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Neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma: The need for patient-centered research

World Journal of Gastroenterology 2020年第4期26卷 375-382页

作者： Jordan M Cloyd Allan Tsung john hays Celia E Wills john FP Bridges Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Internal Medicine The Ohio State UniversityColumbusOH 43210United States College of Nursing The Ohio State UniversityColumbusOH 43210United States Department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210United States

Pancreatic ductal adenocarcinoma is an aggressive cancer with high recurrence rates following surgical *** adjuvant chemotherapy improves survival,a significant proportion of patients are unable to initiate or complete all intended therapy following pancreatectomy due to postoperative complications or poor performance *** administration of chemotherapy prior to surgical resection is an alternative strategy that ensures its early and near universal delivery as well as improves margin-negative resection rates and potentially improves long-term survival *** therapy is increasingly being recommended to patients with pancreatic ductal adenocarcinoma,however,patient-centered research on its use is *** this review,we highlight opportunities to focus research efforts in the domains of patient preferences,patient-reported outcomes,patient experience,and *** research in these areas may identify relevant barriers and facilitators to the use of neoadjuvant therapy thereby increasing its utilization,improve shareddecision making for patients and providers,and optimize the experience of those undergoing neoadjuvant therapy.

关键词： Preoperative therapy Pancreatic ductal adenocarcinoma Quality of life Shared decision making Patient preferences

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Is there an unrecognised role for Campylobacter infections in(chronic) inflammatory diseases?

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World Journal of Clinical Infectious Diseases 2013年第4期3卷 58-69页

作者： Rogier Louwen john P hays Department of Medical Microbiology and Infectious Diseases Erasmus MC University Medical Centre Rotterdam

Campylobacter species are one of the major causes of global bacterial-related diarrheal disease worldwide. The disease is most frequently associated with the ingestion of contaminated meat, raw milk, pets, contaminated water, and the organism may be frequently cultured from the faeces of chicken and other domesticated farm animals. Of the 17 established Campylobacter species, the most important pathogens for humans are Campylobacter jejuni(C. jejuni), Campylobacter coli(C. coli) and Campylobacter fetus(C. fetus), which are all associated with diarrheal disease. Further, C. jejuni and C. coli are also associated with the neuroparalytic diseases Guillain-Barré syndrome and Miller Fischer syndrome, respectively, whereas C. fetus is linked with psoriatic arthritis. The discovery of both "molecular mimicry" and translocation-related virulence in the pathogenesis of C. jejuni-induced disease, indicates, that Campylobacter-related gastrointestinal infections may not only generate localized, acute intestinal infection in the human host, but may also be involved in the establishment of chronic inflammatory diseases. Indeed, pathogenicity studies on several Campylobacter species now suggest that molecular mimicry and translocation-related virulence is not only related to C. jejuni, but may play a role in human disease caused by other Campylobacter spp. In this review, the authors provide a review based on the current literature describing the potential links between Campylobacter spp. and(chronic) inflammatory diseases, and provide their opinions on the likely role of Campylobacter in such diseases.

关键词： Campylobacter spp Infection Autoimmune diseases Chronic diseases

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Diurnal variation in fecal concentrations of acid-detergent insoluble ash and alkaline-peroxide lignin from cattle fed bermudagrass hays of varying nutrient content

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Journal of Animal Science and Biotechnology 2015年第4期6卷 410-415页

作者： Juvenal Kanani Dirk Philipp Kenneth P Coffey Elizabeth B Kegley Charles P West Shane Gadberry john Jennings Ashley N Young Robert T Rhein Division of Agriculture University of Arkansas Department of Plant and Soil Science Texas Tech University

Background： The effect of time of fecal sampling on the accuracy of acid-detergent insoluble ash （ADIA） and alkaline-peroxide lignin （APL） for the prediction of fecal output （FO） in cattle was evaluated. Eight ruminally cannulated cows （594 _＋ 35.5 kg） were allocated randomly to 4 bermudagrass [Cynodon dactylon （L.） Pers.] hay diets markedly different in crude protein concentration （79-164 g/kg） with 2 replicates per diet for 3 periods. Cows were offered hay individually at 20 g DM/kg of body weight daily in equal feedings at 08：00 and 16：00 h for a 10-d adaptation period followed by 5-d of total fecal collection. Fecal grab samples also were taken each day during the fecal collection period at 06：00, 12：00, 18：00, and 24：00 h either directly from the rectum or from freshly voided feces. Samples were composited within cow and time across the 5 d total fecal collection period. Additionally, forage, ort, and fecal samples were analyzed for concentrations of APL and ADIA. Results： Fecal concentrations of ADIA and APL were not affected by sampling time （P 〉 0.22）, even though diet affected （P 〈 0.01） fecal ADIA and APL concentrations. There were no diet x sampling time interactions （P ≥ 0.60）. Estimates of FO and dry matter digestibility （DMD） from ADIA and APL were not affected （P 〉 0.16） by sampling time or the diet x sampling time interaction （P 〉 0.74）. Estimates of FO and DMD from markers from different sampling times or all different combinations of sampling time were not different （P 〉 0.72） from those of total collection among internal markers. Conclusion： Little variation in concentrations of ADIA and APL in daily fecal excretion across time increases flexibility in fecal grab sampling schedules for predicting FO and DMD.

