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GALT基因Duarte变异体(N314D)对体外受精结果无效

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 26-26页

作者： Yoshida s. steele J. Koninckx J. s.Kennedy 马超 Nuffield Department of Obstetrics and Gynaecology University of Oxford John Radcliffe Hospital Oxford OX3 9DU United Kingdom

We assessed the effect of the Duarte (N314D) variant in the GALT gene on in vitro fertilization outcome measures. Our data do not definitely exclude variants in the GALT gene as factors influencing outcome, but the la... 详细信息

关键词：基因变异体 GALT 体外受精结果无效研究资料

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUs registry

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World Journal of Critical Care Medicine 2022年第2期11卷 102-111页

作者： Aysun Tekin shahraz Qamar Romil singh Vikas Bansal Mayank sharma Allison M LeMahieu Andrew C Hanson Phillip J schulte Marija Bogojevic Neha Deo simon Zec Diana J Valencia Morales Katherine A Belden smith F Heavner Margit Kaufman sreekanth Cheruku Valerie C Danesh Valerie M Banner-Goodspeed Catherine A st Hill Amy B Christie syed A Khan Lynn Retford Karen Boman Vishakha KKumar john C O'Horo Juan Pablo Domecq Allan J Walkey Ognjen Gajic Rahul Kashyap salim surani Thesociety of Critical Care Medicine(sCCM)Discovery Viral Infection and Respiratory Illness Universal study(VIRUs):COVID-Registry Investigator Group Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research Education Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmonary and Critical Care Medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinical Trials and Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix school of Medicine Mayo ClinicRochesterMN 55905United States Division of Infectious Diseases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma Health GreenvilleSC 29605United States Englewood Health EnglewoodNJ 07631United States Divisions of Cardiothoracic Anesthesiology and Critical Care Medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States Center for Applied Health Research Baylor Scott and White HealthDallasTX 75246United States Department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina Health MinneapolisMN 55407United States Department of Critical Care Atrium Health NavicentMaconGA 31201United States Division of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States society of Critical Care Medicine Mount ProspectIL 60056United States Division of Infectious Diseases Mayo ClinicRochesterMN 55905United States Division of Nephrology and Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmonary Center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Department of Pulmonary and Critical Care Medicine Texas A&M UniversityBryanTX 77807United States 不详

BACKGROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental *** studies previously suggested a link between climatological factors and COVID-19 fatality ***,individual-level impact of these factors has not been thoroughly evaluated *** To study the association of climatological factors related to patient location with unfavorable outcomes in *** In this observational analysis of the society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital *** for baseline parameters and admission date,multivariable regression modeling was *** estimating equations were used to fit the *** Twenty-two thousand one hundred eight patients from over 20 countries were *** median age was 62(interquartile range:49-74)years,and 54%of the included patients were *** median age increased with increasing latitude as well as the frequency of ***,the percentage of comorbidities was lower in elevated *** within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 *** the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality wi

关键词： 28 d mortality Altitude COVID-19 Hospital-free days Latitude Outcomes

犯罪性的客观观念和主观观念:社会科学在刑法理论中的作用研究

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刑法论丛 2012年第1期1卷 346-399页

作者：保罗·H.罗宾逊约翰·M.达雷王志远(译) 柳冠名(译) stefanie Wen-Ting shih(校) Jie Chai(校) 宾夕法尼亚大学法学院普林斯顿大学吉林大学法学院香港中文大学

作者运用社会科学的方法来检验犯罪性(Criminality)认知问题上的原则性信条转变(doctrinal shift)——从普通法上的客观观念(Objectivist view)转变为现代刑法典中的主观观念(subjectivistview)——是否与正义原则的外行人直观相一致。... 详细信息

