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Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver

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World Journal of Gastroenterology 2008年第44期14卷 6808-6816页

作者： Samuel Wyllie Neal R Barshes Saul J Karpen john a.goss Michael E. DeBakey Department of Surgery Liver Transplant Center LaboratoryBaylor College of MedicineHoustonTX 77030United States

AIM： To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS： The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS： In our isolated blood-perfused rat liver model, pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury, as judged by the elevated aspartate aminotransferase activity. In addition, P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However, total bile production after 120 rain of perfusion was significantly greater in P-selectin antibody-treated livers, compared to control livers. No significant difference in P-selectin and ICAM-1 mRNAs and proteins, GSH, GSSG, and nuclear NF-kB was found between control and P-selectin antibody-treated livers. CONCLUSION： In conclusion, we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model.

关键词： P-selectin Ischemia-reperfusion Antibody-blockade Liver Rat

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Hepatitis C in the pediatric population: Transmission, natural history, treatment and liver transplantation

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World Journal of Gastroenterology 2014年第32期20卷 11281-11286页

作者： Saira Khaderi Ross Shepherd john a.goss Daniel Leung Division of Abdominal Transplantation Micheal E DeBakey Department of Surgery Baylor College of Medicine Houston TX 77030 United States Division of Pediatric Gastroenterology Hepatology Nutrition Texas Children’s Hospital Baylor College of Medicine Houston TX 77030 United States

The number of children affected by the hepatitis C virus (HCV) in the United States is estimated to be between 23000 to 46000. The projected medical cost for children with HCV in the United States is upwards of 200 million over the next decade. The implementation of routine screening of blood supply has virtually eliminated transmission via transfusion and vertical transmission is now the most common mode of infection in children. Infections acquired during infancy are more likely to spontaneously resolve and fibrosis of the liver tends to increase with age suggesting slow progressive histologic injury. Anti-viral treatment may be warranted in children with persistently elevated liver enzymes or with significant fibrosis on liver biopsy. Current standard of care includes weekly pegylated interferon and ribavirin twice daily. Predictors of high sustained viral response include genotype 2 and 3 and low viral load in children with genotype 1 ( 90%). Only 34 pediatric patients were transplanted with hepatitis C between January 2008 and April 2013. The majority of pediatric patients were born prior to universal screening of blood products and, as of June 2013, there are only two pediatric patients awaiting liver transplantation for end-stage liver disease secondary to hepatitis C. Pediatric survival rates post-transplant are excellent but graft survival is noticeably reduced compared to adults (73.73% for pediatric patients at one year compared to 87.69% in adult patients). New safe potent, and all-oral effective antiviral therapies for recurrent HCV should help increase graft survival.

关键词： Hepatitis C Liver transplantation Pediatric Infection Fibrosis Liver disease

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Beyond the Pediatric end-stage liver disease system: Solutions for infants with biliary atresia requiring liver transplant

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World Journal of Gastroenterology 2014年第32期20卷 11062-11068页

作者： Mary Elizabeth M Tessier Sanjiv Harpavat Ross W Shepherd Girish S Hiremath Mary L Brandt Amy Fisher john a.goss Department of Pediatrics Baylor College of Medicine and Texas Children’s Hospital Department of Pediatrics Baylor College of Medicine and Texas Children’s Hospital Houston Department of Surgery Baylor College of Medicine and Texas Children’s HospitalHouston

Biliary atresia(BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant, with up to one half of BA children needing a transplant by age two. In the current pediatric end-stage liver disease system, children with BA face the risk of not receiving a liver in a safe and timely manner. In this review, we discuss a number of possible solutions to help these children. We focus on two general approaches:(1) preventing/delaying need for transplantation, by optimizing the success of the Kasai operation; and(2) expediting transplantation when needed, by performing techniques other than the standard deceased-donor, whole, ABO-matched organ transplant.

关键词： Biliary atresia Liver transplantation Pediatric liver disease Pediatric end-stage liver disease Kasai operation Newborn screening Surgical outcomes Living-related donor transplantation Split liver transplantation ABO-incompatible liver transplantation

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Clinical efficacy of direct-acting antiviral therapy for recurrent hepatitis C virus infection after liver transplantation in patients with hepatocellular carcinoma

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World Journal of Hepatology 2020年第9期12卷 628-640页

