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HP30-2, a mitochondr.al Pr.T pr.tein for.impor. of signal sequence-less pr.cur.or.pr.teins in Ar.bidopsis thaliana

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Jour.al of Integr.tive Plant Biology 2017年第8期59卷 535-551页

作者： Claudia r.ssig john gray Oscar.Valdes Sachin r.stgi Diter.von w.ttstein Chr.stiane r.inbothe Steffen r.inbothe Labor.tor. of Plant Molecular.Genetics and Labor.tor. of Envir.nmental and Systems Biology Grenoble-Alpes-University Grenoble France Depar.ment of Biological Sciences University of Toledo 2801 West Bancroft Street Toledo OH 43606 USA Depar.ment of Plant and Envir.nmental Sciences Pee Dee Research and Education Center Clemson University Florence SC 29506 USA Depar.ment of Cr.p and Soil Sciences Washington State University Pullman WA 99164-6420 USA

Chlor.plasts and mitochondr.a contain a family of putative pr.pr.tein and amino acid tr.nspor.er. designated Pr.T. Her., w. analyzed the r.le of tw. pr.viously char.cter.zed Pr.T pr.tein family member., encoded by At3g49560 （HP30） and At5g24650 （HP30-2）, in planta using a combination of genetic, cell biological and biochemical appr.aches. Expr.ssion studies and gr.en fluor.scent pr.tein tagging identified HP30-2 both in chlor.plasts and mitochondr.a, w.er.as HP30 w.s located exclusively in chlor.plasts. Biochemical evidence w.s obtained for.an association of mitochondr.al HP30-2 w.th tw. distinct pr.tein complexes, one containing the inner.membr.ne tr.nslocase TIM22 and the other.containing an alter.ative NAD（P）H dehydr.genase subunit （NDCI） implicated in a r.spir.tor. complex 1-1ike electr.n tr.ns- por. chain. Thr.ugh its association w.th TIM22, HP30-2 is involved in the uptake of car.ier.pr.teins and other. hydr.phobic membr.ne pr.teins lacking cleavable N H2-ter.inal pr.sequences, w.er.as HP30-2＇s inter.ction w.th NDC1 may per.it contr.lling mitochondr.al biogenesis and activity.

关键词： of as et in HP30-2,a mitochondr.al Pr.T pr.tein for.impor. of signal sequence-less pr.cur.or.pr.teins in Ar.bidopsis thaliana for Figur. NDC w.r. TIM r.Ai that

Individualized vaginal applicator.for.stage IIb pr.mar. vaginal adenocar.inoma:A case r.por.

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w.r.d Jour.al of Clinical Oncology 2024年第8期15卷 1102-1109页

作者： Saijilafu Yan-Jun Gu Ai-w. Huang Chang-Fen xu Li-w.n Qian Hangzhou Lin'an Tr.ditional Chinese Medicine Hospital Affiliated HospitalHangzhou City UniversityHangzhou 311300Zhejiang ProvinceChina Depar.ment of r.diation Oncology Sir Run Run Shaw HospitalHangzhou 310016Zhejiang ProvinceChina Depar.ment of the Gynecology and Obstetr.cs Hangzhou Lin'an Traditional Chinese Medicine HospitalAffiliated HospitalHangzhou City UniversityHangzhou 311300Zhejiang ProvinceChina

BACKGr.UND Pr.mar. vaginal cancer.is r.r. and most vaginal tumor. ar. metastatic,often ar.sing fr.m adjacent gynecologic *** vaginal cancer. ar. also mor. common among postmenopausal w.men and most of these ar. squamous cell car.inomas,w.th adenocar.inomas being r.latively *** bleeding is the most common clinical manifestation of vaginal *** 70%of vaginal adenocar.inomas ar. stage I lesions at the time of diagnosis,for.w.ich r.dical sur.er. is ***,mor. advanced vaginal cancer. ar. not amenable to r.dical sur.ical tr.atment and have poor.clinical *** tr.atments modes ar. still being ***,w. r.por. a r.r. case of stage IIb pr.mar. vaginal adenocar.inoma for.w.ich an individually designed vaginal applicator.for.after.loading r.diother.py w.s used to achieve good tumor.*** SUMMAr. A 62-year.old w.man pr.sented to our.clinic after.3 months of abnor.al postmenopausal vaginal *** examination,computed tomogr.phy(CT),and positr.n emission tomogr.phy-CT show.d a lar.e mass(about 5 cm)on the anter.or.vaginal *** biopsy confir.ed adenocar.inoma of vaginal *** thr.e cycles of car.oplatin plus paclitaxel chemother.py,the lesion par.ially *** patient then r.ceived exter.al ir.adiation of 45 gray(gy)in 25 fr.ctions,w.ich fur.her.r.duced the vaginal lesion,follow.d by after.loading r.diother.py of 30 gy in 5 fr.ctions w.th an individually designed vaginal *** months later.magnetic r.sonance imaging show.d a slight thickening CONCLUSION Pr.mar. vaginal adenocar.inoma is r.r.,and pr.gnosis is poor.in most vaginal cancer. of locally advanced stages,w.ich cannot be tr.ated w.th r.dical *** tumor.contr.l can be achieved w.th an individualized vaginal applicator.that allow. administr.tion of a higher.r.dical dose to the tumor.ar.a w.ile pr.tecting nor.al tissues.

