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Comprehensive molecular analysis to predict the efficacy ofchemotherapy containing bevacizumab in patients with metastaticcolorectal cancer

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Oncology Research 2023年第6期31卷 855-866页

作者： SUNG hee LIM hee JIN CHO KYOUNG-MEE KIM HO YEONG LIM WON KI KANG JEEYUN LEE YOUNG SUK park hee CHEOL KIM SEUNG TAE KIM Division of Hematology/Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea Precision Medicine Research Institute Samsung Medical CenterGangnam-guSeoul06351Korea Department of Biomedical Convergence Science and Technology Kyungpook National UniversityDaegu41566Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul06351Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea

Background:Although bevacizumab is an important treatment for metastatic colorectal cancer(CRC),not allpatients with CRC benefit from it;in unselected patient populations,only modest survival benefits have been ***:We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identifybiomarkers for a response to bevacizumab-containing *** molecular analysis comprised whole-exomesequencing,ribonucleic acid sequencing,and a methylation array on patient ***:Genomic and molecularcharacterization was successfully conducted in 103 *** of 103 CRC samples were hypermutated,and none ofthe non-hypermutant tumors were microsatellite *** those 103 patients,89 had adenocarcinoma(ADC),15 were diagnosed with mucinous ADC,and six had signet-ring cell carcinoma(SRCC).Consensus molecular subtype(CMS)2 was unique to *** the four SRCCs,two were CMS1,one was CMS4,and the other was *** status was a significantly enriched factor in responders to bevacizumab *** growth factorreceptor(FGFR)1/2 signaling was upregulated in non-responders,whereas cell cycle,transfer ribonucleic acidprocessing,nucleotide excision repair,and oxidative phosphorylation pathways were enriched in ***,IGF1 was differentially expressed in non-responders(log2 fold change=−1.43,p=4.11×10^(−5),falsediscovery rate=0.098),and FLT1 was highly methylated in non-responders(p=7.55×10^(−3)).When the molecularpathways were reanalyzed separately according to the backbone chemotherapy(FOLFOX ***),thesignificance of the molecular pathways varied according to the backbone ***:This studysought a subset of CRC patients with a distinct clinical response to chemotherapy containing *** need to be validated in a large group of homogenous patient cohort and examined according to the differentchemotherapy backbones to create personalized therapeutic oppor

关键词： Bevacizumab Whole-exome sequencing Ribonucleic acid sequencing Methylation array Colorectal cancer

Methane Emission from Rice Fields:Necessity for Molecular Approach for Mitigation

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Rice science 2024年第2期31卷 159-178页

作者： Sujeevan RAJENDRAN Hyeonseo park Jiyoung KIM Soon Ju park Dongjin SHIN Jong-hee LEE Young Hun SONG Nam-Chon PAEK Chul Min KIM Department of Horticulture Industry Wonkwang UniversityIksan 54538Korea Plant Molecular Biology and Biotechnology Research Center Gyeongsang National UniversityJinju 52828Korea Department of Southern Area Crop Science National Institute of Crop ScienceMiryang 50424Korea Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Department of Plant Science Plant Genomics and Breeding InstituteResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Korea

Anthropogenic methane emissions are a leading cause of the increase in global averagetemperatures,often referred to as global *** soils play a significant role in methaneproduction,where the anaerobic conditions promote the production of methane by *** fields contribute a considerable portion of agricultural methane emissions,as riceplants provide both factors that enhance and limit methane *** plants harbor both methaneproducingand methane-oxidizing *** from rice roots provide source for methaneproduction,while oxygen delivered from the root aerenchyma enhances methane *** haveshown that the diversity of these microorganisms depends on rice cultivars with some genes characterizedas harboring specific groups of microorganisms related to methane ***,there is still aneed for research to determine the balance between methane production and oxidation,as rice plantspossess the ability to regulate net methane *** agronomical practices,such as fertilizerand water management,have been employed to mitigate methane ***,studiescorrelating agronomic and chemical management of methane with productivity are ***,evidences for breeding low-methane-emitting rice varieties are scattered largely due to the absence ofcoordinated breeding *** has indicated that phenotypic characteristics,such as rootbiomass,shoot architecture,and aerenchyma,are highly correlated with methane *** reviewdiscusses available studies that involve the correlation between plant characteristics and *** emphasizes the necessity and importance of breeding low-methane-emitting rice varieties inaddition to existing agronomic,biological,and chemical *** review also delves into the idealphenotypic and physiological characteristics of low-methane-emitting rice and potential breeding techniques,drawing from studies conducted

