrangement direction is larger than that of the radial cross-section, which causes the direction along the hole of the hollow core slab to carry more moment than the radial direction. The conversion factors of the two directions are proposed from the comparison for four typical areas of the hollow core slab, as are the moment distribution coefficients.

关键词： Reinforced concrete Cast-in-situ Hollow core slab Tube filler Finite element analysis