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Prostaglandin E1 administration post liver transplantation and renal outcomes:A retrospective single center experience

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World Journal of Transplantation 2024年第4期14卷 101-109页

作者： Vinay Jahagirdar Mohamed Ahmed Ifrah Fatima Hassam Ali Laura Alba john H Helzberg Lee s Cummings Matthew Wilkinson Jameson Forster Alisa Likhitsup Department of Internal Medicine Saint Luke’s Health System of Kansas City and the University of Missouri-Kansas CityKansas CityMO 64111United States Department of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Internal Medicine Department of Gastroenterology and HepatologySaint Luke’s Health System of Kansas City and University of Missouri-Kansas CityKansas CityMO 64111United States Department of surgery University of Missouri-Kansas City and Transplant SurgerySaint Luke’s Hospital of Kansas CityKansas CityMO 64111United States Department of Gastroenterology and Hepatology University of MichiganAnn ArborMI 48109United States

BACKGROUND Prostaglandin E1(PGE1),or alprostadil,is a potent vasodilator that improves hepatic blood flow and reduces ischemia-reperfusion injury post-liver transplantation(LT).However,the benefits of PGE1 on renal function after LT have not yet been well *** To assess the impact of PGE1 administration on renal function in patients who underwent liver or liver-kidney *** This retrospective study included all patients who underwent liver or liverkidney transplant at our institution from January,2011 to December,*** were classified based on whether they received ***1 was administered post-LT to those with transaminases>1000 U/L in the immediate postoperative ***,post-LT treatments and/or complications,renal function,and survival were *** logistic regression analysis was performed,and a two-tailed P values considered statistically *** A total of 145 patients underwent LT,with 44(30%)receiving *** patient characteristics were comparable,except the PGE1 group had significantly higher aspartate aminotransferase(AsT)(1961.9 U/L±1862.3 U/L vs 878 U/L±741.4 U/L,P=0.000),alanine aminotransferase(1070.6 U/L±895 U/L vs 547.7 U/L±410 U/L,P=0.000),international normalized ratio on post-LT day 1(2±0.74 vs 1.8±0.4,P=0.03),a longer intensive care unit stay(8.1 days±11.8 days vs 3.8 days±4.6 days,P=0.003),more vasopressor use(55.53 hours±111 hours vs 16.33 hours±26.3 hours,P=0.002),and higher immediate postoperative complications(18.6%vs 4.9%,P=0.04).The PGE1 group also had a significantly higher 90-day readmission rate(29.6%vs 13.1%,P=0.02)and lower 1-year liver graft survival(87.5%vs 98.9%,P=0.005).However,30-day readmission(31.6%vs 27.4%,P=0.64),LT complications(hepatic artery thrombosis,biliary complications,rejection of liver graft,cardiomyopathy),1-year patient survival(96.9%vs 97.8%,P=0.77),overall liver graft survival,and overall patient survival were similar between t

关键词： Liver transplantation Alprostadil Protective agents Transplant Prostaglandin E1

Land use and river-lake connectivity: Biodiversity determinants of lake ecosystems

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Environmental science and Ecotechnology 2024年第5期21卷 329-340页

作者： Huiyu Xie Yu Ma Xiaowei Jin shiqi Jia Xu Zhao Xianfu Zhao Yongjiu Cai Jian Xu Fengchang Wu john P.Giesy state Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing100012China College of Water sciences Beijing Normal UniversityBeijing100875China China National Environmental Monitoring Centre Beijing100012China Key Laboratory of Ecological Impacts of Hydraulic-Projects and Restoration of Aquatic Ecosystem of Ministry of Water Resources Institute of HydroecologyMinistry of Water Resources and Chinese Academy of SciencesWuhan430079China Nanjing Institute of Geography and Limnology Chinese Academy of SciencesNanjing210008China Department of Integrative Biology Michigan State UniversityEast LansingMI48895USA Department of Veterinary Biomedical sciences and Toxicology Centre University of SaskatchewanSaskatoonSaskatchewanS7N 5B3Canada Toxicology Centre and Department of Veterinary Biomedical sciences University of Saskatchewan44 Campus DriveSaskatoonSKS7N 5B3SaskatoonSKCanada

