检索结果-南通市图书馆

A key role for PTP1B in dendritic cell maturation, migration, and T cell activation

Journal of Molecular Cell Biology 2015年第6期7卷 517-528页

作者： Cristina Martin-Granados Alan R.Prescott Samantha Le Sommer Izabela P.Klaska Tian Yu Elizabeth Muckersie Claudiu v.Giuraniuc Louise Grant Mirela Delibegovic john v.forrester Institute of Medical Sciences University of AberdeenCollege of Life Sciences and MedicineAberdeen AB252ZDUK Department of Pharmacology University of CambridgeCambridge CB21PDUK Division of Cell Biology and Immunology College of Life SciencesUniversity of DundeeDundee DD15EHUK Centre for Ophthalmology and visual Science The University of Western AustraliaPerthAustralia Centre for Experimental Immunology Lions Eye InstituteNedlandsWA 6009Australia

Dendritic cells(DC)are the major antigen-presenting cells bridging innate and adaptive immunity,a function they perform by converting quiescent DC to active,mature DC with the capacity to activate naı¨ve T *** do this by migrating from the tissues to the T cell area of the secondary lymphoid ***,wedemonstrate thatmyeloid cell-specific genetic deletion of PTP1B(LysM PTP1B)leads to defects in lipopolysaccharide-driven bone marrow-derivedDC(BMDC)activation associated with increased levels of phosphorylated *** showthatmyeloid cell-specific PTP1Bdeletion also causes decreased migratory capacity of epidermal DC,aswell as reduced CCR7 expression and chemotaxis to CCL19 by ***1B deficiency in BMDC also impairs their migration in ***,immature LysM PTP1B BMDC display fewer podosomes,increased levels of phosphorylated Src at tyrosine 527,and loss of Src localization to podosome *** co-culture with T cells,LysM PTP1B BMDC establish fewer and shorter contacts than control ***,LysMPTP1BBMDCfail to present antigen to T cells as efficiently as *** data provide first evidence for a key regulatory role for PTP1B in mediating a central DC function of initiating adaptive immune responses in response to innate immune cell activation.

关键词： dendritic cell maturation podosomes T cell activation adaptive immune response protein tyrosine phosphatase 1B

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dendritic cells and the extracellular matrix:A challenge for maintaining tolerance/homeostasis

引用

World Journal of Immunology 2015年第3期5卷 113-130页

作者： Sucharita P Shankar May Griffith john v forrester Lucia Kuffová Section of Immunology Inflammation and InfectionDivision of Applied MedicineSchool of Medicine and DentistryUniversity of AberdeenInstitute of Medical Sciences Integrative Regenerative Medicine Centre Department of Clinical and Experimental MedicineCell Biology Bldg.Level 10Linkoping University Department of Ophthalmology Maisonneuve-Rosemont Hospital

The importance of the extracellular matrix （ECM） in contributing to structural, mechanical, functional and tissue-specific features in the body is well appreciated. While the ECM was previously considered to be a passive bystander, it is now evident that it plays active, dynamic and fexible roles in shaping cell survival, differentiation, migration and death to varying extents depending on the specific site in the body. Dendritic cells （DCs） are recognized as potent antigen presenting cells present in many tissues and in blood, continuously scrutinizing the microenvironment for antigens and mounting local and systemic host responses against harmful agents. DCs also play pivotal roles in maintaining homeostasis to harmless self-antigens, critical for preventing autoimmunity. What is less understood are the complex interactions between DCs and the ECM in maintaining this balance between steady-state tissue residence and DC activation during inflammation. DCs are finely tuned to inflammation-induced variations in fragment length, accessible epitopes and post-translational modifications of individual ECM components and correspondingly interpret these changes appropriately by adjusting their profiles of cognate binding receptors and downstream immune activation. The successful design and composition of novel ECM-based mimetics in regenerative medicine and other applications rely on our improved understanding of DC-ECM interplay in homeostasis and the challenges involved in maintaining it.

