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神经元突触内的非受体型酪氨酸激酶底物（英文）

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生理学报 2017年第5期69卷 657-665页

作者：毛利民 Ryan Geosling Brian Penman 王强密苏里州立大学医学院基础医学系密苏里州立大学医学院麻醉学系

非受体型酪氨酸激酶(non-receptor tyrosine kinase,nRTK)是一个较大的激酶家族,其功能是催化蛋白的酪氨酸磷酸化。nRTK家族中的几种常见亚型,比如Src和Fyn,可以在神经系统内表达。近年来的研究表明,神经元的突触部位含有多个nRTK的底... 详细信息

非受体型酪氨酸激酶(non-receptor tyrosine kinase,nRTK)是一个较大的激酶家族,其功能是催化蛋白的酪氨酸磷酸化。nRTK家族中的几种常见亚型,比如Src和Fyn,可以在神经系统内表达。近年来的研究表明,神经元的突触部位含有多个nRTK的底物蛋白,这些底物蛋白主要包括谷氨酸受体(离子型和代谢型谷氨酸受体)、突触后构架蛋白、突触前调节蛋白和突触富含的多种蛋白激酶。在基础或刺激的状态下,nRTK可催化这些底物蛋白内特定酪氨酸的磷酸化,从而调节这些底物蛋白的多种生理、生化和生物物理功能。因为突触内的nRTK对突触变化信号非常敏感,所以突触nRTK被认为参与了突触传导活动的强度和效率等方面的调节。

关键词： N-甲基-D-天冬氨酸受体 AMPA 代谢型谷氨酸受体突触后密度蛋白95 Src Fyn ERK Cdk5 突触素突触蛋白 I

可卡因成瘾的转化和反向转化研究:未来的药物治疗

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转化医学研究（电子版） 2014年第3期4卷 19-30页

作者：薛冰王强密苏里大学堪萨斯城分校医学院基础医学系美国密苏里州堪萨斯城MO64108 北京脑重大疾病研究院首都医科大学北京100069

可卡因(cocaine)成瘾是一种经历依赖性精神障碍,其在医疗、社会和经济等方面所造成的危害日益严重。近年来,通过动物模型的临床前研究,我们加深了对可卡因成瘾的神经化学机制的了解。这些新的知识,促进了对可卡因成瘾的"bench-to-bed"... 详细信息

可卡因(cocaine)成瘾是一种经历依赖性精神障碍,其在医疗、社会和经济等方面所造成的危害日益严重。近年来,通过动物模型的临床前研究,我们加深了对可卡因成瘾的神经化学机制的了解。这些新的知识,促进了对可卡因成瘾的"bench-to-bed"的转化研究。同时,越来越标准化的药物治疗也促进了药物成瘾的"clinie-to-bench"的反向转化研究。本文综述了近年来可卡因成瘾的转化与反向转化研究的最新进展,重点介绍多巴胺和谷氨酸系统在调节中脑边缘奖赏环路中的作用以及在新药转化研究中的重要贡献。

关键词：转化研究多巴胺谷氨酸可卡因成瘾药物治疗

Tree species identity and interaction determine vertical forest structure in young planted forests measured by terrestrial laser scanning

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Forest Ecosystems 2024年第3期11卷 266-275页

作者： Mengxi wang Lander Baeten Frieke Van Coillie Kim Calders Kris Verheyen quentin Ponette Haben Blondeel Bart Muys john Armston Hans Verbeeck q-ForestLab Department of EnvironmentFaculty of Bioscience EngineeringGhent UniversityBelgium Forest&Nature Lab Department of EnvironmentFaculty of Bioscience EngineeringGhent UniversityBelgium Earth and Life Institute Université Catholique de Louvain(UCLouvain)Louvain-la-NeuveBelgium Department of Earth&Environmental Sciences KU LeuvenBelgium Department of Geographical Sciences University of MarylandCollege ParkMDUSA

