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Absence of enhancement in a lesion does not preclude primary central nervous system t-cell lymphoma:A case report

World Journal of Clinical Cases 2024年第2期12卷 374-382页

作者： Chan-Seop Kim Chi-Hoon Choi Kyung Sik Yi Yook Kim Jisun Lee chang Gok Woo Young Hun Jeon Department of Radiology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Radiology Seoul National University HosptialSeoul 03080South Korea

BACKGROUND Primary central nervous system lymphoma(PCNSL)is a non-Hodgkin lymphoma that originates in the central nervous system(CNS)and is exclusively limited to the *** most PCNSLs are diffuse large B-cell lymphomas,primary CNS t-cell lymphomas(PCNStLs)are *** typically demonstrate some degree of enhancement on contrast-enhanced magnetic resonance imaging(MRI).to the best of our knowledge,non-enhancing PCNStL has not been reported *** SUMMARY A 69-year-old male presented to the neurology department with complaints of mild cognitive impairment and gradual onset of left lower leg weakness over a span of two *** MRI showed asymmetric t2-hyperintense lesions within the *** enhancement was observed on the contrast-enhanced t1 *** initial diagnosis was neuro-Behçet’s *** high-dose steroid therapy,no alterations in the lesions were identified on initial *** patient’s symptoms deteriorated *** MRI performed one month after the initial scan revealed an increased lesion ***,brain biopsy confirmed the diagnosis of *** patient underwent definitive combined ***,the patient developed bacteremia and died of septic shock approximately three months after *** the absence of enhancement in the lesion did not rule out PCNStL.A biopsy approach is advisable for pathological confirmation.

关键词： Central nervous system neoplasms Non-Hodgkin Lymphoma t-cell Lymphoma Primary central nervous system lymphoma Primary central nervous system t-cell lymphoma Case report

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Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome

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World Journal of Diabetes 2024年第1期15卷 34-42页

作者： Jie Chen Wan-Chao Zhang Xiao-Qiang tang Ruo-Han Yin tao Wang Xiao-Yu Wei chang-Jie Pan Radiology Department The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Radiology Department The People’s Hospital of WuQia CountyWuqia 845450Xinjiang Uygur Autonomous RegionChina

BACKGROUND Cardiovascular disease is a major complication of diabetes mellitus(DM).type-2 DM(t2DM)is associated with an increased risk of cardiovascular events and mortality,while serum biomarkers may facilitate the prediction of these *** differential diagnosis of t2DM complicated with acute coronary syndrome(ACS)plays an important role in controlling disease progression and improving *** to investigate the correlation of serum bilirubin andγ-glutamyltranspeptidase(γ-GGt)with major adverse cardiovascular events(MACEs)in t2DM patients with *** the clinical data of inpatients from January 2022 to December 2022 were analyzed *** to different conditions,they were divided into the t2DM complicated with ACS group(t2DM+ACS,n=96),simple t2DM group(t2DM,n=85),and simple ACS group(ACS,n=90).the clinical data and laboratory indices were compared among the three groups,and the correlations of serum total bilirubin(tBIL)levels and serumγ-GGt levels with other indices were discussed.t2DM+ACS patients received a 90-day follow-up after discharge and were divided into event(n=15)and nonevent(n=81)groups according to the occurrence of MACEs;Univariate and multivariate analyses were further used to screen the independent influencing factors of MACEs in *** the t2DM+ACS group showed higherγ-GGt,total cholesterol,low-density lipoprotein cholesterol(LDL-C)and glycosylated hemoglobin(HbA1c)and lower tBIL and high-density lipoprotein cholesterol levels than the t2DM and ACS groups(Pte analysis,the event and nonevent groups were significantly different in age(t=3.3612,P=0.0011),tBIL level(t=3.0742,P=0.0028),γ-GGt level(t=2.6887,P=0.0085),LDL-C level(t=2.0816,P=0.0401),HbA1c level(t=2.7862,P=0.0065)and left ventricular ejection fraction(LEVF)levels(t=3.2047,P=0.0018).Multivariate logistic regression analysis further identified that tBIL level and LEVF level were protective factor for MACEs,and age andγ-GGt

关键词： Acute coronary syndrome type-2 diabetes mellitus total bilirubin Major adverse cardiovascular events

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Mangrove wetlands distribution status identification, changing trend analyzation and carbon storage assessment of China

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China Geology 2024年第1期7卷 1-11页