关键词： Pr.mar. vaginal adenocar.inoma After.loading r.diother.py Vaginal applicator Tumor.contr.l Case r.por.

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湖南省农业碳排放特征及碳达峰分析

中国生态农业学报（中英文） 2024年第2期32卷 206-217页

作者：邓维忠许中坚湖南科技大学资源环境与安全工程学院湘潭411201 湖南科技大学煤炭资源清洁利用与矿山环境保护湖南省重点实验室湘潭411201

了解湖南省农业碳排放特征及影响因素,可为湖南省绿色低碳农业发展提供科学依据。基于统计年鉴对作物种植面积、农业物资投入量及畜禽养殖量进行数据整合,利用联合国政府间气候变化专门委员会经典碳排放计算理论计算湖南省2007—2020年... 详细信息

了解湖南省农业碳排放特征及影响因素,可为湖南省绿色低碳农业发展提供科学依据。基于统计年鉴对作物种植面积、农业物资投入量及畜禽养殖量进行数据整合,利用联合国政府间气候变化专门委员会经典碳排放计算理论计算湖南省2007—2020年间农业碳排放量。以2007年为基期年,采用Kaya碳排式和对数均值迪氏分解法(Logar.thmic Mean Divisia Index,以下简称LMDI)分析其影响因素,并引入灰色预测模型[gray for.casting model,以下简称GM(1,1)]预测湖南省2021—2040年间碳排放量。计算结果表明,湖南省农业碳排放量呈现出三段式变化:因2008年特大冰雪灾害对农业产生严重影响,农业碳排放量在2007—2008年间呈下降趋势;2009—2015年稳步上升并于2015年达到峰值(6550万t);2015—2020年间整体呈现下降趋势。与此同时,不同地市间存在明显差异:长沙、湘潭、衡阳、邵阳、岳阳、常德、益阳于2015年前后达峰,而其他地市,如株洲、张家界、郴州、永州、怀化、湘西在2018年前均有一段平稳上升期,娄底波动上升,因此难以在2030年前实现碳达峰。湖南省各地市农业碳排放强度呈下降趋势,2007年农业碳排放强度越大的地市其在后续年份中农业碳排放强度下降幅度越大。2007—2020年间各地市农业碳排放量平均变异系数为42%,农业碳排放强度平均变异系数为20%,说明地市之间的农业碳排放量差异程度远大于农业碳排放强度差异程度。农业碳排放源排放占比从大到小依次为:农田土地利用>畜禽养殖>农资投入。地区经济发展水平、劳动力水平和农村总用电量对增加农业碳排放量起主要作用,其中地区经济发展水平、农村总用电量是主要影响因素;农业生产效率、农业产业结构、地区产业结构、农村居民人均用电量的倒数在农业碳排放量减少的过程中起重要作用。本文提出优化产业结构、各地因地制宜地推动绿色创新、加强政府职能等建议,以期为湖南省农业碳减排决策提供参考。

关键词：农业碳排放碳排放强度时空特征碳达峰碳减排 LMDI模型灰色预测模型湖南省

New.insight into inter.or.an cr.sstalk contr.buting to the pathogenesis of non- alcoholic fatty liver.disease （NAFLD）

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Pr.tein & Cell 2018年第2期9卷 164-177页