Vertical forest structure is closely linked to multiple ecosystem characteristics,such as biodiversity,habitat,and *** tree species in planted forests has the potential to create diverse vertical forest structures due to the different physiological and morphological traits of the composing tree ***,the relative importance of species richness,species identity and species interactions for the variation in vertical forest structure remains unclear,mainly because traditional forest inventories do not observe vertical stand structure in *** laser scanning(TLS),however,allows to study vertical forest structure in an unprecedented ***,we used TLS single scan data from 126 plots across three experimental planted forests of a largescale tree diversity experiment in Belgium to study the drivers of vertical forest *** plots were 9–11years old young pure and mixed forests,characterized by four levels of tree species richness ranging from monocultures to four-species mixtures,across twenty composition *** generated vertical plant profiles from the TLS data and derived six stand structural *** mixed models were used to test the effect of species richness on structural *** a hierarchical diversity interaction modelling framework,we further assessed species identity effect and various species interaction effects on the six stand structural *** results showed that species richness did not significantly influence most of the stand structure variables,except for canopy height and foliage height *** identity on the other hand exhibited a significant impact on vertical forest structure across all *** interaction effects were observed to be site-dependent due to varying site conditions and species pools,and rapidly growing tree species tend to dominate these ***,our results highlighted the importance of considering both species identity an

关键词： TreeDivNet FORBIO Stand structural complexity Terrestrial laser scanning Vertical forest structure Tree diversity Planted forests

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铁磁绝缘体中磁振子的非平衡稳态输运性质

物理学报 2024年第14期73卷 214-221页

作者：杨栋超易立志丁林杰刘敏朱丽娅许云丽何雄沈顺清潘礼庆 john q.Xiao 三峡大学理学院湖北省弱磁探测工程技术研究中心宜昌443002 三峡学院物理系重庆404100 香港大学物理系中国香港999077 Department of Physics and Astronomy University of DelawareNewark 19716USA

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化... 详细信息

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化学势μm的玻色-爱因斯坦统计函数引入到玻尔兹曼输运方程中,获得了以为幂次的输运方程严格解析表达式(当α(=-μm/(k_(B)T))<1时).结果显示,当α<<1时,我们得到了与以往研究不同的化学势μm与非平衡粒子浓度δn_(m)之间的非线性关系δn_(m)∝-α^(1/2)α-(-μm)^(1/2)α;较大时,则还须考虑其高阶项.正因这种非线性关系,导致磁振子扩散方程显著不同于电子自旋扩散特性,其由线性微分方程演变为更复杂的非线性微分方程.本文重点研究了在两种极端温度梯度(即■T~1K/mm和10^(4)K/mm)下非平衡磁振子浓度δn_(m)和化学势μm的空间分布,它们分别对应于μm的值约为-0.1μeV和-6.2meV,均满足前提条件α<1.在远离平衡态的大温度梯度分布下,本文理论计算与实验结果吻合很好.这些理论研究结果将加深人们对铁磁绝缘体中磁振子非平衡输运行为的认识.

关键词：磁振子非平衡输运化学势磁振子扩散方程玻尔兹曼输运方程

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American government The Essentials James q. Wilson, john J. Dilulio 8th ed.; postinaugural ed.

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American government The Essentials James Q. Wilson, John J. ...

Inhibition of the MAPK/ERK cascade: a potential transcription-depen-dent mechanism for the amnesic effect of anesthetic propofol

2001年

作者： James q. Wilson john J. Dilulio

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Neuroscience Bulletin 2007年第2期23卷 119-124页

作者： Eugene E. FIBUCH john q. wang 密苏里-堪萨斯大学医学院圣鲁克医院麻醉科

Intravenous anesthetics are known to cause amnesia, but the underlying molecular mechanisms remain elusive. To identify a possible molecular mechanism, we recently turned our attention to a key intracellular signaling pathway organized by a family of mitogen-activated protein kinases （MAPKs）. As a prominent synapse-to-nucleus superhighway, MAPKs couple surface glutamate receptors to nuclear transcriptional events essential for the development and/or maintenance of different forms of synaptic plasticity （long-term potentiation and long-term depression） and memory formation. To define the role of MAPK-dependent transcription in the amnesic property of anesthetics, we conducted a series of studies to examine the effect of a prototype intravenous anesthetic propofol on the MAPK response to N-methyl-D-aspartate receptor （NMDAR） stimulation in hippocampal neurons. Our results suggest that propofol possesses the ability to inhibit NMDAR-mediated activation of a classic subclass of MAPKs, extracellular signal-regulated protein kinase 1/2 （ERK1/2）. Concurrent inhibition of transcriptional activity also occurs as a result of inhibited responses of ERK1/2 to NMDA. These findings provide first evidence for an inhibitory modulation of the NMDAR-MAPK pathway by an intravenous anesthetic and introduce a new avenue to elucidate a transcription-dependent mechanism processing the amnesic effect of anesthetics.

