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Contrasting f.male mate pref.rences f.r red coloration in a f.sh

Current Zoology 2020年第4期66卷 425-433页

作者： Charel Reulaimd Brett M.CuLBERT Alessandro Devigili Ariel f.Kahrl john L.f.tzpatrick Department of.Zoology Stockholm UniversityStockholmSE-10691Sweden Department of.Integrative Biology University of GuelphGuelphN1G 2W1Canada

Understanding how animals select their mates requires knowing the f.ctors that shape mate *** theoretical and empirical considerations suggest that f.male mating status can inf.uence the degree to which a f.male engages in mate choice,with virgin f.males predicted to be less choosy than mated *** this study,we investigated mate choice in both virgin and mated f.males in the pygmy half.eak Dermogenys *** are small,live-bearing,internally f.rtilizing f.eshwater f.sh that live in mixed-sex groups where f.males have ample opportunity to engage in mate *** a dichotomous choice assay,we quantif.ed and contrasted in virgin and mated f.males mate pref.rences f.r dif.erences in male body size,beak size,and area of.yellow and red *** also examined how mating status inf.uenced the amount of.time a f.male associated with the f.rst male encountered and the relative amount of.time a f.male associated with each *** demonstrate that mate pref.rences of.f.male half.eaks are driven primarily by the size of.red coloration present on *** showed contrasting pref.rences based on mating status,with virgin f.males pref.rentially associating with drab males whereas mated f.males pref.rentially associate with males possessing large areas of.*** to expectations,f.male mating status did not inf.uence how f.males associate with the f.rst males encountered or how f.males biased their association time among *** the precise drivers of.these ef.ects need f.rther studying,our f.nding highlights a possible explanation f.r how variation in male ornamentation can be maintained.

关键词： Dermogenys collettei experience plasticity pygmy half.eak reproductive status sexual selection sperm competition

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Helicobacter pylori inf.ction and extragastric disorders in children: A critical update

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World Journal of.Gastroenterology 2014年第6期20卷 1379-1401页

作者： Lucia Pacif.co john f.Osborn Valeria Tromba Sara Romaggioli Stef.no Bascetta Claudio Chiesa Department of.Pediatrics Sapienza University of Rome Department of.Health Sciences and Inf.ctious Diseases Sapienza University of Rome Institute of.Translational Pharmacology National Research Council

Helicobacter pylori(H. pylori) is a highly prevalent, serious and chronic inf.ction that has been associated causally with a diverse spectrum of.extragastric disorders including iron def.ciency anemia, chronic idiopathic thrombocytopenic purpura, growth retardation, and diabetes mellitus. The inverse relation of.H. pylori prevalence and the increase in allergies, as reported f.om epidemiological studies, has stimulated research f.r elucidating potential underlying pathophysiological mechanisms. Although H. pylori is most f.equently acquired during childhood in both developed and developing countries, clinicians are less f.miliar with the pediatric literature in the f.eld. A better understanding of.the H. pylori disease spectrum in childhood should lead to clearer recommendations about testing f.r and treating H. pylori inf.ction in children who are more likely to develop clinical sequelae. A f.rther clinical challenge is whether the progressive decrease of.H. pylori in thelast decades, abetted by modern clinical practices, may have other health consequences.

关键词： Helicobacter pylori Children Iron def.ciency anemia Chronic idiopathic thrombocytopenic purpura Growth retardation Asthma Allergy Diabetes mellitus

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Human development across the lif.span Updated 5th ed.

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2004年

作者： john S. Dacey john f. Travers.

来源：畅想之星图书光盘版（南... 评论

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Endosomal traf.icking def.cts in patient cells with KIAA1109 biallelic variants

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Genes & Diseases 2019年第1期6卷 56-67页

作者： Megan S.Kane Callie J.Diamonstein Natalie Hauser john f.Deeken john E.Niederhuber Thierry Vilboux Inova Translational Medicine Institute Inova Health SystemFairfaxVAUnited States Department of.Medicine Virginia Commonwealth UniversityRichmondVAUnited States Department of.Public Health Sciences University of Virginia School of MedicineCharlottesvilleVAUnited States Department of.Oncology and Surgery Johns Hopkins University School of MedicineBaltimoreMDUnited States

The uncharacterized gene KIAA1109 has recently been associated with a congenital neurological malf.rmation disorder that variably presents with arthrogryposis,craniof.cial and/or cardiac *** have identif.ed two additional patients with compound heterozygous KIAA1109 variants presenting with the same neurological *** mechanism whereby KIAA1109 loss of.f.nction causes this spectrum of.disorders was the primary f.cus of.our *** hypothesized that KIAA1109 f.nction could be conserved relative to the f.y gene tweek and examined endocytosis and endosome recycling in patient ***,we examined the structure of.the cytoskeleton and cilia based on f.nctional overlap with endocytosis and several known etiologies f.r neuronal migration *** primary dermal f.broblasts f.om one patient and a healthy donor,we perf.rmed immunof.uorescence and endocytosis assays to examine the endosomal,cytoskeletal,and ciliary cellular *** f.und notable abnormalities in endosomal traf.icking and endosome recycling *** also observed changes in the actin cytoskeleton and cilia structural *** conclude that the f.nction of.KIAA1109 in humans may indeed overlap with the f.nction of.the Drosophila ortholog,resulting in perturbations to endosomal traf.icking and the actin *** alterations have ripple ef.ects,altering many pathways that are critical f.r proper neuronal migration and embryonic development.

