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星状玻璃体变性患者眼内3片式硅树脂人工晶体表面钙化:临床病理报道

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 54-54页

作者： Werner l. Kollarits C.R. Mamalis N. Olson R.J. 宋虎平 john A. Moran Eye Center University of Utah50 North Medical Drive Salt Lake City UT 84132 United States

Objective: To illustrate the laboratory findings in a patient with bilateral asteroid hyalosiswho presentedwith calcified deposits on a 3- piece silicone intraocular lens (IOl). Design: Observational case report. Methods: A 76- year- old diabetic woman underwent uneventful cataract surgery in 1994 with implantation of a silicone- optic polypropylene- haptic IOl in the left eye. A neodymium:yttrium- aluminum- garnet (Nd:YAG) laser posterior capsulotomy was performed 2 years after cataract surgery, but persistent whitish deposits were observed on the posterior optic surface of the lens. Over the next 3 years, the opacification increased in the region corresponding to the capsulotomy. The IOl was explanted/exchanged. The right eye had cataract surgery in 1995. The acrylic lens implanted in this eye developed no opacities after 6 years. Main Outcome Measures: Gross, microscopic, and surface analyses of the explanted IOl. Results: Gross and light microscopic analyses revealed the presence of confluent crustlike deposits on the central area of the posterior optic surface, as well as Nd:YAG pits. Individual spherules exhibiting a Maltese- cross pattern under polarizing light were also observed. Energy dispersive x- ray spectroscopic analyses demonstrated the composition of the confluent deposits to be similar to hydroxyapatite. Conclusions: An association between asteroid hyalosis and dystrophic calcification of IOls has been reported only with silicone plate haptic designs. The material opacifying the 3- piece silicone lens probably was derived from the asteroid bodies or from the process that results in this vitreous condition. Clinical evaluation of other pseudophakic patients with asteroid hyalosis will confirm if this phenomenon is restricted to silicone IOls.

关键词：玻璃体变性人工晶体硅树脂片式白内障手术玻璃体星状变性白内障摘除光学面晶体植入晶体相

五羟色胺2C受体结构揭示GPCR多重药理学特性的结构基础

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科学新闻 2019年第2期 48-48页

作者：彭瑶 john D.McCorvy Kasper Harps?e Katherine lansu Shuguang Yuan Petr Popov lu Qu Mengchen Pu Tao Che louise F.Nikolajsen Xi-Ping Huang Yiran Wu ling Shen Walden E.Bj?rn-Yoshimoto Kang Ding Daniel Wacker Gye Won Han Jianjun Cheng Vsevolod Katritch Anders A.Jensen Michael A.Hanson Suwen Zhao David E.Gloriam Bryan l.Roth Raymond C.Stevens 刘志杰上海科技大学iHuman研究所中国科学院生物物理研究所上海科技大学

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2C受体选择性的配体或设计具有明确的多重药理学特... 详细信息

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2C受体选择性的配体或设计具有明确的多重药理学特征的药物仍然是极其困

关键词：五羟色胺

宫内输血两次后大脑中动脉收缩期流速峰值与胎儿血红蛋白的关系

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 20-20页

作者： Mari G. Zimmermann R. Moise Jr. K.J. Deter R.l. 高雪莲 Hutzel Women' s Hospital Rush Center- PRB Obstetrics and Gynecology 3990 John R. Detroit MI 48201 United StatesDr.

The middle cerebral artery peak systolic velocity (MCA- PSV) has been successfully used for timing the first 2 transfusions in fetuses at risk for anemia because of maternal red cell alloimmunization. The Abstract of this study was to assess whether the correlation between the MCA- PSV and fetal hemoglobin is maintained in fetuses that had undergone 2 previous intrauterine transfusions. Study design: Doppler measurement of MCA- PSV was performed before cordocentesis in 39 fetuses. The timing of the third transfusion was based on traditional criteria. The values of MCA- PSV and hemoglobin were expressed as multiples of the median (MoM). Anemia was defined as mild (hemoglobin l age, moderate (hemoglobin lobin lysis was used to assess the correlation between the MCA- PSV MoM and fetal hemoglobin MoM. Results: Gestational age at Doppler study ranged from 22 to 35 weeks. Six fetuses (15% ) had normal hemoglobin concentration; 21 (53% ) had mild anemia; 7 (20% ) had moderate anemia; and 5 (12% ) had severe anemia. There was a linear correlation between fetal hemoglobin (y) and the MCA- PSV (x): y = 1.185 - 0.341x. Conclusion: Previously, concerns have been expressed about the accuracy of Doppler prediction of anemia after previous transfusions. Our data suggest that there is a good correlation between the MCA- PSV and fetal hemoglobin in fetuses that have undergone 2 previous transfusions. Our findings expand the clinical situation in which Doppler can be used to monitor red cell alloimmunized pregnancies.

