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Contemporary outcomes of patients undergoing robotic-assisted radical cystectomy:A comparative analysis between intracorporeal ileal conduit and neobladder urinary diversions

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Asian Journal of Urology 2023年第4期10卷 446-452页

作者： Jordan m.Rich Shivaram Cumarasamy Daniel Ranti Etienne Lavallee Kyrollis Attalla john p.Sfakianos Nikhil Waingankar peter N.Wiklund Reza mehrazin Department of Urology Icahn School of Medicine at Mount SinaiNew YorkNYUSA Department of Urology Karolinska University HospitalSolnaSweden

Objective We aimed to compare perioperative and oncologic outcomes for patients undergoing robotic-assisted radical cystectomy(RARC)with intracorporeal ileal conduit(IC)and neobladder(NB)urinary *** patients undergoing RARC with intracorporeal urinary diversion between January 2017 and January 2022 at the Icahn School of medicine at mount Sinai,New York,NY,USA were *** demographics,clinical characteristics,perioperative,and oncologic outcomes were *** was estimated with Kaplan-meier *** Of 261 patients(206[78.9%]male),190(72.8%)received IC while 71(27.2%)received NB *** age was greater in the IC group(71[interquartile range,IQR 65-78]years vs.64[IQR 59-67]years,pmI was 26.6(IQR 23.2-30.4)kg/m^(2).IC group was more likely to have prior abdominal or pelvic radiation(15.8%vs.2.8%,p=0.014).American Association of Anesthesiologists scores were comparable between *** IC group had a higher proportion of patients with pathological tumor stage 2(pT2)tumors(34[17.9%]vs.10[14.1%],p=0.008)and pathological node stages pN2-N3(28[14.7%]vs.3[4.2%],pp had less median operative time(272[IQR 246-306]min vs.341[IQR 303-378]min,pmated blood loss(250[150-500]mL vs.325[200-575]mL,p=0.002).Thirty-and 90-day complication rates were 44.4%and 50.2%,respectively,and comparable between ***-Dindo grades 3-5 complications occurred in 27(10.3%)and 34(13.0%)patients within 30 and 90 days,respectively,with comparable rates between *** follow-up was 324(IQR 167-552)days,and comparable between ***-meier estimate for overall survival at 24 months was 89%for the IC cohort and 93%for the NB cohort(hazard ratio 1.23,95%confidence interval 1.05-2.42,p=0.02).Kaplan-meier estimate for recurrence-free survival at 24 months was 74%for IC and 87%for NB(hazard ratio 1.81,95%confidence interval 0.82-4.04,p=0.10).Conclusion patients undergoing intracorporeal IC urinary

关键词： Robotic Radical cystectomy Intracorporeal Ileal conduit Neobladder Urinary diversion Oncologic outcome

predicting glass structure by physics-informed machine learning

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npj Computational materials 2022年第1期8卷 1839-1847页

作者： mikkel L.Bødker mathieu Bauchy Tao Du john C.mauro morten m.Smedskjaer Department of Chemistry and Bioscience Aalborg University9220AalborgDenmark physics of AmoRphous and Inorganic Solids Laboratory(pARISlab) Department of Civil and Environmental EngineeringUniversity of CaliforniaLos AngelesCA90095USA Department of materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA

machine learning(mL)is emerging as a powerful tool to predict the properties of materials,including *** mL models with knowledge of how glass composition affects short-range atomic structure has the potential to enhance the ability of composition-property models to extrapolate accurately outside of their training ***,we introduce an approach wherein statistical mechanics informs a mL model that can predict the non-linear composition-structure relations in oxide *** combined model offers an improved prediction compared to models relying solely on statistical physics or machine learning ***,we show that the combined model accurately both interpolates and extrapolates the structure of Na_(2)O–SiO_(2)***,the model is able to extrapolate predictions outside its training set,which is evidenced by the fact that it is able to predict the structure of a glass series that was kept fully hidden from the model during its training.