作者： chang Li Fu Wang Peng Yang Fei-cui Wang Yun-zhuang Hu Yan-lin Zhao Li-zhu tian Rui-bin Zhao tianjin Center(North China Center of Geoscience Innovation) China Geological Survey(CGS)Tianjin 300170China tangshan Hydrological Survey and Research Center of Heibei Province Tangshan063000China Key Laboratory of Coast Geo-Environment China Geological SurveyCGSTianjin 300170China tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China

this research investigates the ecological importance,changes,and status of mangrove wetlands along China’s *** interpretation,geological surveys,and ISO clustering unsupervised classification methods are employed to interpret mangrove distribution from remote sensing images from 2021,utilizing ArcGIS software ***,the carbon storage capacity of mangrove wetlands is quantified using the carbon storage module of InVESt *** show that the mangrove wetlands in China covered an area of 278.85 km2 in 2021,predominantly distributed in Hainan,Guangxi,Guangdong,Fujian,Zhejiang,taiwan,Hong Kong,and *** total carbon storage is assessed at 2.11×10^(6) t,with specific regional data *** since the 1950s reveal periods of increase,decrease,sharp decrease,and slight-steady increases in mangrove areas in *** important finding is the predominant replacement of natural coastlines adjacent to mangrove wetlands by artificial ones,highlighting the need for creating suitable spaces for mangrove *** study is poised to guide future mangroverelated investigations and conservation strategies.

关键词： Mangrove Wetland Carbon storage Ecological conservation ArcGIS software platform Restoration InVESt model Quantitative analysis Coastal zone of China

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Effects of Heterologously Overexpressing PIP5K-Family Genes in Arabidopsis on Inflorescence Development

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Phyton-International Journal of Experimental Botany 2024年第1期93卷 97-117页

作者： Mingda Yin Rui Luo tana Liang Qi Wen Xiaotian Liang Yanpeng Wen Xuemei Hu Zhiyan Wang chang Gao Wenjing Ren Fenglan Huang College of Life Science and Food Engineering Inner Mongolia Minzu UniversityTongliao028000China Key Laboratory of Castor Breeding of the State Ethnic Affairs Commission Inner Mongolia Minzu UniversityTongliao028000China Inner Mongolia Industrial Engineering Research Center of Universities for Castor Inner Mongolia Minzu UniversityTongliao028043China Inner Mongolia Key Laboratory of Castor Breeding and Comprehensive Utilization Inner Mongolia Minzu UniversityTongliao028000China Inner Mongolia Engineering Research Center of Industrial technology Innovation of Castor Inner Mongolia Minzu UniversityTongliao028000China

Castor is one of the top 10 oil crops in the world and has extremely valuable *** inflorescences directly affect yield,so the study of inflorescence development is very important in increasing castor *** previous studies have shown that the PIP5K gene family(PIP5Ks)is associated with inflorescence *** this study,to determine the function of each PIP5K gene in castor,a female Lm-type castor line,aLmAB2,was used to determine the relative expression levels of the PIP5Ks in castor *** PIP5K genes were heterologously overexpressed in Arabidopsis thaliana,the relative expression of each gene and the effect on plants was determined in ***,and the relationships among the PIP5Ks in castor were *** expression levels of the PIP5Ks in the female Lm-type castor line aLmAB2 were *** relative expression levels of the PIP5K9 and PIP5K11 genes were high(pthose of PIP5K1,PIP5K2,PIP5K6,and PIP5K8 were high(pt low(pterologously overexpressed in ***,and t3-generation plants with stable genetic resistance,i.e.,At-PIP5K^(+)plants(At-PIP5K1^(+),At-PIP5K2^(+),At-PIP5K6^(+),At-PIP5K8^(+),At-PIP5K9^(+),and AtPIP5K11^(+) plants),were *** tests of the At-PIP5K+plants showed that the growth of the main stem was significantly delayed in At-PIP5K+plants compared with Columbia wild-type(Wt)*** plants;the PIP5K1 and PIP5K2 genes promoted lateral stem growth and flower and silique development;and the PIP5K6,PIP5K8,PIP5K9 and PIP5K11 genes inhibited lateral stem growth and flower and silique *** correlations among PIP5Ks in castor suggest that there may be a synergistic relationship among PIP5K1,PIP5K2,and PIP5K6 in castor inflorescences,and PIP5K8,PIP5K9,and PIP5K11 are complementary to the other three genes.

关键词： Castor inflorescence development PIP5K gene family gene overexpression

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SMARt GLASSES

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空中英语教室（初级版．大家说英语） 2024年第11期 25-26,53页

作者： john telfer 不详

What if you could work on your computer without using your hands?Smart glasses make that possible!their lenses have a screen that can show information,such as texts and *** glasses can also be used as a *** can not only chat with friends,but you can also send *** talk,and the glasses write the message for *** can also use them to listen to music!Most smart glasses look like normal *** aren't huge and heavy.

