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Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis

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World Journal of Hepatology 2017年第35期9卷 1278-1285页

作者： Suelen A S Miozzo Jorge A john Marcelo C Appel-da-Silva Isabella A Dossin Cristiane v Tovo Angelo A Mattos Graduate Program in Medicine HepatologyUniversidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre CEP 90430-080Brazil

AIM To investigate whether the use of proton pump inhibitors(PPIs) increases the incidence of spontaneous bacterial peritonitis(SBP) in patients with cirrhosis and *** An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. Patient charts were reviewed to collect information on the variables of interest as the use of PPIs. Primary outcome was defined as development of SBP during the study period. SBP was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of *** Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis C virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBP undergoing secondary prophylaxis and 22 patients with insufficient PPI data were further excluded. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP(22.5%). Among 107 non-users of PPIs, 23 developed SBP(21.5%)(HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). The median follow-up time of patients using PPI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBP revealed a significant association of SPB with the severity of liver disease according to the Child-Turcotte-Pugh(CTP) score. Multivariate analysis confirmed that CTP score was the only independent variable influencing the occurrence of SBP. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of PPI, independently of the presence of SBP(58.4% vs 62.7% respectively, P = 0.66). For patients with SBP, survival at 60 mo was 55.1%, vs 61.7% in patients without SBP(P = 0.34). CONCLUSION In conclusion, the rate of SBP was not

关键词： Cirrhosis Bacterial infection Spontaneous bacterial peritonitis Proton pump inhibitors Ascites

Socio-Economic and Scientific Impact Created by Whitefly-Transmitted,Plant-virus Disease Resistant Tomato varieties in Southern India

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Journal of Integrative Agriculture 2012年第2期11卷 337-345页

作者： john Colvin N Nagaraju Carlos Moreno-Leguizamon R M Govindappa T B Manjunatha Reddy S A Padmaja Neena Joshi Peter M Hanson Susan E Seal v Muniyappa Natural Resources Institute University of GreenwichChatham MaritimeKentME4 4TBUnited Kingdom University of Agricultural Sciences G.K.V.K.Bangalore 560065India AvRDC-The World vegetable Center

Research carried out to assess the impact of open-pollinated Tomato leaf curl virus（ToLCv）-resistant tomatoes and hybrids on the livelihoods of resource-poor farmers in Southern India is described and *** high-yielding ToLCv-resistant tomato varieties were developed initially using conventional breeding and screening techniques involving inoculation by ToLCv-viruliferous whitefly,Bemisia *** 2003 and 2004,respectively,these varieties were released officially by the Karnataka State Seed Committee and the Indian Ministry of Agriculture through notification in the Gazette of *** 2003 to 2005,eleven seed companies bought breeder seed of the ToLCv-resistant varieties and used them to begin breeding F1 hybrids from ***-economic studies carried out to assess the benefits obtained from growing the ToLCv-resistant varieties found that farmers could gain up to 10 times the profit by growing the ToLCv-resistant varieties compared to the pre-existing ToLCv-susceptible *** of ToLCv-resistant tomatoes was also associated with reduced pesticide *** income from tomato sales was prioritised by farmers to pay for children＇s education,better nutrition and *** a joint effort with the commercial seed sector in India,a promotional field day was organised in *** well as the three ToLCv-resistant varieties,62 ToLCv-resistant hybrid tomatoes were exhibited during a farmer-field day by 17 commercial seed companies and several public *** with ToLCv-resistance are now grown widely in South India and seeds of the three open-pollinated varieties have been distributed to more than 12 *** 2007,a conservative estimate of the financial-benefit to cost of the research ratio was already more than 837：1.

关键词： Bemisia tabaci begomovirus international development tomato resistance Tomato leaf curl virus

Nasopharyngeal colonization of otopathogens in South Indian children with acuteotitis media -- A case control pilot study

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Journal of Otology 2021年第4期16卷 220-224页

作者： M.Napolean v.Rosemol M.john A.M.varghese J.Periyasamy v.Balaji P.Naina Department of ENT Christian Medical CollegeVelloreTamil NaduIndia Department of Clinical Microbiology Christian Medical CollegeVelloreIndia

Background: Acute otitis media (AOM) is an inflammatory disease of the middle ear causing significantmorbidity in early childhood. A pilot study was undertaken to identify the role of various risk factorsSouth Indian children with AOM, especially the role of nasopharyngeal ***: A prospective case control pilot study was conducted in children aged below six years,presenting to a single tertiary care from 2018 to 2019. Fifty cases with AOM and 45 age and gendermatched controls were recruited. Two nasopharyngeal swabs were collected, one was processed forbacterial culture. The other swab was processed according to the CDC recommended broth enrichmentmethod to identify carriage of S. pneumoniae. Subsequent serotyping was done by Quellung method andconventional sequential multiplex ***: Otalgia was the major presentation seen in 92% of the children with AOM. None of the clinical anddemographic characteristics were found to be statistically significant between the cases and controls. Themost common otopathogen was S. pneumoniae (55%) followed by H. influenza (29%). The commonS. pneumoniae serotypes encountered were 11A and *** colonization with S. pneumoniae[OR 6.57, p < 0.003] and H. influenzae [OR14.18, p < 0.003] were significant risk factors for AOM inchildren. The risk increased with co-colonization (OR 13.89,p < 0.003).Conclusion: This study strengthens the significant association between nasopharyngeal colonization ofotopathogens and AOM as a risk factor that is enhanced by co-colonization.S. pneumoniae was the mainotopathogen in this population, serotypes 11A and 19F being the most common.