作者运用社会科学的方法来检验犯罪性(Criminality)认知问题上的原则性信条转变(doctrinal shift)——从普通法上的客观观念(Objectivist view)转变为现代刑法典中的主观观念(subjectivistview)——是否与正义原则的外行人直观相一致。评论者们已经表明,犯罪性的外行人直观已经以反映在立法模式转变中的方式发生了改变,但是本文的研究结果则得出了一个更加细致的结论:在界定犯罪行为的最低要求时,现代外行直观与现代刑法典相一致,但是在应得惩罚的等级问题上,外行直观则倾向于普通法的客观观念。作者认为,使刑法符合刑事责任和刑罚分配问题上的大众共有直观具有实践价值。正因为如此,研究结论支持设定刑事责任的最低要求时受到经常批评的主观观念,但是反对现代刑法典在确定犯罪等级时改变普通法上的客观观念。

关键词：犯罪性原则性信条转变客观观念主观观念

急性缺血性卒中影像学检查推荐美国心脏协会科学声明

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国际脑血管病杂志 2010年第3期18卷 161-192页

作者： Richard E. Latchaw Mark J. Alberts Michael H. Lev john J. Connors Robert E. Harbaugh Randall T. Higashida Rober Hobson Chelsea s. Kidwell Walter J. Koroshetz Vincent Mathews Pablo Villablanca steven Warach Beverly Walters 林日增(译) 不详济南军区青岛第一疗养院青岛266071

卒中是一种常见的严重疾病，仅在美国每年就有约795000人发病。在全世界范围内，卒中是死亡和残疾的首位病因。

关键词：急性缺血性卒中美国心脏协会影像学检查科学世界范围

初生期异氟烷暴露对小鼠脑细胞发育、成年期行为、学习和记忆的影响

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麻醉与镇痛 2011年第2期7卷 55-69,77页

作者： Andreas W. Loepke, MD, PhD, FAAP George K. Istaphanous, MD john J. McAuliffe, Ⅲ, MD, MBA, FAAP Lili Miles, MD Elizabeth A. Hughes, Bs lohn C. McCann, Bs Kathrvn E. Harlow, Bs C. Dean Kurth, MD, FAAP Michael T. Williams, PhD Charles V. Vorhees, PhD steve C. Danzer, PhD 黎平(译) 闵苏(校) Departments of Anesthesia University of Cincinnati College of Medidne Cindnnati Ohio Pathology Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medidne Cindnnati Ohio Department of Anesthesia Cincinnati Children's Hospital Medical Center Cindnnati Ohio Department of Pediatrics Division of Neurology Cindnnati Children's Research Foundation and University of Cindnnati College of Medidne Cindnnati Ohio 不详

背景异氟烷等吸入麻醉药广泛地应用于婴幼儿。异氟烷、咪达唑仑以及氧化亚氮暴露后，新生小鼠神经变性和神经认知功能损害的一些研究，已经引起越来越多人对儿科麻醉安全问题的关注。新生小鼠异氟烷暴露较长时间会触发可致神经认知功能... 详细信息

背景异氟烷等吸入麻醉药广泛地应用于婴幼儿。异氟烷、咪达唑仑以及氧化亚氮暴露后，新生小鼠神经变性和神经认知功能损害的一些研究，已经引起越来越多人对儿科麻醉安全问题的关注。新生小鼠异氟烷暴露较长时间会触发可致神经认知功能损害的低血糖症。本研究即检测初生期异氟烷暴露和血糖对小鼠的脑细胞存活力、自主活动能力以及空间学习记忆能力的影响。方法出生7天的小鼠随机分配到1．5％异氟烷暴露6小时麻醉组、麻醉并注射葡萄糖组、麻醉并注射生理盐水组和空气暴露不麻醉组。检测动脉血气和血糖。暴露处理后2小时及18小时、11周，脑片染色检测Fluoro-JadeB、caspase3以及NeuN，评价脑细胞存活力。吸入麻醉剂暴露9周后，评价自主活动能力，Morris水迷宫法隐藏平台试验和颠倒平台试验评价空间学习记忆能力。结果与不麻醉组相比，其余组动物几个脑区的细胞凋亡在异氟烷暴露后早期增加。在两个受初生期变性影响显著的脑区，尽管发现新生小鼠暴露后细胞消失，但神经元密度在成年后没有明显差异。各组小鼠成年期的自主活动能力、空间学习记忆能力相似，与初生期异氟烷暴露无关。初生期异氟烷暴露导致18％的死亡率、短暂的PaCO2及乳酸升高、碱缺失以及血糖水平降低。但低血糖似乎不会引起神经退行性变，因为补充葡萄糖未能阻止神经元丢失。结论小鼠较长时间的初生期异氟烷暴露引起早期神经细胞变性增加，但成年期神经元密度并无显著减少，自主活动能力和空间学习记忆能力无明显损害。

