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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： steinunn sara Helgudóttir Anne skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir john Dirk Vestergaard Nieland 2N Pharma Aps NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

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水上运动

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空中英语教室（初级版．大家说英语） 2024年第8期 21-24,52,53,56页

作者： john Telfer 不详

夏天是去海上玩的绝佳时机。有些人只喜欢在海浪当中玩耍或者游泳,有些人则喜欢冲浪。学习冲浪不难,但是需要练习。你只需要一块冲浪板、海浪和良好的平衡感就可以了。你必须学习站在冲浪板上不掉下来!学会这一点需要时间,所以不断尝试... 详细信息

夏天是去海上玩的绝佳时机。有些人只喜欢在海浪当中玩耍或者游泳,有些人则喜欢冲浪。学习冲浪不难,但是需要练习。你只需要一块冲浪板、海浪和良好的平衡感就可以了。你必须学习站在冲浪板上不掉下来!学会这一点需要时间,所以不断尝试就对了。你还可以学习冲浪技巧!有些人甚至能够腾空跃起,越过海浪。

关键词：水上运动平衡感冲浪腾空游泳绝佳时机海浪学习

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新兴和发展中经济体的资本管制与美国货币政策的传导

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新金融 2024年第4期 21-28,36页

作者： Jongrim Ha Haiqin Liu john Rogers 李丽丽(译) 周正铭(译) 世界银行复旦大学不详

与发达经济体相比,新兴市场和发展中经济体(EMDEs)的资产收益波动性要大得多。学术界对此现象的研究结果是“各国无法从全球金融周期中脱钩”。文章利用1995—2019年间78个国家的结构向量自回归模型,以及文献中识别美国货币政策冲击的... 详细信息

与发达经济体相比,新兴市场和发展中经济体(EMDEs)的资产收益波动性要大得多。学术界对此现象的研究结果是“各国无法从全球金融周期中脱钩”。文章利用1995—2019年间78个国家的结构向量自回归模型,以及文献中识别美国货币政策冲击的不同方法,检验了资本账户开放程度较低的国家对美国货币政策冲击的系统性反应小于资本管制宽松的国家这一命题。文章还考虑了汇率制度和外汇干预等其他制度特征在解释各国对冲击的反应差异方面的作用。实证结果表明:较严格的资本管制会使利率和汇率对美国货币政策冲击的反应较小,该结果在新兴市场经济国家中更为显著;只有微弱的证据表明汇率的灵活程度会影响美国对外国利率和汇率的溢出效应。本刊编译此篇世界银行的研究报告,以飨读者。

关键词：资本管制溢出效应资本流动管理全球金融周期美联储

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Machine-learning accelerated structural prediction and confirmation of novel WN_(6)with hexagonal N_(6)rings

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science Bulletin 2021年第14期66卷 1367-1368页

作者： john s.Tse Department of Physics and Engineering Physics University of SaskatchewanSaskatoon S7N 5E2Canada

Nitrogen is the most abundant gas in the *** is a critical element for creating and sustaining *** nitrogen atom is the fundamental ingredient for building proteins and aminoacids in all living *** nucleic acids,such ... 详细信息

关键词： life N_(6)环理论预言

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First-Principles Methods in the Investigation of the Chemical and Transport Properties of Materials under Extreme Conditions

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Engineering 2019年第3期5卷 421-433页

作者： john s. Tse Department of Physics and Engineering Physics University of Saskatchewan Saskatoon SK S7N 5E2 Canada Center for High Pressure science and Technology Advanced Research Shanghai 201203 China

Earth is a dynamic system. The thermodynamics conditions of Earth vary drastically depending on the depth, ranging from ambient temperature and pressure at the surface to 360 GPa and 6600 K at the core. Consequently, the physical and chemical properties of Earth’s constituents (e.g., silicate and carbonate minerals) are strongly affected by their immediate environment. In the past 30 years, there has been a tremendous amount of progress in both experimental techniques and theoretical modeling methods for material characterization under extreme conditions. These advancements have elevated our understanding of the properties of minerals, which is essential in order to achieve full comprehension of the formation of this planet and the origin of life on it. This article reviews recent computational techniques for predicting the behavior of materials under extreme conditions. This survey is limited to the application of the first-principles molecular dynamics (FPMD) method to the investigation of chemical and thermodynamic transport processes relevant to Earth science.

