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Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study

World Journal of Gastroenterology 2016年第13期22卷 3644-3651页

作者： Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR verbeek Martin C Boonstra Henricus JM Handgraaf john v frangioni Cornelis JH van de velde Henk H Hartgrink Alexander L vahrmeijer Department of Surgery Leiden University Medical Center 2333 ZA Leiden The Netherlands Division of Hematology/Oncology Department of Medicine and Department of Radiology Beth Israel Deaconess Medical Center Boston MA 02215 United States Curadel LLC 377 Plantation Street Worcester MA 01605 United States

AIM: To investigate feasibility and accuracy of near-infrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node (SLN) detection in gastric ***: A prospective, single-institution, phase I feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 mL ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE™ NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and ***: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging (mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90% (70%-99%; 95%CI), which decreased by higher pT-stage (100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4 (range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 ***: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified.

关键词： Gastric cancer Sentinel lymph node Near-infrared fluorescence imaging Image-guided surgery Indocyanine green

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Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue

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World Journal of Gastrointestinal Surgery 2012年第7期4卷 180-184页

作者： Joost R van der vorst Alexander L vahrmeijer Merlijn Hutteman Tjalling Bosse vincent THBM Smit Cornelis JH van de velde john v frangioni Bert A Bonsing Department of Surgery Leiden University Medical CenterAlbinusdreef 22300 RC Leiden The Netherlands Department of Pathology Leiden University Medical CenterAlbinusdreef 22300 RC LeidenThe Netherlands Department of Medicine Beth Israel Deaconess Medical Center330 Brookline AvenueBostonMA 02215United States

A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue.

关键词： Pancreatic solitary fibrous tumor Near-in-frared fluorescence Image-guided surgery Methylene blue

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Antifragility Analysis and Measurement Framework for Systems of Systems

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International Journal of Disaster Risk Science 2013年第4期4卷 159-168页

作者： john johnson Adrian v.Gheorghe Engineering Management and Systems Engineering Department Old Dominion University Norfolk VA 23529 USA

The twenty-first century is defined by the social and technical hazards we face.A hazardous situation is a condition,or event,that threatens the well-being of people,organizations,societies,environments,and *** most extreme of the hazards are considered X-Events and are an exogenous source of extreme stress to a system.X-Events can also be the unintended outputs of a system with both positive(serendipitous) and negative(catastrophic) *** can vary in their ability to withstand these stress *** ability exists on a continuum of fragility that ranges from fragile(degrading with stress),to robust(unchanged by stress),to antifragile(improving with stress).The state of the art does not include a method for analyzing or measuring *** that “what we measure we will improve,” the absence of a measurement approach limits the effectiveness of governance in making our systems less fragile and more robust if not *** authors present an antifragile system simulation model,and propose a framework for analyzing and measuring antifragility based on system of systems *** framework reduces a multidimensional concept of fragility into a two-dimensional continuous interval scale.

关键词： extreme unchanged consequences

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Future of non-invasive graft evaluation:A systematic review of proteomics in kidney transplantation

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World Journal of Transplantation 2025年第1期15卷 135-149页

作者： Eleni Avramidou Konstantina Psatha Kallisti St john Georgios Tsoulfas Michalis Aivaliotis Department of Transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationAristotle University of ThessalonikiSchool of MedicineThessaloniki 54642Greece Laboratory of Medical Biology-Genetics School of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece Functional Proteomics and Systems Biology(FunPATh) Center for Interdisciplinary Research and Innovation(CIRI-AUTH)Thessaloniki GR-57001Greece Laboratory of Biological Chemistry School of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece

BACKGROUND Despite the developments in the field of kidney transplantation,the already existing diagnostic techniques for patient monitoring are considered *** biomarkers that can be derived from modern approaches of proteomic analysis of liquid biopsies(serum,urine)represent a promising innovation in the monitoring of kidney transplant *** To investigate the diagnostic utility of protein biomarkers derived from proteomics approaches in renal allograft *** A systematic review was conducted in accordance with PRISMA guidelines,based on research results from the PubMed and Scopus *** primary focus was on evaluating the role of biomarkers in the non-invasive diagnosis of transplant-related *** criteria included protein biomarkers and urine and blood samples,while exclusion criteria were language other than English and the use of low resolution and sensitivity *** selected research articles,were categorized based on the biological sample,condition and methodology and the significantly and reproducibly differentiated proteins were manually selected and *** and network analysis of the selected proteins was *** In 17 included studies,58 proteins were studied,with the cytokine CXCL10 being the most *** pathways related to immune response and fibrosis have shown to be *** of biomarkers for the assessment of renal damage as well as the prediction of short-term and long-term function of the graft were ***,all studies have shown satisfactory diagnostic accuracy of proteins alone or in combination with conventional methods,as far as renal graft assessment is *** Our review suggests that protein biomarkers,evaluated in specific biological fluids,can make a significant contribution to the timely,valid and non-invasive assessment of kidney graft.

关键词： Proteomics Kidney transplantation Graft evaluation Non-invasive diagnosis Kidney graft function

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Early successes and late failures in the prevention of post endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2007年第26期13卷 3567-3574页

作者： john G Lieb II Peter v Draganov Gastroenterology Fellow Division of GastroenterologyDepartment of Internal MedicineUniversity of Florida FL 32610-0214United States Associate Professor of Medicine Division of GastroenterologyUniversity of Florida FL 32610-0214United States

Acute pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). The only way to prevent this complication is to avoid an ERCP all together. Because of the risks involved, a careful consideration should be given to the indication for ERCP and the potential risk/benefit ratio of the test. Once a decision to perform an ERCP is made, the procedure should be carried out with meticulous care by an experienced endoscopist, and with a minimum of pancreatic duct opacification. Several pharmacologic agents have been tested, but to date the most important method of reducing post ERCP pancreatitis is the placement of pancreatic stent. Pancreatic stents should be placed in all patients at high risk of this complication such as those undergoing pancreatic sphincterotomy, pancreatic duct manipulation and intervention, and patients with suspected sphincter of Oddi dysfunction. Pancreatic stents should be also considered in patients requiring precut sphincterotomy to gain biliary access.

关键词： Post endoscopic retrograde cholangiopancre-atography pancreatitits Somatostatin Gabexate IL-10 Pancreatic stents Aspirating catheter Sphincter of Oddidysfunction

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Pancreatic function testing: Here to stay for the 21st century

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World Journal of Gastroenterology 2008年第20期14卷 3149-3158页

作者： john G Lieb II Peter v Draganov University of Florida

The diagnosis of Chronic Pancreatitis （CP） is based on the detection of abnormal structure or function of the diseased pancreas. The pancreatic function tests more accurately determine the presence of CP than tests of structure, especially for early stage disease. The function tests can be divided into two categories： non- invasive and invasive. The invasive ＂tube＂ tests can reliably detect mild, early CP, but are only available at a few referral centers and tend to be poorly tolerated by patients. The non-invasive tests are easy to obtain, but tend to perform poorly in patients with early, mild disease. Therefore, no one test is useful in all clinical situations, and a detailed understanding of the rational, pathophysiologic basis, strengths, and limitations of various tests is needed. This review highlights the role of various pancreatic function tests in the diagnosis of CP including fecal fat analysis, fecal elastase, fecal chymotrypsin, serum trypsin, the secretin stimulation test, the cholecystokinin （CCK） stimulation test, the combined secretin-CCK stimulation test, the intraductal and endoscopic secretin stimulation tests, and the functional magnetic resonance imaging of the pancreas after secretin stimulation.

关键词： Pancreatic function testing Secretinstimulation test CCK stimulation test Fecal elastase Endsocopic secretin stimulation test Chronic pancreatitis

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Association between thyroid function and gallstone disease

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World Journal of Gastroenterology 2005年第35期11卷 5530-5534页

作者： Henry vlzke Daniel M Robinson Ulrich john Ernst Moritz Arndt University Greifswald Institute of Epidemiology and Social Medicine Walther Rathenau Str. 48 D-17487 Greifswald Germany Ernst Moritz Arndt University Greifswald Department of Medicine B Friedrich Loeffler Str. 23a D-17487 Greifswald Germany