关键词：空间学习记忆能力异氟烷细胞发育成年期初生鼠脑 Morris水迷宫法认知功能损害

Nature:研究利用单细胞分析阐明癌症干细胞在脑癌中的关键角色

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现代生物医学进展 2017年第6期17卷 I0003-I0003页

作者： Itay Tirosh, Andrew s. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Jonathan M. Fisher, Christopher Rodman, Mariella G. Filbin, Cyril Neftel, Jackson Nyman, Benjamin Izar, Joshua M. Francis, Kenneth J. Livak, Dave Gennert, Rahul satija, Todd R. Golub, Miguel N. Rivera, Gad Getz, Orit Rozenblatt-Rosen, Bradley E. Bernstein, Aviv Regev Mario L. suv agrave Andrew s. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Mariella G. Filbin, Cyril Neftel, Niyati Desai, Christina C. Luo, Aanand A. Patel, Maristela L. Onozato, Nicolo Riggi, Ravindra Mylvaganam, A. john Iafrate, Matthew P. Frosch, Miguel N. Rivera, Gad Getz, Bradley E. Bernstein, David N. Louis Mario L. suv agrave Andrew s. Venteicher, Anoop P. Patel, Brian V. Nahed, William T. Curry, Robert L. Martuza Daniel P. Cahill Christopher Mount Michelle Monje Mariella G. Filbin Todd R. Golub Joshua M. Francis Todd R. Golub Aviv Regev Broad Institute of Harvard and MIT Cambridge Massachusetts 02142 USA Department of Pathology and Center for Cancer Research Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Department of Neurosurgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Departments of Neurology Neurosurgery Pediatrics and Pathology Stanford University School of Medicine Stanford California 94305 USA Department of Pediatric Oncology Dana-Farber Cancer Institute and Children’s Hospital Cancer Center Boston Massachusetts 02215 USA Department of Medical Oncology Dana-Farber Cancer Institute Boston Massachusetts 02215 USA Howard Hughes Medical Institute Koch Institute Department of Biology MIT Cambridge Massachusetts 02139 USA

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研... 详细信息

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研究刊登于Nature杂志上。同时研究者还首次在人类脑瘤样本中鉴别出了癌症干细胞及其分化的后代细胞。

关键词：干细胞单细胞分析癌症脑瘤神经胶质瘤键角利用研究人员

Rapp-Hodgkin综合征与p63突变

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 46-46页

作者： McGrath J.A. Kivirikko s. 王琼 Genetic skin Disease Group St. John' s Institute of Dermatology St. Thomas' Hospital London United Kingdom

We report the clinical and molecular abnormalities in a 19year-old woman with Rapp-Hodgkin ectodermal dysplasia syndrome. The physical features include mid-facial hypoplasia, uncombable hair, cleft palate and bifid uvula, lacrimal duct obstruction and dry skin. sequencing of the p63 gene reveals a new heterozygous frameshift mutation, 1787delG, in exon 14. The frameshift results in changes to the tail of p63 with the addition of 68 missense amino acids downstream and a delayed termination codon that extends the protein length by 21 amino acids. These changes are predicted to disrupt the normal repressive function of the transactivation inhibitory domain leading to gain-of-function for at least two isoforms of the p63 transcription factor. The expanding p63 mutation database demonstrates that there is overlap between Rapp-Hodgkin syndrome and several other ectodermal dysplasia syndromes, notably Hay-Wells syndrome, and that characterization of the functional consequences of these p63 gene mutations at a molecular and cellular level is likely to provide further insight into the clinical spectrum of these developmental malformation syndromes.