关键词： High pressure temperature Earth mantle Molecular dynamics Density functional method Transport properties Chemical reactivity

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Flow and Heat Transfer of a Dusty Williamson MHD Nanofluid Flow over a Permeable Cylinder in a Porous Medium

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Open Journal of Fluid Dynamics 2024年第2期14卷 100-122页

作者： Oluranti Adejoke Adekanmbi-Akinseye Olugbenga john Fenuga Hamzat Afe Isede Musibau Gbeminiyi sobamowo Department of Mathematics University of Lagos Lagos Nigeria Department of Mechanical Engineering University of Lagos Lagos Nigeria

This study investigates the flow and heat transfer of dusty Williamson (MHD) Nanofluid flow over a stretching permeable cylinder in a porous medium. Dusty Williamson Nanofluid was considered due to its thermal properties and potential benefits of increasing the heat transfer rate. Firstly, partial differential equations are transformed into coupled non-linear ordinary differential equations through a similarity variables transformation. The resulting set of dimensionless equations is solved analytically by using the Homogony Perturbation Method (HPM). The effects of the emerging parameters on the velocity and temperature profiles as well as skin-friction coefficient and Nusselt number are publicized through tables and graphs with appropriate discussions. The present result has been compared with published papers and found to be in agreement. To the best of author’s knowledge, there has been sparse research work in the literature that considers the effect of dust with Williamson Nanofluid and also solving the problem analytically. Therefore to the best of author’s knowledge, this is the first time analytical solution has been established for the problem. The results revealed that the fluid velocity of both the fluid and dust phases decreases as the Williamson parameter increases. Motivated by the above limitations and the gaps in past works, therefore, it is hoped that the present work will assist in providing accurate solutions to many practical problems in science, industry and engineering.

关键词： Williamson Dusty Particles Homotopy Perturbation Method (HPM) Magneto Hydrodynamic (MHD) Nanofluid Porous Medium stretching Cylinder

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Effect of Tillage Practices on Hydro-Physical Properties of soils in a Rice-Grown Environment in North Central Nigeria

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Journal of Environmental Protection 2024年第5期15卷 527-536页

作者： Ebierni Akpoebidimiyen Otuaro john Jiya Musa Felix Oguche Abayomi Ibrahim Kuti Abubakar Ndaman Civil Engineering Department Maritime University Okerenkoko Nigeria Department of Agricultural and Bioresources Engineering Federal University of Technology Minna Nigeria Institute of Water and Environmental Management Faculty of Agricultural and Food Sciences and Environmental Management University of Debrecen Boszormenyi St Hungary

This study details soil’s physical and chemical properties in a rice-grown environment in Minna environs Niger state, Nigeria, under different soil and water conservation practices. soil samples were collected at 0 - 10 cm, 10 - 20 cm and 20 - 30 cm, respectively, using a soil auger to determine their physical and chemical properties such as moisture content, particle size, bulk density, particle density, porosity and organic matter. The textural classification determined the percentage dominance of the soil types in each study site location. The moisture content of site 1 ranged between 14.3% to 13.7%, site 2 ranged between 13.2% to 10.2%, site 3 ranged between 15.4% to 13.2%, site 4 ranged between 15.6% to 13.6% and site 5 ranged between 16.1% to 10.9%. The clay content of sites 3, 4 and 5 is higher than that of sites 1 and 2, while the silt contents of sites 1, 2 and 3 are higher than that of sites 4 and 5. The mean value of soil organic carbon from each study location was 2.37%, 2.03%, 2.43%, 2.07% and 2.17% for sites 1, 2, 3, 4, and 5, respectively. Therefore, site 1 is susceptible to erosion because of poor infiltration rate and well-ploughed or cultivated land by the tractor (harrowed). The particle sizes analysis indicated that the soil type in site 1 and site 2 is mainly sandy loam, while site 3 and site 5 are mainly loamy and predominantly clay loam in site 4.

