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Long non-coding RNA BANCR promotes pancreatic cancer lymphangiogenesis and lymphatic metastasis by regulating the HIF-1α/VEGF-C/VEGFR-3 pathway via miR-143-5p

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Genes & Diseases 2024年第4期11卷 57-60页

作者： Shaolong Hao Yu Ji Weixuan Pan Hao Sun Fang Nie Jonathan Ray Warren Yuchuan ding Wei Han Department of General Surgery Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China Department of Central Laboratory Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China Department of Neurosurgery Wayne State University School of MedicineJohn D.Dingell VA Medical CenterDetroitMI 48201USA

Pancreatic cancer is one of the most aggressive malignant tumors of the digestive *** node metastasis(LNM),as the main way of invasion and metastasis,can occur in the early stage of pancreatic cancer and be considered... 详细信息

关键词： metastasis cancer invasion

杜威是培养范式的典型案例吗?——对比斯塔的一个回应

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全球教育展望 2024年第4期53卷 64-73页

作者：丁道勇北京师范大学教育学部北京100875

在2022年出版的《世界中心教育》中,比斯塔把杜威视为培养范式的典型案例。他进而认为,培养范式的教育只要人适应环境,忽略了人拒绝对环境做调适的可能性。比斯塔的评论,构成了对于杜威教育理论的严厉批评。但是,在对比比斯塔与杜威的... 详细信息

在2022年出版的《世界中心教育》中,比斯塔把杜威视为培养范式的典型案例。他进而认为,培养范式的教育只要人适应环境,忽略了人拒绝对环境做调适的可能性。比斯塔的评论,构成了对于杜威教育理论的严厉批评。但是,在对比比斯塔与杜威的教育理论,尤其是在回顾杜威的环境概念以后可知,比斯塔和杜威在教育上有共同的反对对象,比斯塔对杜威的批评并不公允。

关键词：杜威比斯塔培养范式《世界中心教育》

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铁磁绝缘体中磁振子的非平衡稳态输运性质

物理学报 2024年第14期73卷 214-221页

作者：杨栋超易立志丁林杰刘敏朱丽娅许云丽何雄沈顺清潘礼庆 john Q.Xiao 三峡大学理学院湖北省弱磁探测工程技术研究中心宜昌443002 三峡学院物理系重庆404100 香港大学物理系中国香港999077 Department of Physics and Astronomy University of DelawareNewark 19716USA

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化... 详细信息

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化学势μm的玻色-爱因斯坦统计函数引入到玻尔兹曼输运方程中,获得了以为幂次的输运方程严格解析表达式(当α(=-μm/(k_(B)T))<1时).结果显示,当α<<1时,我们得到了与以往研究不同的化学势μm与非平衡粒子浓度δn_(m)之间的非线性关系δn_(m)∝-α^(1/2)α-(-μm)^(1/2)α;较大时,则还须考虑其高阶项.正因这种非线性关系,导致磁振子扩散方程显著不同于电子自旋扩散特性,其由线性微分方程演变为更复杂的非线性微分方程.本文重点研究了在两种极端温度梯度(即■T~1K/mm和10^(4)K/mm)下非平衡磁振子浓度δn_(m)和化学势μm的空间分布,它们分别对应于μm的值约为-0.1μeV和-6.2meV,均满足前提条件α<1.在远离平衡态的大温度梯度分布下,本文理论计算与实验结果吻合很好.这些理论研究结果将加深人们对铁磁绝缘体中磁振子非平衡输运行为的认识.

