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二氧化氯的制备方法

绿箭信息 2000年第2期1卷 19-21页

作者： john,R john,M

该过程适合由少量盐酸与碱金属氯酸盐反应生产二氧化氯，且在反应装置生产二氧化氯过程中，以过氧化氢作还原剂。由反应装置中抽出二氧化氯和氧气混合物，向反应装置中添加尿素和／或一种或更多种膦酸盐络合剂。添加质量分数为０．０％... 详细信息

该过程适合由少量盐酸与碱金属氯酸盐反应生产二氧化氯，且在反应装置生产二氧化氯过程中，以过氧化氢作还原剂。由反应装置中抽出二氧化氯和氧气混合物，向反应装置中添加尿素和／或一种或更多种膦酸盐络合剂。添加质量分数为０．０％￣５％的稳定剂用来增加反应速度。

关键词：二氧化氯制备方法盐酸碱金属氯酸盐

Assessing the impact of TB/HIV services integration on TB treatment outcomes and their relevance in TB/HIV monitoring in Ghana

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Infectious Diseases of Poverty 2012年第1期1卷 110-117页

作者： Gloria Akosua Ansa john D Walley Kamran Siddiqi Xiaolin Wei University Hospital LegonUniversity of GhanaP.O.Box LG 79LegonAccraGhana Nuffield Centre for International Health and Development University of Leeds101 Clarendon RoadLeeds LS29LJUnited Kingdom Department of Health Sciences The University of YorkSeebohm Rowntree BuildingHeslingtonYork YO105DDUnited Kingdom School of Public Health and Primary Care Chinese University of Hong KongHong KongChina

Background:The impact of the human immunodeficiency virus(HIV)on tuberculosis(TB),and the implications for TB and HIV control,is a public health challenge in Ghana-almost a quarter(23%)of all TB cases were HIV positive in *** integration of TB/HIV services has therefore emerged as an essential component of the national response to TB and *** aim is to reduce fragmentation,improve access,enhance efficiency and improve quality of ***’s TB/HIV policy comprises three linked sets of activities:effective implementation of the Stop TB Strategy for TB control,improved HIV prevention and care,and the implementation of additional TB/HIV *** models of service delivery with increasing integration of TB/HIV activities are expected to provide greater access to more comprehensive *** objective of this paper is to assess the impact of TB/HIV integration on TB treatment outcomes and to explore the usefulness of TB treatment outcomes as TB/HIV ***:A before-and-after study to observe the introduction of TB/HIV activities into TB programmes in three hospitals with different levels of integration was *** patient data was collated from TB registers from each facility,and analysed to determine if TB treatment outcomes changed significantly after ***:TB treatment success was 50%(95%CI 49-52)prior to,and 69%(95%CI 65-73)after,integration(Χ243.96,p<0.00).Treatment success increased from 43%to 53%at the one-stop shop(OSS),from 69%to 78%at the partially integrated site(PIS)and substantially from 46%to 78%at the referral site(RS)(Χ264.54;p<0.01).Defaults and cases transferred out reduced from 14.3%and 15.3%prior to integration,to 1.4%and 9.0%after integration,respectively,accounting for a significant increase in treatment *** rates remained high at 18%in all cases studied and 25%in HIV-associated cases after ***:TB/HIV integration may improve TB treatment success,but its exact impa

关键词： Tuberculosis HIV Integration Indicator Treatment outcome Referral Partial integration One-stop shop

Prophylactic uses of integrin CD18-βA peptide in a murine polymicrobial peritonitis model

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World Journal of Gastroenterology 2010年第21期16卷 2648-2656页

作者： Kwong-Fai Wong Jana Wo David Ho Ronnie T Poon José M Casasnovas john M Luk Department of Pharmacology and Surgery National University Hospital SystemNational University of SingaporeSingapore 117597Singapore Department of Surgery Queen Mary HospitalPokfulamHKSARHong KongChina Centro Nacional de Biotecnología CSICCampus Universidad Autónoma28049 MadridSpain

