检索结果-南通市图书馆

Risk factor analysis and clinical decision tree model construction for diabetic retinopathy in Western China

World Journal of Diabetes 2022年第11期13卷 986-1000页

作者： yuan-yuan Zhou tai-cheng Zhou Nan chen Guo-Zhong Zhou Hong-Jian Zhou Xing-Dong Li Jin-Rui Wang Chao-Fang Bai Rong Long Yu-Xin Xiong Ying Yang Department of Endocrinology and Metabolism The Sixth Affiliated Hospital of Kunming Medical UniversityThe People’s Hospital of Yuxi CityYuxi 653100Yunnan ProvinceChina Department of Endocrinology and Metabolism Affiliated Hospital of Yunnan UniversityThe Second People’s Hospital of Yunnan ProvinceKunming 650021Yunnan ProvinceChina Department of Endocrinology and Metabolism The Frist People’s Hospital of Anning CityAnning City 650300Yunnan ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is the driving force of blindness in patients with type 2 diabetes mellitus(T2DM).DR has a high prevalence and lacks effective therapeutic strategies,underscoring the need for early prevention and *** province,located in the southwest plateau of China,has a high prevalence of DR and an underdeveloped *** To build a clinical prediction model that will enable early prevention and treatment of *** In this cross-sectional study,1654 Han population with T2DM were divided into groups without(n=826)and with DR(n=828)based on fundus *** DR group was further subdivided into non-proliferative DR(n=403)and proliferative DR(n=425)groups.A univariate analysis and logistic regression analysis were conducted and a clinical decision tree model was *** Diabetes duration≥10 years,female sex,standing-or supine systolic blood pressure(SBP)≥140 mmHg,and cholesterol≥6.22 mmol/L were risk factors for DR in logistic regression analysis(odds ratio=2.118,1.520,1.417,1.881,and 1.591,respectively).A greater severity of chronic kidney disease(CKD)or hemoglobin A 1c increased the risk of DR in patients with *** the decision tree model,diabetes duration was the primary risk factor affecting the occurrence of DR in patients with T2DM,followed by CKD stage,supine SBP,standing SBP,and body mass index(BMI).DR classification outcomes were obtained by evaluating standing SBP or BMI according to the CKD stage for diabetes durationtained by evaluating diabetes duration,CKD stage,supine or standing SBP,and BMI.

关键词： Diabetic retinopathy Type 2 diabetes Western China Decision tree

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引用

南昌大学学报（医学版） 2024年第1期64卷 6-13页

作者：潘希望邱模竞郑林林杨新博徐晨李太原胡家萍南昌大学第一附属医院普外科南昌330006

目的筛选结肠癌差异表达的lncRNA和miRNA,探讨其与结肠癌预后的关系及相关生物学功能。方法从TCGA数据库收集结肠癌患者的lncRNA和miRNA表达谱数据及临床资料,利用R软件筛选差异表达的lncRNA和miRNA;单因素Cox回归分析与预后显著相关的... 详细信息

目的筛选结肠癌差异表达的lncRNA和miRNA,探讨其与结肠癌预后的关系及相关生物学功能。方法从TCGA数据库收集结肠癌患者的lncRNA和miRNA表达谱数据及临床资料,利用R软件筛选差异表达的lncRNA和miRNA;单因素Cox回归分析与预后显著相关的差异表达lncRNA和miRNA;miRNet数据库构建预后相关的lncRNA-miRNA网络,利用mirPath v.3软件对其进行功能富集分析;R软件构建预后风险模型并对其进行验证。采用CCK-8实验、划痕实验、流式细胞术及qPCR评估敲减TSPEAR-AS2对人结肠癌HCT116细胞增殖、迁移、凋亡及下游miRNA表达的影响。结果筛选出结肠癌组织中1823个差异表达的lncRNA和524个差异表达的miRNA;发现158个lncRNA和31个miRNA与结肠癌的预后相关;构建由8个lncRNA和14个miRNA组成的lncRNA-miRNA网络;GO和KEGG富集分析显示,lncRNA-miRNA网络主要参与肿瘤相关的生物学功能及通路;鉴定出11个能有效评价结肠癌预后特征的关键基因,由这11个关键基因构建的预后风险模型中高风险组生存时间显著短于低风险组(P<0.001),预测1、3和5年生存的AUC分别为0.70、0.74和0.71。敲减TSPEAR-AS2可抑制HCT116细胞增殖、迁移、促进细胞凋亡,并下调hsa-mir-4731-5p和hsa-mir-342-3p的表达。结论成功筛选结肠癌相关lncRNA-miRNA网络,并由此构建的预后风险模型具有良好的预测效能。TSPEAR-AS2参与调控结肠癌细胞的增殖、迁移、凋亡以及下游miRNA表达。