关键词： Hodgkin p63 干性皮肤泪管闭塞悬雍垂裂移码突变面中部分子学抑制功能发育不全

大鼠蛛网膜下腔出血后sCH79797对血脑屏障的保护作用

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中国民康医学 2015年第14期 121-121页

作者：闫军浩 Manaenko Anatol Chen sheng Klebe Damon Ma Qingyi Caner Basak Fujii Mutsumi 周长满 Zhang john H 北京大学医学部解剖学系 Department of Physiology and Pharmacology Loma Linda University Medical Center

目的:蛛网膜下腔出血(subarachnoid hemorrhage,sAH)后,血浆凝血酶含量明显增加。但是,凝血酶受体(protease-activated receptor-1,PAR-1)对血脑屏障(blood-brain barrier,BBB)的影响还不清楚。本文欲探讨PAR-1抑制剂sCH79797是否对大鼠sAH后BBB具有保护作用。方法:应用sD大鼠建立sAH模型,sCH79797腹腔注射。sAH后24h,对大鼠脑水含量、神经功能等进行评估。应用Western blot和免疫印迹等方法探讨sCH79797的作用机制。结果:经sCH79797治疗的sAH大鼠脑水含量明显下降,神经功能有所恢复。PAR-1水平下降,VE-Caderin表达增加。在sAH后,PAR-1下游蛋白c-src和PAK-1使VE-Caderin磷酸化增加,与β-arrestin-2结合增多而被内噬,而sCH79797可以减轻上述病理过程。结论:在sAH后,sCH79797可以通过抑制PAR-1活性对BBB发挥保护作用。

关键词：蛛网膜下腔出血 sAH sCH79797 血脑屏障大鼠保护作用

正常体重、超重及肥胖孕妇伴和不伴先兆子痫时瘦素、脂联素及抑素水平的比较

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 13-13页

作者： Hendler I. Blackwell s. C. Mehta s. H. 陈霞(译) 高雪莲(校) Dr. I. Hendler Division of Maternal-Fetal-Medicine Department of Obstetrics and Gynecology Hutzel Hospital-Wayne State University 3990 John R Road Detroit MI 48201 United States 不详

The purpose of this study was to compare adipokines’ levels between women with and without preeclampsia based on maternal body mass index (BMI). study design: This was a cross-sectional study among third-trimester pregnancies with preeclampsia (PIH) compared with normotensive controls. serum levels of adiponectin, leptin, and resistin were measured before delivery by radioimmunoassay or enzyme-linked immunosorbent assay (ELIsA). Results: The study included 22 normotensive and 77 PIH women. Leptin levels increased with maternal BMI. In patients with severe preeclampsia, overweight, and obese women had increased leptin levels (33.4 ± 14.8 vs 23.0 ± 10.8 ng/mL respectively, P = .02), and decreased adiponectin levels (8.4 ± 5.3 vs 12.6 ± 6.0 ng/mL, P = .03) compared with normal weight women. In women with BMI s increased in patients with preeclampsia compared with controls (11.5 ± 5.6 vs 9.6 ± 4.6 and 7.0 ± 3.2 ng/mL, respectively, P = .005). There was no association between resistin levels and preeclampsia or maternal BMI. Conclusion: Women with severe preeclampsia and BMI ≥ 25 kg/m2 have decreased adiponectin and increased leptin levels, while normal weight women with preeclampsia have increased adiponectin levels.

关键词：血清瘦素水平血清脂联素肥胖孕妇先兆于痫正常体重超重抑素 ELIsA测定血压正常先兆子痫