关键词： glasses structure glass

“Digging in the Dirt”faecal microRNAs as dietary biomarkers of host-microbe interactions

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 292-294页

作者： Gerard m.moloney john F.Cryan Gerard Clarke Department of Anatomy&Neuroscience University College CorkCorkIreland ApC microbiome Ireland University College CorkCorkIreland Department of psychiatry and Neurobehavioural Science University College CorkCorkIreland

The role of diet and nutrition in maintaining a healthy lifestyle has become a central part of chronic disease prevention(1).Chronic conditions such as cancer,Inflammatory bowel disease(IBD)and obesity are more prevalent in people with poor diets(2).Food consumption is controlled by physiological systems such as the gut-microbiome and distinct neuroendocrine pathways that overlap to promote host nutritional gain resulting in people living longer healthier lives(3).A recent analysis of the global burden of disease by the World Health Organization(WHO),noted that factors associated with poor diet,including obesity and malnutrition,critically undermine health and *** note that undernutrition,deficiencies in key nutrients and obesity have high social and economic *** disease,cancer,diabetes,and respiratory diseases account for 77%of all diseases and are responsible for 86%of all premature deaths(4).There is an appreciation that diets that reduce or eliminate red meats and animal fats results in the reduction of many of the indicators of poor diet,such as body mass index(BmI)and levels of cholesterol in the blood.

关键词： prevention eliminate overlap

Regression of recurrent granulosa cell tumor liver metastases following selective internal radiation therapy

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Hepatobiliary & pancreatic Diseases International 2023年第4期22卷 406-408页

作者： Omar A mownah john D Leahy Jeffrey Summers Stephen m Gregory Nigel D Heaton Institute of Liver Studies King’s Healthcare PartnersKing’s College Hospital NHS Foundation TrustDenmark HillLondon SE59RSUK Department of Oncology Maidstone and Tunbridge Wells NHS TrustMaidstone ME169QQUK

Granulosa cell tumor(GCT)is the most common sex cordstromal tumor,comprising 5%of all ovarian malignancies[1].The disease course is indolent,and the majority of cases present at stage ***,metastases may develop with potential sites being peritoneum,lung,brain,liver and bone[2].Due to the rarity of the disease,published evidence for management of granulosa cell tumor liver metastases(GCTLm)is *** resection is the optimal treatment in instances where there is a high chance of achieving complete resection[3].With regards to unresectable GCTLm there is a paucity of evidence to guide treatment strategy.

关键词： metastases liver lung

prediction of pressure gradient and hold-up in horizontal liquid-liquid pipe flow

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petroleum Science 2023年第6期20卷 3766-3782页

作者： Syed Amjad Ahmed Bibin john School of mechanical Engineering Vellore Institute of TechnologyIndia Department of mechanical Engineering C Abdul Hakeem College of Engineering&TechnologyIndia

This paper aims to propose correlations to predict pressure gradient,friction factor and fluid phase hold-up in liquid-liquid horizontal pipe *** develop the correlations,experiments are conducted using high viscous oils(202 and 630 mpa⋅s)in a steel pipe of length 11.25 m and length-to-diameter ratio of *** addition,the experimental data from the literature comprising wide range of flow and fluid properties is *** the analysis,the liquid-liquid pipe flow data is categorized into two as:stratified and *** existing friction factor correlations are modified to incorporate the effects of viscosity of the oil phase,interfacial curvature(contact/wetting angle-in lieu of material of the pipe)and fluid phase *** the two-fluid model of stratified flow,the wall stress and interfacial stress correlations are substituted with superficial velocities of fluids and superficial Reynolds numbers of fluid phases replacing fluid phase velocities and fluid Reynolds ***,for dispersed flow,an effective Reynolds number is described as the sum of superficial Reynolds number of oil and water *** the generally employed mean or mixture Reynolds number with the effective Reynolds number into the existing single-phase turbulent flow friction factor correlation,an effective friction factor for oil-water flow is *** the proposed correlations,the pressure gradient across the oil-water flow and hold-up volume fraction are predicted with significant reduction in error compared with that of conventionally employed *** average error and standard deviation values of−7.06%,20.72%and 0.31%,18.79%are found for stratified flow and dispersed flow respectively.