关键词：结肠癌长链非编码RNA 微小RNA 生物信息学预后模型 TSPEAR-AS2

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lane Detection:A Survey with New Results

引用

Journal of Computer Science & Technology 2020年第3期35卷 493-505页

作者： Dun Liang yuan-chen Guo Shao-Kui Zhang tai-Jiang Mu Xiaolei Huang Department of Computer Science and Technology BNRistTsinghua UniversityBeijing100084China College of Information Sciences and Technology Pennsylvania State UniversityUniversity ParkPA16802USA

Lane detection is essential for many aspects of autonomous driving,such as lane-based navigation and high-definition(HD)map *** lane detection is challenging especially with complex road conditions,considerable progress has been witnessed in this area in the past several *** this survey,we review recent visual-based lane detection datasets and *** datasets,we categorize them by annotations,provide detailed descriptions for each category,and show comparisons among *** methods,we focus on methods based on deep learning and organize them in terms of their detection ***,we introduce a new dataset with more detailed annotations for HD map modeling,a new direction for lane detection that is applicable to autonomous driving in complex road conditions,a deep neural network LineNet for lane detection,and show its application to HD map modeling.

关键词： convolutional neural network(CNN) dataset deep learning high-definition(HD)map lane detection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

不同杀虫剂防治苜蓿蚜虫效果及对捕食性天敌影响

引用

山东农业大学学报（自然科学版） 2024年第4期55卷 587-592页

作者：刘锦陈鹏迟宝杰翟孟圆杨向黎刘永杰山东农业工程学院林业工程学院山东济南250100 山东农业大学植物保护学院山东泰安271018

为明确不同杀虫剂对紫花苜蓿蚜虫及其捕食性天敌的影响,本研究比较了吡虫啉、啶虫脒、烯啶虫胺、氟啶虫胺腈、吡蚜酮和螺虫乙酯6种杀虫剂施药后不同时间对苜蓿蚜虫的防治效果及其对捕食性天敌的影响。结果表明,喷药后至10d,6种杀虫剂的... 详细信息

为明确不同杀虫剂对紫花苜蓿蚜虫及其捕食性天敌的影响,本研究比较了吡虫啉、啶虫脒、烯啶虫胺、氟啶虫胺腈、吡蚜酮和螺虫乙酯6种杀虫剂施药后不同时间对苜蓿蚜虫的防治效果及其对捕食性天敌的影响。结果表明,喷药后至10d,6种杀虫剂的防治效果均在85%以上,之后防效均出现不同程度下降,喷药后20d~35d,吡虫啉、啶虫脒、烯啶虫胺和氟啶虫胺腈4种杀虫剂防效为19.17%~40.13%,吡蚜酮和螺虫乙酯防效为58.01%~71.32%,吡蚜酮和螺虫乙酯持续防控效果显著高于前4种杀虫剂。蚜虫和天敌发生动态趋势表明,喷药后蚜虫数量均迅速下降至低水平并保持到4月底;5月上旬吡虫啉、啶虫脒、烯啶虫胺和氟啶虫胺腈4种杀虫剂处理区蚜虫数量开始快速上升,同一调查时间蚜虫数量均显著大于吡蚜酮和螺虫乙酯处理区数量,而天敌数量和益害比却均显著小于吡蚜酮和螺虫乙酯处理区;吡蚜酮和螺虫乙酯防控蚜虫的同时可避免杀伤天敌,自然天敌捕食蚜虫亦抑制蚜虫数量增长,二者协同控制蚜虫危害作用时间长,为苜蓿蚜虫高效绿色防控提供科学依据。

