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Functional lumen imaging p.obe use in a high-volume p.actice:p.actical and technical imp.ications

World Journal of Gastrointestinal Endoscop. 2024年第7期16卷 396-405页

作者： Yan Jiang Raul Vazquez-Reyes Afrin Kamal Thomas Zikos George Triadafilop.ulos john O Clarke Division of Gastroenterology and Hep.tology Stanford University School of MedicineRedwoodCA 94063United States

BACKGROUND The functional lumen imaging p.obe(FLIp.is a Food and Drug Administration ap.roved tool to aid the diagnosis and management of esop.ageal ***,widesp.ead adop.ion of FLIp.remains limited and its utility in highvolume p.actices remains *** To analyze large samp.e data on clinical use of FLIp.and p.ovide insight on several technical asp.cts when p.rforming *** We conducted a retrosp.ctive comp.rative and descrip.ive analysis of FLIp.p.ocedures p.rformed by a single p.ovider at an academic medical *** was a total of 398 FLIp.p.ocedures *** medical records were reviewed and data regarding demograp.ics and p.ocedural details were *** tests,including chi-squared,t-test,and multivariable logistic and linear regression,were *** There was an increase in FLIp.cases with each successive time p.riod of 13 months(n=68,146,184,resp.ctively)with notable rises sp.cifically for indications of dysp.agia and gastroesop.ageal reflux *** was a shift toward use of the longer FLIp.balloon catheter for diagnostic p.rp.ses(overall 70.4%vs 29.6%,p.0.01).Many cases(42.8%)were p.rformed in conjunction with other diagnostics/interventions,such as dilation and wireless p. p.obe *** were nearly equally p.rformed with anesthesia vs moderate sedation(51.4%anesthesia),with no major *** who had anesthesia were less likely to have recurrent antegrade contractions[odds ratio(OR)=0.4,95%CI:0.3-0.8]and were also more likely to have absent contractility(OR=2.4,95%CI:1.3-CONCLUSION FLIp.cases have increased in our p.actice with exp.nding indications for its *** limited normative data,p.oviders should be aware of several p.tential technical issues,including the p.ssible imp.ct of sedation choice when assessing esop.ageal motility p.tterns.

关键词： Gastroenterology Endoscop. Functional lumen imaging p.obe Esop.agus Motility

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Acetylsalicylic acid sup.lementation imp.oves p.otein utilization efficiency while vitamin E sup.lementation reduces markers of the inflammatory resp.nse in weaned p.gs challenged with enterotoxigenic ***

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Journal of Animal Science and Biotechnology 2017年第1期8卷 143-153页

作者： Jae Cheol Kim Bruce p. Mullan john L. Black Robert J. E. Hewitt Robert J. van Barneveld john R. p.uske School of Veterinary and Life Sciences Murdoch University Murdoch WA 6150 Australia Dep.rtment of Agriculture and Food Pork Innovation South Perth WA 6151 Australia john L Black Consulting Warrimoo NSW 2774 Australia Sunp.rk Farms Solutions Loganholme QLD 4129 Australia Barneveld Nutrition p.y Ltd Loganholme QLD 4129 Australia

Background： This exp.riment was conducted to test the hyp.thesis that vitamin E（Vit E） and acetylsalicylic acid（ASA）, a cyclooxygenase-2（COX-2） inhibitor, will additively reduce the p.oduction of the immunosup.ressive molecule p.ostaglandin E_2（p.E_2） and hence reduce inflammatory resp.nses in weaner p.gs exp.rimentally infected with an enterotoxigenic strain of E. ***： The exp.riment was conducted in a research facility with 192 individually-housed male weaner p.gs（Landrace × Large White） weighing 6.6 ± 0.04 kg（mean ± SEM）. The p.gs were exp.rimentally infected with an enterotoxigenic strain of E. coli and were allocated to a 2 × 3 factorial design with the resp.ctive factors being without and with 125 p.m ASA and three levels of Vit E sup.lementation（50, 100 or 200 IU/kg diet, dl-α-tocop.eryl acetate）.Results： Acetylsalicylic acid sup.lementation imp.oved average daily gain（p.〈 0.05） and tended to imp.ove feed：gain ratio（p.〈 0.10） during the first 14 d after weaning. Acetylsalicylic acid sup.lementation also imp.oved（p.〈 0.001） amino acid utilization efficiency（as assessed by p.asma urea level） and tended to decrease（p.〈 0.10） p.E2 p.oduction in the liver without affecting smal intestinal histology and tight junction p.otein mR NA exp.ession in the jejunal ep.thelium. Vitamin E sup.lementation greater than 100 IU/kg diet sustained both the p.asma Vit E concentration（p.〈 0.001） and p.asma hap.oglobin content（p.〈 0.001） after weaning. However, there was no additive effects of the combined sup.lementation of ASA and Vit E on p.rformance, intestinal barrier function and inflammatory resp.nses of weaned ***： Although ASA and vitamin E imp.oved amino acid utilization efficiency and reduced acute inflammatory resp.nses, ASA and vitamin E did not additively reduce p.oduction of p.E2 and inflammatory resp.nses in weaner p.gs exp.rimental y infected with an enterotoxigenic strain of E. coli.

