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Surgery for inflammatory bowel disease

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World Journal of gastroenterology 2008年第17期14卷 2678-2690页

作者： john m Hwang madhulika g Varma Center for Colorectal Surgery Department of Surgery University of California San Francisco

Despite the new and ever expanding array of medications for the treatment of inflammatory bowel disease (IBD), there are still clear indications for operative management of IBD and its complications. We present an ove... 详细信息

关键词： Crohn's disease Ulcerative colitis Operation Surgical treatment Ileal pouch

TRS Scheduling for Improved QoS performance in Cloud System

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Computers, materials & Continua 2023年第4期75卷 1547-1559页

作者： g.john Samuel Babu m.Baskar Department of Computer Science and Engineering School of ComputingCollege of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India Department of Computing Technologies School of ComputingCollege of Engineering andTechnologySRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India

Numerous methods are analysed in detail to improve task schedulingand data security performance in the cloud environment. The methodsinvolve scheduling according to the factors like makespan, waiting time,cost, deadline, and popularity. However, the methods are inappropriate forachieving higher scheduling performance. Regarding data security, existingmethods use various encryption schemes but introduce significant serviceinterruption. This article sketches a practical Real-time Application CentricTRS (Throughput-Resource utilization–Success) Scheduling with Data Security(RATRSDS) model by considering all these issues in task scheduling anddata security. The method identifies the required resource and their claim timeby receiving the service requests. Further, for the list of resources as services,the method computes throughput support (Thrs) according to the number ofstatements executed and the complete statements of the service. Similarly, themethod computes Resource utilization support (Ruts) according to the idletime on any duty cycle and total servicing time. Also, the method computesthe value of Success support (Sus) according to the number of completions forthe number of allocations. The method estimates the TRS score (ThroughputResource utilization Success) for different resources using all these supportmeasures. According to the value of the TRS score, the services are rankedand scheduled. On the other side, based on the requirement of service requests,the method computes Requirement Support (RS). The selection of service isperformed and allocated. Similarly, choosing the route according to the RouteSupport measure (RSm) enforced route security. Finally, data security hasgets implemented with a service-based encryption technique. The RATRSDSscheme has claimed higher performance in data security and scheduling.

关键词： Cloud task scheduling TRS quality of service RSm route security data security SDE RATRSDS

The Virtual geoscience Workbench, VgW: Open Source tools for discontinuous systems

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particuology 2010年第2期8卷 100-105页

作者： A. munjiza J. Xiang X. garcia J.p. Latham g.g. Schiava D'Albano N.W.m. john Department of Engineering Queen Mary London University London UK Department of Earth Science and Engineering Imperial College London UK

In 1989 work began on merging finite and discrete elements. During 1990 algorithmic solutions for the new combined method were developed, together with a C-based implementation known as the Y code. In 2004 these developments and implementations were published as a textbook. Queen mary University of London ~QmUL） and Imperial College are currently engaged in a research project to make Y codes in both 2D and 3D available in Open Source format and with mainly geoscience problems in mind. The result is a set of Open Source tools for geoscience （VgW）, key components of which are summarised in this paper, together with illustrative range of simulation results. 2009 Chinese Society of particuology and Institute of process Engineering, Chinese Academy of Sciences. published by Elsevier B.V. All rights reserved.

关键词： Combined finite-discrete elementWorkbenchmodellinggeoscience

predation changes the shape of thermal performance curves for population growth rate

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Current Zoology 2016年第5期62卷 501-505页

作者： Thomas m. LUHRINg john p. DELONg School of Biological Sciences University of Nebraska Lincoln Nebraska 68588 USA