关键词：磁振子非平衡输运化学势磁振子扩散方程玻尔兹曼输运方程

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Systematic identification of wheat spike developmental regulators by integrated multiomics, transcriptional network, GWAS, and genetic analyses

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Molecular Plant 2024年第3期17卷 438-459页

作者： Xuelei Lin Yongxin Xu Dongzhi Wang Yiman Yang Xiaoyu Zhang Xiaomin Bie Lixuan Gui Zhongxu Chen Yiliang ding Long Mao Xueyong Zhang Fei Lu Xiansheng Zhang Cristobal Uauyo Xiangdong Fu Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Nanjing Agricultural University NanjingJiangsu 210095China Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTaianShandong 271018China Department of Life Science Tcuni Inc.ChengduSichuan 610000China john Innes Centre Norwich Research ParkNorwich NR47UHUK Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyCASBeijing 100101China

The spike architecture of wheat plays a crucial role in determining grain number,making it a key trait for optimization in wheat breeding *** this study,we used a multi-omic approach to analyze the transcriptome and epigenome profiles of the young spike at eight developmental stages,revealing co-ordinated changes in chromatin accessibility and H3K27me3 abundance during the flowering *** constructed a core transcriptional regulatory network(TRN)that drives wheat spike formation and experimentally validated a multi-layer regulatorymodule involving TaSPL15,TaAGLG1,and *** integrating the TRN with genome-wide association studies,we identified 227 transcription factors,including 42 with known functions and 185 with unknown *** investigation of 61 novel transcription factors using multiple homozygous mutant lines revealed 36 transcription factors that regulate spike architecture or flowering time,such as TaMYC2-A1,TaMYB30-A1,and *** particular interest,TaMYB30-A1,downstream of and repressed by WFzP,was found to regulate fertile spikelet ***,the excellent haplotype of TaMYB30-A1,which contains a C allele at the WFzP binding site,was enriched during wheat breeding improvement in China,leading to improved agronomic ***,we constructed a free and open access Wheat Spike Multi-Omic Database(http://39.***.48.156:8800/#/).Our study identifies novel and high-confidence regulators and offers an effective strategy for dissecting the genetic basis of wheat spike development,with practical value forwheat breeding.

关键词： wheat spike development epigenome TRN TaMYB30-A1 breeding selection

A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort

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Genes & Diseases 2024年第4期11卷 400-410页

作者： Han Chan Fenfen Ni Bo Zhao Huimin Jiang Juanjuan ding Li Wang Xiaowen Wang Jingjing Cui Shipin Feng Xiaojie Gao Xueying Yang Huan Chi Hao Lee Xuelan Chen Xiaoqin Li Jia Jiao Daoqi Wu Gaofu Zhang Mo Wang Yupeng Cun Xiongzhong Ruan Haiping Yang Qiu Li Department of Nephrology Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Nephrology Shenzhen Children's HospitalShenzhenGuangdong 518034China Department of Nephrology Kunming Children's HospitalKunming Medical UniversityKunmingYunnan 650228China Department of Nephrology Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430015China Department of Nephrology Chengdu Women and Children Central HospitalChengduSichuan 610073China Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Nephrology John Moorhead Research LaboratoryUniversity College London Medical SchoolRoyal Free CampusUniversity College LondonLondon NW32PFUnited Kingdom

Dissecting the genetic components that contribute to the two main subphenotypes of steroid-sensitive nephrotic syndrome(SSNS)using genome-wide association studies(GWAS)strategy is important for understanding the *** conducted a multicenter cohort study(360 patients and 1835 controls)combined with a GWAS strategy to identify susceptibility var-iants associated with the following two subphenotypes of ssNS:steroid-sensitive nephrotic syn-drome without relapse(SSNswR,181 patients)and steroid-dependent/frequent relapse nephrotic syndrome(SDNS/FRNS,179 patients).The distribution of two single-nucleotide poly-morphisms(SNPs)in ANKRD36 and ALPG was significant between SSNSWR and healthy controls,and that of two SNPs in GAD1 and HLA-DQA1 was significant between SDNS/FRNS and healthy ***,rs1047989 in HLA-DQA1 was a candidate locus for SDNS/FRNS but not for *** significant SNPs were observed between SSNSWR and SDNS/***,chromosome 2:171713702 in GAD1 was associated with a greater steroid dose(>0.75 mg/kg/d)upon relapse to first remission in patients with SDNS/FRNS(odds ratio=3.14;95%confidence interval,0.97-9.87;P=0.034).rs117014418 in APOL4 was significantly associated with a decrease in eGFR of greater than 20%compared with the baseline in SDNS/FRNS patients(P=0.0001).Protein-protein intersection network construction suggested that HLA-DQA1 and HLA-DQB1 function together through ***,SSNSWR belongs to non-HLA region-dependent nephropathy,and the HLA-DQA/DQB region is likely strongly associated with dis-ease relapse,especially in SDNS/*** study provides a novel approach for the GWAS strategy of SsNS and contributes to our understanding of the pathological mechanisms of SSNSWRandSDNS/FRNS.