关键词： Digestibility Fecal sampling time Internal markers Bermudagrass Cattle

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Comparison of acid-detergent lignin,alkaline-peroxide lignin,and acid-detergent insoluble ash as internal markers for predicting fecal output and digestibility by cattle offered bermudagrass hays of varying nutrient composition

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Journal of Animal Science and Biotechnology 2014年第3期5卷 310-317页

Background： The potential for acid-detergent insoluble ash （ADIA）, alkaline-peroxide lignin （APL）, and acid-detergent lignin （ADL） to predict fecal output （FO） and dry matter digestibility （DMD） by cattle offered bermudagrass [Cynodon doctylon （L） Pers.] hays of different qualities was evaluated. Eight ruminally cannulated cows （594 ± 35.5 kg） were allocated randomly to 4 hay diets： low （L）, medium low （ML）, medium high （MH）, and high （H） crude protein （CP） concentration （79, 111,131, and 164 g CP/kg on a DM basis, respectively）. Diets were offered in 3 periods with 2 diet replicates per period and were rotated across cows between periods. Cows were individually fed 20 g DM/kg of body weight in equal feedings at 08：00 and 16：00 h for a 10-d adaptation followed by a 5-d total fecal collection. Actual DM intake （DMI）, DMD, and FO were determined based on hay offered, ort, and feces excreted. These components were then analyzed for ADL, APL, and ADIA concentration to determine marker recovery and marker-based estimates of FO and DMD. Results： Forage DMI was affected by diet （P = 0.02）, and DMI from MH and H was greater （P 〈 0.05） than from L. Apparent DMD tended （P = 0.08） to differ among diets while FO （P = 0.20） was not affected by diet treatments. Average ADL recovery （1.16） was greater （P 〈 0.05） than that of ADIA （1.03） and APL （1.06）, but ADIA and APL did not differ （P = 0.42）. Estimates of FO and DMD derived using APL and ADIA were not different （P≥0.05） from total fecal collection while those using ADL differed （P 〈 0.05）. There was no diet by marker interaction （P≥ 0.22） for either FO or DMD. Conclusion： Acid-detergent insoluble ash and APL accurately predicted FO and DMD of cattle fed bermudagrass hay of varying nutrient composition. These internal markers may facilitate studies involving large numbers of animals and forages. Results from such studies may be used to develop improved equations to predict energy values of forages based on the relationship of di

关键词： Acid-detergent insoluble ash Alkaline-peroxide lignin Bermudagrass Cattle Digestibility Marker

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Attitudes Toward People Who Stutter in the Chinese Context: An Exploratory Study on the Impact of Knowledge Sources

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Chinese Journal of Applied Linguistics 2024年第4期47卷 591-611,687页

作者： Ran AN Judith D.OXLEY john A.TETNOWSKI Department of Communication Sciences and Disorders Fort Hays State UniversityUSA Department of Communicative Disorders University of Louisiana at LafayetteUSA Department of Communication Sciences and Disorders Oklahoma State UniversityUSA

The public’s attitudes can affect the experience of stuttering of people who *** study investigated the attitudes held by the public about people who stutter in China.A web-based written survey with closed and open-ended questions was implemented to develop a rich *** hundred and two respondents in 26 provinces and 3 municipalities provided comments on people who stutter in their life aspects such as personality,speech,social life,work,life participation,education,dating and marriage,capability,and communication *** predominantly negative attitudes towards the overall domains were *** to people who stutter varied according to the different sources of *** with people who stutter might reduce ***,knowledge from the media might aggravate *** and future research orientation were also discussed.

关键词： public’s attitudes people who stutter personality communication skills familiarity media

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