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SERVICE VALUE NETWORKS:INTO PRACTICE

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Journal of Systems Science and Systems Engineering 2007年第4期16卷 414-423页

作者： john HAmILTON Director of E-Business James Cook UniversityCairns4870Australia

modeling a business to match its customer perceived （and customer desired） outcomes, remains an on-going task. This paper considers shows how a service value networks （SVNs） approach may be engaged to model, and deliver, understanding of the front-end business and its direct engagement with its immediate （or front-end） customers. These front-end customers may be either：（1） its off-line, in-store customers - engaging directly with the business sales staff （or representative）, or-（2） its on-line, virtual customers - engaging with the business via internet or remote access. In this situation, both the business, and the customer draw upon their respective viewpoints, and both sides influence the interaction. External to these business and customer influences are additional factors that capture the immediate and broader global effects - termed environmental effects. These three business-customer engagement areas of influence are captured by a SVN SEm approach. Without a business-customer encounter of some kind the likelihood of a services business, and a prospecting customer, successfully engaging in an exchange process is reduced. This exchange may be a physical, and/or services exchange, and/or an information and/or ideas exchange. To the business, this encounter is, in effect, a trade, and as a result, the business targets acquiring an economic exchange that will ultimately deliver a net positive economic outcome. To the customer, external and internal information feeds, servicing, perceived value, and satisfaction, are key encounter drivers. SVNs offers a new way to understand the business-customer encounter, and to then utilize this acquired knowledge to either：（1） build a strategic management model, or （2） reengineer its business networks, and to then create a re-positioned, more customer-aligned business operation - one that is capable of delivering win - win, competitive business-customer solutions.

关键词： Service value networks alignment structural equation modeling

Towards smart self-clearing glaucoma drainage device

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microsystems & Nanoengineering 2018年第1期4卷 73-84页

作者： Hyunsu Park Amir Hossein Raffiee Simon W.m.john Arezoo m.Ardekani Hyowon Lee Weldon School of Biomedical Engineering Birck Nanotechnology CenterCenter for Implantable DevicesPurdue UniversityWest LafayetteIN 47907USA School of mechanical Engineering Purdue UniversityWest LafayetteIN 47907USA Howard Hughes medical Institute The Jackson LaboratoryBar HarborME 04609USA

For patients who are unresponsive to pharmacological treatments of glaucoma,an implantable glaucoma drainage devices(GDD)are often used to manage the intraocular ***,the microscale channel that removes excess aqueous humor from the anterior chamber often gets obstructed due to biofouling,which necessitates additional surgical *** we demonstrate the proof-of-concept for smart self-clearing GDD by integrating magnetic microactuators inside the drainage tube of *** magnetic microactuators can be controlled using externally applied magnetic fields to mechanically clear biofouling-based obstruction,thereby eliminating the need for surgical *** this work,our prototype magnetic microactuators were fabricated using low-cost maskless photolithography to expedite design *** fabricated devices were evaluated for their static and dynamic mechanical *** transient numerical analysis,the fluid–structure interaction of our microactuator inside a microtube was characterized to better understand the amount of shear force generated by the device ***,the anti-biofouling performance of our device was evaluated using fluorescein isothiocyanate labeled bovine serum *** microactuators were effective in removing proteinaceous film deposited on device surface as well as on the inner surface of the microchannel,which supports our hypothesis that a smart self-clearing GDD may be possible by integrating microfabricated magnetic actuators in chronically implanted microtubes.

关键词： fouling integrating removing

Interfacial assembly of two-dimensional mXenes

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Journal of Energy Chemistry 2021年第9期30卷 417-434页

作者： Chuanfang(john)Zhang Laboratory for Functional Polymers Swiss Federal Laboratories for Materials Science and Technology(Empa)ETH DomainUberlandstrasse 129CH-8600 DubendorfSwitzerland

Two-dimensional(2D) transition metal carbides, carbonitrides and nitrides, known as mXenes, are emerging quickly at the frontiers of 2D materials world. Their exotic properties such as the highest electrical conductivity among all solution-processed 2 D materials, the best electromagnetic interference shielding performance outperforming that of copper or aluminum at a nanoscale thickness, as well as the highest volumetric capacitance for pseudocapacitors, have been attracting extensive fundamental research and applications. Their unique surface chemistries, that is, hydrophilic groups terminated on the surface of mXenes after etching and delamination, enable plenty of opportunities for assembling into mXene building blocks. Particularly, assembling at liquid–liquid, liquid–solid, liquid–air, and solid–solid interfaces allows the efficient fabrication of various structures, including mXene surfactants, mXene heterostructures, mXene transparent films. Interfacial assembly of mXenes is of significance in unveiling more versatilities of mXenes as well as impacts on novel mXene-based architectures, based on which enhanced performance of devices is achieved. As such, this review focuses on the interfacial assembly of mXenes, explaining mechanisms behind various assembling and providing classical examples for corresponding interfacial assembling techniques. Applications of these as-assembled architectures are also discussed in brief. We believe this review may shed light on the interfacial chemistry of mXenes, thus guiding more efficient fabrication of mXene-based functional films/coatings/electrodes/devices.

