检索结果-南通市图书馆

Targeting TrkB–PsD-95 coupling to mitigate neurological disorders

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oscillating spacetime: The Foundation of the Universe

引用

Journal of Modern Physics 2024年第8期15卷 1097-1143页

作者： john A. Macken santa Rosa California USA

In this article, spacetime is modeled as a quantum mechanical sonic medium consisting of Planck length oscillations at Planck frequency. Planck length-time oscillations give spacetime its physical constants of c, G and ħ. Oscillating spacetime is proposed to be the single universal field that generates and unifies everything in the universe. The 17 fields of quantum field theory are modeled as lower frequency resonances of oscillating spacetime. A model of an electron is proposed to be a rotating soliton wave in this medium. An electron appears to have wave-particle duality even though it is fundamentally a quantized wave. This soliton wave can momentarily be smaller than a proton in a high energy collision or can have a relatively large volume of an atom’s orbital wave function. Finding an electron causes it to undergo a superluminal collapse to a smaller wave size. This gives an electron its particle-like properties when detected. The proposed wave-based electron model is tested and shown to have an electron’s approximate energy, de Broglie wave properties and undetectable volume. Most important, this electron model is shown to also generate an electron’s electrostatic and gravitational forces. The gravitational properties are derived from the nonlinearity of this medium. When an electron’s gravitational and electrostatic forces are modeled as distortions of soliton waves, the equations become very simple, and a clear connection emerges between these forces. For example, the gravitational force between two Planck masses equals the electrostatic force between two Planck charges. Both force magnitudes equal ħc/r2.

关键词： Unification of Forces Electron Model Cosmological Constant Problem Foundation of Physics Aether

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bile acid metabolism and signaling in health and disease:molecular mechanisms and therapeutic targets

引用

signal Transduction and Targeted Therapy 2024年第5期9卷 2014-2064页

作者： Joshua s.Fleishman sunil Kumar Department of Pharmaceutical sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNYUSA

Bile acids,once considered mere dietary surfactants,now emerge as critical modulators of macronutrient(lipid,carbohydrate,protein)metabolism and the systemic pro-inflammatory/anti-inflammatory *** acid metabolism and signaling pathways play a crucial role in protecting against,or if aberrant,inducing cardiometabolic,inflammatory,and neoplastic conditions,strongly influencing health and *** curative treatment exists for any bile acid influenced disease,while the most promising and well-developed bile acid therapeutic was recently rejected by the ***,we provide a bottom-up approach on bile acids,mechanistically explaining their biochemistry,physiology,and pharmacology at canonical and non-canonical *** this mechanistic model of bile acids,we explain how abnormal bile acid physiology drives disease pathogenesis,emphasizing how ceramide synthesis may serve as a unifying pathogenic feature for cardiometabolic *** provide an in-depth summary on pre-existing bile acid receptor modulators,explain their shortcomings,and propose solutions for how they may be ***,we rationalize novel targets for further translational drug discovery and provide future *** than dismissing bile acid therapeutics due to recent setbacks,we believe that there is immense clinical potential and a high likelihood for the future success of bile acid therapeutics.

关键词： metabolism rejected shortcomings

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of a Wireless solar Powered Personal Weather station

引用

Agricultural sciences 2024年第1期15卷 36-53页

作者： Robert J. Lascano Timothy s. Goebel Dennis C. Gitz III john E. stout Cropping systems Research Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland cotton production in Martin County, Texas, measuring cotton lint yield per unit of rainfall. Our goal is to collect rainfall data per 250 - 400 ha. Upon selection of a rainfall gauge, we realized that the cost of using, for example, a tipping bucket-type rain gauge would be too expensive and thus searched for an alternative method. We selected an all-in-one commercially available weather station;hereafter, referred to as a Personal Weather station (PWs) that is both wireless and solar powered. Our objective was to evaluate average measurements of rainfall obtained with the PWs and to compare these to measurements obtained with an automatic weather station (AWs). For this purpose, we installed four PWs deployed within 20 m of the Plant stress and Water Conservation Meteorological Tower that was used as our AWs, located at UsDA-ARs Cropping systems Research Laboratory, Lubbock, TX. In addition, we measured and compared hourly average values of short-wave irradiance (Rsub>gsub>), air temperature (Tsub>airsub>) and relative humidity (RH), and wind speed (Ws), and calculated values of dewpoint temperature (Tsub>dewsub>). This comparison was done over a 242-day period (1 October 2022-31 May 2023) and results indicated that there was no statistical difference in measurements of rainfall between the PWs and AWs. Hourly average values of Rsub>gsub> measured with the PWs and AWs agreed on clear days, but PWs measurements were higher on cloudy days. There was no statistical difference between PWs and AWs hourly average measurements of Tsub>airsub>, RH, and calculated Tsub>dewsub>. Hourly average measurements of Rsub>gsub> and Ws were more variable. We concluded that the PWs we selected will provide adequate values of rainfall and other weather variables to meet our goal of evaluating dryland cotton lint yield per unit rainfall.

