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world Journal of Gastroenterology 2006年第6期12卷 928-934页

作者： Yan Li john m wo mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G martin Division of Surgical Oncology University of Louisville School ofMedicine Louisville KY 40202 United States Division of Gastroenterology/Hepatology University of Louisville School of MedicineLouisville KY 40202 United States Department of Anatomical Pathology University of Louisville School of Medicine Louisville KY40202 United States

AIm： To investigate the expression of cyclooxygenase-2 （COX-2） and epithelial growth factor receptor （EGFR） throughout the progression of Barrett＇s esophagus （BE）. mETHODS： COX-2 and EGFR protein expressions were detected by using immunohistochemical method. A detailed cytomorphological changes were determined. Areas of COX-2 and EGFR expression were quantified by using computer Imaging System. RESULTS： The expressions of both COX-2 and EGFR increased along with the progression from BE to esophagus adenocarcinoma （EAC）. A positive correlation was found between COX-2 expression and EGFR expression. CONCLUSION： COX-2 and EGFR may be cooperative in the stepwise progression from BE to EAC, thereby leading to carcinogenesis.

关键词： Cycloxygenase -2 (COX-2) Epithelial growth factor receptor (EGFR) Barrett's esophagus Carcinogenesis

Note on the Stability of a Slowly Rotating Timoshenko Beam with Damping

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Advances in Applied mathematics and mechanics 2015年第6期7卷 736-753页

作者： J.wo´zniak m.Firkowski Institute of mathematics University of SzczecinWielkopolska 1570-451 SzczecinPoland Department of mathematics and Physics University of SzczecinWielkopolska 1570-451 SzczecinPoland

This paper continues the senior author’s previous investigation of the slowly rotating Timoshenko beam in a horizontal plane whose movement is controlled by the angular acceleration of the disk of the driving motor into which the beam is rigidly *** was shown before that this system preserves the total *** consider the problem of stability of the system after introducing a particular type of *** show that the energy of only part of the system *** illustrate obtained solution with the critical case of the infinite value of the damping coefficient.

关键词： Timoshenko beam stability transfer function

Prophylactic uses of integrin CD18-βA peptide in a murine polymicrobial peritonitis model

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world Journal of Gastroenterology 2010年第21期16卷 2648-2656页

作者： Kwong-Fai wong Jana wo David Ho Ronnie T Poon José m Casasnovas john m Luk Department of Pharmacology and Surgery National University Hospital SystemNational University of SingaporeSingapore 117597Singapore Department of Surgery Queen Mary HospitalPokfulamHKSARHong KongChina Centro Nacional de Biotecnología CSICCampus Universidad Autónoma28049 MadridSpain

AIm:To evaluate the prophylactic properties of integrin CD18-βA peptide in a murine model of abdominal polymicrobial peritonitis and ***:Bacterial sepsis was induced in Institute of Cancer Research(ICR) mice by cecal ligation and puncture(CLP) *** mice were then injected with either sterile saline or CD18-βA peptide intraperitoneally at 2 h after surgery,and were sacrificed at 12 and 24 h after *** samples were immediately collected,and analyzed for endotoxin activity and tumor necrosis factor(TNF)-α and interleukin(IL)-*** and liver were studied for CD45+ leukocyte and CD3 mRNA *** expression of intercellular adhesion molecule(ICAm)-1,vascular cell adhesion molecule(VCAm) and E-selectin was also ***:Intraperitoneal injection of CD18-βA peptide significantly suppressed circulating endotoxin activity(Pm levels of TNF-α(PmRNA ***,the peptide significantly reduced pulmonary expression of VCAm(Pm-1(Pmice against lethality(P<0.01).CONCLUSION:CD18-βA peptide is a potent endotoxin antagonist that can protect surgical patients against sepsis-associated lethality.

关键词： Bacterial endotoxin Integrin CD18 Inflammation Biotherapeutic peptide

Human-tiger conflict:A review and call for comprehensive plans

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Integrative Zoology 2010年第4期5卷 300-312页

作者： john m.GOODRICH Wildlife Conservation Society BronxNew YorkNYUSA

Human-tiger(Panthera tigris Linnaeus,1758)conflicts(HTC),manifested primarily as attacks on people and domestic animals,exacerbate at least 2 major threats to tigers:(i)conflicts often result in mortality or removal of tigers from the wild;and(ii)they result in negative attitudes towards tigers by local people,thereby reducing support for tiger *** HTC has decreased over the past century,it will likely increase if current and proposed conservation initiatives to double tiger populations are *** HTC could undermine successful conservation initiatives if proactive steps are not taken to reduce *** present paper provides a review of the impacts of HTC and the measures taken to reduce it in ways that reduce negative impacts on both humans and tigers,and stresses the need for development and implementation of comprehensive plans to reduce HTC.

关键词： carnivore depredation human-tiger conflict Panthera tigris tiger

Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer

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Chinese Journal of Cancer 2014年第3期33卷 133-139页

作者： john m.Pawelek Department of Dermatology and the Yale Cancer Center Yale University School of Medicine

This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome.

关键词： Bone marrow-derived cell-cancer cell hybrids metastasis cell fusion

Study on a 5.0 W/80 K single stage Stirling type pulse tube cryocooler

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第9期9卷 1277-1282页

作者： Zhi-hua GAN Guo-jun LIU Ying-zhe wo Qiang CAO Li-min QIU Guo-bang CHEN J.m. PFOTENHAUER Cryogenics Laboratory Institute of Refrigeration and Cryogenics School of Mechanical and Energy Engineering Zhejiang University Hanghzou 310027 China Cryogenic Engineering Laboratory University of Wisconsin-Madison Madison WI 53706 USA

A single stage Stifling pulse tube cryocooler was designed based on REGEN 3.2 and fabricated for testing. The experimental results show that the cooler can provide a cooling capacity of 5.0 W at 79.1 K, and produce a no-load temperature of 57.0 K, operating with an average pressure of 2.50 mPa and a frequency of 60 Hz, performance results that are very close to the calculated values. The cryocooler can be cooled from room temperature to 80 K in 8.5 min. The fast cooldown time is a result of the small regenerator.