关键词： Interfacial assembly mXene Interfacial tension Crosslinking Heterostructures

Finite Element modeling in Drilling of Nimonic C-263 Alloy Using Deform-3D

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Computer modeling in Engineering & Sciences 2019年第3期118卷 679-692页

作者： m.Nagaraj A.john Presin Kumar C.Ezilarasan Rishab Betala Research Scholar Department of Mechanical EngineeringHindustan Institute of Technology and ScienceChennai-603103India Associate Professor Department of Mechanical EngineeringHindustan Institute of Technology and ScienceChennai-603103India Professor Department of Mechanical EngineeringSMK Fomra Institute of TechnologyKelambakkamChennai-603103India Design Engineer ARE PEE PolymerGummidipoondiTiruvallur-601201India

The paper proposes a simulated 3D Finite Element model(FEm)for drilling of Nickel based super alloy known as Nimonic *** Lagrangian finite element model-based simulations were performed to determine the thrust force,temperature generation,effective stress,and effective *** simulations were performed according to the L27 orthogonal array.A perfect plastic work piece was assumed,and the shape is considered to be *** spindle speed,feed rate,and point angle were considered as the input *** work piece was modeled by johnson-Cook(JC)material model and tungsten carbide(WC)was chosen as the drill bit and the body was assumed to be *** demonstrative results of the thrust force and the temperature at drill bit cutting edge were substantiated with the simulated results and a percentage error was observed within 10%.Further,simulated results of effective stress and strain were also observed.

关键词： Nimonic C-263 Thrust force temperature effective stress effective strain deform-3D simulation

Tuning the intentional corona of cerium oxide nanoparticles to promote angiogenesis via fibroblast growth factor 2 signalling

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Regenerative Biomaterials 2022年第1期9卷 963-978页

作者： Lu Fu Rupeng Li john m.Whitelock megan S.Lord Graduate School of Biomedical Engineering UNSW SydneySydneyNSW 2052Australia School of minerals and Energy Resources Engineering UNSW SydneySydneyNSW 2052Australia

Inadequate angiogenesis is a hallmark of conditions including cardiovascular diseases,stroke and chronic diabetic wounds,which exhibit tissue ischaemia ensuring that therapeutic strategies to promote angiogenesis are of great ***,many angiogenic treatments involve the delivery of growth factors which have limited clinical success due to poor stability,high manufacturing cost and poor *** oxide nanoparticles(nanoceria)can either promote or inhibit angiogenesis depending on their surface corona ***,nanoceria were functionalized with an intentional heparin corona,a polysaccharide which binds and signals growth factors,of different chain lengths and surface grafting density to establish their effect on *** nanoparticles promoted angiogenesis in vivo with the surface grafting density positively correlated with angiogenesis over the widest concentration range;however,chain length did not play a *** heparin–nanoceria supported fibroblast growth factor 2(FGF2)signalling in vitro and promoted FGF2-mediated angiogenesis in *** nanoparticles were internalized by endothelial cells in vitro where they trafficked to the lysosomes and reduced cell viability suggesting that the angiogenic activity of heparin–nanoceria is mediated in the extracellular ***,this study adds to our knowledge of the angiogenic effects of heparin–nanoceria towards finding new angiogenic treatments.

关键词： cerium oxide nanoparticle endothelial angiogenesis

Prototype chemical synapse chip for spatially patterned neurotransmitter stimulation of the retina ex vivo

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microsystems & Nanoengineering 2017年第1期3卷 59-70页

作者： Corey m.Rountree Ashwin Raghunathan john B.Troy Laxman Saggere Department of mechanical and Industrial Engineering University of Illinois at ChicagoChicagoIL 60607USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA

Biomimetic stimulation of the retina with neurotransmitters,the natural agents of communication at chemical synapses,could be more effective than electrical stimulation for treating blindness from photoreceptor degenerative *** studies have demonstrated the feasibility of neurotransmitter stimulation by injecting glutamate,a primary retinal neurotransmitter,into the retina at isolated single ***,we demonstrate spatially patterned multisite stimulation of the retina with glutamate,offering the first experimental evidence for applicability of this strategy for translating visual patterns into afferent neural *** accomplish pattern stimulation,we fabricated a special microfluidic device comprising an array of independently addressable microports connected to tiny on-chip glutamate reservoirs via *** device prefilled with glutamate was interfaced with explanted rat retinas placed over a multielectrode array(mEA)with the retinal ganglion cells(RGC)contacting the electrodes and photoreceptor surface contacting the *** independently and simultaneously activating a subset of the microports with modulated pressure pulses,small boluses of glutamate were convectively injected at multiple sites in alphabet patterns over the photoreceptor *** found that the glutamate-driven RGC responses recorded through the mEA system were robust and spatially laid out in patterns strongly resembling the injection *** stimulations were also highly localized with spatial resolutions comparable to or better than electrical retinal *** findings suggest that surface stimulation of the retina with neurotransmitters in pixelated patterns of visual images is feasible and an artificial chemical synapse chip based on this approach could potentially circumvent the limitations of electrical retinal prostheses.