关键词： Frequentrelapse Genome-wide association study Human leukocyte antigen region Steroid-sensitive nephrotic syndrome

Field experimental study on optimal design of the rotary strip-till tools applied in rice-wheat rotation cropping system

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International Journal of Agricultural and Biological Engineering 2018年第2期11卷 88-94页

作者： Yanshan Yang john Fielke Qishuo ding Ruiyin He College of Engineering Nanjing Agricultural UniversityNanjing 210031China School of Engineering University of South AustraliaMawson LakesSA 5095Australia

The rice-wheat rotation system plays a significant role in Asian *** introduction of strip-tillage into the rice-wheat system for wheat planting offers a way to use conservation tillage practices to improve the seedbed quality,retain residue between rows and reduce energy input.A field experiment was conducted using an in-situ test *** types of blade(bent C,straight and hoe)were evaluated in four tool configurations at four rotary speeds(180 r/min,280 r/min,380 r/min and 510 r/min)in a paddy *** shape parameters,tillage-induced soil structures and energy consumption were *** showed that the straight blade configuration failed to create a continuous furrow at either 180 r/min or 510 r/*** bent C blade configuration produced a uniform furrow profile but its furrow backfill was poor and unsuitable for *** hoe blade configuration cut a continuous furrow and better tillage-induced soil structure,but it produced a much wider and non-uniform furrow *** mixed blade configuration(central hoe blades with two straight blades aside)provided a uniform furrow with good backfill and fine tilth by utilizing both the cutting effect of straight blades on the furrow boundaries and tensile fracturing of the furrow soil by the hoe *** torque of the mixed blade configuration was comparable with the bent C blade but was less than the hoe ***,a mixed blade configuration was recommended for rotary strip-tillage seeding using in rice-wheat system.

关键词： strip tillage rotary strip-till tool blade configuration furrow quality tilth torque rice-wheat rotation system

Present status and future prospect of design of Pt-cerium oxide electrodes for fuel cell applications

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Progress in Natural Science:Materials International 2012年第6期22卷 561-571页

作者： Toshiyuki Mori ding Rong Ou Jin Zou john Drennan Graduate School of Chemical Sciences and Engineering.Hokkaido University Kita13Nishi8Kita-ku.Sapporo.Hokkaido 060-8628.Japan Hetero interface design group.Global Research Center for Environment and Energy based on Nanomaterials Science(GREEN).National Institute for Materials Science.1-1 Namiki Tsukuba.Ibaraki 305-0044.Japan Centre for Microscopy and Microanalysis The University of QueenslandSt.LuciaBrisbaneQld 4072Australia Laboratory of Fuel Cells Dalian Institute of Chemical Physics Chinese Academy of Sciences457 Zhongshan RoadDalian

In the research field of proton exchange membrane fuel cells,the design of electrocatalytic activities on Pt-oxide promoter in the anode side has attracted attention for improvement of CO tolerance of Pt in anode side and a lowering of large over-potential loss of the oxygen reduction reaction on the cathode in the fuel *** the Pt-oxide promoter series,Pt-CeOx/C is one of the unique *** is because the unique behavior of CeOxsuch as electrochemical redox reaction between Ce3+and Ce4+in the anodic and cathodic reactions of fuel cell is *** present short review gives an overview of the recent works for improvement of the CO tolerance of Pt in the Pt-CeOx/C anodes and enhancement of the oxygen reduction reaction activity on Pt in the Pt-CeOx/C cathodes for fuel cell *** show the design paradigm for fabrication of high quality Pt-CeOx/C electrodes,the authors re-introduced parts of our research results to highlight the important role of interface structure of Pt-CeOxbased on the ultimate analysis results. The usefulness of the combined approach of microanalysis and the processing route design is presented.