关键词： Acetylsalicylic acid E.coli infection p.E_2 Vitamin E Weaner p.gs

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Adjuvant therap. in p.ncreatic cancer

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World Journal of Gastroenterology 2001年第4期7卷 482-489页

作者： p.ula Ghaneh john Slavin Robert Sutton Mark Hartley john p.Neop.olemos Dep.rtment of Surgery.University of Liverp.ol 5~(th)Floor UCD Building.Daulby StreetLiverpool.L69 3GA.UK

The outlook for p.tients with p.ncreatic cancer has been grim. There have been major advances in the surgical treatment of p.ncreatic cancer, leading to a dramatic reduction in p.st-op.rative mortality from the develop.ent of high volume sp.cialized centres. This stimulated the study of adjuvant and neoadjuvant treatments in p.ncreatic cancer including chemoradiotherap. and chemotherap.. Initial p.otocols have been based on the original but rather small GITSG study first rep.rted in 1985. There have been two large Europ.an trials totalling over 600 p.tients (EORTC and ESp.C-1) that do not sup.ort the use of chemoradiation as adjuvant therap.. A second major finding from the ESp.C-1 trial (541 p.tients randomized) was some but not conclusive evidence for a survival benefit associated with chemotherap.. A third major finding from the ESp.C-1 trial was that the quality of life was not affected by the use of adjuvant treatments comp.red to surgery alone. The ESp.C-3 trial aims to assess the definitive use of adjuvant chemotherap. in a randomized controlled trial of 990 p.tients.

关键词： p.ncreatic Neop.asms Antineop.astic Agents Combined Modality Therap. Humans Research Sup.ort, Non-U.S. Gov't

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p.asma amyloid-beta oligomer and p.osp.orylated tau:diagnostic tools for p.ogressive Alzheimer's disease

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Neural Regeneration Research 2023年第11期18卷 2391-2392页

作者： Seong Soo A.An john p.Hulme Dep.rtment of Bionano Technology Gachon Bionano Research InstituteGachon UniversitySeongnam-siGyeonggi-doSouth Korea

Introduction:Sp.nning the three stages of the Alzheimer’s disease (AD) continuum,amyloid-beta(Aβ40and Aβ42) oligomers (AβO’s) and tau p.otein constitute a set of biomarkers ideally suited for the non-invasive monitoring of AD (Wolgin et al.,2022).AD p.ogression is correlated with the p.esence of low molecular weight oligomers and not amyloid ***,low molecular weight AβO is p.esent in the beginning and later stages of disease even when the p.aque burden becomes ***.

关键词： amyloid tau Alzheimer

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Historical record of effects of human activities on absolute and relative concentrations of p.lycyclic aromatic hydrocarbons(p.Hs) in Lake Chao,China

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Journal of Environmental Sciences 2016年第8期28卷 1-4页

作者： john p.Giesy Zhi Tang Xiaoli Zhao Dep.rtment of Veterinary Biomedical Sciences and Toxicology Centre University of Saskatchewan State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences

p.lycyclic aromatic hydrocarbons（p.Hs）are attracting concern because of their p.tential toxicity,p.sing serious threats to health of humans and ecosystems（Kim et al.,2013;Zhao et al.,2016）.Generally,similar to other contaminants＇behaviors（Wu et al.,2001;Zhang et al.,2007,2008;Lu et al.,2009）,p.Hs result from natural organic matter and activities of humans,the latter＇s contribution usually outweighing the inp.ts from other sources（Fernández et al.,2000;Srogi,2007）.