关键词： Dendritic cells Extracellular matrix Tolerance Biomaterials Homeostasis Regenerative medicine Biointeractive implants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-risk corneal allografts: A therapeutic challenge

引用

World Journal of Transplantation 2016年第1期6卷 10-27页

作者： Tian Yu vijayalakshmi Rajendran May Griffith john v forrester Lucia Kuffová Section of Immunity Infection and Inflammation Division of Applied Medicine School of Medicine and Dentistry Institute of Medical Sciences University of Aberdeen Integrative Regenerative Medicine Centre Depart-ment of Clinical and Experimental Medicine Linkoping University Department of Ophthalmology Maisonneuve- Rosemont Hospital Ocular Immunology Program Centre for Ophthalmology and Visual Science University of Western Australia

Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in "low-risk" settings. Furthermore, although corneal graft survival in "lowrisk" recipients is favourable, the prognosis in "high-risk" recipients for corneal graft is poor. In "high-risk" grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of "high-risk" recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in "high-risk" recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem

关键词： "High-risk" grafts Graft rejection Systemic immunosuppression Cell-based immunomodulation Keratoprosthesis Collagen-based hydrogels

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

葡萄膜炎的发病机理

引用

国外医学（眼科学分册） 1992年第5期16卷 289-292页

作者： john v.forrester 刘宏伟

外源性葡萄膜炎与细菌、病毒和寄生虫的感染有关;内源性葡萄膜炎的病因却很复杂,一般认为与自身免疫反应有关。本文从葡萄膜炎的病理学、自身免疫损伤的机制及与其它自身免疫病的关系方面,探讨了它的发病机理。

关键词：葡萄膜炎病理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

初级医疗中关于非炎症性眼疼痛的评估

引用

英国医学杂志中文版 2016年第3期19卷 160-163页

作者： Lucia Kuffova john v forrester Andrew Dick 郝洁李树宁 Section of Immunity Infection and Inflammation Division of Applied Medicine University of Aberdeen Schoolof Medicine and Dentistry Aberdeen AB25 2ZD UK Ocular Immunology Program Centre for Ophthalmology and Visual ScienceUniversity of Western Australia Western Australia 6009 Australia Centrefor Experimental Immunology Lions Eye InstituteNedlands WA 6009Australia Academic Unit of Ophthalmology School of Clinical Sciences University of Bristol Bristol BS81TD NationalInstitute for Health Research (NIHR)Biomedical Research Centre at Moorfields Eye Hospital and University College London Institute of Ophthalmology London EC1V 2PDUK 首都医科大学附属北京同仁医院眼科

眼部疼痛很普遍，大约2％～5％的综合门诊患者主诉涉及眼部及眼周边疼痛的情况（眼部、眼周边、眼眶周边的疼痛在文中统称为眼部疼痛）。在新西兰眼科急诊的患者中，大于50％的患者由综合门诊转诊而来。，绝大部分主诉都包含眼部疼痛。... 详细信息

眼部疼痛很普遍，大约2％～5％的综合门诊患者主诉涉及眼部及眼周边疼痛的情况（眼部、眼周边、眼眶周边的疼痛在文中统称为眼部疼痛）。在新西兰眼科急诊的患者中，大于50％的患者由综合门诊转诊而来。，绝大部分主诉都包含眼部疼痛。笔者建议，这些人中，如果在初诊时可以得到较好的诊断，那么转诊人数将会下降。

关键词：初级医疗非炎症性眼部疼痛检查视力

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thinking in cases

Thinking in cases

引用

作者： (1949-2015 )forrester john

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Antifragility Analysis and Measurement Framework for Systems of Systems

引用

International Journal of Disaster Risk Science 2013年第4期4卷 159-168页

作者： john johnson Adrian v.Gheorghe Engineering Management and Systems Engineering Department Old Dominion University Norfolk VA 23529 USA

