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检索条件"作者=John Paul shen, Dongxin Zhao, Dan Du, Assen Roguev, Jason F Kreisberg, Nevan Krogan, Lei Qi, Trey Ideker, Prashant Mali"
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Nat Methods:利用CRISPR-Cas9组合筛选发现癌症弱点
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现代生物医学进展 2017年 第17期17卷 I0001-I0001页
作者: john paul shen, Ana Bojorquez-Gomez, Katherine Licon, Kristin Klepper, daniel Pekin, Alex N Beckett, Kyle Salinas Sanchez, jason f kreisberg, trey ideker john paul shen, trey ideker, prashant mali john paul shen, dongxin zhao, dan du, assen roguev, jason f kreisberg, nevan krogan, lei qi, trey ideker, prashant mali dongxin zhao, Chih-Chung Kuo, prashant mali Roman Sasik, Amanda Birmingham, Aaron N Chang, trey ideker Jens Luebeck, Alex Thomas Alex Thomas, Chih-Chung Kuo, Nathan E Lewis dan du assen roguev, nevan krogan Nathan E Lewis lei qi Department of Medicine Division of Genetics University of California San Diego La Jolla California USA Moores UCSD Cancer Center La Jolla California USA The Cancer Cell Map Initiative (CCMI) La Jolla and San Francisco California USA Department of Bioengineering University of California San Diego La Jolla California USA Center for Computational Biology & Bioinformatics University of California San Diego La Jolla California USA Bioinformatics & Systems Biology Program University of California San Diego La Jolla California USA Novo Nordisk Center for Biosustainability at the University of California San Diego La Jolla California USA Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Department of Cell and Tissue Biology University of California San Francisco San Francisco California USA Department of Cellular and Molecular Pharmacology University of California San Francisco San Francisco California USA Department of Pediatrics University of California San Diego La Jolla California USA Department of Bioengineering Stanford University Stanford California USA.
导致癌症的基因突变也会削弱癌细胞,从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性(synthetic lethality)”,这是因为这些药物仅对发生突变的(或者说合成的)细胞是致命性的。在... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论