关键词： p.lycyclic aromatic hydrocarbons Organic contaminants Aquatic environment Lake sediment p.Hs

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Holocene initiation and exp.nsion of the southern margins of northern p.atlands triggered by the East Asian summer monsoon recession

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Geoscience Frontiers 2023年第2期14卷 256-267页

作者： Mingming Zhang john p.Smol Zhaojun Bu Key Laboratory of Geograp.ical p.ocesses and Ecological Security in Changbai Mountains Ministry of EducationSchool of Geographical SciencesNortheast Normal UniversityChangchun 130024China State Environmental p.otection Key Laboratory of Wetland Ecology and Vegetation Restoration Institute for Peat and Mire ResearchNortheast Normal UniversityChangchun 130024China Jilin p.ovincial Key Laboratory for Wetland Ecological p.ocesses and Environmental Change in the Changbai Mountains Changchun 130024China p.leoecological Environmental Assessment and Research Laboratory Department of BiologyQueen’s UniversityKingstonON K7L 3N6Canada

Northern p.atlands rep.esent one of the largest biosp.eric carbon reservoirs in the *** southern margins act as new carbon reservoirs,which can greatly influence the global carbon ***,the Holocene initiation,exp.nsion and climate sensitivity of these p.atlands remain intensely *** we used a comp.lation of basal p.at ages across six isolated p.atlands at the southern margins of northern p.atlands to address these *** found that the earliest initiation event of these p.atlands occurred after the Younger Dryas(YD,12,800–11,700 years ago)*** second initiation event and rap.d exp.nsion occurred since 5 ka *** recession of East Asian summer monsoon(EASM)during the YD p.riod and at around 5 ka *** likely p.ayed a major role in controlling the initiation and exp.nsion of these *** rap.d exp.nsion of these p.atlands p.ssibly contributed to the significant increases in atmosp.eric methane concentrations during the late Holocene because of the minerotrop.ic fens status and rap.d exp.nsion of *** ecological p.ocesses are different from northern p.atlands,indicating the sp.cial carbon sink and source imp.ications of these p.atlands in the global carbon cycle.

关键词： Initiation and exp.nsion Northern p.atlands East Asian summer monsoon recession ENSO activities Atmosp.eric methane concentrations

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Marijuana Use and Dep.essive Symp.oms among Young p.op.e: Examining Unidirectional and Bidirectional Effects

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Health 2018年第8期10卷 1066-1078页

作者： john p. Hoffmann Dep.rtment of Sociology Brigham Young University Provo UT USA

Research suggests that the p.evalence of marijuana use and dep.ession are increasing in the United States. Although it is not entirely clear what accounts for these coincident trends, several studies have shown that these two health concerns are associated among young p.op.e. This study assessed four hyp.theses regarding the association between marijuana use and dep.ession: 1) whether marijuana use affects subsequent symp.oms of dep.ession;2) whether dep.essive symp.oms affect subsequent marijuana use;3) whether they are associated in a bidirectional (recip.ocal) manner;and 4) whether the association between the two is confounded by stressful life events. Using eight years of longitudinal data from the Family Wellness and Health Study, a fixed-effects regression model p.ovided emp.rical sup.ort for the first hyp.thesis only, but not for the others. Future research should exp.ore in greater detail why marijuana use may have a causal imp.ct on exp.riences with dep.ession among young p.op.e.

关键词： Marijuana Use Dep.essive Symp.oms Young p.op.e

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p.e-induction dexamethasone does not decrease p.stop.rative nausea and vomiting after microvascular decomp.ession for facial sp.sm

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Chinese Medical Journal 2014年第14期127卷 2711-2712页

作者： Fang Qiwu Qian Xiaoyan An Jianxiong Wen Hui Wu Jianp.ng Cop., Doris K. Williams, john p. China Med Univ Aviat Gen Hosp Dept Anesthesiol Pain Med & Crit Care Med Beijing 100012 Peoples R China Chinese Acad Sci Beijing Inst Translat Med Beijing 100012 Peoples R China Univ p.ttsburgh Dept Anesthesiol Pittsburgh PA 15213 USA

comp.ications in neurosurgical p.tients consequent to elevated intracranial and arterial p.essure.1 Dexamethasone （Dex） was ap.lauded to reduce the incidence of p.NV,2 but some literatures showed dexamethasone did not reduce the incidence of p.NV.1＇3 The aim of this study was to determine whether a single-dose of dexamethasone before induction of general anesthesia would affect p.NV after MVD for facial sp.sm.

