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Identification of patients with pancreatic adenocarcinoma due to inheritable mutation:Challenges of daily clinical practice

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World Journal of Gastrointestinal oncology 2019年第2期11卷 102-116页

作者： Alexander JP Fulton Angela Lamarca Christina Nuttall Lynne McCallum Rille Pihlak Derek o'reilly Fiona Lalloo Mairéad G McNamara Richard A Hubner Tara Clancy Juan W Valle Department of Medical oncology The Christie NHS Foundation Trust Hepato-pancreato-biliary Surgical Department Manchester Royal InfirmaryCentral Manchester University Hospitals NHS Foundation Trust Manchester Centre for Genomic Medicine Central Manchester University Hospitals NHS Foundation Trust Saint Mary's Hospital

BACKGRoUND Identification of germ-line mutations in pancreatic ductal adenocarcinoma(PDAC) could impact on patient/*** To assess the referral pathways for genetic consultations in *** Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer(EURoPAC)*** Four-hundred patients were eligible. of 113 patients(28.3%) meeting EURoPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole *** referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.

关键词： Genetic counselling Pancreatic adenocarcinoma Genetic consultation BRCA Germline

Prognostic factors in patients hospitalized with acute heart failure syndrome

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Journal of Geriatric Cardiology 2006年第4期3卷 199-209页

作者： Liviu Klein john B.o’Connell Division of Cardiology Center for Heart Failure Northwestern University Feinberg School of MedicineChicagoIL 60611USA

Each year, there are over one million hospitalizations for acute heart failure syndrome (AHFS) in the United States alone,with a similar number in Western Europe. These patients have very high short-term (2-6 months) mortality and readmission rates, while the healthcare system incurs substantial costs. Until recently, the clinical characteristics, management patterns, and outcomes of these patients have been poorly understood and, in consequence, risk stratification for these patients has not been well defined. Several risk prediction models that can accurately identify high-risk patients have been developed in the last year using data from clinical trials, large registries or administrative databases. Use of multi-variable risk models at the time of hospital admission or discharge offers better risk stratification and should be encouraged, as it allows for appropriate allocation of existing resources and development of clinical trials testing new treatment strategies for patients admitted with AHFS. The emerging observation that the prognosis for the ensuing three to six months may be obtained at presentation for AHFS has major implications for development of future therapies.

关键词： heart failure hospitalization risk factors prognosis

Tunneled peritoneal catheters for the palliative therapy of malignant ascites

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Family Medicine and Community Health 2013年第1期1卷 17-22页

作者： YVoNNE RYAN KAREN LYoNS john HANSEN AISLING o’GoRMAN North Eastern General Practice Training Scheme Department of Radiology Beaumont HospitalDublin our Lady of Lourdes Hospital DroghedaCo.Louth

objective:Malignant ascites presents difficult management issues in the palliative care population and results in distressing symptoms and recurrent hospital *** palliative care services in our Lady of Lourdes Hospital have been using radiologically guided tunneled peritoneal catheters for the palliative therapy of troublesome malignant *** conducted a review of this management ***:There were 10 catheters inserted in 9 patients between May 2007 and June 2011 in patients with malignant ***:There were no procedural related mortalities or major *** catheter life was 98.9 *** catheter re-hospitalization rate was 1.55 times per *** patient survival post insertion was 140 *** eight percent of patients achieved death at ***:We conclude that this is a safe and useful strategy in the management of malignant ascites in a palliative care population.

关键词： Tunneled peritoneal catheter Palliative therapy Malignant ascites

雷州半岛英峰岭玄武岩中的铁铝榴石巨晶及母岩浆成因

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科学通报 2001年第6期46卷 492-497页

作者：于津海 S.Y. o'reilly 南京大学地球科学系内生矿床成矿机制研究国家重点实验室南京210093 GEMoC Department of Earth and Planetary Sciences Macquarie University

英峰岭火山岩中的石榴石巨晶以富铁(>20%)、低镁(5.88%～10.87%)和高钙(6.92%～8.16%)为特征. 成分明显变化, 随着Mg#减小, 石榴石中的Ni, V, Sc, Co和重稀土含量逐渐降低, 而Zr, Hf, Ga, Y, Sr, Nb, Zn和轻、中稀土含量逐渐升高. 石榴... 详细信息

英峰岭火山岩中的石榴石巨晶以富铁(>20%)、低镁(5.88%～10.87%)和高钙(6.92%～8.16%)为特征. 成分明显变化, 随着Mg#减小, 石榴石中的Ni, V, Sc, Co和重稀土含量逐渐降低, 而Zr, Hf, Ga, Y, Sr, Nb, Zn和轻、中稀土含量逐渐升高. 石榴石母岩浆是一种高度演化的残余岩浆, 强烈亏损Ti, Sr, Hf, Nb和重稀土元素. 母岩浆是由石英拉斑质玄武岩浆经60%以上的单斜辉石、石榴石、斜长石和钛铁矿的分离结晶形成. 这种母岩浆没有喷出地表, 而是滞留于地幔结晶成巨晶堆晶岩. 巨晶与寄主岩是非平衡的.