Lake ecosystems confront escalating challenges to their stability and resilience,most intuitively leading to biodiversity loss,necessitating effective preservation strategies to safeguard aquatic ***,the complexity of ecological processes governing lake biodiversity under multi-stressor interactions remains an ongoing concern,primarily due to insufficient long-term bioindicator data,particularly concerning macroinvertebrate *** we utilize a unique,continuous,and in situ biomonitoring dataset spanning from 2011 to 2019 to investigate the spatio-temporal variation of macroinvertebrate *** assess the impact of four crucial environmental parameters on Lake Dongting and Lake Taihu,i.e.,water quality,hydrology,climate change,and land *** two systems are representative of lakes with Yangtze-connected and disconnected subtropical floodplains in *** find an alarming trend of declining taxonomic and functional diversities among macroinvertebrate communities despite improvements in water *** contributing factors to this decline include persistent anthropogenic pressures,particularly alterations in human land use around the lakes,including intensified nutrient loads and reduced habitat ***,river-lake connectivity is pivotal in shaping differential responses to multiple *** results highlight a strong correlation between biodiversity alterations and land use within a 2e5 km radius and 0.05e2.5 km from the shorelines of Lakes Dongting and Taihu,*** findings highlight the importance of implementing land buffer zones with specific spatial scales to enhance taxonomic and functional diversity,securing essential ecosystem services and enhancing the resilience of crucial lake ecosystems.

关键词： Taxonomic richness Functional diversity Biotic homogenization River-lake connectivity Multiple stressors

5G green cellular networks considering power allocation schemes

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science China(Information sciences) 2016年第2期59卷 112-125页

作者： Xiaohu GE Jiaqi CHEN Cheng-Xiang WANG john thompson Jing ZHANG school of Electronics Information and Communications Huazhong University of Science and Technology Joint Research Institute for signal and Image Processing School of Engineering & Physical SciencesHeriot-Watt University

It is important to assess the effect of transmit power allocation schemes on the energy consumption on random cellular networks. The energy efficiency of 5G green cellular networks with average and water-filling power allocation schemes is studied in this paper. Based on the proposed interference and achievable rate model,an energy efficiency model is proposed for MIMO random cellular networks. Furthermore, the energy efficiency with average and water-filling power allocation schemes are presented, respectively. Numerical results indicate that the maximum limits of energy efficiency are always there for MIMO random cellular networks with different intensity ratios of mobile stations(Mss) to base stations(Bss) and channel conditions. Compared with the average power allocation scheme, the water-filling scheme is shown to improve the energy efficiency of MIMO random cellular networks when channel state information(CsI) is attainable for both transmitters and receivers.

关键词： energy efficiency cellular networks MIMO achievable rate model power allocation scheme

Implementation and evaluation of Exercise is Medicine in primary care clinics within a large academic health system

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Family Medicine and Community Health 2024年第1期12卷 16-27页

作者： john Kevin Ong Dayao Caroline E L Duffy Amalia M Cristiano Gene'Rusty'Kallenberg sarah E Linke University of California san Diego school of Medicine La JollaCaliforniaUSA Milken Institute of Public Health The George Washington UniversityWashingtonDistrict of ColumbiaUSA The University of Texas Medical Branch at Galveston school of Medicine GalvestonTexasUSA scripps Family Medicine Residency Scripps Mercy Hospital Chula VistaChula VistaCaliforniaUSA Herbert Wertheim school of Public Health&Human Longevity science University of California San DiegoLa JollaCaliforniaUSA Department of Family Medicine University of California San DiegoLa JollaCaliforniaUSA Omada Health San FranciscoCaliforniaUSA