关键词：胎儿血红蛋白收缩期流速峰值胎儿大脑中动脉宫内输血血红蛋白浓度轻度贫血重度贫血 PSV MCA 高危状态

卒中医疗体系之急诊医疗服务的实施策略美国心脏协会/美国卒中协会急诊医疗服务体系专家组和卒中委员会的政策声明

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中华脑血管病杂志（电子版） 2008年第6期2卷 354-370页

作者： Joe E.AckerⅢ Arthur M.Pancioli Todd J.Crocco Marc K.Eckstein Edward C.Jauch Hollynn larrabee Neil M.Meltzer William C.Mergendahl john W.Munn Susanne M.Prentiss Charles Sand Jeffrey l.Saver Brian Eigel Brian R.Gilpin Mark Schoeberl Penelope Solis JoAnne R.Bailey Katie B.Horton Steven K.Stranne 曹勇军李瑞霞刘建芳刘春风苏州大学附属第二医院神经内科 215004

尽管卒中的预防、诊断、治疗和康复已取得一些进展，但卒中在美国仍然是第三大死亡原因和长期残疾的主要原因。每年约有70万人新发或复发卒中。在过去10年里，急性卒中诊治的一些进展，包括纤溶和其他短期疗法的引入，

关键词：美国心脏协会急诊医疗服务体系卒中协会医疗体系委员会专家组死亡原因急性卒中

卒中医疗体系之急诊医疗服务的实施策略美国心脏协会／美国卒中协会急诊医疗服务体系专家组和卒中委员会的政策声明

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国际脑血管病杂志 2008年第7期16卷 481-498页

作者： Joe E. Acker Ⅲ Arthur M. Pancioli Todd J. Crocco Marc K. Eckstein Edward C. Jauch Hollynn larrabee Neil M. Meltzer William C. Mergendahl john W. Mann Susanne M. Premiss Charles Sand Jeffrey l. Saver Brian Eigel Brian R. Gilpin Mark Schoeberl Penelope Solis JoAnne R. Bailey Katie B. Horton Steven K. Stranne 曹勇军(译) 李瑞霞(译) 刘建芳(译) 刘春风(译) 不详苏州大学附属第二医院神经内科 215004

尽管卒中的预防、诊断、治疗和康复已取得一些进展，但卒中在美国仍然是第三大死亡原因和长期残疾的主要原因。每年约有70万人新发或复发卒中。在过去10年里，急性卒中诊治的一些进展，包括纤溶和其他短期疗法的引入，突出显示了急诊医... 详细信息

尽管卒中的预防、诊断、治疗和康复已取得一些进展，但卒中在美国仍然是第三大死亡原因和长期残疾的主要原因。每年约有70万人新发或复发卒中。在过去10年里，急性卒中诊治的一些进展，包括纤溶和其他短期疗法的引入，突出显示了急诊医疗服务（emergency medical services，EMS）机构和急诊医疗服务体系（emergency medical services systems，EMSS）在优化卒中医疗中的关键作用。

关键词：急诊医疗服务体系美国心脏协会卒中协会医疗体系委员会专家组死亡原因急性卒中

Diterpenoids from Scutellaria barbata induce tumour-selective cytotoxicity by taking the brakes off apoptosis

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Medicinal Plant Biology 2022年第1期1卷 8-23页

作者： Matthew l.Tomlinson Man Zhao Elaine J.Barclay Jie li Haixiu li Juri Felix lionel Hill Gerhard Saalbach Martin Rejzek Dongfeng Yang Qing Zhao Paul Kroon Wei Wang Yongping Bao Melanie-Jayne R.Howes Evangelos C.Tatsis Cathie Martin The john Innes Centre NorwichNR47UHUnited Kingdom College of Bioengineering and Biotechnology Zhejiang University of TechnologyHangzhou 310058China National Key laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Royal Botanic Gardens Kew RichmondSurreyLondon TW93ABUnited Kingdom College of life Sciences Zhejiang Sci-Tech UniversityXiasha Higher Education ZoneHangzhou 310018China Shanghai Key laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghai 201602China Quadram Institute Bioscience Norwich Research ParkNorwichNR47UAUnited Kingdom Norwich Medical School University of East AngliaNorwichNorfolkNR47TJUnited Kingdom CEPAMS:CAS-JIC Centre of Excellence in Plant and Microbial Sciences

Medicinal plants are an excellent source of structurally diverse,bio-active compounds with potential in the fight against *** of the most promising is Scutellaria barbata,prescribed traditionally for the treatment of *** A is the major diterpenoid,produced in specialized large,peltate trichomes on leaves of *** induces dose-dependent apoptosis,specifically in cancer *** major class of proteins down-regulated are pro-survival proteins,the Inhibitors of Apoptosis(IAPs),and IAP regulating *** propose that scutebarbatine A works by releasing the molecular brakes(the IAPs)on apoptosis in cell death-evading cancer *** between the cytotoxicity of methanolic extracts of *** leaves and decoctions(Ban Zhi lian)prepared traditionally,showed substantially different chemical compositions and differential induction of *** suggest polyvalency between the constituents in both extracts,and ways to produce enhanced chemopreventive preparations for the treatment of cancer.