作者： xu Zhang xuetao Ji Qian w.ng john Zhong Li Depar.ment of Biochemistr. and Molecular.Biology School of Basic Medical Sciences Nanjing Medical University Nanjing 211166 China Jiangsu Pr.vince Key Labor.tor. of Human Functional Genomics Nanjing Medical University Nanjing 211166 China

Non-alcoholic fatty liver.disease （NAFLD） is the most common cause of chr.nic liver.dysfunction and a sig- nificant global health pr.blem w.th substantial r.se in pr.valence over.the last decades. It is becoming incr.asingly clear.that NALFD is not only pr.dominantly a hepatic manifestation of metabolic syndr.me, but also involves extr.-hepatic or.ans and r.gulator. pathw.ys. Ther.peutic options ar. limited for.the tr.atment of NAFLD. Accor.ingly, a better.under.tanding of the pathogenesis of NAFLD is cr.tical for.gaining new.insight into the r.gulator. netw.r. of NAFLD and for.identifying new.tar.ets for.the pr.vention and tr.atment of NAFLD. In this r.view. w. emphasize on the cur.ent under.tanding of the inter.or.an cr.sstalk betw.en the liver.and per.pher.l or.ans that contr.buting to the pathogenesis of NAFLD.

关键词： non-alcoholic fatty liver.disease hepatic lipid metabolism hypothalamus gut-liver.axis adipose tissue

基于数据-模型融合驱动的新能源场站宽频阻抗在线辨识及稳定性评估

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中国电机工程学报 2024年第7期44卷 2670-2684,I0013页

作者：饶仪明吕敬王众蔡旭电力传输与功率变换控制教育部重点实验室(上海交通大学) 上海市闵行区200240

风电、光伏等新能源在电网中的渗透率不断提高,导致一系列宽频振荡问题。阻抗法是研究新能源并网系统宽频振荡稳定性的有效方法之一,然而由于商业化新能源机组的“黑/灰箱”问题、新能源场站运行状态的随机不确定性等因素,导致新能源场... 详细信息

风电、光伏等新能源在电网中的渗透率不断提高,导致一系列宽频振荡问题。阻抗法是研究新能源并网系统宽频振荡稳定性的有效方法之一,然而由于商业化新能源机组的“黑/灰箱”问题、新能源场站运行状态的随机不确定性等因素,导致新能源场站的精确阻抗/导纳建模困难。为此,提出基于数据-模型融合驱动的新能源场站宽频阻抗/导纳在线辨识方法,针对输入随机不确定的新能源机组,采用数据驱动方法建立其覆盖整个稳态运行工况的宽频阻抗/导纳辨识模型,然后结合新能源场站的物理结构模型,构建数据-模型融合驱动的新能源场站宽频阻抗/导纳在线辨识模型。最后,以风电并网系统为例,利用建立的导纳辨识模型对风电并网系统的宽频振荡稳定性进行在线评估,并通过时域仿真验证稳定性在线分析的正确性。

关键词：数据驱动风电场神经网络阻抗导纳稳定性在线评估

Metabolomic Pr.filing in Selaginella lepidophylla at Var.ous Hydr.tion States Pr.vides New.Insights into the Mechanistic Basis of Desiccation Toler.nce

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Molecular.Plant 2013年第2期6卷 369-385页

作者： Abou Yobi Ber.ar. w.M. w.ne w.nxin xu Danny C. Alexander.Lining Guo john A. r.als Melvin J. Oliver.john C. Cushman Depar.ment of Biochemistr. and Molecular.Biology University of Nevada Reno NV 89557-0330 USA Depar.ment of Biological Sciences University of Nevada Reno NV 89557-0314 USA Metabolon Inc. 800 Capitola Drive Suite 1 Durham NC 27713 USA US Depar.ment of Agr.cultur.-Agr.cultur.l r.sear.h Ser.ice Plant Genetic Research Unit University of Missouri Columbia MI 65211 USA