关键词： Cryocooler Regenerator High frequency Pulse tube

Synthesis of LiSm_(0.01)mn_(1.99)O_4 by molten salt technique

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Journal of Rare Earths 2010年第2期28卷 255-259页

作者： m Helan L john Berchmans Department of Chemistry Jamal Mohamed College (Autonomous) Electropyrometallurgy Division Central Electrochemical Research Institute

Samarium substituted lithium manganese oxide powders were successfully prepared by molten-salt synthesis(mSS) using eutectic mixture of LiCl,SmCl3.6H2O and mnO2 salt at 700 °*** synthesis was carried out in open *** crystalline powders were characterized for their phase identification using X-ray diffraction(XRD) *** physico-chemical properties of the samarium substituted lithium manganese oxide powders were investigated by thermal analysis(TGA/DTA),FT-IR spectroscopy,EDAX,electron par...

关键词： LiSm0.01mn1.99O4 molten salt synthesis cathode materials rare earth ion

Fuzzy modeling of Surficial Uranium Prospectivity in British Columbia(Canada)with a Weighted Fuzzy Algebraic Sum Operator

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Journal of Earth Science 2021年第2期32卷 293-309页

作者： Emmanuel john m.Carranza School of Agricultural Earth and Environmental SciencesUniversity of KwaZulu-NatalWestville CampusDurban 4041South Africa

This paper demonstrates knowledge-guided fuzzy logic modeling of regional-scale surficial uranium(U)prospectivity in British Columbia(Canada).The deposits/occurrences of surficial U in this region vary from those in Western Australia and Namibia;thus,requiring innovative and carefully-thought techniques of spatial evidence generation and *** novelty,this papers introduces a new weighted fuzzy algebraic sum operator to combine certain spatial evidence *** analysis trialed several layers of spatial evidence based on conceptual mineral system model of surficial U in British Columbia(Canada)as well as tested various models of evidence ***-linear weighted functions of(a)spatial closeness to U-enriched felsic igneous rocks was employed as U-source spatial evidence,(b)spatial closeness to paleochannels as fluid pathways spatial evidence,and(c)surface water U content as chemical trap spatial *** best models of prospectivity created by integrating the layers of spatial evidence for U-source,pathways and traps predicted at least 85%of the known surficial U deposits/occurrences in>10%of the study region with the highest prospectivity fuzzy *** results of analyses demonstrate that,employing the known deposits/occurrences of surficial U for scrutinizing the spatial evidence layers and the final models of prospectivity can pinpoint the most suitable critical processes and models of data integration to reduce bias in the analysis of mineral prospectivity.

关键词： fuzzy logic mineral systems surficial uranium fuzzy algebraic sum

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Sorption and phase distribution of ethanol and butanol blended gasoline vapours in the vadose zone after release

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Journal of Environmental Sciences 2014年第3期26卷 608-616页

作者： Ejikeme Ugwoha john m. Andresen Chemical and Environmental Engineering University of Nottingham School of Engineering and Physical Sciences Heriot-Watt University

The sorption and phase distribution of 20% ethanol and butanol blended gasoline （E20 and B20） vapours have been examined in soils with varying soil organic matter （SOm） and water contents via laboratory microcosm experiments. The presence of 20% alcohol reduced the sorption of gasoline compounds by soil as well as the mass distribution of the compounds to soil solids. This effect was greater for ethanol than butanol. Compared with the sorption coefficient （Kd） of unblended gasoline compounds, the Kd of E20 gasoline compounds decreased by 54% for pentane, 54% for methylcyclopentane （mCP） and 63% for benzene, while the Kd of B20 gasoline compounds decreased by 39% for pentane, 38% for mCP and 49% for benzene, The retardation factor （R） of E20 gasoline compounds decreased by 53% for pentane, 53% for mCP and 48% for benzene, while the R of B20 gasoline compounds decreased by 39% for pentane, 37% for mCP and 38% for benzene. For all SOm and water contents tested, the Kd and R of all gasoline compounds were in the order of unblended gasoline 〉 B20 〉 E20, indicating that the use of high ethanol volume in gasoline to combat climate change could put the groundwater at greater risk of contamination,

关键词： butanol-blended gasoline ethanol-blended gasoline phase distribution soil organic matter soil water content sorption vadose zone

Host RNA circles and the origin of hepatitis delta virus

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world Journal of Gastroenterology 2014年第11期20卷 2971-2978页

作者： john m Taylor Fox Chase Cancer Center PhiladelphiaPA 19111United States

Recent reports show that many cellular RNAs are processed to form circular species that are relatively abundant and resistant to host *** some cases,such circles actually bind host *** depletion of available microRNAs appears to have biological roles;for instance,in homeostasis and *** findings regarding host RNA circles support a speculative reappraisal of the origin and mode of replication of hepatitis delta virus,hepatitis delta virus(HDV),an agent with a small circular RNA genome;specifically,it is proposed that in hepatocytes infected with hepatitis B virus(HBV),some viral RNA species are processed to circular forms,which by a series of chance events lead to an RNA that can be both replicated by host enzymes and assembled,using HBV envelope proteins,to form particles some of which are *** a model also may provide some new insights into the potential pathogenic potential of HDV *** return,new insights into HDV might provide information leading to a better understanding of the roles of the host RNA circles.

关键词： Hepatitis B virus Hepatitis delta virus Circular RNA Ribozymes microRNA