关键词： Pt-CeO_x electrode CO tolerance of Pt Oxygen reduction reaction Interface of Pt and cerium oxide Microanalysis

Collaborative Simulation Method with Spatiotemporal Synchronization Process Control

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1074-1082页

作者： ZOU Yisheng ding Guofu ZHANG Weihua ZHANG Jian QIN Shengfeng TAN john Kian School of Mechanical Engineering Southwest Jiaotong University Chengdu 610031 China State Key Laboratory of Traction Power Southwest Jiaotong University Chengdu 610031 China Northumbria School of Design Northumbria University Newcastle upon Tyne NE1 8ST UK School of Mechanical and Construction Engineering Northumbria University Newcastle upon Tyne NE1 8ST UK

When designing a complex mechatronics system, such as high speed trains, it is relatively difficult to effectively simulate the entire system＇s dynamic behaviors because it involves multi-disciplinary subsystems. Currently, a most practical approach for multi-disciplinary simulation is interface based coupling simulation method, but it faces a twofold challenge： spatial and time unsynchronizations among multi-directional coupling simulation of subsystems. A new collaborative simulation method with spatiotemporal synchronization process control is proposed for coupling simulating a given complex mechatronics system across multiple subsystems on different platforms. The method consists of 1） a coupler-based coupling mechanisms to define the interfacing and interaction mechanisms among subsystems, and 2） a simulation process control algorithm to realize the coupling simulation in a spatiotemporal synchronized manner. The test results from a case study show that the proposed method 1） can certainly be used to simulate the sub-systems interactions under different simulation conditions in an engineering system, and 2） effectively supports multi-directional coupling simulation among multi-disciplinary subsystems. This method has been successfully applied in China high speed train design and development processes, demonstrating that it can be applied in a wide range of engineering systems design and simulation with improved efficiency and effectiveness.

关键词： design automation collaborative simulation space and time synchronization process control coupling algorithms mechatronic system design

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Testing reintroduction as a conservation strategy for the critically endangered Chinese alligator: Movements and home range of released captive individuals

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Chinese Science Bulletin 2011年第24期56卷 2586-2593页

作者： WANG ZhengHuan YAO Hong ding YouZhong THORBJARNARSON john WANG XiaoMing School of Life Sciences East China Normal University Shanghai 200062 China Shanghai Key Laboratory of Urbanization and Ecological Restoration East China Normal University Shanghai 200062 China Wildhfe Conservation Society 2300 Southern Boulevard Bronx New York 10460 USA Shanghai Science and Technology Museum Shanghai 200171 China

The Chinese alligator (Alligator sinensis) is considered the most critically endangered crocodilian as a result of the near total loss of its habitat and its extremely small and fragmented wild populations. Plans for population recovery lie mostly with wetland res- toration and the reintroduction of captive-reared animals. We carried out a first-trial release of 3 adult Chinese alligators (1♂, 2♀) into a pond at the Hongxing conservation site, Xuancheng, southern Anhui Province; the animals were radio-tracked from May to October in 2003. We hypothesized that after a period of adaptation, the alligators would establish definable home ranges. Two (1♂, 1♀) of the 3 alligators were monitored for the whole of the tracking period. The male had an annual home-range size of 7.61 hm2, and the female 4.00 hm2. Water temperature and pond water level were two important factors influencing the alligators' distributions, and daily movements. The radio-tracked alligators had overlapping home ranges, which notably included the one substantial island in the pond; that island is the only known nesting site of the local native wild alligators. Aggressive interactions between the released alligators and native wild alligators were observed during the breeding season around this island. All the three reintroduced alligators survived the winter of 2003 and were alive in the same pond in 2008. We concluded that the Hongxing conservation site provided a suitable habitat for the reintroduced alligators. However, the low water level in the pond resulting from farmland irrigation in August and September can be a substantial threat to the alligators' survival. Therefore, regu- lations on irrigation in summer and autumn are needed to balance the water needs of the alligators and agriculture.

关键词：野生扬子鳄动物放归保护运动濒危无线电跟踪家庭测试

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