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Materials-oriented integrated design and construction of structures in civil engineering—A review

Frontiers of Structural and Civil Engineering 2022年第1期16卷 24-44页

作者： Xing MING john C.huang Zongjin LI Institute of Applied Physics and Materials Engineering University of MacaoMacao SAR 999078China CHC Engineering LLCFairfaxVA 20030USA

Design is a goal-oriented planning activity for creating products,processes,and systems with desired functions through *** is a decision-making exploration:the design outcome may vary greatly depending on the designer’s knowledge and *** design is one type of design philosophy that takes an interdisciplinary and holistic *** civil engineering,structural design is such an activity for creating buildings and ***,structural design in many countries has emphasized a performance-based philosophy that simultaneously considers a structure’s safety,durability,serviceability,and ***,integrated design in civil engineering has become more popular,useful,and ***-oriented integrated design and construction of structures(MIDCS)combine materials engineering and structural engineering in the design stage:it fully utilizes the strengths of materials by selecting the most suitable structural forms and construction *** paper will explore real-world examples of MIDCS,including the realization of MIDCS in timber seismic-resistant structures,masonry arch structures,long-span steel bridges,prefabricated/on-site extruded light-weight steel structures,fiber-reinforced cementitious composites structures,and fiber-reinforced polymer bridge ***,advanced material design methods such as bioinspired design and structure construction technology of additive manufacturing are briefly reviewed and discussed to demonstrate how MIDCS can combine materials and structures.A unified strengthdurability design theory is also introduced,which is a human-centric,interdisciplinary,and holistic approach to the description and development of any civil infrastructure and includes all processes directly involved in the life cycle of the ***,this paper lays out future research directions for further development in the field.

关键词： integrated design and construction fiber-reinforced concrete fiber-reinforced polymer light-weight steel structures digital fabrication composites

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An In Vitro Investigation of Pulmonary Alveolar Macrophage Cytotoxicity Introduced by Fibrous and Grainy Mineral Dusts

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Acta Geologica Sinica(English Edition) 2006年第4期80卷 589-596页

作者： DONG Faqin DENG Jianjun WU Fengchun PU Xiaoyong john huang FENG Qiming HE Xiaochun Institute of Mineral Materials andApplication Southwest University of Science and Technology Mianyang Sichuan 621002 China Clinical Laboratory Fourth People＇s Hospital ofMianyang Mianyang Sichuan 621000 China Department of Clinical Laboratory Third Military Medical University Chongqing 400038 China Central Analytical Facility Laurentian University Sudbury Ontario P3E 2C6 Canada

In order to study the damage mechanism of mineral dusts on the pulmonary alveolar macrophage （AM）, the changes in their death ratio, malandialdthyde （MDA） content and activities of lactate dehydrogenase （LDH） and superoxide dismutase （SOD） were measured, and the technique of cell culture in vitro was used to investigate the cytotoxicity of six mineral dusts （twelve crystal habits） from twelve mineral deposits. The results show that woUastonite and clinoptilolite have no AM cytotoxicity, while other fibrous and grainy mineral dusts damage pulmonary AM in various degrees. The cytotoxicity of fibrous mineral dusts was greater than that of the grainy ones, and the cytotoxicity of dusts was positively correlated with the active OH- content in dusts, but not necessarily so with its SiO2 content. The high pH values produced by dust was unfavorable for the survival of cells and the dusts with low bio-resistance were safe for cells. The content of variable valence elements in dusts might influence their cytotoxicity and the surface charge of dusts was not a stable factor for their toxicity. It is demonstrated that the shape of mineral dusts was one of the factors affecting cytotoxicity, and that the cytotoxicity of mineral dusts depends mainly on their properties.

关键词： grainy mineral fibrous mineral dust pulmonary alveolar macrophage cytotoxicity

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Adenoviral-mediated localized CTLA-4Ig gene expression induces long-term allograft pancreas survival and donor-specific immune tolerance in rats

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Journal of Medical Colleges of PLA(China) 2008年第6期23卷 313-323页

作者： Chen Xianhua john huang Health Branch Southwest Hospital Third Military Medical University Chongqing 400038 China Department of Medicine University of California San Francisco CA 94143-0780 USA

T cell activation following alloantigen recognition plays a critical role in the development of the rejection in all solid organ, tissue and cell transplantation. A recombinant molecule, cytotoxic T lymphocyte antigen 4 antibody （CTLA-4Ig）, is known to induce to T-cell into ＂anergy＂ by blocking the costimulatory B7-CD28 interaction. Either systemic or localized administration of CTLA-Ig has been shown to prolong allograft survival and induce donor-specific tolerance in some transplant models. In this study, we characterized the expression and immunosuppressive effectiveness of adenoviral-mediated CTLA-4Ig gene transfer. We demonstrated transduction of the allografts with AdCTLA-4Ig resulted in localized expression, permanent graft survival and stable donor-specific tolerance. In addition, by performing simultaneous dual-organ through a local expression of CTLA-4Ig via adenoviral-mediated transplantation, we targeted on immunosuppression gene transfer into pancreatic allografts.

