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Challenges facing early detection of acute kidney injury in the critically ill

World Journal of Critical Care Medicine 2012年第3期1卷 61-66页

作者： john W pickering Zoltán H Endre john pickering Christchurch Kidney Research Group Department of MedicineUniversity of OtagoChristchurch 8140New Zealand Department of Nephrology Prince of Wales Clinical SchoolUniversity of New South WalesSydney NSW 2052Australia Christchurch Kidney Research Group Department of MedicineUniversity of OtagoPO Box 4345Christchurch 8140New Zealand

Recent advances in the detection of acute kidney injury(AKI) afford the possibility of early intervention. Proteomics and genomics have identified many markers of tubular cell injury, some of which are manifest in the urine. One trial has used novel injury biomarkers to recruit patients to an intervention prior to an elevation in plasma creatinine. This trial and other recent studies have shown that the use of biomarkers of injury will depend on the time the patient presents following insult to the kidney, the likely cause of that insult, and the pre-injury renal function of that patient. The definition of AKI is likely to change in the near future to include a measure of injury. We anticipate novel therapies becoming available following successful trials that utilize the methodology of early intervention following an elevated injury biomarker.

关键词： Acute kidney injury Acute renal failure Biomarkers Creatinine

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Seismic considerations for spent nuclear fuel storage in dry casks

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Engineering Sciences 2013年第3期11卷 20-30页

作者： john L Bignell Jeffrey A Smith Christopher A Jones Susan Y pickering Sandia National Laboratories Albuquerque

To aid the United States Nuclear Regulatory Commission,Sandia National Laboratories (SNL) was contracted to investigate the seismic behavior of typical dry cask storage systems. Parametric evaluations characterized the sensitivity of calculated cask response characteristics to input parameters. The parametric evaluation investigated two generic cask designs (cylindrical and rectangular),three different foundation types (soft soil,hard soil,and rock),and three different casks to pad coefficients of friction (0.2,0.55,0.8) for earthquakes with peak ground accelerations of 0.25g,0.6g,1.0g and 1.25g. A total of 1 165 analyses were completed,with regression analyses being performed on the resulting cask response data to determine relationships relating the mean (16 % and 84 % confidence intervals on the mean) to peak ground acceleration,peak ground velocity,and pseudo-spectral acceleration at 1 Hz and 5 % damping. In general,the cylindrical casks experienced significantly larger responses in comparison to the rectangular cask. The cylindrical cask experienced larger top of cask displacements,larger cask rotations (rocking),and more occurrences of cask toppling (the rectangular cask never toppled over). The cylindrical cask was also susceptible to rolling once rocking had been initiated,a behavior not observed in the rectangular cask. Cask response was not overly sensitive to foundation type,but was significantly dependent on the response spectrum employed.

关键词： dry cask storage spent nuclear fuel seismic analysis

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Team sport, power, and combat athletes are at high genetic risk for coronavirus disease-2019 severity

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Journal of Sport and Health Science 2020年第5期9卷 430-431页

作者： PIldus I.Ahmetov Oleg V.Borisov Ekaterina A.Semenova Oleg N.Andryushchenko Liliya B.Andryushchenko Edward V.Generozov Craig pickering Research Institute for Sport and Exercise Sciences Liverpool John Moores UniversityLiverpool L35AFUK Sports Genetics Laboratory St Petersburg Research Institute of Physical CultureSt Petersburg 191040Russia Department of Physical Education Plekhanov Russian University of EconomicsMoscow 115093Russia Laboratory of Molecular Genetics Central Research LaboratoryKazan State Medical UniversityKazan 420012Russia Department of Molecular Biology and Genetics Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological AgencyMoscow 119435Russia Institute for Genomic Statistics and Bioinformatics University Hospital BonnBonn 53127Germany Department of Physical Education Financial University under the Government of the Russian FederationMoscow 125167Russia School of Sport and Wellbeing Institute of Coaching and PerformanceUniversity of Central LancashirePreston PR12HEUK

Dear editor,As government restrictions put in place to slow the acceleration of the coronavirus disease-2019(COVID-19)pandemic start to ease,many people,including elite athletes,will begin to return back to their norm... 详细信息

关键词： severity respiratory return

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