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Spatial and Temporal patterns of In Situ Sea Surface Temperatures within the Gulf of Mexico from 1901-2010

American Journal of Climate Change 2016年第3期5卷 314-343页

作者： Jason Allard john V. Clarke iii Barry D. Keim Department of physics Astronomy & Geosciences Valdosta State University Valdosta GA USA Department of Geography and Anthropology Louisiana State University Baton Rouge LA USA

This work examines the spatial and temporal patterns of seasonal sea surface temperatures (SSTs) across the Gulf of Mexico (GoM) for the period 1901-2010. The Extended Reconstructed Sea Surface Temperature, version 4 (ERSST.v4), dataset was selected for this study over other reconstructions because of its 2° × 2° grid cell spatial resolution, its recent update to adjust for known biases in SST observations, and its ability to be compared to other in situ studies of GoM SSTs. The monthly ERSST.v4 data were averaged seasonally for each year and grid cell in the GoM. Seasonal SST trends were then calculated for each grid cell with varying start dates (e.g., 1901-2010, 1911- 2010) to account for nonlinear SST changes over the study period. Results indicate that the GoM SSTs closely resemble those of global annual temperature trends: SSTs warmed from 1901 to ~1940, followed by a period with little trend or a slight cooling until the mid-1970s, and then a warming afterwards through 2010. The spatial patterns and magnitudes of SST changes, however, varied by season and location within the GoM. The spatial patterns involved gradients with latitudinal and/or longitudinal components: a southwest-northeast (warmer-cooler) gradient in winter, an east-west (warmer-cooler) gradient in spring and fall, and a northwest-southeast (warmer-cooler) gradient in summer. The magnitude of SST changes tended to be largest in summer, followed by spring, fall, and winter. The long-term (1901-2010) SST trends were significant throughout the GoM in summer and fall, but only significant towards the southwestern GoM in winter and spring. These results have implications in discussion of climate change and its impacts on tropical activity in the GoM Basin.

关键词： Sea Surface Temperature Gulf of Mexico Temperature Reconstructions Temperature Variability

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perioperative immunotherapy for pancreatic cancer is on its way

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 537-540页

作者： Christoph Springfeld peter Bailey Thilo Hackert john p.Neoptolemos Department of Medical Oncology National Center for Tumor DiseasesHeidelberg University HospitalHeidelbergGermany Department of Surgery Heidelberg University HospitalHeidelbergGermany Institute of Cancer Sciences University of GlasgowScotlandUK

Interdisciplinary perioperative treatment has greatly improved the outcome of pancreatic cancer *** on randomized,controlled phase iii clinical trials,adjuvant chemotherapy with mFOLFIRINOX(pRODIGE-24 study),gemcitabine/capecitabine(ESpAC-4)or 5-fluorouracil/gemcitabine monotherapy(ESpAC-1,CONKO-001,ESpAC-3)is now the clinical standard after curative resection(1).

关键词： chemotherapy curative FOLFIRI

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Mixed Cerebrovascular and Alzheimer’s Type pathology Mimicking Lewy Body Disease and Its possible Contribution to Cognitive Impairment in Elderly patients with Bipolar Disorder/Schizophrenia

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Open Journal of pathology 2022年第3期12卷 88-99页

作者： Andrey Frolov Lokesh Coomar Miguel A. Guzman john R. Martin iii Center for Anatomical Science and Education Department of Surgery Saint Louis University School of Medicine Saint Louis MO USA Departments of pathology and Neurology Saint Louis University School of Medicine Saint Louis MO USA

The fast aging human population requires new approaches to reliable diagnosis and proper treatment of dementia in elderly patients with psychiatric disorders such as bipolar disorder (BD) and schizophrenia (SCZ). As compared to other psychiatric disorders, BD and SCZ are characterized by increased and similar risk for dementia as well as cerebrovascular (CVD) and parkinson’s (pD) diseases independent of the patient’s age. There are reports in the literature suggesting BD and SCZ in older patients could cause dementia without contribution from the neurodegenerative diseases, including Alzheimer’s disease (AD), due to the absence of the known neuropathology associated with cognitive decline in such individuals. This view contradicts a plethora of data highlighting AD as a major cause of dementia in the elderly. This issue was addressed by examining postmortem cerebral pathology in an 83-year-old female diagnosed with BD, SCZ, and pD (D1) and comparing it to that of a second donor (D2), an age-matched male diagnosed with Lewy Body Dementia (LBD). Upon thorough histochemical and immunohistochemical examinations of both brains, the pD and LBD diagnoses in D1 and D2 were not confirmed. Instead, AD-related pathology was observed in both subjects with AD advancing to its clinical stage (mild to moderate) only in D1. Diffuse β-amyloid peptide 1-42 (Aβ1-42) staining, most likely reflecting a presence of the Aβ1-42 soluble form, was also detected in cerebellar neurons and cerebellar extracellular space in D1 and D2. Cerebrovascular pathology was pronounced and distinct in both brains and included amyloid angiopathy, hyaline atherosclerosis, microbleeds, and dilated Virchow Robin spaces in D1 as well as thick-walled blood vessels with microbleeds in D2. It was concluded that a mixed AD and cerebrovascular pathology could mimic Lewy Body Disease and potentially contribute to dementia development in elderly BD and SCZ patients.