The twenty-first century is defined by the social and technical hazards we face.A hazardous situation is a condition,or event,that threatens the well-being of people,organizations,societies,environments,and *** most extreme of the hazards are considered X-Events and are an exogenous source of extreme stress to a system.X-Events can also be the unintended outputs of a system with both positive(serendipitous) and negative(catastrophic) *** can vary in their ability to withstand these stress *** ability exists on a continuum of fragility that ranges from fragile(degrading with stress),to robust(unchanged by stress),to antifragile(improving with stress).The state of the art does not include a method for analyzing or measuring *** that “what we measure we will improve,” the absence of a measurement approach limits the effectiveness of governance in making our systems less fragile and more robust if not *** authors present an antifragile system simulation model,and propose a framework for analyzing and measuring antifragility based on system of systems *** framework reduces a multidimensional concept of fragility into a two-dimensional continuous interval scale.

关键词： extreme unchanged consequences

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Challenges and opportunities in flexible,stretchable and morphable bio-interfaced technologies

引用

National Science Review 2022年第10期9卷 10-13页

作者： Abraham vázquez-Guardado Yiyuan Yang john A.Rogers Center for Bio-Integrated Electronics Northwestern University Querrey Simpson Institute for Bioelectronics Northwestern University Department of Mechanical Engineering Northwestern University Department of Materials Science and Engineering Northwestern University Department of Biomedical Engineering Northwestern University Department of Neurological Surgery Feinberg School of Medicine Northwestern University

Living organisms operate on the basis of dynamic biochemical processes elicited by a rich diversity of endogenous and exogenous *** higher-level forms of life,the result manifests as complex patterns of behavior and ultimately in the form of intelligence and *** classes of biocompatible electronic interfaces support expanding possibilities in bidirectional communication.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Positional goods and the challenge of Chinese regional inequality

引用

Economic and Political Studies 2018年第1期6卷 4-10页

作者： john v.C.Nye Department of Economics George Mason UniversityFairfaxVAUSA NRU-Higher Schoolof Economics MoscowRussia

Scholars have focussed on income inequality as a major source of social *** the focus on crude income inequality has masked the deeper developmental problem facing many fast-growing *** is an extreme case of this issue inasmuch as its coastal regions can be viewed as comparable to middle income states,while the greater part of its rural and west-erm areas would be comparable to the poorer nations of the *** means that the new middle class pays attention to issues such as pollution and status or positional goods than simple material *** costs of houses are in particular less than *** status goods are similar because they are not amenable to simple productivity *** will make policies more difficult as conflict increases between those areas who are still eager for basic economic development and those richer areas whose wants and needs start to more closely resemble the preferences of richer developed countries.

关键词： Positional goods regional inequality statusgoods

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

DETERMINANTS OF STRUCTURE IN AQUATIC NON-PELAGIC PROTOZOAN COMMUNITIES

引用

Chinese Journal of Oceanology and Limnology 1993年第3期11卷 215-228页

作者： john Cairns Jr Paul v.McCormick University Center for Environmental and Hazardous Materials Studies Virginia Polytechnic Institute and State University Blacksburg Virginia 24061 U.S.AUniversity Center for Environmental and Hazardous Materials Studies Virginia Polytechnic Institute and State University Blacksburg Virginia 24061 U.S.AUniversity Center for Environmental and Hazardous Materials Studies Virginia Polytechnic Institute and State University Blacksburg Virginia 24061 U.S.A

Although microbes have traditionally been used as models for testing ecological theory, research on the organization of these communities has largely been isolated from other areas of community ecology. Early studies indicated that microbial populations can form dynamic, interacting assemblages. Observations of distributional patterns suggest that certain deterministic forces regulate community structure. It appears that protozoans are tolerant of a wide range of environmental conditions although evidence for this is largely based on gross environmental analyses. Laboratory studies have suggested the importance of negative and positive biotic interactions in determining community membership, but little field evidence for this exists. The importance of transport processes in controlling community composition is being increasingly recognized. All three types of processes likely act to regulate the colonization and successional dynamics of these communities. A simple model is presented to promote the

关键词： determinants structure protozoan communities

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：