Selaginella lepidophylla is one of only a few.species of spike mosses （Selaginellaceae） that have evolved des-iccation toler.nce （DT） or.the ability to ＇r.sur.ect＇ fr.m an air.dr.ed state. In or.er.to under.tand the metabolic basis of DT, S, lepidophylla w.s subjected to a five-stage, r.hydr.tion/dehydr.tion cycle, then analyzed using non-biased, global metabolomics pr.filing technology based on GC/MS and UHLC/MS/MS2 platfor.s. A total of 251 metabolites including 167 named （66.5%） and 84 （33.4%） unnamed compounds w.r. char.cter.zed. Only 42 （16.7%） and 74 （29.5%） of compounds show.d significantly incr.ased or.decr.ased abundance, r.spectively, indicating that most compounds w.r. pr.duced con-stitutively, including highly abundant tr.halose, sucr.se, and glucose. Sever.l glycolysis/gluconeogenesis and tr.car.oxylic acid （TCA） cycle inter.ediates show.d incr.ased abundance at 100% r.lative w.ter.content （r.C） and 50% r.C. Vanillate, a potent antioxidant, w.s also mor. abundant in the hydr.ted state. Many differ.nt sugar.alcohols and sugar.acids w.r. mor. abundant in the hydr.ted state. These polyols likely deceler.te the r.te of w.ter.loss dur.ng the dr.ing pr.cess as w.ll as slow.w.ter.absor.tion dur.ng r.hydr.tion, stabilize pr.teins, and scavenge r.active oxygen species （r.S）. In contr.st, nitr.gen-r.ch and y-glutamyl amino acids, citr.lline, and nucleotide catabolism pr.ducts （e.g. allantoin） w.r. mor. abundant in the dr. states, suggesting that these compounds might play impor.ant r.les in nitr.gen r.mobilization dur.ng r.hydr.tion or.in r.S scavenging. UV-pr.tective compounds such as 3-（3-hydr.xyphenyl）pr.pionate, apigenin, and nar.ngenin, w.r. mor. abundant in the dr. states. Most lipids w.r. pr.duced constitutively, w.th the exception of choline phosphate, w.ich w.s mor. abundant in dr. states and likely plays a r.le in membr.ne hydr.tion and stabilization. In contr.st, sever.l poly- unsatur.ted fatty acids w.r. mor. abundant in the hydr.ted states, suggestin

关键词： abiotic/envir.nmental str.ss mass spectr.metr. metabolomics oxidative/photooxidative str.ss desiccationtoler.nce Selaginella.

COOr.INATION OF INTEr.ATIONAL BEDLOAD r.SEAr.H

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COORDINATION OF INTERNATIONAL BEDLOAD RESEARCH

基于w.ier.tr.ss-Mandelbr.t函数的岩体裂隙映射重构

第九次河流泥沙国际学术大会

作者： john r.gray Jonathan B.LAr.NNE U.S. Geological Sur.ey Reston Virginia U.S.A. 20192. The Ben Gur.on Univer.ity of the Negev Beer Sheva 84105 Israel.

＜正＞The state of the science of bedload r.sear.h and monitor.ng in the last quar.er.centur. has pr.gr.ssed at a much slow.r.r.te than that for.suspended sediment due to a number.of constr.ints. Most tr.ditional devices still entail r.utine collection and subsequent analyses of physical samples. The amount and r.liability of the bedload data r.main limited by the char.cter.stics of the collecting instr.ment, vagar.es associated w.th manual deployment, a lack of tempor.l continuity in measur.ments, and hydr.ulic and bed conditions. Acceptable and quantifiably accur.te measur.ment of bedload dischar.e at discr.te time inter.als, let alone as a time ser.es, is r.r.ly an attainable goal. The accur.cy of equations for.estimating bedload tr.nspor., pr.dicated on data r.liability, r.mains unquantifiable for.most conditions. On-going r.sear.h on bedload-measur.ment instr.ments and measur.ng techniques has been taking place on an ad hoc basis w.thin and betw.en var.ous countr.es, w.th little coor.ination among r.sear.her.. Bedload studies often lack adequate funding and adequate local or.institutional scientific suppor.. w. pr.pose establishing a Bedload r.sear.h Inter.ational Cooper.tive （Br.C） to addr.ss some of these constr.ints. The Br.C w.uld be by, for. and r.sponsive to the inter.ational bedload r.sear.h and monitor.ng community. It w.uld pr.vide an inter.ational focal point for.bedload r.sear.h, methods development and data shar.ng. Member.hip w.uld be fr.e, as w.uld be acquisition of Br.C data. Infor.ation compiled and disseminated as par. of the Br.C w.uld enable coor.ination of r.sear.h to fill cr.tical gaps in our.know.edge of bedload pr.cesses and measur.ment techniques. The concept of the Br.C is evolving;suggestions ar. sought as the concept matur.s.