Objective Exercise is Medicine(EIM)is a global initiative encouraging healthcare providers to routinely assess and promote physical activity(PA)among *** objective of this study was to evaluate the feasibility,adoption,implementation and effectiveness of EIM from patient,clinician and healthcare staff perspectives using a combination of electronic health record(EHR),survey and interview *** This study used a combination of the Practical Robust Implementation and sustainability Model(PRIsM)and the Learning Evaluation model to implement *** captured from the EHR,including Physical Activity Vital sign(PAVs)scores,and data collected from qualitative surveys and interviews were used to evaluate the programme’s Reach,Effectiveness,Adoption,Implementation,Maintenance(RE-AIM,which is embedded within PRIsM)from provider,staff and patient *** Five primary care clinics within a large academic health *** A total of 24443 patients from all participating clinics had at least one PAVs score during the study period.A total of 17 clinicians completed surveys,and 4 clinicians,8 medical assistants and 9 patients completed *** Implementation fidelity metrics varied widely between components and across clinics but were generally consistent over time,indicating a high degree of programme *** was highest during the first 6 months of the COVID-19 pandemic when most visits were *** PAVs scores increased from 57.7(95%CI:56 to 59.4)to 95.2(95%CI:91.6 to 98.8)min per week at 6 months for patients not meeting PA guidelines at baseline and decreased from 253.84(95%CI:252 to 255.7)to 208.3(95%CI:204.2 to 212.4)min per week at 6 months for patients meeting PA guidelines at *** EIM implementation,clinician-estimated time spent discussing PA with patients increased for 35%of providers and stayed the same for 53%.Conclusion Overall,this study established EIM’s feasibility,adoption,implementation

关键词： routine qualitative completed

Determinants and Outcomes of Pregnancies among Booked versus Unbooked Patients in a Tertiary Hospital south East, Nigeria

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 144-161页

作者： Chijioke s. Anyigor-Ogah john O. Egede Chijioke O. Ogeh Chika C. Agunanne Alphosus I. Ozioko Chinyere C. Duru Department of Family Medicine Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State Nigeria Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State Nigeria Department of Paediatrics Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State Nigeria

Background: Inadequate antenatal care, both in coverage and standard, has been linked with poor pregnancy outcomes. In a resource poor setting, home delivery is considered very cheap, but the possible outcome of such pregnancies has been a subject of interest. This study evaluated the association of booking status with pregnancy outcomes. Objectives: To examine the factors that influence booking and impact of the booking status on pregnancy outcomes. Methods: This was a hospital-based prospective cohort study of 240 (120 booked and 120 un-booked) pregnant mothers selected through systematic random sampling. The study was carried out at the Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Nigeria. Chi-square test, t-test and logistic regression were used for analysis. Results: The mean age of the participants was 30.39 ± 5.05 years and 29.05 ± 6.36 years respectively for the booked and unbooked. Marital status (OR = 6.35, 95% CI = 1.24 - 32.59), educational status (OR = 36.40, 95% CI = 5.26-152.83), place of residence (OR = 0.15, 95% CI = 0.06 - 0.41), partner’s support (OR = 0.05, 95% CI = 0.01 - 0.37), family support (OR = 0.03, 95% CI = 0.01 - 0.13), mode of delivery (OR = 0.23, 95% CI = 0.12 - 0.46), APGAR score in first minute (OR = 6.02, 95% CI = 2.45 - 14.83) and NBICU admission (OR = 3.75, 95% CI = 1.67 - 8.43) were associated with booked status. However, being unmarried, nulliparity/grandmultiparity, low level of education, blue colar jobs, low income, rural dwelling and poor partner and poor family support were associated with the unbooked. The booked parturients had a better perinatal outcome compared the unbooked. Conclusion/Recommendation: There was high prevalence of operative deliveries, perinatal morbidity and mortality among the unbooked mothers. Girl child education, employment and poverty alleviation would improve antenatal care utilization.