作者： Mohamed Saleh Ismail Manal Hassan Saira Aijaz Khaderi Wael Ahmed Yousry Maha Mohsen Kamal El-Din Mohamed Mohamed Bahaa El-Din Osama Aboelfotoh El Sayed Ahmed Omar Kaseb john Alan goss FasihaKanwal Prasun Kumar Jalal Division of Gastroenterology Baylor College of MedicineHoustonTX 77030United States Department of Internal medicine Gastroenterology and HepatologyAin Shams UniversityCairo 11566Egypt Department of Surgery Division of Abdominal TransplantationBaylor College of MedicineHoustonTX 77030United States Department of Epidemiology the University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Surgery Ain Shams UniversityCairo 11566Egypt Department of Gastrointestinal Medical Oncology the University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

BACKGROUND Recurrent hepatitis C virus(HCV)infection of transplanted liver allografts is universal in patients with detectable HCV viremia at the time of ***-acting antiviral(DAA)therapy has been adopted as the standard of care for recurrent HCV infection in the post-transplant ***,there are insufficient data regarding its efficacy in liver transplant(LT)recipients with a history of hepatocellular carcinoma(HCC),and the risk of HCC recurrence after DAA therapy is *** of DAA treatment failure and HCC recurrence in LT *** A total of 106 LT recipients given DAAs for recurrent HCV infection from 2015 to 2019 were identified(68 with and 38 without HCC).Descriptive statistics and logistic regression models were used to estimate the multivariate odds ratios and respective 95%confidence intervals for predictors of treatment failure and HCC *** Six patients(6%)experienced DAA therapy failure post-LT and 100(94%)had a sustained virologic response at follow-up week 12.A high alanine transaminase level>35 U/L at treatment week 4 was a significant predictor of treatment *** to pre-LT DAA therapy is a predictor of post-LT HCC recurrence,P=*** relapse post-LT was also associated with post-transplantation HCC recurrence,P=*** DAAs are effective and safe in the treatment of recurrent HCV infection in LT recipients with history of *** to pre-and post-LT DAA therapy is associated with post-transplantation HCC recurrence.

关键词： Direct-acting antiviral Liver transplant Hepatocellular carcinoma Recurrence

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欢迎你使用望远镜!

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中国国家天文 2014年第10期8卷 116-119页

作者： john Jardine goss 吴蕴豪(译)

在过去30年中，业余天文经历了许多重大变化。然而，一个令人不安而且常被人们议论的趋势是，有这种爱好的年轻人的数量正在萎缩。尽管缺乏年轻观星者的原因非常复杂，但其中有一个因素很明显：如果你看不到繁星密布的夜空，你就不太可... 详细信息

在过去30年中，业余天文经历了许多重大变化。然而，一个令人不安而且常被人们议论的趋势是，有这种爱好的年轻人的数量正在萎缩。尽管缺乏年轻观星者的原因非常复杂，但其中有一个因素很明显：如果你看不到繁星密布的夜空，你就不太可能去爱好业余天文。

关键词：望远镜年轻人天文爱好

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企业租用电力设备的财务效益

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广东造船 2009年第4期28卷 67-68页

作者：高山河国际思捷有限公司

由于当前的金融危机,许多企业正在寻找出路,避免大额资本支出、固定资产投资和雇佣昂贵的雇员。与此同时,这些企业需要为将来经济的好转做打算,他们知道在不远的将来经济形势必有所改善,那时他们的企业必须为经济复苏做好准备。

关键词：电力租赁资产购置降低营运成本电力设备购置

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中国卫生政策制定应基于卫生研究

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中国医院院长 2018年第16期14卷 65-67页

作者：傅卫赵树理张毓辉柴培培 john goss 国家卫健委卫生发展研究中心国家卫健委财务司澳大利亚堪培拉大学

以《＂健康中国2030＂规划纲要》中个人卫生支出占比的目标设定为例,表明卫生研究在中国卫生政策制定中发挥着越来越重要的作用。健康是人的基本权利,是国家发展和繁荣的重要基础。为更好满足人民群众的健康需要,党中央、国务院实施了... 详细信息

以《＂健康中国2030＂规划纲要》中个人卫生支出占比的目标设定为例,表明卫生研究在中国卫生政策制定中发挥着越来越重要的作用。健康是人的基本权利,是国家发展和繁荣的重要基础。为更好满足人民群众的健康需要,党中央、国务院实施了多轮重大医疗卫生改革。为保障人民群众人人享有基本医疗卫生服务,2009年中国启动了新一轮深化医药卫生体制改革,改革取得了重大成功,尤其是在全面医疗保险覆盖方面。

关键词：卫生政策制定中国基本医疗卫生服务医药卫生体制改革医疗卫生改革人民群众 2009年目标设定

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研究在中国卫生政策制定中的作用：以《“健康中国2030”规划纲要》中个人卫生支出占比的目标设定为例

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英国医学杂志中文版 2018年第6期21卷 309-312页