关键词： Degradation Erosion Fertility Irrigation Management

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The barnacle and the building:a modern morality tale

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Integrative Zoology 2008年第2期3卷 68-74页

作者： john s.BUCKERIDGE Earth and Oceanic systems Research Group RMIT UniversityMelbourneVictoriaAustralia

A rare and almost complete barnacle fossil,previously described on the basis of two isolated shell fragments,wasrecently exposed in a limestone block on the outer wall of Melbourne’s Old Magistrates’Courts in Victoria,*** courts comprise one of the oldest and grandest buildings in Melbourne and because of this they have aheritage *** heritage-listed buildings are protected from alteration by law,and as removal of the fossil wouldbe deemed“alteration”,official permission had to be obtained to extract the *** paper discusses theprocesses involved with extraction of a unique specimen from a protected building and provides an overview of thepalaeontological significance of the *** is given to the likely fate of a fossil of this nature,situateda little below eye level on a busy city street,if it was left in situ;finally,the implications of designating a holotypefrom material removed from a building are assessed.

关键词： conservation fossil barnacle heritage-listed buildings.

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Opportunism and the resilience of barnacles (Cirripedia: Thoracica) to environmental change

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Integrative Zoology 2012年第2期7卷 137-146页

作者： john s.BUCKERIDGE Earth and Oceanic systems RMIT UniversityMelbourneAustralia

Cirripede-like organisms have their origins in the Palaeozoic,but until the Cainozoic,were represented primarily by pedunculated forms,such as the *** barnacles(Balanomorpha)are first recorded after the Cretaceous-Tertiary extinction *** the late Palaeogene,rapid radiation of cirripedes resulted in sufficient diversification for them to occupy most marine *** they survived both the Palaeocene-Eocene Thermal Maximum and the Pleistocene glaciation is testament to their ability to rapidly adapt to *** wide habitat distribution of balanomorphs in particular is unparalleled;they are known from the upper littoral(Chthamalus)to depths of 3600 m(Tetrachaelasma)and within this attached to rock,wood and miscellaneous flotsam,plus in symbiosis or commensalism with larger marine ***’s(1854)view of the Tertiary as the age of barnacles is reflected in this diversity,distribution and *** cirripedes are,nonetheless,at risk,from rapid habitat change,competition,pollution and,especially in light of their sessile habit,from *** paper assesses the viability of a number of cirripedes and concludes that the Lepadiformes,scalpelliformes and Balanomorpha are the most resilient,and will most quickly adapt to occupy new niches when opportunities arise.

关键词： adaptation Cirripedia distribution environmental change

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some biological consequences of environmental change:A study using barnacles(Cirripedia:Balanomorpha)and gum trees(Angiospermae:Myrtaceae)

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Integrative Zoology 2010年第2期5卷 122-131页

作者： john s.BUCKERIDGE Earth and Oceanic systems RMIT UniversityMelbourneAustralia

Uniformitarianism permits understanding of the past on the basis of the present,and modeling the future through consideration of the fossil *** present paper addresses the impact environmental(climatic)change has had on acorn barnacles and eucalyptus *** barnacles(Balanomorpha)are first recorded after the K/T massextinction *** the Paleogene,rapid radiation resulted in their occupying most marine *** balanomorphs survived both the Paleocene–Eocene thermal maximum and the Pleistocene glaciation is testament to their ability to adapt to opportunities;they are known from the littoral(Chamaesipho)to depths of 3600 m(Tetrachaelasma)and within this from diverse substrates:rock,wood and miscellaneous flotsam,plus in symbiosis or commensalism with most larger marine ***’s(1854)view of the late Tertiary as the age of barnacles is reflected in their diversity,distribution and *** are contrasted with the Australian Myrtaceae:plants ranging from woody shrubs to tall *** most significant is Eucalyptus sensu lato,which typifies Australia’s flora,and is characterized by aromatic leaves that produce *** has evolved strategies that result in its domination of Australian open woodlands:these include production of highly flammable eucalyptol oil(with a flashpoint of 49℃)and an unprecedented ability to regenerate following forest *** trees and barnacles first appear in the Paleogene,their earliest records are Australasian,and they both demonstrate extraordinary resilience when environmental conditions are optimal.

关键词： adaption barnacles environmental change eucalypts evolution

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