关键词：紫花苜蓿蚜虫捕食性天敌益害比防治效果

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Analysis of textbook outcomes for ampullary carcinoma patients following pancreaticoduodenectomy

引用

World Journal of Gastrointestinal Surgery 2023年第10期15卷 2259-2271页

作者： Xiao-Jie Zhang He Fei Chun-Guang Guo Chong-yuan Sun Ze-Feng Li Zheng Li Ying-tai chen Xu Che Dong-Bing Zhao Department of Pancreatic and Gastric Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary and Pancreatic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen518116China

BACKGROUND Textbook outcomes(TOs)have been used to assess the quality of surgical treatment for many digestive tumours but not ampullary carcinoma(AC).AIM To discuss the factors associated with achieving a TO and further explore the prognostic value of a TO for AC patients undergoing curative pancreaticoduodenectomy(PD).METHODS Patients who underwent PD at the China National Cancer Center between 1998 and 2020 were identified.A TO was defined by R0 resection,examination of≥12 Lymph nodes,no prolonged hospitalization,no intensive care unit treatment,no postoperative complications,and no 30-day readmission or *** regression analysis was used to identify the prognostic value of a TO for overall survival(OS)and recurrence-free survival(RFS).Logistic regression was used to identify predictors of a *** rate of a TO and of each indicator were compared in patients who underwent surgery before and after *** Ultimately,only 24.3%of 272 AC patients achieved a TO.A TO was independently associated with improved OS[hazard ratio(HR):0.443,95%confidence interval(95%CI):0.276-0.711,P=0.001]and RFS(HR:0.379,95%CI:0.228-0.629,P<0.001)in the Cox regression *** independently associated with a TO included a year of surgery between 2010 and 2020(OR:4.549,95%CI:2.064-10.028,P<0.001)and N1 stage disease(OR:2.251,95%CI:1.023-4.954,P=0.044).In addition,the TO rate was significantly higher in patients who underwent surgery after 2010(P<0.001)than in those who underwent surgery before *** Only approximately a quarter(24.3%)of AC patients achieved a TO following PD.A TO was independently related to favourable oncological outcomes in AC and should be considered as an outcome measure for the quality of *** multicentre research is warranted to better elucidate its impact.

关键词： Ampullary carcinoma Textbook outcomes Pancreaticoduodenectomy Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation dose detection using a high-power portable optically stimulated luminescence real-time reading system

引用

Nuclear Science and Techniques 2018年第10期29卷 245-253页

作者： Yi-Hang Wang Hua chen Fei chen Yong-Gang yuan tai-Ping Peng Institute of Nuclear Physics and Chemistry Chinese Academy of Engineering Physics

Optically stimulated luminescence(OSL) reading systems are becoming smaller and capable of real-time detection. To improve real-time and multipurpose radiation dosimetry readings, we built a real-time continuous-wave(RCW) OSL reading system. This system is both small and lightweight, and it employs powerful laser excitation(478 mW/cm^2) at the dosimetry probe location. We investigate the possibility of using the RCW mode to read the radiation luminescence(RL) or OSL by using a singlecrystal Al_2O_3:C dosimeter in a low-dose-rate137 Cs y *** results indicate that the RL/OSL follows a stable and uniform distribution. The minimum detected doses associated with the RL, OSL, and RL + OSL signals are2.1 9 10^(-2), 3.17 9 10^(-1), and 5.7 9 10^(-2) l Gy, respectively. This device provides a framework for the future development of applications for practical radiation dose measurements.