作者：傅卫赵树理张毓辉柴培培 john goss 国家卫生计生委卫生发展研究中心中国国家卫生和计划生育委员会财务司中国堪培拉大学澳大利亚

健康是人的基本权利，是国家发展和繁荣的重要基础。为更好满足人民群众的健康需要，中国共产党和中国政府实施了多轮重大医疗卫生改革。为保障人民群众人人享有基本医疗卫生服务，2009年中国启动了新一轮深化医药卫生体制改革，改革取... 详细信息

健康是人的基本权利，是国家发展和繁荣的重要基础。为更好满足人民群众的健康需要，中国共产党和中国政府实施了多轮重大医疗卫生改革。为保障人民群众人人享有基本医疗卫生服务，2009年中国启动了新一轮深化医药卫生体制改革，改革取得了重大成功，尤其是在全面医疗保险覆盖方面。

关键词：中国政府卫生政策制定目标设定卫生支出健康基本医疗卫生服务医药卫生体制改革医疗卫生改革

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Role of liver transplantation in the management of hepatoblastoma in the pediatric population

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World Journal of Transplantation 2014年第4期4卷 294-298页

作者： Saira Khaderi Jacfranz Guiteau Ronald T Cotton Christine O'Mahony Abbas Rana john a.goss Division of Abdominal Transplantation Michael E. De Bakey Department of Surgery Baylor College of Medicine Houston TX 77030 United States

Hepatoblastoma(HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB(unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplantation is an excellent option. The etiology of HB is mostly obscure because of its extreme rarity although some inherited syndromes and very low birth weight have been associated with it. The prognosis for children with HB has significantly improved in the past three decades thanks to advancements in chemotherapy, surgical resection and postoperative care. In 2002 a surgical staging system called pretreatment extent of disease(PRETEXT) was designed to allow a universal, multidisciplinary approach to patients with HB. Between one-third to two-thirds of patients initially present with unresectable tumors or distant metastases, but up to 85% of these tumors become operable after neoadjuvant chemotherapy. Patients with PRETEXT categories 1, 2, and some 3 are referred for neoadjuvant chemotherapy followed by surgical resection with the goal of complete tumor removal. Classic treatments regimens include a combination of cisplatin, fluorouracil, and vincristine or cisplatin and doxorubicin. Liver transplantation is the only treatment option for unresectable HB. In 2010 the pediatric end-stage liver disease, a pediatric-specific scoring system that determines a patient's ranking on the liver transplant list, began to award additional "exception" points for patients with HB. We analyzed the Standard Transplant Analysis and Research dataset to assess the impact of changes in exception point criteria for HB on outcomes after liver transplantation at Texas Children's Hospital in Houston, Texas. We found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras.

关键词： Liver transplant Hepatoblastoma Pediatric Chemotherapy Cancer

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Predictors of 2 Kilometer Rowing Ergometer Time Trial Performance

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Journal of Sports Science 2019年第3期7卷 81-87页

作者： Jason W. Metz Fredric L. goss Robert J. Robertson Elizabeth F. Nagle john P. Abt Department of Health and Physical Activity University of Pittsburgh Pittsburgh PA 15260 USA

Predictors of performance can aid coaches and trainers in prescribing exercise programs for rowing athletes. To date, most of the prediction models have been developed for runners and cyclists. Purpose: The aim of this study was to develop a regression model to predict performance of a simulated 2 kilometer rowing ergometer time trial. Methods: A group of mixed gender rowing athletes (n = 12) completed in a counterbalanced order a 2 kilometer rowing time trial and a continuous progressively incremented graded exercise test on a rowing ergometer. Subjects were 23.91 ± 4.99 years old, weighed 79.14 ± 12.85 kg, were 187.38 ± 12.60 cm, had a VO2max of 55.48 ± 10.32 mL/kg/min and had 3.17 ± 2.79 years of rowing experience. Physiological measures were recorded during both testing protocols. Results: Maximum power/stroke ratio (r =-0.96, p < 0.001), power/stroke ratio at the ventilatory breakpoint (r =-0.90, p < 0.001), maximal oxygen uptake (r =-0.84, p < 0.001) and oxygen uptake at the ventilatory breakpoint (r =-0.82, p < 0.001) were found to be strong and significant predictors of 2 kilometer rowing performance. Conclusion: The four significant predictors of rowing performance suggest training should focus on improving both aerobic capacity and strength. Practical Application: Rowing training should focus on developing hip and leg aerobic and anaerobic capacities to improve performance. Developing strength improves mechanical efficiency as well as raising anaerobic thresholds allowing athletes to utilize a larger portion of their aerobic capacity.

关键词： Maximal oxygen uptake ventilatory threshold power/stroke ratio.

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