关键词： Bipolar Disorder Schizophrenia Alzheimer’s Disease Cerebrovascular Disease Neuropathology

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Saving wild tigers:A case study in biodiversity loss and challenges to be met for recovery beyond 2010

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Integrative Zoology 2010年第4期5卷 285-299页

作者： john SEIDENSTICKER Smithsonian Conservation Biology Institute National Zoological ParkWashingtonDCUSA

Wild tigers are being *** range countries and their partners met at the 1st Asian Ministerial Conference on Tiger Conservation in January 2010 to mandate the creation of the Global Tiger Recovery program to double the number of tigers by *** 3200-3600 wild adult tigers remain,approximately half of the population estimated a decade *** now live in only 13 countries,all of which are experiencing severe environmental challenges and degradation from the effects of human population growth,brisk economic expansion,rapid urbanization,massive infrastructure development and climate *** overarching challenge of tiger conservation,and the conservation of biodiversity generally,is that there is insufficient demand for the survival of wild tigers living in natural *** allows the criminal activities of poaching wild tigers and their prey and trafficking in tiger derivatives to flourish and tiger landscapes to be *** Global Tiger Recovery program will support scaling up of practices already proven effective in one or more tiger range countries that need wider policy support,usually resources,and new transnational actions that enhance the effectiveness of individual country *** program is built on robust National Tiger Recovery priorities that are grouped into themes:(i)strengthening policies that protect tigers;(ii)protecting tiger conservation landscapes;(iii)scientific management and monitoring;(iv)engaging communities;(v)cooperative management of international tiger landscapes;(vi)eliminating transnational illegal wildlife trade;(vii)persuading people to stop consuming tiger;(viii)enhancing professional capacity of policy-makers and practitioners;and(ix)developing sustainable,long-term financing mechanisms for tiger and biodiversity conservation.

关键词： Asia biodiversity Global Tiger Recovery program panthera tigris Tiger Conservation Landscape

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Benchmarking the performance of Bayesian optimization across multiple experimental materials science domains

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npj Computational Materials 2021年第1期7卷 1742-1751页

作者： Qiaohao Liang Aldair E.Gongora Zekun Ren Armi Tiihonen Zhe Liu Shijing Sun James R.Deneault Daniil Bash Flore Mekki-Berrada Saif A.Khan Kedar Hippalgaonkar Benji Maruyama Keith A.Brown john Fisher iii Tonio Buonassisi Massachusetts Institute of Technology CambridgeMAUnited States Boston University BostonMAUnited States Singapore-MIT Alliance for Research and Technology SingaporeSingapore Air Force Research Laboratory DaytonOhioUnited States Agency for Science Technology and Research(A*STAR)SingaporeSingapore National University of Singapore SingaporeSingapore present address:Aalto University EspooFinland present address:Northwestern polytechincal University(NpU) Xi’anShaanxi P.R.China

Bayesian optimization(BO)has been leveraged for guiding autonomous and high-throughput experiments in materials ***,few have evaluated the efficiency of BO across a broad range of experimental materials *** this work,we quantify the performance of BO with a collection of surrogate model and acquisition function pairs across five diverse experimental materials *** defining acceleration and enhancement metrics for materials optimization objectives,we find that surrogate models such as Gaussian process(Gp)with anisotropic kernels and Random Forest(RF)have comparable performance in BO,and both outperform the commonly used Gp with isotropic *** with anisotropic kernels has demonstrated the most robustness,yet RF is a close alternative and warrants more consideration because it is free from distribution assumptions,has smaller time complexity,and requires less effort in initial hyperparameter *** also raise awareness about the benefits of using Gp with anisotropic kernels in future materials optimization campaigns.

关键词： optimization performance acceleration

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Computational Tools for the Integrated Design of Advanced Nuclear Reactors

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Engineering 2017年第4期3卷 518-526页

作者： Nicholas W. Touran john Gilleland Graham T. Malmgren Charles Whitmer William H. Gates iii Terrapovcer LLC Bellevue WA 98005 USA

Advanced nuclear reactors offer safe, clean, and reliable energy at the global scale. The development of such devices relies heavily upon computational models, from the pre-conceptual stages through detailed design, licensing, and operation. An integrated reactor modeling framework that enables seamless communication, coupling, automation, and continuous development brings significant new capabilities and efficiencies to the practice of reactor design. In such a system, key performance metrics （e.g., optimal fuel management, peak cladding temperature in design-basis accidents, levelized cost of electricity） can be explicitly linked to design inputs （e.g., assembly duct thickness, tolerances）, enabling an exceptional level of design consistency. Coupled with high-performance computing, thousands of integrated cases can be executed simultaneously to analyze the full system, perform complete sensitivity studies, and efficiently and robustly evaluate various design tradeoffs. Terrapower has developed such a tool-the Advanced Reactor Modeling Interface （ARMI） code system-and has deployed it to support the Terrapower Traveling Wave Reactor design and other innovative energy products currently under development. The ARMI code system employs pre-existing tools with strong pedigrees alongside many new physics and data management modules necessary for innovative design. Verification and validation against previous and new physical measurements, which remain an essential element of any sound design, are being carried out. This paper summarizes the integrated core engineering tools and practices in production at Terrapower.