关键词： prescribed methanol structurally

脑动脉粥样硬化的颅内血管成形和支架置入术美国介入和治疗神经放射学学会、介入放射学学会和美国神经放射学学会的立场声明

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中华脑血管病杂志（电子版） 2008年第2期2卷 118-123页

作者： Randall T. Higashida P.M. Meyers J.J. Connors David Sacks C.M. Strother john D. Barr Joan C. Wojak Gary R. Duckwiler 周志明徐格林刘新峰 From the Departments of Radiology Neurology Neurological Surgery and Anesthesiology Neurointerventional Radiology Division University of California San Francisco Medical Center 505 Parnassus Avenue L-352 San Francisco CA 94143-0628 Departments of Radiology and Neurological Surgery Neuroendovascular Service Columbia University Medical Center 710 West 168th Street Rm 404 New York NY 10032 Interventional Neuroradiology Division Baptist Hospital of Miami Miami FL 33176 Department of Radiology Reading Hospital and Medical Center West Reading Pennsylvania 19611 Department of Radiology and Division of Interventional Neuroradiology Methodist Hospital Houston Texas 77030 Interventional Neuroradiology Baptist Memorial Hospitals Memphis Tennessee 38120 Our lady of lourdes Regional Medical Center Lafayette Louisiana 70506 Department of Radiology and Division of Endovascular Neuroradiology University of California Los Angeles Los Angeles California 90095 南京军区南京总医院神经内科

在北美、欧洲和亚洲,卒中是第3 位死亡原因和成人残疾的首要病因[1,2].颅内动脉粥样硬化所致的卒中约占所有缺血性卒中的8%～10%,据报道,在亚洲、非洲和西班牙裔人群中这一比例更高[3-5].

关键词：颅内动脉粥样硬化脑动脉粥样硬化神经放射学介入放射学支架置入术美国血管成形学会

脑动脉粥样硬化的颅内血管成形和支架置入术：美国介入和治疗神经放射学学会、介入放射学学会和美国神经放射学学会的立场声明

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国际脑血管病杂志 2008年第1期16卷 3-8页

作者： Randall T. Higashida P.M. Meyers J.J. Connors David Sacks C.M. Strother john D. Barr Joan C. Wojak Gary R. Duckwiler 周志明(译) 徐格林(译) 刘新峰(译) From the Departments of Radiology Neurology Neurological Surgeryand Anesthesiology Neurointerventional Radiology Division University of California San Francisco Medical Center 505 Parnassus Avenue L-352 San Francisco CA 94143-0628 Departments of Radiology and Neurological Surgery Neuroendovascular Service Colurnbia University Medical Center 710 West 168th Street Rm 404 New York NY 10032 Interventional Neuroradiology Division Baptist Hospital of Miami Miami FL 33176 Department of Radiology Reading Hospital and Medical Center West Read- ing Pennsylvania 19611 Department of Radiology and Division of Interven- tional Neuroradiology Methodist Hospital Houston Texas 77030 Interventional Neuroradiology Baptist Memorial Hospitals Memphis Tennessee 38120 Interventional Neuroradiology Our lady of lourdes Regional Medical Center Lafayette Louisiana 70506 Department of Radiology and Division of Endovascular Neuroradiology University of California Los Angeles Los Angeles California 90095 南京军区南京总医院神经内科 210002

在北美、欧洲和亚洲，卒中是第3位死亡原因和成人残疾的首要病因。颅内动脉粥样硬化所致的卒中约占所有缺血性卒中的8％～10％，据报道，在亚洲、非洲和西班牙裔人群中这一比例更高。其危险因素包括胰岛素依赖性糖尿病、高胆固醇血症、... 详细信息

在北美、欧洲和亚洲，卒中是第3位死亡原因和成人残疾的首要病因。颅内动脉粥样硬化所致的卒中约占所有缺血性卒中的8％～10％，据报道，在亚洲、非洲和西班牙裔人群中这一比例更高。其危险因素包括胰岛素依赖性糖尿病、高胆固醇血症、高血压和吸烟。在美国，估计每年有40000～60000例新发卒中是由于颅内动脉粥样硬化所致。

关键词：颅内动脉粥样硬化脑动脉粥样硬化神经放射学介入放射学支架置入术美国血管成形学会

Accretion in strong field gravity with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley liJun Gou Yuan liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun lu Bin luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu linares Zhu liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna liJing Shao Malgosia Sobolewska Eva Sramkova Abigail l.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski Xinlin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and Department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of Physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physics Anhui Normal University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion