检索结果-南通市图书馆

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

引用

Cancer Innovation 2024年第3期3卷 81-94页

作者： sahil seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben susan Varghese Carmen Behrens Tina McDowell Luisa solis soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le Natalie I Vokes Chao Cheng john V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate school of Biomedical sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PsC)is a rare and aggressive subtype of non-small cell lung cancer(NsCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PsC has not been well ***:Multiomics profiling of 21 pairs of PsCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PsC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAs mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PsC *** identified two distinct molecular subtypes of PsC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PsC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PsCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genetic parameters of drinking and feeding traits of wean-to-finish pigs under a polymicrobial natural disease challenge

引用

Journal of Animal science and Biotechnology 2022年第1期13卷 17-35页

作者： Jian Cheng Austin M.Putz john C.s.Harding Michael K.Dyck Frederic Fortin Graham s.Plastow Pig Gen Canada Jack C.M.Dekkers Department of Animal science Iowa State UniversityAmesIA 50011USA Hendrix Genetics Swine Business UnitBoxmeerThe Netherlands 5831CK Department of Large Animal Clinical science University of SaskatchewanSaskatoonSK S7N 5A2Canada Department of Agriculture Food and Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2R3Canada Centre de Developpement du Porc du Quebec Inc. Quebec City G1V 4M6Canada PigGen Canada Research Consortium GuelphOntario N1H4G8Canada

Background:The pork industry faces unprecedented challenges from disease,which increases cost of production and use of antibiotics,and reduces production efficiency,carcass quality,and animal *** solution is to improve the overall resilience of pigs to a broad array of common diseases through genetic *** changes in feeding and drinking are usually the very first clinical signs when animals are exposed to stressors such as *** in feeding and drinking behaviors in diseased pigs may reflect the way they cope with the challenge and,thus,could be used as indicator traits to select for disease *** objectives of this study were to estimate genetic parameters of feeding and drinking traits for wean-to-finish pigs in a natural polymicrobial disease challenge model,to estimate genetic correlations of feeding and drinking traits with growth rate and clinical disease traits,and to develop indicator traits to select for disease ***:In general,drinking traits had moderate to high estimates of heritability,especially average daily water dispensed,duration,and number of visits(0.44 to 0.58).similar estimates were observed for corresponding feeding traits(0.35 to 0.51).Most genetic correlation estimates among drinking traits were moderate to high(0.30 to 0.92)and higher than among feeding traits(0 to 0.11).Compared to other drinking traits,water intake duration and number of visits had relatively stronger negative genetic correlation estimates with treatment rate and mortality,especially across the challenge nursery and finisher(−0.39 and−0.45 for treatment rate;−0.20 and−0.19 for mortality).Conclusion:Most of the recorded drinking and feeding traits under a severe disease challenge had moderate to high estimates of heritability,especially for feed or water intake duration and number of *** and genetic correlations among the recorded feeding traits under disease were generally low but drinking traits show

关键词： Disease resilience Feeding and drinking behavior Genetic parameters Pigs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

sharing the salt bowl: counterion identity drives N-alkyl resorcinarene affinity for pyrophosphate in water

引用

Organic Chemistry Frontiers 2022年第5期9卷 1267-1275页

作者： Kwaku Twum seyed Iraj sadraei Jordan Feder s.Maryamdokht Taimoory Kari Rissanen john F.Trant Ngong Kodiah Beyeh Department of Chemistry Oakland University146 Library DriveRochesterMI 48309-4479USA Department of Chemistry and Biochemistry University of Windsor401 Sunset AvenueWindsorONN9B 3P4Canada University of Michigan Department of ChemistryAnn ArborMIUSA University of Jyvaskyla Department of ChemistryP.O.Box 3540014 JyvaskylaFinland

N-Alkyl ammonium resorcinarene chloride receptors,NARX_(4),have been shown to act as high-sensitivity detectors of pyrophosphate(PPi),a biomarker of disease,in aqueous media through the chloride-to-PPi exchange[NAR(Cl... 详细信息