Ectotherms generally demonstrate nonlinear changes in performance （e.g., movement speed, indi- vidual growth, population growth） as a function of temperature that are characterized by thermal performance curves （TpC）. predation risk elicits phenotypic and behavioral changes that likewise impact performance measures. We tested whether exposure to predation Orthocyclops modestus impacts the maximum population growth rate （rmax） TpC of the protist paramecium aurelia. We fit predator and non-predator exposed p. aurelia population growth rates to a function previously shown to best describe paramecium population growth rate TpC＇s （Lactin-2） and compared subse- quent parameter estimates between curves. For paramecium exposed to predation risk, maximum population growth increased more rapidly as temperatures rose and decreased more rapidly as temperatures fell compared to the initial temperature. The area under each TpC curve remained ap- proximately the same, consistent with the idea of a trade-off in performance across temperatures. Our results indicate TpCs are flexible given variation in food web context and that trophic inter- actions may play an important role in shaping TpCs. Furthermore, this and other studies illustrate the need for a mechanistic model of TpCs with parameters tied to biologically meaningful properties.

关键词： paramecium phenotypic plasticity predation reaction norm temperature thermal performance curve.

pitting and stress corrosion cracking studies on AISI type 316N stainless steel weldments

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Defence Technology（防务技术） 2018年第3期14卷 226-237页

作者： Anita Toppo m.g.pujar N.Sreevidya john philip Corrosion Science and Technology Division Indira Gandhi Centre for Atomic Research materials Development and Technology Division Indira Gandhi Centre for Atomic Research

pitting and stress corrosion cracking(SCC) studies on the 316 N stainless steel(SS) weldments in aswelded(AW) and thermally aged(solution annealing(SA), 550C/4 h and 750C/1 h) conditions were carried out in acidic and acidic chloride media. pitting corrosion and SCC resistance was the highest for SA weldment, which was attributed to homogenization of microstructural and microchemical heterogeneities during solution annealing. SA specimen showed the most stable passive film as compared to AW weldment because of higher amount of delta-ferrite in AW weld metal, which resulted in an increased heterogeneity and inferior SCC resistance in AW. Stability of passive film was found to be adversely affected due to heat treatments(at 550C/4 h and 750C/1 h) because of the precipitation of carbide and sigma phases.

关键词：压力腐蚀不锈钢 AISI 焊接金属 SCC 稳定性氯化物微结构

platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model

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World Journal of Orthopedics 2015年第11期6卷 961-969页

作者： Lorraine A Boakye Keir A Ross john m pinski Niall A Smyth Amgad m Haleem Charles p Hannon Lisa A Fortier john g Kennedy Department of Orthopaedic Surgery Hospital for Special Surgery Department of Orthopaedic Surgery Rush University Medical Center Department of Clinical Sciences Cornell University College of Veterinary Medicine

AIm: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TgF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect ***: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(pRp) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TgF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using meta morph. percentage of chondrocytes positive for TgF-β1 was then ***: percentage of chondrocytes positive for TgF-β1 was higher in pRp treated knees for selected ROIs(left; p = 0.03, center; p = 0.05) compared to control and was also higher in the pRp group at each post-operative time point(p = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TgF-β1 expression was higher in chondrocytes of pRp-treated knees(36% ± 29% vs 15% ± 18%)(p = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and pRp exhibit increased TgF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive pRp may increase TgF-β1 expression, which may play a role in the chondrogenic effect of pRp in vivo.

关键词： platelet rich plasma Transforming growth factor-beta Autologous osteochondral transplantation

Can bedside needle arthroscopy of the ankle be an accurate option for intra-articular delivery of injectable agents?

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World Journal of Orthopedics 2022年第1期13卷 78-86页

作者： Tobias Stornebrink Sjoerd A S Stufkens Nathaniel p mercer john g Kennedy gino m m J Kerkhoffs Department of Orthopedic Surgery Amsterdam UMCUniversity of AmsterdamAmsterdam Movement SciencesAmsterdam 1105AZNetherlands Academic Center for Evidence based Sports medicine Amsterdam 1105AZNetherlands Amsterdam Collaboration for Health and Safety in Sports International Olympic Committee Research Center Amsterdam UMCAmsterdam 1105AZNetherlands Department of Orthopedic Surgery NYU Langone HealthNew YorkNY 10010United States

BACKgROUND Bedside needle arthroscopy of the ankle under local anesthesia has been proposed for intra-articular delivery of injectable *** and tolerability of this approach in the clinical setting–including patients with end-stage ankle pathology and/or a history of prior surgery–is not *** To assess clinical accuracy and tolerability of bedside needle arthroscopy as a delivery system for injectable agents into the tibiotalar *** This was a prospective study that included adult patients who were scheduled for an injection with hyaluronic acid to the tibiotalar *** our center,these injections are used as a last resort prior to extensive *** primary outcome was injection accuracy,which was defined as injecting through the arthroscopic cannula with intra-articular positioning confirmed by a clear arthroscopic view of the joint *** outcome measures included a patientreported numeric rating scale(NRS,0-10)of pain during the procedure and willingness of patients to return for the same *** of ankle pain at rest and during walking was collected at baseline and at 2-wk *** were monitored from inclusion up to a 2-wk control *** We performed 24 ***(46%)participants were male,and mean age was 46.8±14.5 *** was the indication for injection in 20(83%)cases,of which 8(33%)patients suffered from osteoarthritis Kellgren-Lawrence grade IV,and 10(42%)patients from Kellgren-Lawrence grade *** osteochondral defect was the indication for injection in 4(17%)cases.A history of ankle surgery was present in 14(58%)participants and a history of multiple ankle surgeries in 11(46%)*** was possible to confirm accuracy in 21(88%)*** 3(12%)participants where needle arthroscopy did not reach a clear view of the joint space all suffered from Kellgren-Lawrence grade IV *** during the procedure was reported with a median of 1[i

关键词： Ankle arthroscopy NanoScope Needle arthroscopy Injections proof of concept patient experience

LIQUID CRYSTAL BASED ROTATINg ORTHOgONAL pOLARIZATION ImAgINg SYSTEm

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 245-251页

作者： QUN ZHU IAN m.STOCKFORD john A.CROWE STEpHEN p.mORgAN School of Electrical and Electronic Engineering University of Nottingham University Park NottinghamUK NG72RD

Rotating orthogonal polarization imaging provides images of the polarization properties of scattering media which are free from surface *** the technique has been demonstrated using manually rotated glan–Thompson polarizers to control and analyze the polarization state of the light entering and emerging from the *** paper describes a system that performs these functions using liquid crystal *** system is tested using a polarizing target embedded within a scattering medium and is compared with monte Carlo *** results compare well with those obtained with manual rotation of *** liquid crystal based approach has advantages over the previous system in terms of ease of use,speed,and repeatability and is therefore an important step towards taking the technique into routine clinical use.

关键词： Liquid crystal polarization orthogonal surface reflection scattering tissue.

Chebyshev Spectral methods and the Lane-Emden problem

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Numerical mathematics(Theory,methods and Applications) 2011年第2期4卷 142-157页

作者： john p.Boyd Department of Atmospheric Oceanic and Space ScienceUniversity of Michigan2455 Hayward AvenueAnn ArborMI 48109-2143USA

The three-dimensional spherical polytropic Lane-Emden problem is yr r+(2/r)y_(r)+y^(m)=0,y(0)=1,y_(r)(0)=0 where m∈[0,5]is a constant *** domain is r∈[0,ξ]whereξis the first root of y(r).We recast this as a nonlinear eigenproblem,with three boundary conditions andξas the eigenvalue allowing imposition of the extra boundary condition,by making the change of coordinate x≡r/ξ:y_(xx)+(2/x)y_(x)+ξ^(2) y^(m)=0,y(0)=1,y_(x)(0)=0,y(1)=*** find that a Newton-Kantorovich iteration always converges from an m-independent starting point y^((0))(x)=cos([π/2]x),ξ^((0))=*** apply a Chebyshev pseudospectral method to discretize *** Lane-Emden equation has branch point singularities at the endpoint x=1 whenever m is not an integer;we show that the Chebyshev coefficients are a_(n)∼constant/n^(2m+5) as n→∞.However,a Chebyshev truncation of N=100 always gives at least ten decimal places of accuracy—much more accuracy when m is an *** numerical algorithm is so simple that the complete code(in maple)is given as a one page table.

关键词： Lane-Emden Chebyshev polynomial pseudospectral