关键词： socio-Demographic Characteristics Booking status Antenatal Delivery

shear wave velocity prediction:A review of recent progress and future opportunities

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Energy Geoscience 2024年第4期5卷 36-54页

作者： john Oluwadamilola Olutoki Jian-guo Zhao Numair Ahmed siddiqui Mohamed Elsaadany AKM Eahsanul Haque Oluwaseun Daniel Akinyemi Amany H.said Zhaoyang Zhao state Key Laboratory of Petroleum Resources and Prospecting CNPC Key Laboratory of Geophysical ExplorationCollege of GeophysicsChina University of PetroleumBeijingChina Center of Excellence in subsurface seismic Imaging and Hydrocarbon Prediction Department of GeoscienceFaculty of Geoscience&Petroleum EngineeringUniversiti Teknologi PETRONAS(UTP)Malaysia Geology Department Faculty of ScienceAssiut UniversityAssiut71516Egypt

shear logs,also known as shear velocity logs,are used for various types of seismic analysis,such as determining the relationship between amplitude variation with offset(AVO)and interpreting multiple types of seismic *** log is an important tool for analyzing the properties of rocks and interpreting seismic data to identify potential areas of oil and gas ***,these logs are often not collected due to cost constraints or poor borehole conditions possibly leading to poor data quality,though there are various approaches in practice for estimating shear wave *** this study,a detailed review of the recent advances in the various techniques used to measure shear wave(s-wave)velocity is carried *** techniques include direct and indirect measurement,determination of empirical relationships between s-wave velocity and other parameters,machine learning,and rock physics ***,this study creates a collection of employed techniques,enhancing the existing knowledge of this significant topic and offering a progressive approach for practical implementation in the field.

关键词： shear wave(s-wave)velocity Direct and indirect measurement Empirical relationship Artificial intelligence(AI) Machine learning Rock physics model

single-center experience with Knee+^(TM) augmented reality navigation system in primary total knee arthroplasty

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World Journal of Orthopedics 2024年第3期15卷 247-256页

作者： Evangelos sakellariou Panagiotis Alevrogiannis Fani Alevrogianni Athanasios Galanis Michail Vavourakis Panagiotis Karampinas Panagiotis Gavriil john Vlamis stavros Alevrogiannis The 3^(rd)Department of Orthopaedic surgery National&Kapodistrian University of AthensKAT General HospitalAthens 14561Greece The 1^(st)Department of Orthopaedic surgery National&Kapodistrian University of AthensAttikon General HospitalAthens 14561Greece Department of Anesthesiology KAT General HospitalAthens 14561Greece Department of Robotic Hip&Knee Orthopaedic surgery Metropolitan General HospitalAthens 14561Greece

BACKGROUND Computer-assisted systems obtained an increased interest in orthopaedic surgery over the last years,as they enhance precision compared to conventional *** expansion of computer assistance is evolving with the employment of augmented ***,the accuracy of augmented reality navigation systems has not been *** To examine the accuracy of component alignment and restoration of the affected limb’s mechanical axis in primary total knee arthroplasty(TKA),utilizing an augmented reality navigation system and to assess whether such systems are conspicuously fruitful for an accomplished knee *** From May 2021 to December 2021,30 patients,25 women and five men,under-went a primary unilateral *** cases were excluded.A preoperative radiographic procedure was performed to evaluate the limb’s axial *** patients were operated on by the same team,without a tourniquet,utilizing three distinct prostheses with the assistance of the Knee+™augmented reality navigation system in every ***,the same radiographic exam protocol was executed to evaluate the implants’position,orientation and coronal plane *** recorded measurements in 3 stages regarding femoral varus and flexion,tibial varus and posterior ***,the expected values from the Augmented Reality system were *** we calculated the same values after each cut and finally,the same measurements were recorded radiolo-gically after the *** statistical analysis,Lin’s concordance correlation coefficient was estimated,while Wilcoxon signed Rank Test was performed when *** A statistically significant difference was observed regarding mean expected values and radiographic mea-surements for femoral flexion measurements only(Z score=2.67,P value=0.01).Nonetheless,this difference was statistically significantly lower than 1 degree(Z score=-4.21,P values of discrepancies in the calculations of