关键词： Simulation Nuclear energy Electricity generation Advanced reactor Traveling wave reactor

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Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN john Okesanya DON Eliseo Lucero-prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of public Health Daffodil International UniversityDhaka-1216Bangladesh Department of public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

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A Rare Case of 83-Year-Old Transgender Female: Can Thyroid Hormone Deficiency Be Involved in Transgenderism and Gender Dysphoria?

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Advances in Sexual Medicine 2020年第2期10卷 23-40页

作者： Andrey Frolov Lauren polcaro Craig Lawson Yun Tan john R. Martin iii Center for Anatomical Science and Education Department of Surgery School of Medicine Saint Louis University Saint Louis Missouri USA

In the current report, we describe an 83-year-old biological male who self- identified as a female by legally changing his first and middle names to female ones and whose death certificate states his sex as a female. The medical history of this individual indicated complete penectomy without further specification. postmortem physical examination revealed an absence of penis with a large scrotum, transposed urethral orifice, and small testes. The histological analysis of the testes identified abnormal epithelium in the seminiferous tubules that lacked germ and Sertoli cells as well as the interstitium without Leydig cells present. The exome sequencing of the individual’s DNA using the Next Generation Sequencing (NGS) Illumina platform revealed no genetic variants associated with either penile or urethral cancer that could have explained the complete penectomy, but pointed toward a potentially impaired production of T3 and T4 thyroid hormones which could account for the observed testicular malformation. Overall, the data obtained raise an important question as to whether the thyroid hormone axis could be an important part of the hormonal architecture supporting male sexual behavior.

关键词： Transgenderism Gender Dysphoria Next Generation Sequencing Thyroid peroxidase Cilia

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Evaluation of a Wireless Solar powered personal Weather Station

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Agricultural Sciences 2024年第1期15卷 36-53页

作者： Robert J. Lascano Timothy S. Goebel Dennis C. Gitz iii john E. Stout Cropping Systems Research Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland cotton production in Martin County, Texas, measuring cotton lint yield per unit of rainfall. Our goal is to collect rainfall data per 250 - 400 ha. Upon selection of a rainfall gauge, we realized that the cost of using, for example, a tipping bucket-type rain gauge would be too expensive and thus searched for an alternative method. We selected an all-in-one commercially available weather station;hereafter, referred to as a personal Weather Station (pWS) that is both wireless and solar powered. Our objective was to evaluate average measurements of rainfall obtained with the pWS and to compare these to measurements obtained with an automatic weather station (AWS). For this purpose, we installed four pWS deployed within 20 m of the plant Stress and Water Conservation Meteorological Tower that was used as our AWS, located at USDA-ARS Cropping Systems Research Laboratory, Lubbock, TX. In addition, we measured and compared hourly average values of short-wave irradiance (Rg), air temperature (Tair) and relative humidity (RH), and wind speed (WS), and calculated values of dewpoint temperature (Tdew). This comparison was done over a 242-day period (1 October 2022-31 May 2023) and results indicated that there was no statistical difference in measurements of rainfall between the pWS and AWS. Hourly average values of Rg measured with the pWS and AWS agreed on clear days, but pWS measurements were higher on cloudy days. There was no statistical difference between pWS and AWS hourly average measurements of Tair, RH, and calculated Tdew. Hourly average measurements of Rg and WS were more variable. We concluded that the pWS we selected will provide adequate values of rainfall and other weather variables to meet our goal of evaluating dryland cotton lint yield per unit rainfall.

关键词： Automation Sensors Citizen Weather Station Mesonet Rainfall Weather Variables

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核的绿灯谈科学、外交及原子能用于和平

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国际原子能机构通报 1999年第2期41卷 2-7页

作者： john B.RITCH iii

在人类即将跨入下个千年之际,与世界的可持续发展有关的课题向能源生产者提出巨大挑战。21世纪政治舞台和市场上,将有更多考验。核能在帮助满足电力需求和抑制气候变化的威胁方面能起什么作用呢?今年9月在维也纳,IAEA大会将举办一个科... 详细信息

在人类即将跨入下个千年之际,与世界的可持续发展有关的课题向能源生产者提出巨大挑战。21世纪政治舞台和市场上,将有更多考验。核能在帮助满足电力需求和抑制气候变化的威胁方面能起什么作用呢?今年9月在维也纳,IAEA大会将举办一个科学论坛,届时重要专家将探讨核电在国际可持续发展方面的作用。在这短文中,美国大使john *** Ⅲ从世界外交成就、能源与环境目标,以及影响公众理解原子能用于和平的问题等角度,就核能的全球发展提出了非常坦率的看法。

关键词：反应堆温室气体排放可持续发展原子能核武器国家切尔诺贝利事故能源需求气候变化核能核电

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