关键词： oil-water flow two-fluid model pressure gradient stratified flow dispersed flow

Obesity is associated with decreased risk of microscopic colitis in women

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World Journal of Gastroenterology 2022年第2期28卷 230-241页

作者： Robert S Sandler Temitope O Keku john T Woosley Dale p Sandler Joseph A Galanko Anne F peery Department of medicine University of North CarolinaChapel HillNC 27514-7555United States Department of medicine University of North CarolinaChapel HillNC 27514-7555United States Department of PathologyUniversity of North CarolinaChapel HillNC 27514United States Department of Health and Human Services National Institute of Environmental Health SciencesDurhamNC 27709United States

BACKGROUND microscopic colitis is a leading cause of diarrhea in the older *** is limited information about risk *** hypothesized that obesity would be associated with microscopic *** To examine the association between obesity and microscopic colitis in men and women undergoing *** We conducted a case-control study at the University of North Carolina *** identified and enrolled men and women referred for elective,outpatient colonoscopy for chronic *** excluded patients with a past diagnosis of Crohn’s disease or ulcerative colitis.A research pathologist reviewed biopsies on every patient and classified them as microscopic colitis cases or non-microscopic colitis *** provided information on body weight,height and exposure to medications via structured interviews or Internet based *** analysis included 110 patients with microscopic colitis(cases)and 252 nonmicroscopic colitis *** analyses were performed using logistic regression to estimate odds ratios and 95%confidence *** Cases were older and more likely than controls to be white *** subjects were well educated,but cases were better educated than *** with microscopic colitis had lower body mass index than controls and reported more weight loss after the onset of *** to patients who were normal or under-weight,obese(BmI>30 kg/m2)patients were substantially less likely to have microscopic colitis after adjusting for age and education,adjusted OR(aOR)0.35,95%confidence interval(CI)0.18-0.66).When stratified by sex,the association was limited to obese women,aOR 0.21,95%CI:*** with microscopic colitis were more likely to report weight loss after the onset of *** stratifying by weight loss,there remained a strong inverse association between obesity and microscopic colitis,aOR 0.33,95%CI:0.10-1.11 among the patients who did not lose *** use of birth

关键词： Colitis microscopic/epidemiology Humans Diarrhea/epidemiology Obesity

Cs_(3)Bi_(2)l_(9)-hydroxyapatite composite waste forms for cesium and iodine immobilization

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Journal of Advanced Ceramics 2022年第5期11卷 712-728页

作者： Kun YANG Yachun WANG Junhua SHEN Spencer m.SCOTT Brian J.RILEY john D.VIENNA Jie LIAN Department of mechanical Aerospaceand Nuclear EngineeringRensselaer Polytechnic InstituteTroyUSA Department of materials Science&Engineering Rensselaer Polytechnic InstituteTroyUSA Savannah River National Laboratory AikenUSA pacific Northwest National Laboratory RichlandUSA

perovskite-based ceramic composites were developed as potential waste form materials for immobilizing cesium(Cs)and iodine(I)with high waste loadings and chemical *** perovskite Cs_(3)Bi_(2)I_(9)has high Cs(22 wt%)and I(58 wt%)content,and thus can be used as a potential host phase to immobilize these critical *** this work,the perovskite Cs_(3)Bi_(2)I_(9)phase was synthesized by a cost effective solution-based approach,and was embedded into a highly durable hydroxyapatite matrix by spark plasma sintering to form dense ceramic composite waste *** chemical durabilities of the monolithic Cs_(3)Bi_(2)I_(9)and Cs_(3)Bi_(2)I_(9)-hydroxyapatite composite pellets were investigated by static and semi-dynamic leaching tests,*** and I are incongruently released from the matrix for both pure Cs_(3)Bi_(2)I_(9)and composite *** normalized Cs release rate is faster than that of I,which can be explained by the difference in the strengths between Cs-I and Bi-I bonds as well as the formation of insoluble micrometer-sized BiOI *** activation energies of elemental releases based on dissolution and diffusion-controlled mechanisms are determined with significantly higher energy barriers for dissolution from the composite versus that of the monolithic Cs_(3)Bi_(2)I_(9).The ceramic-based composite waste forms exhibit excellent chemical durabilities and waste loadings,commensurate with the state-of-the-art glass-bonded perovskite composites for I and Cs immobilization.