关键词： Cytotoxic Tlymphocyte antigen 4 antibody Immunosuppression Tolerance Diabetes Adenovirus Gene transfer Pancreatic transplantation

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纤维水镁石在无机铵盐中的溶解行为研究

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岩石矿物学杂志 2000年第3期19卷 212-219,242页

作者：董发勤 john huang 万朴西南工学院四川绵阳621002 Laurentian University

纤维水镁石在水中可放出自由基 ,其在酸性环境中呈现化学活性 ,在体液环境中有细胞毒性。在水体环境中 ,它与一切释放出铵离子的物质反应并使自身发生溶解 ,其机理是可溶性铵盐在溶液中可离解出铵离子并放出质子 ,而水镁石在水中可电离... 详细信息

纤维水镁石在水中可放出自由基 ,其在酸性环境中呈现化学活性 ,在体液环境中有细胞毒性。在水体环境中 ,它与一切释放出铵离子的物质反应并使自身发生溶解 ,其机理是可溶性铵盐在溶液中可离解出铵离子并放出质子 ,而水镁石在水中可电离出羟基。二价铁的存在使氧化还原反应常常伴生 ,最终形成三价铁铵盐复盐。因此 ,人体内的可溶性铵盐和体液中存在的铵离子可与水镁石粉尘作用并使之部分溶解。粒度增大和温度升高有利于镁元素在平衡体系中溶解量的增加。高浓度铵盐在较高温度下具有良好的溶解能力。平衡溶液中镁、铁离子的总量取决于生成复盐的溶解度 ,反应的速度是由铵盐电离的速度和水镁石电离的速度共同决定的。NH4Cl(1 .2 5mol/L)、(NH4) 2 SO4(0 .5mol/L)、NH4HSO4(1 .2 5mol/L)在 40～ 80℃条件下是既能防止Fe2 + 氧化或产生沉淀。

关键词：纤维水镁石铵盐反应溶解提纯体液粉尘

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异形矿物粉尘巨噬细胞毒性研究

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生物医学工程学杂志 2006年第4期23卷 848-851页

作者：董发勤邓建军蒲小允 john huang 西南科技大学矿物材料及其应用研究所绵阳621010 四川省绵阳市第四人民医院绵阳621000 第三军医大学重庆400038 The Central Analytical Facility Laurentian UniversitySudburyOntarioCanada P3E 2C6

为研究粉尘样品对兔肺泡巨噬细胞(AM)产生的不同毒性,探讨巨噬细胞受损的机制,采用体外细胞培养技术,观测兔肺泡巨噬细胞死亡率,丙二醛(M DA)、乳酸脱氢酶(LDH)及超氧化物歧化酶(SOD)的活性及变化。结果表明,沸石、硅灰石无细胞毒性,而... 详细信息

为研究粉尘样品对兔肺泡巨噬细胞(AM)产生的不同毒性,探讨巨噬细胞受损的机制,采用体外细胞培养技术,观测兔肺泡巨噬细胞死亡率,丙二醛(M DA)、乳酸脱氢酶(LDH)及超氧化物歧化酶(SOD)的活性及变化。结果表明,沸石、硅灰石无细胞毒性,而其它的纤维状及颗粒状矿物粉尘则表现出不同程度的细胞毒性。纤维状矿物尘对AM毒性大于颗粒状矿物,毒性程度与粉尘中的活性OH-含量正相关,但并不一定与S iO2含量相关。粉尘所形成的高pH值不利于细胞的生存,低生物持久性的粉尘对人体是安全的。粉尘中变价元素的含量可能影响其毒性。表面电位是粉尘毒性的非稳定因素。矿物尘的微形态是影响其毒性的因素之一,而矿物尘的毒性主要依赖于其特性。

关键词：粒状矿物纤维状矿物粉尘肺泡巨噬细胞细胞毒性

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