关键词： methane emission rice breeding aerenchyma greenhouse gas radial oxygen loss

Adaptive Electrospinning System Based on Reinforcement Learning for Uniform‑Thickness Nanofiber Air Filters

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Advanced Fiber Materials 2023年第2期5卷 617-631页

作者： Seok Hyeon Hwang Jin Yeong Song Hyun Il Ryu Jae hee Oh Seungwook Lee Donggeun Lee Dong Yong park Sang Min park School of Mechanical Engineering Pusan National University63‑2 Busan University‑roGeumjeong‑guBusan 46241South Korea Smart Manufacturing Technology R&D Group Korea Institute of Industrial Technology320 Techno Sunhwan‑roYuga‑eupDalseong‑gunDaegu 42994Republic of Korea

Electrospinning is a simple and versatile method to produce nanofiber ***,owing to bending instability that occurs during the electrospinning process,electrospinning has frequently produced a non-uniform-thickness nanofiber filter,which deteriorates its air ***,an adaptive electrospinning system based on reinforcement learning(E-RL)was developed to produce uniform-thickness nanofiber *** E-RL accomplished a real-time thickness measurement of an electrospun nanofiber filter by measuring the transmitted light through the nanofiber filter using a camera placed at the bottom of the collector and converting it into thickness using the Beer–Lambert *** on the measured thickness,the E-RL detected the non-uniformity of the nanofiber filter thickness and manipulated the movable collector to alleviate the non-uniformity of the thickness by a pre-trained reinforcement learning(RL)*** the training of the RL algo-rithm,the nanofiber production simulation software based on the empirical model of the deposition of the nanofiber filter was developed,and the training process of the RL algorithm was repeated until the optimal policy was *** the training process with the simulation software,the trained model was transferred to the adaptive electrospinning *** the movement of the collector under the optimal strategy of RL algorithm,the non-uniformity of such nanofiber filters was significantly reduced by approximately five times in standard deviation and error for both simulation and *** finding has great potential in improving the reliability of electrospinning process and nanofiber filters used in research and industrial fields such as environment,energy,and biomedicine.

关键词： Electrospinning Nanofiber filter Uniform thickness Reinforcement learning Deep Q-network

MXene ink hosting zinc anode for high performance aqueous zinc metal batteries

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Journal of Energy Chemistry 2023年第1期76卷 187-194,I0005页

作者： Jae Min park Milan Jana Sang Ha Baek Taehun Kang Peixun Xiong Jeong hee park Jun Soo Kim Ali Shayesteh Zeraati Mikhail Shekhirev Paul V.Braun Yury Gogotsi Ho Seok park School of Chemical Engineering Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746Republic of Korea Department of Chemical and Petroleum Engineering University of Calgary2500 University Dr NWCalgary T2N 1N4Canada Department of Materials Science and Engineering Materials Research LaboratoryBeckman Institute for Advanced Science and TechnologyUniversity of Ilinois at Urbana-ChampaignUrbanaIL61801USA A.J.Drexel Nanomaterials Institute and Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA 19104USA SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University 2066SeoburoJangan-guSuwon 440-746Republic of Korea

Despite the safety,low cost,and high theoretical capacity(820 mA h g^(-1))of Zn metal anodes,the practical application of aqueous Zn metal batteries remains a critical challenge due to the Zn dendrite growth,corrosion,and hydrogen evolution ***,we demonstrate the MXene ink hosting Zn metal anodes(MX@Zn)for high-performance and patternable Zn metal full *** as-designed MX@Zn electrode is more facile and reversible than bare Zn and CC@Zn,as verified by better cyclic stability and lower overpotentials of symmetric cells with the plating capacity of 0.05 mA h cm^(-2)at 0.1 m A cm^(-2)and of 1 m A h cm^(-2)at 1 m A cm^(-2).The MX@Zn|MnO_(2)full cells deliver a high specific capacity of 281.9 m A h g^(-1),91.5%of the theoretical capacity,achieving 50%capacity retention from 60 mA g^(-1)to 300 mA g^(-1)and 79.7%of initial capacity after 200 ***,the patterned devices based on the MX@Zn electrode achieve high energy and power densities of 348.57 Wh kg^(-1)and 1556 W kg^(-1),respectively,along with a capacity retention of 64%and Coulombic efficiency of 99%over 500 *** high performance of MX@Zn is attributed to the high electrical conductivity and hydrophilicity of MXene and rapid ion diffusion through the 3D interconnected porous channels.

关键词： MXene ink Zinc anode Metal batteries Patterning Electrodeposition

Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer

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World Journal of Gastroenterology 2014年第21期20卷 6586-6593页

作者： Wan park Bun Kim Soo Jung park Jae hee Cheon Tae Il Kim Won Ho Kim Sung Pil Hong Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea

AIM: To evaluate the depth of invasion of small, early colorectal cancers (ECCs) using conventional endoscopic features.

关键词： Colonoscopy Colorectal neoplasms Differential diagnosis

Variations in microstructure and bending formability of extruded Mg–Al–Zn–Ca–Y–MM alloy with precompression and subsequent annealing treatment conditions

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Journal of Magnesium and Alloys 2022年第9期10卷 2475-2490页

作者： Jong Un Lee Sang-Hoon Kim Dong hee Lee Hyun Ji Kim Young Min Kim Sung Hyuk park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Agency for Defense Development Daejeon 34186Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study, the bending formability of an extruded Mg–9Al–1Zn–0.3Mn–0.9Ca–0.6Y–0.5 MM(AZXWMM91100, wt%) alloy at room temperature is significantly improved through application of a combined precompression and subsequent annealing(PCA) treatment. As the amount of precompression applied along the extrusion direction(ED)(i.e., the total strain) increases from 4% to 6%, the area fraction of ED-oriented grains of the PCA-treated alloy increases, which consequently causes an improvement in its bending formability because these grains accommodate larger tensile strain along the ED during bending. As the temperature of the subsequent annealing treatment increases from 350 ℃ to 450 ℃, both the area fraction of the ED-oriented grains and the average grain size increase, and the residual dislocation density decreases owing to the promotion of boundary migration and occurrence of the recovery process at higher ***, the bending formability of both the 4%-precompressed and the 6%-precompressed samples increases with an increase in the annealing temperature. However, when the precompressed samples are annealed at 300 ℃, their bending formability is lower than that of the extruded alloy because the dislocations formed by precompression remain even after the subsequent annealing at this temperature.

关键词： Magnesium Extrusion Bending Formability Texture

Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019

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World Journal of Pediatrics 2024年第7期20卷 692-700页

作者： Joonsik park Sook-Hyun park Yu-ra Kwon So Jin Yoon Joo hee Lim Jung Ho Han Jeong Eun Shin Ho Seon Eun Min Soo park Soon Min Lee Department of Pediatrics Yonsei University College of Medicine211 Eonjuro GangnamguSeoul 06273Republic of Korea

Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)*** study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a *** Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live ***-related claims data,encompassing diagnostic codes,diagnostic test costs,and administered procedures were sourced from the NHIS *** results of the developmental assessments are categorized into four groups based on standard deviation(SD)*** characteristics and complications were compared among the *** regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95%confidence intervals for each risk factor associated with mortality and morbidity in ***-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12%in VLBW and 16%in extremely low birth weight(ELBW)*** the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improvements in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with *** percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ventriculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over *** IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(P<0.0001).Surgical treatments were also significantly associated with abnormal developmental screening test *** The neurodevelopmental outcomes of infa

关键词： Cerebral intraventricular hemorrhage Developmental Hydrocephalus Mortality Posthemorrhagic ventricular dilatation Surgery

Effects of electrochemical synthetic conditions on surface property and photocatalytic performance of copper and iron-mixed p-type oxide electrodes

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Journal of Materials Science & Technology 2018年第9期34卷 1503-1510页

作者： Sun hee Yoon Dong Suk Han Unseock Kang Seung Yo Choi Wubulikasimu Yiming Ahmed Abdel-Wahab Hyunwoong park Chemical Engineering Program Texas A&M University at Qatar School of Energy Engineering Kyungpook National University Department of Mechanical Engineering Texas A&M University at Qatar

Earth-abundant copper and iron-mixed oxide（CuO/CuFeO_2; CFO） film electrodes are synthesized using an electrochemical deposition（ED） technique at two different ED potentials（-0.36 and-0.66 V vs saturated calomel electrode（SCE）; denoted as ED-1 and ED-2, respectively）. Then, their surface morphologies are compared, and the photo（electro）catalytic activities for the reduction of Cr（VI） are examined in aqueous solutions at pH 7 under simulated sunlight（AM 1.5 G; 100 mW cm（-2））. The degree of the electrical potential applied to the ED process significantly affects the thickness of the synthesized electrode film and the intensity ratio of the diffraction peaks of CuO（111） and CuFeO_2（012）. A 200 μm thick ED-2 sample with a distinct stacking of CuO on CuFeO_2 exhibits a larger broadband absorption spectrum than the 50-μm thick ED-1 with less separate stacking. Furthermore, the ED-2 sample has a higher intensity ratio of the diffraction peaks of CuO（111） and CuFe02（012） than ED-1. As-synthesized ED-2 samples produce larger photocurrents, leading to faster Cr（VI） reduction on the surface under given potential bias（-0.5 V vs SCE）or bias-free conditions. The energy levels（i.e., flatband potential） for the two samples are almost the same（only 10 mV difference）, presumably supposing that the enhanced photoactivity of the ED-2 sample for Cr（VI） reduction is due to the facilitated charge transfer. The time-resolved photoluminescence emission spectra analysis reveal that the lifetime（r） of the charge carriers in the ED-1 sample is 0.103 ns, which decreases to 0.0876 ns in the ED-2. The ED-2 sample synthesized at a high negative potential is expected to contribute greatly to the application of other solar-to-fuel energy conversion fields as a highly efficient electrode material.

关键词： Artificial photosynthesis Solar fuel Delafossites Morphology Charge transfer

Femtosecond laser-mediated anchoring of polymer layers on the surface of a biodegradable metal

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Journal of Magnesium and Alloys 2021年第4期9卷 1380-1388页

作者： Jaeho park Bo-In park Young Ju Son Sun hee Lee Seung-Hoon Um Yu-Chan Kim Myoung-Ryul Ok Jeong-Yun Sun Hyung-Seop Han Hojeong Jeon Center for Biomaterials Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Materials science and Engineering Seoul National University(SNU)Seoul 08826Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

Mg has received much attention as a next-generation implantable material owing to its biocompatibility,bone-like mechanical properties,and biodegradability in physiological *** application of various polymer coatings has been conducted in the past to reduce the rapid formation of hydrogen gas and the local change in pH during the initial phase of the chemical reaction with the body ***,we propose femtosecond(fs)laser-mediated Mg surface patterning for significant enhancement of the binding strength of the coating material,which eventually reduces the corrosion *** of the structural,physical,crystallographic,and chemical properties of the Mg surface have been conducted in order to understand the mechanism by which the surface adhesion increases between Mg and the polymer coating *** on the fs laser conditions,the surface structure becomes rough owing to the presence of several microscaled pits and grooves of nanoporous MgO,resulting in a tightly bonded poly(lactic-co-glycolic acid)(PLGA)*** corrosion rate of the PLGA-coated,fs laser-treated Mg is considerably slow compared with the non-treated Mg;the treated Mg is also more biocompatible compared with the non-treated *** fs laser-based surface modification technique offers a simple and quick method for introducing a rough coating on Mg;further,it does not require any chemical treatment,thereby overcoming a potential obstacle for its clinical use.

关键词： Femtosecond laser Biodegradable metal Polymer coating Surface modification Surface adhesion