关键词：铁铝榴石巨晶地球化学雷州半岛英峰岭玄武岩母岩浆石榴分离结晶

Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori

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World Journal of Gastroenterology 2005年第47期11卷 7499-7507页

作者： Rachel o'Mahony Huda Al-Khtheeri Deepaka Weerasekera Neluka Fernando Dino Vaira john Holton Christelle Basset Centre for Infectious Diseases and International Health Royal Free and University College London Medical SchoolLondonUnited Kingdom Department of Surgery University of Sri JayewardenapuraColomboSri Lanka Department of Microbiology University of Sri JayewardenapuraColomboSri Lanka Department of Internal Medicine and Gastroenterology University of BolognaBolognaItaly INSERM 0114 Physiopathologie des Maladies Inflammatoires IntestinalesCHU LilleFrance

AIM： To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori （H pylon）. METHoDS： Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled Hpylori to stomach sections. RESULTS： of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against Hpylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric, borage and parsley were able to inhibit the adhesion of H pylori strains to the stomach sections. CoNCLUSIoN： Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on Hpylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment.

关键词： Hpylori Inhibition Adhesion Killing Plants

Nigerian Population Research on Environment,Gene and Health (NIPREGH)-objectives and protocol

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The Journal of Biomedical Research 2014年第5期28卷 360-367页

作者： Augustine N odili john o ogedengbe Maxwell Nwegbu Felicia o Anumah Samuel Asala Jan A Staessen Department of Internal Medicine Faculty of Clinical SciencesCollege of Health SciencesUniversity of Abuja Studies Coordinating Centre Division of Hypertension and Cardiovascular RehabilitationDepartment of Cardiovascular DiseasesUniversity of Leuven Department of Human Physiology Faculty of Basic Medical ScienceChemical PathologyFaculty of Basic ClinicalAnatomical SciencesFaculty of Basic Medical SciencesCollege of Health SciencesUniversity of Abuja Department of Epidemiology University of MaastrichtMaastrichtThe Netherlands

Sub-Saharan Africa is currently undergoing an epidemiological transition from a disease burden largely attributable to communicable diseases to that resulting from a combination of both communicable and chronic non-communicable *** on chronic disease incidence,lifestyle,environmental and genetic risk factors are sparse in this *** report aimed at providing relevant information in respect to risk factors that increase blood pressure and lead to development of intermediate cardiovascular *** presented the rationale,objectives and key methodological features of the Nigerian Population Research on Environment,Gene and Health（NIPREGH） *** challenges encountered in carrying out population study in this part of the world and the approaches at surmounting them were also *** preliminary data as at 20 November 2013 showed that out of the 205 individuals invited starting from early April 2013,160（72 women） consented and were enrolled;giving a response rate of 78%.Participants＇ age ranged from 18 to 80 years,with a mean（SD） of 39.8（12.4） years and they were of 34 different ethnic groups spread over 24 states out of the 36 states that constitute *** mean（SD） of office and home blood pressures were 113.0（15.2） mm Hg systolic,73.5（12.5） mm Hg diastolic and 117.3（15.0） mm Hg systolic,and 76.0（9.6） mm Hg diastolic,***-three（26.8%） participants were hypertensive and 8（5.0%） were *** addition to having the unique potential of recruiting a cohort that is a true representative of the entire Nigerian population,NIPREGH is feasible and the objectives realisable.

关键词： Africa black populations blood pressure hypertension population science

Integrating global land cover products for improved forest cover characterization: an application in North America

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International Journal of Digital Earth 2014年第9期7卷 709-724页

作者： Xiao-Peng Song Chengquan Huang Min Feng Joseph o.Sexton Saurabh Channan john R.Townshend Global Land Cover Facility Department of Geographical SciencesUniversity of MarylandCollege ParkMDUSA

Six widely used coarse-resolution global land cover data-sets–Global Land Cover Characterization(GLCC),Global Land Cover 2000(GLC2000),GlobCover land cover product(GlobCover),MoDIS land cover product(MoDIS LC),the University of Maryland land cover product(UMD LC),and the MoDIS Vegetation Continuous Fields tree cover layer(MoDIS VCF)disagree substantially in their estimates of forest *** a regression tree model trained on higher-resolution,Landsat-based data,these multisource multiresolution maps were integrated for an improved characterization of forest cover over North *** using a withheld test sample,the integrated percent forest cover(IPFC)data-set has a root mean square error of 11.75%–substantially better than the 17.37% of GLCC,17.61% of GLC2000,17.96% of GlobCover,15.23% of MoDIS LC,19.25%of MoDIS VCF,and 15.15%of UMD LC,*** demonstrated for forest,this approach based on integration of multiple products has potential for improved characterization of other land cover types as well.