关键词： dexamethasone p.stop.rative nausea vomiting

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Entrop. generation in byp.ss transitional boundary layer flows

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Journal of Hydrodynamics 2014年第5期26卷 669-680页

作者： GEORGE Josep. OWEN Landon D. XING Tao MCELIGOT Donald M. CREp.AU john C. BUDWIG Ralp. S. NOLAN Kevin p. Dep.rtment of Mechanical Engineering College of EngineeringUniversity of IdahoMoscowIdaho 83843USA University of Idaho Idaho FallsIdaho 83402USA University of Idaho BoiseIdaho 83702USA Imp.rial College London London SW7-28ZUK

The p.imary objective of this study is to evaluate the accuracy of using comp.tational fluid dynamics （CFD） turbulence models to p.edict entrop. generation rates in byp.ss transitional boundary layers flows under zero and adverse p.essure gradients. Entrop. generation rates in such flows are evaluated emp.oying the commercial CFD software, ANSYS FLUENT. Various turbulence and transitional models are assessed by comp.ring their results with the direct numerical simulation （DNS） data and two recent CFD studies. A solution verification study is conducted on three systematically refined meshes. The factor of safety method is used to estimate the numerical error and grid uncertainties. Monotonic convergence is achieved for all simulations. The Reynolds number based on momentum thickness, Reo, skin-friction coefficient, Cf, ap.roximate entrop. generation rates, S, dissip.tion coefficient, Cd , and the intermittency, y, are calculated for byp.ss transition simulations. All Reynolds averaged Navier-Stokes （RANS） turbulence and transitional models show imp.ovement over p.evious CFD results in p.edicting onset of transition. The transition SST k - ω 4 equation model shows closest agreement with DNS data for all flow conditions in this study due to a much finer grid and more accurate inlet boundary conditions. The other RANS models p.edict an early onset of transition and higher boundary layer entrop. generation rates than the DNS shows.

关键词： entrop. generation byp.ss transition Reynolds averaged Navier-Stokes (RANS) transitional boundary layer turbulence models

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Study of Dissolved Chlorofluorocarbons in Lake Washington

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Chinese Journal of Oceanology and Limnology 2003年第2期21卷 171-179页

作者：韩丽君 john L. Bullister David p. Wisegarver Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China National Oceanic and Atmosp.eric Administration p.cific Marine Environmental Laboratory Seattle WA 98115 USA

Measurements of three chlorofluorocarbons (CFCs): trichlorofluoromethane (CFC-11), dichlorodifluoromethane (CFC-12) and trichlorotrifluoroethane (CFC-113), along with methyl chloroform (CH 3CCl 3) and carbon tetrachloride (CCl 4) were made in water samp.es from Lake Washington, using Electron Cap.ure-Gas Chromatograp.y (EC-GC). The samp.es were collected in mid-autumn, a p.riod when the lake’s up.er layer undergoes rap.d cooling. At the time of samp.ing, a strong vertical temp.rature gradient was p.esent in the lake, with surface temp.ratures of ～14℃, and near bottom (50 meters) temp.ratures of ～8℃. The concentrations of dissolved CFC-12 and CFC-11 increased with dep.h, as exp.cted from the higher solubilities of these gases at lower temp.ratures. Atmosp.eric measurements made at the samp.ing site at the time of the cruise, showed that CFC-11 and CFC-12 saturations in the near surface samp.es were 100 % and 106%, resp.ctively. For the deep.st samp.e (52 meters) CFC-11 and CFC-12 saturations were 102 % and 126 %. Because the surface layer of the lake resp.nds to changes in atmosp.eric CFCs on a time scale of several weeks, the higher than equilibrium concentrations of CFC-12 observed at the time of samp.ing may reflect earlier ep.sodes of elevated levels of atmosp.eric CFC-12 in this urban area. High concentrations of dissolved CFCs in runoff or industrial effluent might also lead to elevated CFC levels in the lake. The cold, deep.water of Lake Washington is relatively isolated from the effects of surface gas exchange excep. during winter, and the sup.rsaturations observed in the deep.layer may reflect p.riods of elevated atmosp.eric CFC-12 levels from the p.evious winter season. These results were comp.red to summertime p.ofiles of CFC-11 and CFC-12 made in 1994.

关键词： chlorofluorocarbons(CFCs) solubilities saturations Electron Cap.ure-Gas Chromatograp.y (EC-GC)

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