AIM:To evaluate the prophylactic properties of integrin CD18-βA peptide in a murine model of abdominal polymicrobial peritonitis and ***:Bacterial sepsis was induced in Institute of Cancer Research(ICR) mice by cecal ligation and puncture(CLP) *** mice were then injected with either sterile saline or CD18-βA peptide intraperitoneally at 2 h after surgery,and were sacrificed at 12 and 24 h after *** samples were immediately collected,and analyzed for endotoxin activity and tumor necrosis factor(TNF)-α and interleukin(IL)-*** and liver were studied for CD45+ leukocyte and CD3 mRNA *** expression of intercellular adhesion molecule(ICAM)-1,vascular cell adhesion molecule(VCAM) and E-selectin was also ***:Intraperitoneal injection of CD18-βA peptide significantly suppressed circulating endotoxin activity(P<0.01) at 24 h,as well as serum levels of TNF-α(P<0.05 at 12 and 24 h) and IL-6(P<0.01 at 12 h,P<0.05 at 24 h) in CLP-inflicted ***18-βA peptide also abrogated leukocyte infiltration into liver and lungs as unveiled by reduced CD45+ leukocyte and CD3 mRNA ***,the peptide significantly reduced pulmonary expression of VCAM(P<0.01 at 12 h,P<0.001 at 24 h),E-selectin(P<0.01 at 12 and 24 h),and ICAM-1(P<0.01 at 12 h,P<0.001 at 24 h).These actions of CD18-βA peptide collectively protected septic mice against lethality(P<0.01).CONCLUSION:CD18-βA peptide is a potent endotoxin antagonist that can protect surgical patients against sepsis-associated lethality.

关键词： Bacterial endotoxin Integrin CD18 Inflammation Biotherapeutic peptide

Species Identification of Mealie Meal Spoilage Organisms and Pathogenic Bacteria from Selected Food Stores in Lusaka District of Zambia

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Open Journal of Preventive Medicine 2020年第8期10卷 225-232页

作者： Adeyemo Dayo Omodele Hang’Ombe Bernard Mudenda john Bwalywa Muma Musso Munyeme University of Zambia Lusaka Zambia

Background: Mealie Meal is one of the by-products of maize from dry milling. It constitutes more significant part of the daily diet of growing population of the Lusaka District of Zambia. However, reported cases of a cholera outbreak in October 2017-May 2018 were attributed to water contamination in the households of Lusaka. Hitherto there is no previous study or documented data for gastroenteritis caused by microbial contamination from food stores. Aim: The main objective of the study was to carry out species identification of Mealie meal spoilage organisms and pathogenic bacteria from selected food stores in Lusaka district from September 2019-March 2020. Crosssectional survey was conducted for food spoilage organisms and pathogenic bacteria of packaged maize meal flour from a selected food store. The number of packaged Mealie meal samples from selected food stores included in the study was 143 samples. Samples were obtained by a simple stratified random selection from food stores in Lusaka District. Thus Mealie Meal samples bought from Street food vendors were 96 (67%), Shops—30 (21%), Malls—17 (11.9%). Subsequently isolation by spread and pour plate methods, and species identification of microbial contamination by Cell Culture processes coupled to microbial morphological and biochemical characterization was performed. Microsoft Office Excel (version 2007) Spreadsheet was employed for the categorical data analysis and summarized graphical presentation of data. Laboratory findings revealed: Spoilage organisms—Aspergillum species, Mucor Species, Candida Species, Clostridium Species and Bacillus Species;Pathogenic Bacteria Species—Clostridium perfringens, Staphylococcus aureus, Clostridium tetani, Bacillus, Escherichia coli, Pseudomonas aeruginosa and Yesinia pestis. It can be established from the laboratory results earlier me

关键词： Mealie Meal Lusaka District Food Safety Spoilage Organisms and Pathogenic Bacteria

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薛定谔传

Investigation of the Radiological Risk of Farmlands and the Transfer Factor from Soil to Crops in Jalingo and Wukari L.G.A of Taraba State, Nigeria

丛书名：科学与人译丛

2001年

作者：沃尔特·穆尔（Walter john Moore）班立勤译

本书记述了物理学家薛定谔的科学工作，私人友谊，以及对神秘的兴趣，同时也记录了他的政治态度和只身从纳粹铁蹄下逃离的经过。

ISBN: (纸本)7500108591

本书记述了物理学家薛定谔的科学工作，私人友谊，以及对神秘的兴趣，同时也记录了他的政治态度和只身从纳粹铁蹄下逃离的经过。

关键词：薛定谔传记

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Journal of Environmental Protection 2022年第1期13卷 1-14页