关键词： alkyl ammonium exchange

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

sifting for small primes from an arithmetic progression

引用

science China Mathematics 2023年第12期66卷 2715-2730页

作者： john B.Friedlander Henryk Iwaniec Department of Mathematics University of TorontoTorontoON M5S 2E4Canada Department of Mathematics Rutgers UniversityPiscatawayNJ 08903USA

In this work and its sister paper(Friedlander and Iwaniec(2023)),we give a new proof of the famous Linnik theorem bounding the least prime in an arithmetic *** sieve machinery in both papers,we are able to dispensh with the log-free zero density bounds and the repulsion property of exceptional zeros,two deep innovations begun by Linnik and relied on in earlier proofs.

关键词： sieve small primes Linnik theorem

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

synchronous formation of the‘forearc’Bay of Islands ophiolite and its basal high-temperature metamorphic sole constrained by U-Pb zircon ages

引用

Geoscience Frontiers 2023年第6期14卷 234-272页

作者： Weiyao Yan john F.Casey Department of Earth and Atmospheric sciences University of HoustonHoustonTXUSA

The welded metamorphic sole at the base of the Bay of Islands Ophiolite Complex(BOIC)in the Northern Appalachians of Newfoundland shows a typical inverted pressure-temperature(P-T)metamorphic gradient from HT-MP granulite to LT-LP greenschist *** incorporates mafic volcanic/plutonic protoliths mixed with pelagic,hemi-pelagic and coarser epiclastic sedimentary *** LA-ICP-Ms U–Pb concordia ages,trace elements,and Ti-in-zircon geothermometry for -250 zircon analyses from three metabasites of the upper HT sole amphibolites with N-MORB-like protoliths are *** samples collected within meters of the ophiolite peridotite-sole contact of the Blow Me Down Mountain and North Arm Mountain massifs yielded the oldest comparable concordia ages of 487.7±2.6 Ma and 489.1±3.1 Ma,respectively,that are both within error of the igneous age of 488.3±1.5 Ma of the directly overlying BOIC ophiolite,which formed at a supra-subduction zone(ssZ)forearc spreading center.A third slightly younger age of 484.2±2.4 Ma was obtained for an upper HT amphibolite sample with similar phase assemblages but collected30 m below the peridotite contact of the Table Mountain *** crystals analyzed have similar size and morphologies,subparallel rare earth element(REE)variation patterns,and steep heavy REE-enrichments((Lu/Gd)_(cn)>20),significant positive Ce anomalies(dominantly>5)and slight positive to dominantly negative Eu anomalies(1.2–0.4).Zircon shows Th/U mean values of 0.37–0.48 with little to no rim to core *** Ti-in-zircon mean crystallization temperatures range from764–787℃.These neocrystallized zircon crystals appear to be derived from thin leucosomes within the three *** other samples also from the upper HT sole show evidence of inherited detrital zircon with core dates spanning the Cambrian Notre Dame Arc through older Laurentian-like basement and rift age *** of the sole took place below a hot forearc asthenospheric wed

关键词： Ophiolite metamorphic sole U-Pb zircon ages Hot subduction interface supra-subduction forearc spreading center Arc-continent collision Taconic Orogeny

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hybrids production as a potential method to control prolific breeding in tilapia and adaptation to aquaculture climate-induced drought

引用

Aquaculture and Fisheries 2022年第6期7卷 647-652页

作者： Kulwa Mtaki samwel Mchele Limbu Aviti john Mmochi Matern s.P.Mtolera Institute of Marine sciences P.O.Box 668University of Dar es SalaamZanzibarTanzania Department of Aquaculture Technology School of Aquatic Sciences and Fisheries TechnologyUniversity of Dar es SalaamP.O.Box 60091Dar es SalaamTanzania East China Normal University Department of BiologySchool of Life SciencesLaboratory of Aquaculture Nutrition and Environmental Health500 Dong Chuan Road200241ShanghaiChina