关键词： Augmented reality Orthopedics Total knee arthroplasty Robotics Knee Navigation

Adjuvant Rectal Diclofenac for Post Operative Analgesia after Caesarean section—A Randomized Controlled study

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 591-609页

作者： Eziaha Eric s. Ede Ayodele A. Olaleye john C. Irechukwu Uchenna Nelson Nwaedu Borniface N. Ejikeme Vincent Chidiebere Ali Bartholomew I. Olinya Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria

BACKGROUND: Pain management following caesarean section still remains a challenge in our environment. Most potent analgesics are either not readily available or expensive. Diclofenac suppository is an NsAID that can be used for postoperative analgesia. It is available and affordable. OBJECTIVE: To compare the efficacy and safety of combined rectal diclofenac and intramuscular pentazocine with intramuscular pentazocine alone for post operative pain control following lower segment caesarean section. METHODOLOGY: A total of 120 women who met the selection criteria scheduled for caesarean section under spinal anaesthesia with bupivacaine were randomized into two equal groups to receive either 75 mg diclofenac suppository 12 hourly for 24 hours or one anusol suppository (the placebo) 12 hourly for 24 hours. Both groups received pentazocine as primary analgesia. REsULT: The primary outcome measure is the proportion of patients with severe pain at 24 hours using the visual analogue rating scale. secondary outcome measures are the time from surgery to ambulation, Passage of flatus, maternal satisfaction and presence of complications. statistical analysis was done using spss version 22 and graph pad statistical package. student T-test was used for continuous variables whereas chi square was used for categorical variables P CONCLUsION: Adjuvant rectal diclofenac is superior to pentazocine alone in the management of pain after caesarean section. Less number of patients had moderate to severe pain at 24 hours post operation. Maternal satisfaction in relation to pain management is better with diclofenac suppository. The levels of complications were comparable in both groups.

关键词： Pain Caesarean section Diclofenac Placebo suppository

Enhancing Pneumonia Detection in Pediatric Chest X-Rays Using CGAN-Augmented Datasets and Lightweight Deep Transfer Learning Models

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Journal of Data Analysis and Information Processing 2024年第1期12卷 1-23页

作者： Coulibaly Mohamed Ronald Waweru Mwangi john M. Kihoro Department of Mathematics Pan African University Institute for Basic Sciences Technology and Innovation (PAUSTI) Nairobi Kenya Department of Computing Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya school of Computing and Mathematics The Cooperative University of Kenya Nairobi Kenya

Pneumonia ranks as a leading cause of mortality, particularly in children aged five and under. Detecting this disease typically requires radiologists to examine chest X-rays and report their findings to physicians, a task susceptible to human error. The application of Deep Transfer Learning (DTL) for the identification of pneumonia through chest X-rays is hindered by a shortage of available images, which has led to less than optimal DTL performance and issues with overfitting. Overfitting is characterized by a model’s learning that is too closely fitted to the training data, reducing its effectiveness on unseen data. The problem of overfitting is especially prevalent in medical image processing due to the high costs and extensive time required for image annotation, as well as the challenge of collecting substantial datasets that also respect patient privacy concerning infectious diseases such as pneumonia. To mitigate these challenges, this paper introduces the use of conditional generative adversarial networks (CGAN) to enrich the pneumonia dataset with 2690 synthesized X-ray images of the minority class, aiming to even out the dataset distribution for improved diagnostic performance. subsequently, we applied four modified lightweight deep transfer learning models such as Xception, MobileNetV2, MobileNet, and EfficientNetB0. These models have been fine-tuned and evaluated, demonstrating remarkable detection accuracies of 99.26%, 98.23%, 97.06%, and 94.55%, respectively, across fifty epochs. The experimental results validate that the models we have proposed achieve high detection accuracy rates, with the best model reaching up to 99.26% effectiveness, outperforming other models in the diagnosis of pneumonia from X-ray images.

关键词： Pneumonia Detection Pediatric Radiology CGAN (Conditional Generative Adversarial Networks) Deep Transfer Learning Medical Image Analysis