作者： Alexander A. Tyovenda john A. Ocheje Sombo Terver Effiong U. Uttah Department of Physics Federal University of Agriculture Makurdi Makurdi Benue State Nigeria Department of Pure and Applied Physics Federal University Wukari Wukari Taraba State Nigeria Department of Physics University of Uyo Uyo Akwa-Ibom State Nigeria

The activity concentrations of radionuclides, absorbed dose rate, excess lifetime cancer risk, and soil-to-plant transfer factor have been evaluated in soil and crop samples from Jalingo and Wukari Local Government Area of Taraba State, Nigeria. The activity concentrations were determined with the aid of High Purity Germanium detector. The absorbed dose and excess lifetime cancer risk were evaluated and forecasted for 60 years using the ResRad off-site model. The average activity concentration of 40K, 232Th, and 238U in the soil samples were 633.13, 141.15, and 71.20 Bq·kg-1 respectively, for the Jalingo study area, and while that of the Wukari study area was;199.21, 87.23, and 25.37 Bq·kg-1 respectively. The average soil-to-plant transfer factors for 40K, 232Th, and 238U were 0.51, 0.10, and 0.27 respectively for the Jalingo study area while that of Wukari are 0.40, 0.57, and 0.74 respectively. The mean annual effective dose equivalent for the study area is higher than the world average of 0.07 mS·vy-1. The excess lifetime cancer risk for the study areas has values that are higher than the safety limit. The ResRed model showed that direct radiation from the crops is the major contributor to excess cancer risk among other pathways. The radiological hazard indices reveal health risks to farmers, especially in the Jalingo area.

关键词： Activity Concentration Transfer Factor Absorbed Dose Excess Lifetime Cancer Risk

Cancer Chemopreventive Retinoids: Validation and Analysis of in Vivo and in Vitro Bioassay Results

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Journal of Cancer Therapy 2016年第13期7卷 1008-1033页

作者： john J. Wille Jong Y. Park Y. Fulmer Shealy Department of Biochemistry Southern Research Institute Birmingham AL USA Department of Cell Biology Bioplast Medical LLC Chesterfield NJ USA Department of Cancer Epidemiology Moffitt Cancer Center Tampa FL USA

Several natural and synthetic retinoids (vitamin-A derived analogies) were examined for their potential anti-cancer activity in both in vivo animal models and a novel in vitro human keratinocyte clonal growth bioassay system. The natural retinoids included all-trans-retinoic (RA), 13-cis-retinoic acid, 4-oxoretinoic acid, and retinol. Among the synthetic retinoids tested were all trans N-(4-hydroxy(phenyl)retinamide, 3-substituted oxoretinoic acids, and 13 cis-N-ethylretinamide. The animal models employed were: 1) vitamin A-deficient hamster tracheal organ assay (HTOC);2) the benzo(α)pyrene-induced squamous metaplasia in a hamster tracheal organ system (BP-HTOC);3) the mouse skin tumor promoter (TPA)-induced ornithine decarboxylase enzyme assay(ODC);4) the mouse skin papilloma (MPA) assay;and 5) a novel retinoid bioassay in which retinoids display IC50 values to inhibit clonal growth of NHK. All-trans-RA, 4-oxoretinoic acid and retinol were consistently more active than any of the synthetic derivatives in all bioassays tested. A statistical model was developed and significant positive correlations were found between: 1) ED50 values in the HTOC system and reduction in TPA-induced ODC enzyme activity;2) tumors per animal in the MPA bioassay and suppression of TPA-induced ODC activity;and 3) a positive correlation between suppression of tumors per animal in the MPA assay, and retinoid inhibition of keratinocyte clonal growth. Test retinoids, were tested for their capacity to inhibit the clonal growth of a squamous carcinoma cell line (SCC-25), which were found to be 2 - 3 logs less sensitive for each tested retinoid than the corresponding activity against NHK cells. Antineoplastic retinoid drugs were reviewed.