Establishing suitable salt tolerant all-male tilapia strains with fast growth rate is a crucial requirement for successful euryhaline farming required for controlling prolific breeding and as an adaptation to the effect of climateinduced *** study assessed the percentage of tilapia male hybrids,their growth performance and survival rate produced by crossing female Nile tilapia(Oreochromis niloticus)and male Rufiji tilapia(Oreochromis urolepis urolepis)at different *** fingerlings were reared for 70 days in triplicate concrete tanks(1 m3),each stocked with 15 fish weighing 1.62±0.03 g,1.69±0.02 g and 1.41±0.06 g exposed to 2,15 and 35 ppt salinities,*** was done by adding seawater to freshwater at a rate of 2 ppt per day for 18 *** sexing was done by visual assessment of the genital papilla followed by rearing the hybrids for six months to observe *** showed that,the cross between ***(female)and *** urolepis(male)produced hybrids that were all-males without any reproduction within six months post hybrid*** hybrids reared at a salinity of 2 ppt had higher growth performance than those reared at 15 and 35 ***,hybrids cultured at 15 ppt had significantly higher growth performance than those reared at 35 *** the hybrids produced had survival rates of 100%.This study indicated that,all-male tilapia produced by crossing between ***(female)and ***(male)can be used by fish farmers as alternative species for mariculture development to control prolific breeding and as an adaptation strategy to climate change.

关键词： Monosex culture Hybridization Mariculture All-male hybrids Aquaculture climate-induced drought

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wrapping up the role of pericytes in Parkinson's disease

引用

Neural Regeneration Research 2023年第11期18卷 2395-2396页

作者： Taylor john stevenson Birger Victor Dieriks Department of Pharmacology University of AucklandAucklandNew Zealand Centre for Brain Research University of AucklandAucklandNew Zealand Department of Anatomy and Medical Imaging University of AucklandAucklandNew Zealand

Pericytes are classically defined as contra ctile cells within the central nervous system that regulate blood flow and permeability of the blood-brain barrier(BBB).This one-sided view is gradually changing,and pericytes are now considered versatile cells that can switch their function in response to different stimuli(Uemura et al.,2020).In addition to their role as gatekeepers of the BBB and maintaining homeostasis of the brain’s microenvironment through adj usting the vascular intraluminal dia meter,pericytes are both sensors and initiators of inflammation.

关键词： homeostasis pericyte

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fast prediction of indoor airflow distribution inspired by synthetic image generation artificial intelligence

引用

Building simulation 2023年第7期16卷 1219-1238页

作者： Cary A.Faulkner Dominik s.Jankowski john E.Castellini Jr Wangda Zuo Philipp Epple Michael D.sohn Ali Taleb Zadeh Kasgari Walid saad Department of Mechanical Engineering University of Colorado BoulderBoulderCOUSA HysON Institut SonnebergGermany Department of Architectural Engineering Pennsylvania State UniversityUniversity ParkPAUSA Department of Mechanical Engineering Coburg University of Applied SciencesCoburgGermany Energy Analysis and Environmental Impacts Division Lawrence Berkeley National LaboratoryBerkeleyCAUSA Department of Electrical and Computer Engineering Virginia TechArlingtonVAUSA