关键词： glutamate NMDA long-term potentiation Elk cyclic AMP response element-binding protein c-fos proteins hippocampus propofol

Left-handed materials in magnetized metallic magnetic thin films

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第1期7卷 71-75页

作者：伍瑞新 XIAO john q. Department of Electronic Sciences and Engineering Nanjing UniversityNanjing 210093 China Department of Physics and Astronomy University of Delaware Newark Delaware 19716 USA

The authors＇ theoretical investigation on the high-frequency response of magnetized metallic magnetic films showed that magnetic films may become left-handed materials （LHMs） near the ferromagnetic resonance frequency of incident waves with right-handed circular polarization （RCP） and linear polarization （LP）. The frequency range where LHM exists depends on the waves polarization, the magnetic damping coefficient, and the ferromagnetic characteristic frequency corn of the film. There also exists a critical damping coefficient ac, above which the left-handed properties disappear completely.

关键词： Left-handed materials (LHMs) Magnetic thin film Ferromagnetic resonance frequency

Solution processed MnBi-FeCo magnetic nanocomposites

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Nano Research 2016年第11期9卷 3222-3228页

作者： qilin Dai Muhammad Asif warsi john q. Xiao Shenqiang Ren Department of Mechanical Engineering Temple University Philadelphia PA 19122 USA Department of Physics University of Delaware Newark DE 19716 USA

Advanced permanent magnets based on rare-earth-free MnBi intermetallic alloys are considered energy-critical materials due to their applications in high temperature power electronics and green energy-related generators and motors, owing to their positive temperature coefficient of magnetic anisotropy. However, a direct method to achieve high saturation magnetization, without the significant loss of coercivity, is critical for attaining high performance MnBi magnets. Here, we demonstrate the synthesis and processing of magnetic nanocomposites, consisting of metal-redox MnBi nanoparticles and electro-spun FeCo nanowires. The composition ratio, processing dependent magnetism, and increased coercivity with increasing temperature, were studied in MnBi-FeCo nanocomposites. The magnetic performance of nanocomposites was dictated by interfacial coupling between magnetically hard MnBi and semi-hard FeCo nanowires, as well as the composition ratio and processing conditions. Solution processed MnBi-FeCo nanocomposites allow the potential for the development of high temperature and high performance rare-earth-free permanent magnets.

关键词： magnetic nanocomposites energy product MnBi hard magnets

Interactive Image Enhancement by Fuzzy Relaxation

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International Journal of Automation and computing 2007年第3期4卷 229-235页

作者： Shang-Ming Zhou john q.Can Li-Da Xu Robert john School of Computing De Montfort UniversityLeicester LE1 9BHUK Department of Computer Science University of EssexColchester CO3 4SQUK Department of Information Technology and Decision Sciences Old Dominion UniversityNorfolk VA23529-0218USA

In this paper, an interactive image enhancement （HE） technique based on fuzzy relaxation is presented, which allows the user to select different intensity levels for enhancement and intermit the enhancement process according to his/her preference in applications. First, based on an analysis of the convergence of a fuzzy relaxation algorithm for image contrast enhancement, an improved version of this algorithm, which is called FuzzIIE Method 1, is suggested by deriving a relationship between the convergence regions and the parameters in the transformations defined in the algorithm. Then a method called FuzzIIE Method 2 is introduced by using a different fuzzy relaxation function, in which there is no need to re-select the parameter values for interactive image enhancement. Experimental results are presented demonstrating the enhancement capabilities of the proposed methods under different conditions.

关键词： Interactive image enhancement fuzzy relaxation fuzzy set crossover point convergence.