关键词： glasses Smart email

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Molecular phylogenetic relationships based on mitochondrial genomes of novel deep-sea corals(Octocorallia:Alcyonacea):Insights into slow evolution and adaptation to extreme deep-sea environments

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Zoological Research 2024年第1期45卷 215-225页

作者： Zhan-Fei Wei Kai-Wen ta Nan-Nan Zhang Shan-Shan Liu Liang Meng Kai-Qiang Liu Chong-Yang Cai Xiao-tong Peng chang-Wei Shao National Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China BGI-Qingdao BGI-ShenzhenQingdaoShandong 266555China Institute of Deep-Sea Science and Engineering Chinese Academy of SciencesSanyaHainan 572000China

A total of 10 specimens of Alcyonacea corals were collected at depths ranging from 905 m to 1633 m by the manned submersible Shenhai Yongshi during two cruises in the South China Sea(SCS).Based on mitochondrial genomic characteristics,morphological examination,and sclerite scanning electron microscopy,the samples were categorized into four suborders(Calcaxonia,Holaxonia,Scleraxonia,and Stolonifera),and identified as 9 possible new cold-water coral *** of GC-skew dissimilarity,phylogenetic distance,and average nucleotide identity(ANI)revealed a slow evolutionary rate for the octocoral mitochondrial *** nonsynonymous(Ka)to synonymous(Ks)substitution ratio(Ka/Ks)suggested that the 14 protein-coding genes(PCGs)were under purifying selection,likely due to specific deep-sea environmental *** analysis of the median Ka/Ks values of five gene families and environmental factors indicated that the genes encoding cytochrome b(cyt b)and DNA mismatch repair protein(mutS)may be influenced by environmental factors in the context of deep-sea species *** study highlights the slow evolutionary pace and adaptive mechanisms of deep-sea corals.

关键词： Mitochondrial genome Alcyonacea Ka/Ks evolution Environmental factors

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Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic t cells

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Marine Life Science & technology 2024年第3期6卷 502-514页

作者： Jian-Yu Liu Yao-Yao Jiang Peng-Jie Li Bo Yao Yi-Jing Song Ji-Xiu Gao Gulab Said Yang Gao Jun-Yu Lai chang-Lun Shao Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Chemistry Women University SwabiSwabi 23430Pakistan Laoshan Laboratory Qingdao 266237China Key Laboratory of tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

As one of the common malignancies that threaten human life,bladder cancer occurs frequently with a high mortality rate in the world,due to its invasion,recurrence and drug *** products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities,especially in the area of *** A(BFA)is a natural Arf-GEFs inhibitor,but due to the low aqueous solubility,strong toxicity,and poor bioavailability,it is urgent to conduct structural optimization ***,a new BFA pyridine acrylate derivative CHNQD-01281 with improved solubility was prepared and found to exert moderate to strong antiproliferative activity on a variety of human cancer cell *** was noteworthy that CHNQD-01281 was most sensitive to two bladder cancer cell lines t24 and J82(IC50=0.079 and 0.081μmol/L)with high selectivity index(SI=14.68 and 14.32),suggesting a superior safety to *** vivo studies revealed that CHNQD-01281 remarkably suppressed tumor growth in a t24 nude mice xenograft model(tGI=52.63%)and prolonged the survival time(ILS=68.16%)in an MB49 allogeneic mouse model via inducing infiltration of cytotoxic t *** mechanism exploration indicated that CHNQD-01281 regulated both EGFR/PI3K/AKt and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector ***,CHNQD-01281 may serve as a potential therapeutic agent for bladder cancer through multiple mechanisms.

关键词： Bladder cancer Marine natural products Brefeldin A EGFR/PI3K/AKt EGFR/ERK t-cell infiltration

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Association of miR-499 rs3746444, miR-149 rs2292832 polymorphisms and their expression levels with helicobacter pylori-related gastric diseases and traditional Chinese Medicine syndromes

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Journal of traditional Chinese Medicine 2024年第5期44卷 1024-1034页

作者： LIU Qi YU chang YE Jintong ZHANG Ling LI Danyan DAI Yunkai ZHANG Yunzhan LUO Qi CHEN Weijing PAN Huaigeng LI Ruliu HU Ling Institute of Gastroenterology Science and Technology Innovation CenterGuangzhou University of Chinese Medicine First Affiliated Hospital of Guangzhou University of Chinese Medicine