关键词： Acute otitis media Nasopharyngeal Otopathogens Case control study Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis Staphylococcus aureus

A system for underground road condition monitoring

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International Journal of Mining Science and Technology 2020年第3期30卷 405-411页

作者： Max Astrand Erik Jakobsson Martin Lindfors john Svensson KTH Royal Institute of Technology SE-10044 StockholmSweden ABB Corporate Research SE-72226 VästeråsSweden Epiroc SE-70191ÖrebroSweden Linköping University SE-58183 LinköpingSweden Boliden Mines SE-93632 BolidenSweden

Poor road conditions in underground mine tunnels can lead to decreased production efficiency and increased wear on production vehicles. A prototype system for road condition monitoring is presented in this paper to counteract this. The system consists of three components i.e. localization, road monitoring, and scheduling. The localization of vehicles is performed using a Rao-Blackwellized extended particle filter, combining vehicle mounted sensors with signal strengths of Wi Fi access points. Two methods for road monitoring are described: a Kalman filter used together with a model of the vehicle suspension system, and a relative condition measure based on the power spectral density. Lastly, a method for taking automatic action on an ill-conditioned road segment is proposed in the form of a rescheduling *** scheduling algorithm is based on the large neighborhood search and is used to integrate road service activities in the short-term production schedule while minimizing introduced production *** system is demonstrated on experimental data collected in a Swedish underground mine.

关键词： Localization Road condition monitoring Scheduling Underground mining

Anisotropic estimates for sub-elliptic operators

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Science China Mathematics 2008年第4期51卷 509-522页

作者： john BLAND Tom DUCHAMP Department of Mathematics University of Toronto Department of Mathematics Box 354350University of Washington

In the 1970’s, Folland and Stein studied a family of subelliptic scalar operators $ \mathcal{L}_\lambda $ which arise naturally in the $ \bar \partial _b $ -complex. They introduced weighted Sobolev spaces as the natural spaces for this complex, and then obtained sharp estimates for $ \bar \partial _b $ in these spaces using integral kernels and approximate inverses. In the 1990’s, Rumin introduced a differential complex for compact contact manifolds, showed that the Folland-Stein operators are central to the analysis for the corresponding Laplace operator, and derived the necessary estimates for the Laplacian from the Folland Stein analysis. In this paper, we give a self-contained derivation of sharp estimates in the anisotropic Folland-Stein spaces for the operators studied by Rumin using integration by parts and a modified approach to bootstrapping.

关键词： sub-elliptic operators anisotropic estimates anisotropic Sobolev spaces Rumin complex contact manifolds 35H20 35B45 53D10 32v20

深部俯冲板片三维构造重建及其几何学、运动学研究——以汤加—克马德克地区俯冲板片为例

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地球物理学报 2013年第11期56卷 3837-3845页

作者：鲁人齐 john Suppe 何登发 Jonny Wu Ravi v S Kanda 刘波陈于高北京大学地球与空间科学学院北京100871 台湾大学地质科学系台北10617 中国地质大学(北京)能源学院北京100083

西南太平洋板块与澳大利亚板块之间的汤加-克马德克俯冲带，是研究地球动力学最重要的区域之一．本文研究根据MIT～P08地震数据，结合板块构造边界、地震活动分布、海岸地形数据等，基于GOCAD软件平台建立三维地震层析成像，对西南太平... 详细信息

西南太平洋板块与澳大利亚板块之间的汤加-克马德克俯冲带，是研究地球动力学最重要的区域之一．本文研究根据MIT～P08地震数据，结合板块构造边界、地震活动分布、海岸地形数据等，基于GOCAD软件平台建立三维地震层析成像，对西南太平洋板块的汤加-克马德克俯冲板片进行三维解释．地震层析成像显示汤加-斐济地区地幔至少存在三个“高速”异常体．早期汤加-克马德克俯冲板片穿过地幔转换带，并进入下地幔，最大深度达1600km．三维构造模型揭示了汤加克马德克板片在深度600～800km处存在断折形变，该俯冲板片去褶皱恢复后，测量其俯冲的最大位移达2600km．汤加-克马德克板片开始快速俯冲的时间至少在30Ma之前，平均移动速率约为68～104mrn／a．俯冲板片三维构造重建和恢复，可以有效揭示俯冲板片几何学、运动学，为研究深源地震成因、地球深部变化过程和动力学机制提供约束．

关键词：地震层析成像俯冲板片三维构造模型几何学运动学汤加-克马德克地区

Role of phase separation in nanocomposite indium-tin-oxide films for transparent thermoelectric applications