关键词： Automation sensors Citizen Weather station Mesonet Rainfall Weather Variables

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A survey on Event Tracking in social Media Data streams

引用

Big Data Mining and Analytics 2024年第1期7卷 217-243页

作者： Zixuan Han Leilei shi Lu Liu Liang Jiang Jiawei Fang Fanyuan Lin Jinjuan Zhang john Panneerselvam Nick Antonopoulos school of Computer science and Communication Engineering and Jiangsu Key Laboratory of security Technology for Industrial Cyberspace Jiangsu UniversityZhenjiang 212013China school of Computing and Mathematical sciences University of LeicesterLeicesterLE17RHUK Ocean College Jiangsu University of Science and TechnologyZhenjiang 212100China University Executive Office Edinburgh Napier UniversityEdinburghEH114BNUK

social networks are inevitable parts of our daily life,where an unprecedented amount of complex data corresponding to a diverse range of applications are *** such,it is imperative to conduct research on social events and patterns from the perspectives of conventional sociology to optimize services that originate from social *** tracking in social networks finds various applications,such as network security and societal governance,which involves analyzing data generated by user groups on social networks in real ***,as deep learning techniques continue to advance and make important breakthroughs in various fields,researchers are using this technology to progressively optimize the effectiveness of Event Detection(ED)and tracking *** this regard,this paper presents an in-depth comprehensive review of the concept and methods involved in ED and tracking in social *** introduce mainstream event tracking methods,which involve three primary technical steps:ED,event propagation,and event ***,we introduce benchmark datasets and evaluation metrics for ED and tracking,which allow comparative analysis on the performance of mainstream ***,we present a comprehensive analysis of the main research findings and existing limitations in this field,as well as future research prospects and challenges.

关键词： Event Detection(ED) event propagation event evolution social networks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing strengths,Limitations,and Its Therapeutic Landscape Position

引用

Biomedical and Environmental sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue sAFAYET Jamil OLALEKAN john Okesanya DON Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Misty Mood of Chinese shoegaze

引用

城市漫步（GBA版） 2024年第5期 12-17页

作者： Kirby john Carney 不详

Music likeshoegaze can easily hypnotize youwith itsdreamlike,*** atmospheric indie rock subgenrefirst emerged in the UK in the late1980s,pioneered bybands such as My Bloody Valentine and *** has unexpectedly embraced shoegaze in recent *** chilled seasidevibes of Xiamen tothe urban pulse of shanghai,an underground community of Chinese shoegazers has been steadily crafting their own wistful,immersive sound.

关键词： Xiamen indie underground

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Another ssOR Iteration Method

引用

American Journal of Computational Mathematics 2024年第2期14卷 248-256页

作者： Thomas smotzer john Buoni Department of Mathematics and statistics Youngstown State University Youngstown Ohio USA

Kellogg gave a version of the Peaceman-Radford method. In this paper, we introduce a ssOR iteration method which uses Kellogg’s method. The new algorithm has some advantages over the traditional ssOR algorithm. A Cyc... 详细信息

关键词： Matrix splitting ssOR Iteration KssOR Iteration Method Kellogg-Type ssOR Iteration Cyclic Reduction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Warm Reception for the Year of the Dragon

引用

国际人才交流 2024年第3期 61-62页

作者： Michael john Harrold Documentary Dept CGTN

A dragon year,so I read somewhere,is one in which,individually and collectively,we are filled with energy and ***’s supposed to be a year of transformation,good fortune and prosperity;all of which,it seems to me,is j... 详细信息

关键词： collective filled dragon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain Research on Mental Disorders: A Criticism

引用

Open Journal of Medical Psychology 2024年第3期13卷 71-85页

作者： john R. Rossiter Faculty of Business and Law University of Wollongong Wollongong Australia school of Psychology Charles Sturt University Wagga Wagga Australia

Objective: To expose the problems and inherent limitations of neuroscience-based brain research on mental disorders. Method: Discussion of the theory underlying brain research on mental disorders, followed by a systematic evaluation of typical studies. Results: The fundamental problem is that brain researchers fail to differentiate between biological mental disorders in which brain processes cause the disorder (notably schizophrenia, bipolar disorder, and melancholic depression) and learned mental disorders in which brain processes mediate but do not cause the disorder (which is the case with reactive depression, reactive anxiety, OCD, and PTsD). Researchers have been unsuccessful in identifying mechanisms in the brain that cause biological mental disorders, and will never be able to locate the innumerable specific neural connections that mediate learned mental disorders. Moreover, the author’s review of typical studies in this field shows that they have serious problems with theory, measurement, and data analysis, and that their findings cannot be trusted. Conclusions: Neuroscience-based brain research on mental disorders, unlike other neurological research, has been an expensive failure and it is not worth continuing.

关键词： Neuroscience-Based Brain Research Biological Mental Disorders Learned Mental Disorders Research Problems

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：