OBJECtIVE: to provide an objective experimental basis for the gastric mucosa pathological evolution and the transformation of different traditional Chinese Medicine(tCM) syndromes in helicobacter pylori(H. pylori)-related gastric diseases(HPGD) patients, based on the combination of tCM syndrome differentiation, molecular biology and ***: A total of 203 participants were enrolled in this study. the expressions of miR-499/miR-149 and *** infection in the gastric tissues from all participants were detected. the genotyping for miR-499 rs3746444 and miR-149 rs2292832 was ***: In H. pylori positive subjects, the proportion of precancerous gastric lesions(PGL) in liver-stomach disharmony syndrome(LSDS) group was higher than in spleen Qi deficiency syndrome(SQDS) group(P the proportion of gastric cancer(GC) in SQDS group was higher than in spleen-stomach damp-heat syndrome(SSDHS) group and LSDS group(all P to lower risk of gastric atrophy [miR-149 rs2292832 C vs t:adjusted odds ratio = 0.207; 95% confidence interval(0.043-0.989); P = 0.048]. Compared with healthy control(HC) group, the expression of miR-499 was significantly increased in GC group, while the expression of miR-149was significantly decreased in chronic inflammation group,PGL group and GC group(all P test for trend showed that GC risk was on a rising trend with the increasing expression of miR-499 and decreasing expression of miR-149(both P for trend the C allele of miR-149 rs2292832 may be a protective factor for gastric mucosal atrophy. *** may participate in the evolution of benign to malignant gastric mucosa lesions by inducing the overexpression of miR-499 and down regulation of miR-149. In addition, patients with H. pylori infection combined SQDS or LSDS may have higher risk of gastric mucosal malignant lesions.

关键词： helicobacter pylori microRNAs polymorphism, genetic stomach diseases syndrome complex

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黄土高原全新世土壤碳酸盐团簇同位素的温度重建

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第四纪研究 2024年第5期44卷 1411-1420页

作者：董吉宝 john EILER 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室陕西西安710061 California Institute of technology PasadenaCA 91125USA

黄土高原黄土-古土壤序列中保存有丰富的土壤碳酸盐,是利用碳酸盐团簇同位素(Δ_(47))定量重建古温度的重要地质载体之一。然而,黄土高原全新世土壤碳酸盐Δ_(47)及其气候指示意义的系统研究仍然缺乏。本研究分析了黄土高原南缘渭南剖... 详细信息

黄土高原黄土-古土壤序列中保存有丰富的土壤碳酸盐,是利用碳酸盐团簇同位素(Δ_(47))定量重建古温度的重要地质载体之一。然而,黄土高原全新世土壤碳酸盐Δ_(47)及其气候指示意义的系统研究仍然缺乏。本研究分析了黄土高原南缘渭南剖面和中部洛川剖面上部3 m沉积中保存的全新世土壤碳酸盐(钙结核)的团簇同位素组成,监测了现在地形条件下距地表4 m以内不同深度的土壤温度。结果显示,Δ_(47)定量重建的全新世土壤碳酸盐团簇同位素温度(t_(47))与现代暖季节温度相近,渭南剖面t_(47)平均值约为25℃,洛川剖面约为18℃,较区域年均温高8~10℃。根据t_(47)和土壤碳酸盐氧同位素组成(δ18O)重建的土壤水δ18O也与暖季节降水的δ18O基本一致,这些数据表明黄土高原土壤碳酸盐记录了暖季节的环境信息。值得注意的是,渭南和洛川剖面钙结核t_(47)值与其形成深度的土壤温度基本吻合,结合前人研究结果,这暗示了土壤碳酸盐形成深度对其t_(47)具有显著影响。因此,在将来土壤碳酸盐Δ_(47)的研究中,评估土壤碳酸盐形成深度至关重要。

关键词：土壤碳酸盐团簇同位素(Δ_(47)) 全新世黄土高原季节性

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从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用

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Engineering 2024年第1期32卷 41-56页

作者： Ram Prasad Aganja Amal Senevirathne Chandran Sivasankar john Hwa Lee Department of Veterinary Public Health College of Veterinary MedicineJeonbuk National UniversityIksan 54596Republic of Korea Department of Preventive Medicine College of Veterinary MedicineChungnam National UniversityDaejeon 34134Republic of Korea

A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza *** this study,a strategy called computationally optimized broadly reactive antigen(COBRA)was used to generate a consensus sequence of the hemagglutinin globular head portion(HA1)of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed *** carrying different HA1regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RNA-dependent RNApolymerase(RdRp)-based eukaryotic expression system,*** protein expression was confirmed by Western blot and immunofluorescence *** immunized with the designed constructs produced a humoral response,with a significant increase in immunoglobulin G(IgG)levels,and a cell-mediated immune response,including a 1.5-fold increase in CD4^(+) and CD8^(+)t ***,constructs #1 and #5 increased the production of interferon-γ(IFN-γ)producing CD4^(+)and CD8^(+)t cells,skewing the response toward the t helper type 1 cell(th1)***,interleukin-4(IL-4)-producing t cells were upregulated *** efficacy was demonstrated,with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer>40 against the selected viral *** designed constructs conferred a broadly protective immune response,resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34,A/Brisbane/59/2007,A/California/07/2009,KBPV VR-92,and NCCP 43021 *** discovery revolutionizes influenza vaccine design and delivery;Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation *** approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.

关键词： COBRA Influenza A Salmonella Vaccine Broad spectral protection

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