关键词： OSL Real-time reading Al2O3:C Radiation dose

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

刘铜华教授治疗自身免疫性甲状腺炎用药经验

引用

世界科学技术-中医药现代化 2024年第2期26卷 517-522页

作者：马知遥陈源宁洲俊秦灵灵吴丽丽刘铜华北京中医药大学第二临床医学院北京100078 北京中医药大学科技处北京100029 北京中医药大学教育部中医养生学重点实验室北京100029

自身免疫性甲状腺炎(Autoimmune thyroiditis,AIT)是一种自身免疫性疾病,包括桥本甲状腺炎(Hashimoto’s thyroiditis,HT)、弥漫性毒性甲状腺肿(Toxic diffuse goiter)等,以桥本甲状腺炎者居多。刘铜华教授认为情志内伤及先天禀赋不足是... 详细信息

自身免疫性甲状腺炎(Autoimmune thyroiditis,AIT)是一种自身免疫性疾病,包括桥本甲状腺炎(Hashimoto’s thyroiditis,HT)、弥漫性毒性甲状腺肿(Toxic diffuse goiter)等,以桥本甲状腺炎者居多。刘铜华教授认为情志内伤及先天禀赋不足是AIT发病的关键因素,肝郁气滞火热是本病的关键病机,在临床治疗中重视疏肝理气类和清热泻火解毒类药物的使用,重视“火”类病机,重视“虚实”辨证以及心理疏导,常以自拟的甲炎康泰方为底方,辨证加减论治。本文就刘铜华教授应用甲炎康泰方化裁治疗AIT的临床经验和体会进行论述,以期指导AIT的中医治疗。

关键词：自身免疫性甲状腺炎瘿病桥本甲状腺炎名医经验

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury

引用

Neural Regeneration Research 2021年第11期16卷 2284-2292页

作者： Shuo Liu yuan-yuan Xie Liu-Di Wang chen-Xu tai Dong chen Dan Mu Yan-Yan Cui Bin Wang Clinical Stem Cell Center Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Department of Radiology Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Department of Cell Biology and Genetics Chongqing Medical UniversityChongqingChina

Collagen scaffolds possess a three-dimensional porous structure that provides sufficient space for cell growth and proliferation,the passage of nutrients and oxygen,and the discharge of *** this study,a porous collagen scaffold with axially-aligned luminal conduits was *** vitro biocompatibility analysis of the collagen scaffold revealed that it enhances the activity of neural stem cells and promotes cell extension,without affecting cell *** collagen scaffold loaded with neural stem cells improved the hindlimb motor function in the rat model of T8 complete transection and promoted nerve *** collagen scaffold was completely degraded in vivo within 5 weeks of implantation,exhibiting good *** temperature,C-reactive protein expression and CD68 staining demonstrated that rats with spinal cord injury that underwent implantation of the collagen scaffold had no notable inflammatory *** findings suggest that this novel collagen scaffold is a good carrier for neural stem cell transplantation,thereby enhancing spinal cord repair following *** study was approved by the Animal Ethics Committee of Nanjing Drum Tower Hospital(the Affiliated Hospital of Nanjing University Medical School),China(approval No.2019AE02005)on June 15,2019.

关键词： axially-aligned luminal conduits biomaterial cell transplantation collagen complete transection inflammation neural stem cell regeneration scaffold spinal cord injury tissue engineering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

室旁核H_(2)S通过TLR4/MyD88/NF-κB信号通路对盐敏感性高血压大鼠的影响

引用

生物医学工程与临床 2024年第4期28卷 457-465页

作者：梁衍锋陈淑月任永波郑咏太苏嘉璐秦驁王轩袁博洋张东东佳木斯大学基础医学院黑龙江佳木斯154007 佳木斯大学临床医学院黑龙江佳木斯154002

目的研究室旁核(PVN)硫化氢(H_(2)S)对高盐诱导的高血压大鼠Toll样受体4(TLR4)/髓样分化因子88(MyD88)/核转录因子κB(NF-κB)信号通路的影响,探讨H_(2)S降压的作用机制。方法选择40只成年雄性Dahl盐敏感性大鼠,鼠龄8周,体质量260~280 ... 详细信息