关键词： land cover forest data fusion regression tree North America

Formation history and protolith characteristics of granulite facies metamorphic rock in Central Cathaysia deduced from U-Pb and Lu-Hf isotopic studies of single zircon grains

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Science Bulletin 2005年第18期 114-123页

作者： Y. S. o’reilly,W. L. Griffin GEMoC ARC National Key Centre Department of Earth and Plane-tary Sciences Macquarie University Sydney N.S.W. 2109 Australia GEMoC ARC National Key Centre Department of Earth and Plane-tary Sciences Macquarie University Sydney N.S.W. 2109 Australia

The petrochemical as well as zircon U-Pb andLu-Hf isotopic studies of granulite facies metamorphic rockfrom the Taoxi Group in eastern Nanling Range, CentralCathaysia indicate that its protolith is the sedimentary rockwith low maturation index. The clastic materials are mostlyfrom middle Neoproterozoic （736 Ma） granitoid rocks withminor Neoarchaean and Paleoproterozoic rocks. The timingof this Neoproterozoic magmatism is in agreement with thesecond period of magmatism widespread surrounding theYangtze Block. Hf isotopic data indicate that the Neopro-terozoic granitoids resulted from the recycled Paleoprotero-zoic mantle-derived crustal materials. The sedimentary rockwas deposited in Late Neoproterozoic Era, and carried intolow crust in Early Paleozoic. The partial melting of themeta-sedimentary rock took place at about 480 Ma and sub-sequently granulite facies metamorphism occurred at ca. 443Ma. The zircons forming during this time interval （EarlyPaleozoic） show large Hf isotope variations, and their εHf（t）values increase from ?13.2 to +2.36 with decreasing age,suggesting the injection of mantle-derived materials duringpartial melting and metamorphism processes in the EarlyPaleozoic. Calculation results show that this metamorphicrock, if evolved to Mesozoic, has similar isotopic compositionto the nearby Mesozoic high Si peraluminous granites, im-plying that this kind of granulite facies metamorphic rock isprobably the source material of some Mesozoic peralumi-nous granitoids in eastern Nanling Range.

关键词： Granulite Zircon U-Pb-Hf isotope Central Cathaysia.

Circadian variation in expression of G_1 phase cyclins D_1 and E and cyclin-dependent kinase inhibitors p16 and p21 in human bowel mucosa

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World Journal of Gastroenterology 2006年第13期12卷 2109-2114页

作者： john Griniatsos othon P Michail Stamatios Theocharis Antonios Arvelakis Ioannis Papaconstantinou Evangelos Felekouras Emmanouel Pikoulis Ioannis Karavokyros Chris Bakoyiannis George Marinos john Bramis Panayiotis o Michail 1st Department of Surgery Medical School University of AthensGreece Department of Forensic Medicine and Toxicology Medical School University of AthensGreece

AIM： To evaluate whether the cellular proliferation rate in the large bowel epithelial cells is characterized by circadian rhythm. METHoDS： Between January 2003 and December 2004, twenty patients who were diagnosed as suffering from primary, resectable, non-metastatic adenocarcinoma of the lower rectum, infiltrating the sphincter mechanism, underwent abdominoperineal resection, total mesorectal excision and permanent left iliac colostomy. In formalinfixed and paraffin-embedded biopsy specimens obtained from the colostomy mucosa every six hours （00：00, 06：00, 12：00, 18：00 and 24：00）, we studied the expression of G1 phase cyclins （D1 and E） as well as the expression of the G1 phase cyclin-dependent kinase （CDK） inhibitors p16 and p21 as indicators of cell cycle progres- sion in colonic epithelial cells using immunohistochemical methods. RESULTS： The expression of both cyclins showed a similar circadian fashion obtaining their lowest and highest values at 00：00 and 18：00, respectively （P〈 0.001）. A circadian rhythm in the expression of CDK inhibitor proteins p16 and p21 was also observed, with the lowest levels obtained at 12：00 and 18：00 （P〈0.001）, respectively. When the complexes cyclins D1-p21 and E-p21 were examined, the expression of the cyclins was adversely correlated to the p21 expression throughout the day. When the complexes the cyclins D1-p16 and E-p16 were examined, high levels of p16 expression were correlated to low levels of cyclin expression at 00：00, 06：00 and 24：00. Meanwhile, the highest expression levels of both cyclins were correlated to high levels of p16 expression at 18：00. CoNCLUSIoN： Colonic epithelial cells seem to enter the G1 phase of the cell cycle during afternoon （between 12：00 and 18：00） with the highest rates obtained at 18：00. From a clinical point of view, the present results suggest that G1-phase specific anticancer therapies in afternoon might maximize their anti-tumor effect while minimizing toxicity.

关键词： G1 phase proteins CDK inhibitors Cell proliferation Circadian rhythm