Prediction of indoor airflow distribution often relies on high-fidelity,computationally intensive computational fluid dynamics(CFD)*** intelligence(Al)models trained by CFD data can be used for fast and accurate prediction of indoor airflow,but current methods have limitations,such as only predicting limited outputs rather than the entire flow ***,conventional Al models are not always designed to predict different outputs based on a continuous input range,and instead make predictions for one or a few discrete *** work addresses these gaps using a conditional generative adversarial network(CGAN)model approach,which is inspired by current state-of-the-art Al for synthetic image *** create a new Boundary Condition CGAN(BC-CGAN)model by extending the original CGAN model to generate 2D airflow distribution images based on a continuous input parameter,such as a boundary ***,we design a novel feature-driven algorithm to strategically generate training data,with the goal of minimizing the amount of computationally expensive data while ensuring training quality of the Al *** BC-CGAN model is evaluated for two benchmark airflow cases:an isothermal lid-driven cavity flow and a non-isothermal mixed convection flow with a heated *** also investigate the performance of the BC-CGAN models when training is stopped based on different levels of validation error *** results show that the trained BC-CGAN model can predict the 2D distribution of velocity and temperature with less than 5%relative error and up to about 75,ooo times faster when compared to reference CFD *** proposed feature-driven algorithm shows potential for reducing the amount of data and epochs required to train the Al models while maintaining prediction accuracy,particularly when the flow changes non-linearlywith respectto an input.

关键词： artificial intelligence indoor airflow conditional generative adversarial network computational fluid dynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of inter-grain cementation stiffness on the effective elastic properties of porous Bentheim sandstone

引用

Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 573-583页

作者： Bin Chen Jiansheng Xiang john-Paul Latham Department of Earth science and Engineering Faculty of EngineeringImperial College LondonLondonSW72BXUK

Effective elastic properties of porous media are known to be significantly influenced by *** this paper,we investigated the influence of another critical factor,the inter-grain cementation stiffness,on the effective elastic properties of a granular porous rock(Bentheim sandstone)using an advanced numerical workflow with realistic rock microstructure and a theoretical ***,the disparity between the experimentally tested elastic properties of Bentheim sandstone and the effective elastic properties predicted by empirical equations was ***,a micro-computed tomography(CT)-scan based approach was implemented with digital imaging software AVIZO to construct the 3D(three-dimensional)realistic microstructure of Bentheim *** microstructural model was imported to a mechanics solver based on the 3D finite element model with inter-grain boundaries modelled by cohesive *** simulations were run to test the effective elastic properties for different shear and normal intergrain cementation ***,a relation between the macroscale Young’s modulus and inter-grain cementation stiffness was derived with a theoretical model which can also account for porosity *** the numerical and theoretical results indicate the influence of the inter-grain cementation stiffness,on the effective elastic properties is significant for porous *** calibrated normal and shear stiffnesses at the inter-grain boundaries are 1.2×10^(5) and 4×10^(4) GPa/m,respectively.

关键词： Porous sandstone Cohesive finite element model Grain-based model Rock microstructure Micro-computed tomography(CT)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exsolved materials for CO_(2)reduction in high-temperature electrolysis cells

引用

Materials Reports(Energy) 2023年第2期3卷 62-81,I0003页

作者： Min Xu Ran Cao Han Qin Nuoxi Zhang Wenle Yan Liming Liu john T.s.Irvine Di Chen The Future Laboratory Tsinghua UniversityBeijing100084China Academy of Arts&Design Tsinghua UniversityBeijing100084China Weiyang College Tsinghua UniversityBeijing100084China school of Materials science and Engineering Tsinghua UniversityBeijing100084China school of Chemistry University of St AndrewsSt AndrewsFifeKY169STUK

Electrochemical reduction of CO_(2)into valuable fuels and chemicals has become a contemporary research area,where the heterogeneous catalyst plays a critical *** nanoparticles supported on oxides performing as active sites of electrochemical reactions have been the focus of intensive ***,we review the CO_(2)reduction with active materials prepared by *** fundamental of exsolution was summarized in terms of mechanism and models,materials,and driven *** advances in the exsolved materials used in hightemperature CO_(2)electrolysis were catalogued into tailored interfaces,synergistic effects on alloy particles,phase transition,reversibility and electrochemical switching.

关键词： CO_(2)reduction Exsolution solid oxide electrolysis cells Catalysts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：