关键词： Bedload Bedload monitor.ng Bedload r.sear.h Inter.ational collabor.tion

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岩土力学 2024年第10期45卷 3058-3070页

作者：刘宏伟陈世江许有俊张旭鲍先凯内蒙古科技大学土木工程学院内蒙古包头014010 内蒙古科技大学矿山安全与地下工程院士工作站内蒙古包头014010 内蒙古科技大学内蒙古自治区高校城市地下工程研究中心内蒙古包头014010 六盘水师范学院矿业与机械工程学院贵州六盘水553004

重构岩体裂隙对精准构建裂隙岩体模型以及准确获取其力学性质具有重要意义。鉴于此,为使重构裂隙与天然状态相吻合,提出了D-n_(max)阈值公式,修正了用于岩体裂隙模拟的w.ier.tr.ss-Mandelbr.t(w.M)函数。通过二值化灰度图像对Bar.on10... 详细信息

重构岩体裂隙对精准构建裂隙岩体模型以及准确获取其力学性质具有重要意义。鉴于此,为使重构裂隙与天然状态相吻合,提出了D-n_(max)阈值公式,修正了用于岩体裂隙模拟的w.ier.tr.ss-Mandelbr.t(w.M)函数。通过二值化灰度图像对Bar.on10条剖面线进行数字化,经试错法及综合分析法,以等差方式确定10个粗糙度水平的Hur.t值。通过对10条剖面线进行傅里叶变换得到了幅值特征新参数Spp,结合起伏角标准差σ_i线性构建新裂隙粗糙度系数(joint r.ughness coefficient,简称Jr.)计算公式。采用二分法获得目标Jr.值对应w.M函数的最佳尺度常数G值,建立了Jr.与w.M函数的映射关系。w.M函数考虑了随机项,实现了重构裂隙的差异化。对重构裂隙进行粗糙度定量化研究和室内试验,验证了新参数Spp、新Jr.计算公式及映射关系的有效性。所作研究为拓展岩体裂隙获取方法提供了新的思路,为裂隙岩体力学性质研究奠定了基础。

关键词：岩体裂隙自仿射分形 w.ier.tr.ss-Mandelbr.t函数裂隙粗糙度系数(Jr.) 映射重构

Numer.cal investigation of par.icle saltation in the bed-load r.gime

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Science China(Technological Sciences) 2014年第8期57卷 1500-1511页

作者： JI ChunNing ANTE Munjiza ELDAD Avital xu Dong john w.lliams State Key Labor.tor. of Hydr.ulic Engineer.ng Simulation and Safety Tianjin University School of Engineer.ng & Mater.als Science Queen MaryUniversity of London

This paper.numer.cally investigates par.icle saltation in a tur.ulent channel flow.having a r.ugh bed consisting of 2–3 layer. of densely packed *** this study,w. combined thr.e the state-of-the-ar. technologies,i.e.,the dir.ct numer.cal simulation of tur.ulent flow.the combined finite-discr.te element modelling of the defor.ation,movement and collision of the par.icles,and the immer.ed boundar. method for.the fluid-solid *** w. ver.fy our.code by compar.ng the flow.and par.icle statistical featur.s w.th the published data and then pr.sent the hydr.dynamic for.es acting on a par.icle together.w.th the par.icle coor.inates and velocities,dur.ng a typical *** found str.ng cor.elation betw.en the abr.ptly decr.asing par.icle str.am-w.se velocity and the incr.asing ver.ical velocity at collision,w.ich indicates that the continuous saltation of lar.e gr.in-size par.icles is contr.lled by collision par.meter. such as par.icle incident angle,local r.ugh bed packing ar.angement,and par.icle density,*** physical pr.cess is differ.nt fr.m that of par.icle entr.inment in w.ich tur.ulence coher.nce str.ctur.s play an impor.ant *** distr.bution functions of sever.l impor.ant saltation par.meter. and the r.lationships betw.en them ar. *** r.sults show.that the saltating par.icles hitting the w.ndw.r. side of the bed par.icles ar. mor. likely to bounce off the r.ugh bed than those hitting the *** on the above findings,saltation mechanisms of lar.e gr.in-size par.icles in tur.ulent channel flow.ar. pr.sented.

关键词： par.icle saltation bed-load r.gime hydr.dynamic for.es tur.ulent channel flow