关键词： Cancer Chemoprevention in Vivo Bioassays in Vitro Bioassays Retinoids

Molecular Marker-Assisted Backcrossing of Anthracnose Resistance Genes into Common Beans (<i>Phaseolus vulgaris</i>L.) Varieties

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American Journal of Plant Sciences 2021年第5期12卷 771-781页

作者： Annuarite Uwera john Nzungize Rusagara Susan Nchimbi Msolla Augustine Musoni Teshale Assefa Sokoine University of Agriculture Morogoro Tanzania Rwanda Agriculture and Animal Resources Development Board Kigali Rwanda International Crops Research Institute for the Semi-Arid Tropics Bamako Mali Alliance Biodiversity International and CIAT Arusha Tanzania

Anthracnose, caused by Colletotrichum lindemuthianum, is a major disease of common bean and results in high yield loss. Due to the high degree of pathogenic variability of the fungus and the continual emergence of new races, genetic resistance in the host is not durable. Gene pyramiding using Marker Assisted Selection (MAS) is proposed as a viable approach to improve the durability of major genes conditioning resistance to anthracnose. In this study a common bean line Urugezi x AND 1062 susceptible to anthracnose but already improved for Pythium root rot resistance was improved for anthracnose resistance through a backcross breeding program. Genotypic selection was done in Rubilizi laboratory in Kigali, Rwanada whereas phenotypic selection was conducted in an anthracnose hotspot at Rwerere, a research Centre of the Rwanda Agricultural and Animal Resources Development Board (RAB). Analysis of variance for effect of bean varieties and anthracnose isolates on disease expression showed significant differences (p 2F1 plants were 41% of them resistant and 59% susceptible to anthracnose. However, the observed proportion of 26 resistants and 37 susceptible in BC2F1 plants didn’t fit the goodness of fit of the expected proportion of 75 resistan

关键词： Anthracnose Common Bean Resistance Genes Pythium Root Rot

Mixed Cerebrovascular and Alzheimer’s Type Pathology Mimicking Lewy Body Disease and Its Possible Contribution to Cognitive Impairment in Elderly Patients with Bipolar Disorder/Schizophrenia

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Open Journal of Pathology 2022年第3期12卷 88-99页

作者： Andrey Frolov Lokesh Coomar Miguel A. Guzman john R. Martin III Center for Anatomical Science and Education Department of Surgery Saint Louis University School of Medicine Saint Louis MO USA Departments of Pathology and Neurology Saint Louis University School of Medicine Saint Louis MO USA

The fast aging human population requires new approaches to reliable diagnosis and proper treatment of dementia in elderly patients with psychiatric disorders such as bipolar disorder (BD) and schizophrenia (SCZ). As compared to other psychiatric disorders, BD and SCZ are characterized by increased and similar risk for dementia as well as cerebrovascular (CVD) and Parkinson’s (PD) diseases independent of the patient’s age. There are reports in the literature suggesting BD and SCZ in older patients could cause dementia without contribution from the neurodegenerative diseases, including Alzheimer’s disease (AD), due to the absence of the known neuropathology associated with cognitive decline in such individuals. This view contradicts a plethora of data highlighting AD as a major cause of dementia in the elderly. This issue was addressed by examining postmortem cerebral pathology in an 83-year-old female diagnosed with BD, SCZ, and PD (D1) and comparing it to that of a second donor (D2), an age-matched male diagnosed with Lewy Body Dementia (LBD). Upon thorough histochemical and immunohistochemical examinations of both brains, the PD and LBD diagnoses in D1 and D2 were not confirmed. Instead, AD-related pathology was observed in both subjects with AD advancing to its clinical stage (mild to moderate) only in D1. Diffuse β-amyloid peptide 1-42 (Aβ1-42) staining, most likely reflecting a presence of the Aβ1-42 soluble form, was also detected in cerebellar neurons and cerebellar extracellular space in D1 and D2. Cerebrovascular pathology was pronounced and distinct in both brains and included amyloid angiopathy, hyaline atherosclerosis, microbleeds, and dilated Virchow Robin spaces in D1 as well as thick-walled blood vessels with microbleeds in D2. It was concluded that a mixed AD and cerebrovascular pathology could mimic Lewy Body Disease and potentially contribute to dementia development in elderly BD and SCZ patients.

关键词： Bipolar Disorder Schizophrenia Alzheimer’s Disease Cerebrovascular Disease Neuropathology