关键词： cesium(Cs) iodine(Ⅰ) perovskite nuclear waste hydroxyapatite

Natural regeneration responses to thinning and burning treatments in ponderosa pine forests and implications for restoration

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Journal of Forestry Research 2022年第3期33卷 741-753页

作者： Tzeidle N.Wasserman Amy E.m.Waltz john paul Roccaforte Judith D.Springer Joseph E.Crouse Ecological Restoration Institute Northern Arizona UniversityP.O.Box 15017FlagstaffAZ86011-5017USA

Understanding naturally occurring pine regeneration dynamics in response to thinning and burning treatments is necessary not only to measure the longevity of the restoration or fuels treatment,but also to assess how well regeneration meets forest sustainability guidelines and whether natural regeneration is sufficient for maintaining a sustainable forest structure and composition.A synthesis review was carried out on the effects of mechanical thinning and prescribed burn treatments on natural pine regeneration response in frequent-fire ponderosa pine forests across the western United *** focus was on site-specific variability in pine regeneration dynamics,temporal trends in regeneration presence and abundance,and response to treatment as described in the current literature using 29 studies that met our evidence-based review *** showed that the effects of thinning and burning treatments on regeneration depended on time since *** thinning,prescribed burning,and thinning plus burn treatments all increased seedling density,but there was high variability among sites and *** were mixed results in the short-term(m studies(>20 years)concluded that stands can return to pre-treatment densities in terms of total trees per hectare and forest floor duff levels when there are no maintenance treatments *** studies showed the average ponderosa pine seedling presence,survival and growth found in today’s forests to be at a high density;this combined with missed fire cycles could contribute to future fire risk and reduce the efficacy of maintaining fuel reduction goals.

关键词： Regeneration ponderosa pine Frequent-fire Treatments Thinning Burning

Hybrids production as a potential method to control prolific breeding in tilapia and adaptation to aquaculture climate-induced drought

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Aquaculture and Fisheries 2022年第6期7卷 647-652页

作者： Kulwa mtaki Samwel mchele Limbu Aviti john mmochi matern S.p.mtolera Institute of marine Sciences P.O.Box 668University of Dar es SalaamZanzibarTanzania Department of Aquaculture Technology School of Aquatic Sciences and Fisheries TechnologyUniversity of Dar es SalaamP.O.Box 60091Dar es SalaamTanzania East China Normal University Department of BiologySchool of Life SciencesLaboratory of Aquaculture Nutrition and Environmental Health500 Dong Chuan Road200241ShanghaiChina

Establishing suitable salt tolerant all-male tilapia strains with fast growth rate is a crucial requirement for successful euryhaline farming required for controlling prolific breeding and as an adaptation to the effect of climateinduced *** study assessed the percentage of tilapia male hybrids,their growth performance and survival rate produced by crossing female Nile tilapia(Oreochromis niloticus)and male Rufiji tilapia(Oreochromis urolepis urolepis)at different *** fingerlings were reared for 70 days in triplicate concrete tanks(1 m3),each stocked with 15 fish weighing 1.62±0.03 g,1.69±0.02 g and 1.41±0.06 g exposed to 2,15 and 35 ppt salinities,*** was done by adding seawater to freshwater at a rate of 2 ppt per day for 18 *** sexing was done by visual assessment of the genital papilla followed by rearing the hybrids for six months to observe *** showed that,the cross between ***(female)and *** urolepis(male)produced hybrids that were all-males without any reproduction within six months post hybrid*** hybrids reared at a salinity of 2 ppt had higher growth performance than those reared at 15 and 35 ***,hybrids cultured at 15 ppt had significantly higher growth performance than those reared at 35 *** the hybrids produced had survival rates of 100%.This study indicated that,all-male tilapia produced by crossing between ***(female)and ***(male)can be used by fish farmers as alternative species for mariculture development to control prolific breeding and as an adaptation strategy to climate change.

关键词： monosex culture Hybridization mariculture All-male hybrids Aquaculture climate-induced drought