关键词： artificial vision neurotransmitter stimulation photoreceptor degeneration retina synapse chip visual prosthesis

Interface-induced warping in hybrid two-dimensional materials

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Nano Research 2015年第6期8卷 2015-2023页

作者： john m. Aired Zhuhua Zhang Zhili Hu Boris I. Yakobson Department of material Science and Nanoengineering Rice University Houston Texas 77005 USA

Two-dimensional hybrid materials consisting of heterogeneous domains have been of great interest. Using empirical molecular dynamical simulation, we show that the morphology of such hybrid 2D materials can extend into the third dimension via strong warping intrinsic to the interfaces between the domains. The interface warping stems from the compressive stress in the domain with a larger lattice constant and even penetrates into the stretched domain. Based on classic plate theory, we analytically quantify the amplitude, wave length and penetration depth of the interface warping as functions of the lattice mismatch, achieving good agreement with the simulations. moreover, we propose that periodically placing pentagon-heptagon dislocations along the interface can eliminate the warping in the 2D material and such defective interface can be more favorable than the warped one over a critical domain size, which is consistent with recent experimental observations. Our results suggest that the interface warping in 2D hybrid materials should be considered in further exploring their promising properties.

关键词： graphene interface rippling mechanical property hybrid 2D materials

History and evaluation of national-scale geochemical data sets for the United States

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Geoscience Frontiers 2013年第2期4卷 167-183页

作者： David B.Smith Steven m.Smith john D.Horton U.S.Geological Survey.Denver Federal Center MS 973.DenverCO 80225USA

Six national-scale,or near national-scale,geochemical data sets for soils or stream sediments exist for the United *** earliest of these,here termed the ＇Shacklette＇ data set,was generated by a U.S. Geological Survey（USGS） project conducted from 1961 to *** project used soil collected from a depth of about 20 cm as the sampling medium at 1323 sites throughout the conterminous *** National Uranium Resource Evaluation Hydrogeochemical and Stream Sediment Reconnaissance（NUREHSSR） Program of the *** of Energy was conducted from 1975 to 1984 and collected either stream sediments,lake sediments,or soils at more than 378,000 sites in both the conterminous *** *** sampled area represented about 65%of the *** Natural Resources Conservation Service（NRCS）,from 1978 to 1982,collected samples from multiple soil horizons at sites within the major crop-growing regions of the conterminous *** data set contains analyses of more than 3000 *** National Geochemical Survey,a USGS project conducted from 1997 to 2009,used a subset of the NURE-HSSR archival samples as its starting point and then collected primarily stream sediments, with occasional soils,in the parts of the *** covered by the NURE-HSSR *** data set contains chemical analyses for more than 70,000 *** USGS,in collaboration with the mexican Geological Survey and the Geological Survey of Canada,initiated soil sampling for the North American Soil Geochemical Landscapes Project in *** of three horizons or depths at more than 4800 sites in the *** completed in 2010,and chemical analyses are currently *** NRCS initiated a project in the 1990s to analyze the various soil horizons from selected pedons throughout the *** data set currently contains data from more than 1400 *** paper（1） discusses each data set in terms of its purpose,sample collection protocols,and analytical methods;and（2） evaluates each data set in terms

关键词： Geochemical mapping National-scale geochemical data Geochemical baselines United States

Chemoprevention of esophageal adenocarcinoma

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Gastroenterology Report 2020年第4期8卷 253-260,I0001页

作者： Erik J.Snider Andrew m.Kaz john m.Inadomi William m.Grady Division of Gastroenterology Department of Internal MedicineUniversity of Washington School of MedicineSeattleWAUSA Gastroenterology Section VA Puget Sound Health Care SystemSeattleWAUSA Clinical Research Division Fred Hutchinson Cancer Research CenterSeattleWAUSA

Esophageal adenocarcinoma(EAC)is a major cause of cancer-related death,particularly in Western populations,and is rapidly rising in Asian populations at this *** all EACs develop from the precursor lesion Barrett’s esophagus(BE),which is the most significant risk factor for ***,the rates of progression from BE to EAC are low and patients with BE are ***,any strategy for EAC prevention must carry a low risk of harm in order to be clinically *** current EAC-screening and BE-surveillance methods carry some procedural risk and are burdensome,there is an opportunity for chemoprevention,*** or dietary factors that may prevent BE from progressing to EAC.A variety of candidate chemoprevention therapies have been assessed to ***-pump inhibitors(PPIs)are the best studied and have modest EAC-chemoprevention efficacy in BE patients,with a recent randomized trial showing that high-dose PPI may be more effective than low-dose *** and other non-steroidal anti-inflammatory drugs have moderate quality observational and randomized-trial evidence for preventing progression of BE to EAC,but their risks for harm have precluded their routine clinical *** therapies(statins,metformin,female sex hormones)generally do not have strong evidence to support their use in EAC *** progress has been made in this field,there is still a need for more effective and safe chemoprevention therapies for EAC.

关键词： Barrett’s esophagus esophageal adenocarcinoma chemoprevention