AIM： To investigate those associations using data of the population-based Study of Health in Pomerania. METHODS： A study population of 3 749 residents aged 20-79 years without previously diagnosed thyroid disease was available for analyses. Serum TSH was used to assess thyroid function. Cholelithiasis was defined by either a prior history of cholecystectomy or the presence of gallstones on ultrasound. Logistic regression was performed to analyze independent associations between thyroid function and cholelithiasis. RESULTS： There were 385 persons （10.3%） with low （〈0.3 mIU/L）, 3 321 persons （88.6%） with normal and 43 persons （1.2%） with high serum TSH levels （〉3 mIU/L）. The proportion of cholelithiasis among males and females was 14.4% and 25.3%, respectively. Among males, there was an independent relation between high serum TSH and cholelithiasis （OR 3.77; 95%-CI 1.06-13.41; P〈0.05）. Also among males, there was a tendency towards an elevated risk of cholelithiasis in persons with low serum TSH （OR 1.40; 95%-CI 0.96-2.02; P= 0.07）. In the female population, no such relation was identified. CONCLUSION： There is an association between thyroid and gallstone disease with a gender-specific relation between hypothyroidism and cholelithiasis.

关键词： Thyroid function Gallstones Cholelithiasis SHIP

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Challenges and opportunities in flexible,stretchable and morphable bio-interfaced technologies

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National Science Review 2022年第10期9卷 10-13页

作者： Abraham vázquez-Guardado Yiyuan Yang john A.Rogers Center for Bio-Integrated Electronics Northwestern University Querrey Simpson Institute for Bioelectronics Northwestern University Department of Mechanical Engineering Northwestern University Department of Materials Science and Engineering Northwestern University Department of Biomedical Engineering Northwestern University Department of Neurological Surgery Feinberg School of Medicine Northwestern University

Living organisms operate on the basis of dynamic biochemical processes elicited by a rich diversity of endogenous and exogenous *** higher-level forms of life,the result manifests as complex patterns of behavior and ultimately in the form of intelligence and *** classes of biocompatible electronic interfaces support expanding possibilities in bidirectional communication.

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Positional goods and the challenge of Chinese regional inequality

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Economic and Political Studies 2018年第1期6卷 4-10页

作者： john v.C.Nye Department of Economics George Mason UniversityFairfaxVAUSA NRU-Higher Schoolof Economics MoscowRussia

Scholars have focussed on income inequality as a major source of social *** the focus on crude income inequality has masked the deeper developmental problem facing many fast-growing *** is an extreme case of this issue inasmuch as its coastal regions can be viewed as comparable to middle income states,while the greater part of its rural and west-erm areas would be comparable to the poorer nations of the *** means that the new middle class pays attention to issues such as pollution and status or positional goods than simple material *** costs of houses are in particular less than *** status goods are similar because they are not amenable to simple productivity *** will make policies more difficult as conflict increases between those areas who are still eager for basic economic development and those richer areas whose wants and needs start to more closely resemble the preferences of richer developed countries.

关键词： Positional goods regional inequality statusgoods

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DETERMINANTS OF STRUCTURE IN AQUATIC NON-PELAGIC PROTOZOAN COMMUNITIES

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Chinese Journal of Oceanology and Limnology 1993年第3期11卷 215-228页

作者： john Cairns Jr Paul v.McCormick University Center for Environmental and Hazardous Materials Studies Virginia Polytechnic Institute and State University Blacksburg Virginia 24061 U.S.AUniversity Center for Environmental and Hazardous Materials Studies Virginia Polytechnic Institute and State University Blacksburg Virginia 24061 U.S.AUniversity Center for Environmental and Hazardous Materials Studies Virginia Polytechnic Institute and State University Blacksburg Virginia 24061 U.S.A

Although microbes have traditionally been used as models for testing ecological theory, research on the organization of these communities has largely been isolated from other areas of community ecology. Early studies indicated that microbial populations can form dynamic, interacting assemblages. Observations of distributional patterns suggest that certain deterministic forces regulate community structure. It appears that protozoans are tolerant of a wide range of environmental conditions although evidence for this is largely based on gross environmental analyses. Laboratory studies have suggested the importance of negative and positive biotic interactions in determining community membership, but little field evidence for this exists. The importance of transport processes in controlling community composition is being increasingly recognized. All three types of processes likely act to regulate the colonization and successional dynamics of these communities. A simple model is presented to promote the

关键词： determinants structure protozoan communities

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