目的研究室旁核(PVN)硫化氢(H_(2)S)对高盐诱导的高血压大鼠Toll样受体4(TLR4)/髓样分化因子88(MyD88)/核转录因子κB(NF-κB)信号通路的影响,探讨H_(2)S降压的作用机制。方法选择40只成年雄性Dahl盐敏感性大鼠,鼠龄8周,体质量260~280 g。随机把大鼠分成正常对照组(Control组)、正常给药组(Control+GYY组)、高盐模型组(Model组)、高盐给药组(Model+GYY组),每组10只。于第4周末,利用微型渗透泵向Control+GYY组和Model+GYY组大鼠双侧PVN区域持续注射H_(2)S的缓释供体GYY4137,其余组大鼠全部注射等量人工脑脊液。连续注射6周后进行取材,通过酶联免疫吸附分析(ELISA)法来检测PVN H_(2)S及血浆去甲肾上腺素(NE)的水平,免疫荧光法检测TLR4、MyD88的表达,免疫组化法检测磷酸化核转录因子κB(p-NF-κB p65)、磷酸化κB抑制蛋白激酶β(p-IKKβ)的表达,通过Western blot法检测TLR4、MyD88、p-NF-κB p65/NF-κB p65的蛋白表达。结果Model组平均动脉压(MAP)、血浆NE较Control组升高(t=10.204、24.155、23.967、25.657、22.069、31.036、23.054、28.189,P<0.05),PVN中H_(2)S水平降低(t=14.348,P<0.05),Model+GYY组与Model组相比MAP、NE水平降低(t=8.295、12.931、10.992、16.064、12.228、16.017,P<0.05),PVN中H_(2)S水平升高(t=7.889,P<0.05)。免疫荧光或免疫组化结果显示,Model组PVN中TLR4、MyD88、pNF-κB p65、p-IKKβ因子的表达水平较Control组均升高(t=8.844、10.344、6.813、3.909,P<0.05),Model+GYY组与Model组相比PVN中TLR4、MyD88、p-NF-κB p65、p-IKKβ因子的表达水平均降低(t=4.719、4.313、3.234、4.955,P<0.05)。Western blot结果表明,与Control组相比,Model组大鼠PVN中TLR4、MyD88、p-NF-κB p65/NF-κB p65蛋白表达水平升高(t=15.951、6.537、7.394,P<0.05);与Model组大鼠相比,Model+GYY组TLR4、MyD88、p-NF-κB p65/NF-κB p65蛋白表达水平下降(t=9.415、4.901、8.997,P<0.05)。结论室旁核H_(2)S可明显降低高盐诱导的高血压大鼠的血压、降低外周交感神经活动,其机制可能与抑制TLR4/MyD88/NF-κB信号通路有关。

关键词：高血压室旁核硫化氢 Toll样受体4 髓样分化因子88 核转录因子κB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The regional difference in engineering-control and tillage factors of Chinese Soil Loss Equation

引用

Journal of Mountain Science 2021年第3期18卷 658-670页

作者： chen Rui-yin YAN Dong-chun WEN An-bang SHI Zhong-lin chen Jia-cun LIU yuan chen tai-li Key Laboratory of Mountain Surface Processes and Ecological Regulation Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China

Accurate assessment of soil erosion is an important prerequisite for controlling soil *** engineering-control(E)and tillage(T)factors are the keys for Chinese Soil Loss Equation(CSLE)to accurately evaluate water erosion in ***,the E and T factors can reflect the water and soil conservation effects of engineering-control and tillage *** in the current full coverage of soil erosion surveys in China(such as soil erosion dynamic monitoring),for the same practice,the E or T factors are assigned the same value across the *** selected 469 E and T factors data based on runoff plots from 73 publications,and they came from six soil and water conservation *** analysis,regression analysis,and nonparametric tests were used to determine the comparability of the data,and it was proved that the runoff plots dimensions are consistent with the local *** results of one-way ANOVA and nonparametric tests for E and T factors in different regions showed that the engineering-control practices have good soil and water conservation effects and weaken the regional differences of other environmental factors,so there were no significant differences in E factors between different ***,there were significant differences in T factors between different regions,and the geodetector was applied to explore the intrinsic driving force of the spatial distribution of T *** results of the geodetector showed that the dominant driving forces of the spatial distribution of different types of tillage practices were not completely the *** using CSLE to calculate water erosion,the E factor of the same practice can be used uniformly throughout the country,and the T factor needs to be considered and selected according to regional *** the same time,when choosing tillage practices in each water and soil conservation region,practices with better sediment reduction benefits should also be selected according to the regiona

关键词： Engineering-control factor Tillage factor Runoff plot Soil and water conservation regions Geodetector

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：