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Journal of Materiomics 2021年第3期7卷 612-620页

作者： Peter P.Murmu Akhil Shettigar Shen v.Chong Zihang Liu Dana Goodacre vedran Jovic Takao Mori Kevin E.Smith john Kennedy National Isotope Centre GNS SciencePO Box 30368Lower Hutt5010New Zealand The MacDiarmid Institute for Advanced Materials and Nanotechnology New Zealand Robinson Research Institute Victoria University of WellingtonPO Box 33436Lower Hutt5046New Zealand International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukubaIbaraki305-0044Japan School of Chemical Sciences University of AucklandAuckland1142New Zealand Department of Physics Boston University BostonMA02215USA

We report that oxygen vacancies have a profound impact on phase separation and thermoelectric properties of ITO films grown at room *** vacancies in non-stoichiometric In1.8Sn0.2O2.5 films aided the formation of In-rich metallic *** yields a high electrical conductivity s=1540 Scm1 and Seebeck coefficient|a|=27.2 mvK1,which resulted in the highest power factor(a2 s=113.8 mW m1 K2)but low optical transmission(Top-25%).An increase in oxygen partial pressure resulted in stochiometric In1.8Sn0.2O3 films which improved the optical transparency by 300%(Top-75.4%),but power factor was reduced by-85%due to a decrease in a and s.A decrease in a was due to the lack of energy filtering of charge carriers in the stoichiometric ITO film which did not have In-rich metallic *** results showed that the valence band energy shifts with a change in oxygen partial pressure due to a decrease in carrier density,which implied a change in Fermi energy due to the reverse Moss-Burstein *** results showed that phase separation can be obtained in nanocomposite ITO films by tuning their stoichiometry simply by varying the oxygen partial pressure during deposition of thermoelectric materials at low temperatures.

关键词： Thermoelectric Indium-tin-oxide(ITO) Seebeck coefficient Power factor X-ray photoelectron spectroscopy(XPS)

Hydrodynamics and solids mixing in fluidized beds with inclined-hole distributors

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Particuology 2019年第2期17卷 19-28页

作者： Alhussain Bakhurji Xiaotao Bi john R. Grace Fluidization Research Centre Department of Chemical and Biological Engineering University of British Columbia Vancouver V6TJZ3 Canada

Experimental fluidization results were compared for three gas distributors with the same opening ratio but different orifice in clinations (30,45 , and 90 ). Hydrodynamic studies were con ducted with glass beads (diameter 154p.m) to evaluate the impacts of orifice inclination and static bed depth on pressure drop, pressure drop fluctuations, bed expansion, and minimum fluidization velocity. Solids residence time distributions were determined using phosphoresce nt tracer particles (mea n diameter 76 pm), activated by ultraviolet light. The bed pressure drop was higher with the inclined-hole distributors and increased with static bed height. In a shallow bed, the inclined-hole distributors gave less expansion;however, in deep beds, the orifice angle had negligible influence on bed expansion. The minimum fluidization velocity varied with static bed height for the inclined-hole distributors and was higher for steeper angles. The turnover time estimated using bubbling-bed equations matched the experimental results well for vertical mixing. Probes and ports at the walls of the fluidization column reduced the dense-phase downward velocity by up to 40%. The tangential particle velocity was highest for the 30 -hole distributor and decreased with increasing orifice angle. Tangential mixing was described by a dispersion model;the dispersion coefficient for the inclined-hole distributors was approximately twice that for the 90 -hole distributor in a shallow bed.

关键词： Swirling fluidized bed Fluidization Solids mixing Inclined-hole distributor

Evidence of Diminishing Marginal Product of Wetlands for Damage Mitigation

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Natural Resources 2015年第1期6卷 48-55页

作者： J. Luke Boutwell john v. Westra Department of Agricultural Economics Louisiana State University Baton Rouge USA

Communities along the USA coast are highly vulnerable to coastal storms. Trends in population growth, climatic events and land use are likely to exacerbate future damages. Coastal management entities are faced with decisions about how to manage resources in a manner that improves environmental quality and provides the maximum benefit for coastal populations. This is particularly true along the USA coast of the Gulf of Mexico, where coastal storms are common, land loss is rapid and states are planning ambitious and costly coastal restoration projects. Many of these projects are intended to mitigate hurricane damages by using wetlands as storm buffers. The physical science literature shows that wetlands do provide situational protection from storm surge. However, little economic analysis has explored the effect of wetlands on economic losses. This analysis uses hurricane simulation data to estimate county- or parish-level damages based on observed damages from coastal storms making landfall along the Gulf coast. A model describing these damages as a function of wetland area, socio-economic conditions and storm intensity allows the estimation of the value of wetlands for their protective ecosystem services. This analysis finds that wetlands are valuable for storm damage mitigation and that wetland area change is most impactful where wetlands are most scarce. The implications of these finding are significant for coastal restoration decisions in a changing environment.

关键词： Wetlands Hurricane Economic Damage Storm Surge Resilience