关键词： Cilia Endocytosis KIAA1109 Neurological malf.rmation Vesicular traf.icking

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“Digging in the Dirt”f.ecal microRNAs as dietary biomarkers of.host-microbe interactions

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 292-294页

作者： Gerard M.Moloney john f.Cryan Gerard Clarke Department of.Anatomy&Neuroscience University College CorkCorkIreland APC Microbiome Ireland University College CorkCorkIreland Department of.Psychiatry and Neurobehavioural Science University College CorkCorkIreland

The role of.diet and nutrition in maintaining a healthy lif.style has become a central part of.chronic disease prevention(1).Chronic conditions such as cancer,Inf.ammatory bowel disease(IBD)and obesity are more prevalent in people with poor diets(2).f.od consumption is controlled by physiological systems such as the gut-microbiome and distinct neuroendocrine pathways that overlap to promote host nutritional gain resulting in people living longer healthier lives(3).A recent analysis of.the global burden of.disease by the World Health Organization(WHO),noted that f.ctors associated with poor diet,including obesity and malnutrition,critically undermine health and *** note that undernutrition,def.ciencies in key nutrients and obesity have high social and economic *** disease,cancer,diabetes,and respiratory diseases account f.r 77%of.all diseases and are responsible f.r 86%of.all premature deaths(4).There is an appreciation that diets that reduce or eliminate red meats and animal f.ts results in the reduction of.many of.the indicators of.poor diet,such as body mass index(BMI)and levels of.cholesterol in the blood.

关键词： prevention eliminate overlap

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Active surveillance monitoring： the role of.nove biomarkers and imaging

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Asian Journal of.Andrology 2015年第6期17卷 882-884,I0006页

作者： john f.Ward Scott E Eggener Department of.Urology The University of TexasMD Anderson Cancer Center Houston TX USA Department of.Urology University of ChicagoChicago IL USA.

＂CANCER＂ is a disease state that leads to progressive illness that is unif.rmly f.tal without treatment. Hippocrates invoked the Greek word karkinos, or ＂crab＂ to describe tumors he observed. f.r centuries, ＂CANCER＂ remained a disease that was recognized primarily in its locally advanced or metastatic stage, when it was almost unif.rmly f.tal.

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Mechanisms of.dysregulation of.low-density lipoprotein receptor expression in HepG2 cells induced by inf.ammatory cytokines

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Chinese Medical Journal 2007年第24期120卷 2185-2190页

作者： CHEN Ya-xi RUAN Xiong-zhong HUANG Ai-long LI Qiu john f. Moorhead Zac Varghese Centre f.r Lipid Research Key Laboratory of Molecular Biologyon Infectious Diseases Ministry of Education Second Af.iliatedHospital Chongqing Medical University Chongqing 400010China Centre f.r Nephrology Royal-Free and University CollegeMedical School Royal Free Campus London UK

Background Low-density lipoprotein （LDL） receptor is normally regulated via a f.edback system that is dependent on intracellular cholesterol levels. We have demonstrated that cytokines disrupt cholesterol-mediated LDL receptor f.edback regulation causing intracellular accumulation of.unmodif.ed LDL in peripheral cells. Liver is the central organ f.r lipid homeostasis. The aim of.this study was to investigate the regulation of.cholesterol exogenous uptake via LDL receptor and its underlying mechanisms in human hepatic cell line （HepG2） cells under physiological and inf.ammatory conditions. Methods Intracellular total cholesterol （TC）, f.ee cholesterol （f.） and cholesterol ester （CE） were measured by an enzymic assay. Oil Red O staining was used to visualize lipid droplet accumulation in cells. Total cellular RNA was isolated f.om cells f.r detecting LDL receptor, sterol regulatory element binding protein （SREBP）-2 and SREBP cleavage-activating protein （SCAP） mRNA levels using real-time quantitative PCR. LDL receptor and SREBP-2 protein expression were examined by Western blotting. Conf.cal microscopy was used to investigate the translocation of.SCAP-SREBP complex f.om the endoplasmic reticulum （ER） to the Golgi by dual staining with anti-human SCAP and anti-Golgin antibodies. Results LDL loading increased intracellular cholesterol level, thereby reduced LDL receptor mRNA and protein expression in HepG2 cells under physiological conditions. However, interleukin 1β （IL-1β） f.rther increased intracellular cholesterol level in the presence of.LDL by increasing both LDL receptor mRNA and protein expression in HepG2. LDL also reduced the SREBP and SCAP mRNA level under physiological conditions. Exposure to IL-1β caused over-expression of.SREBP-2 and also disrupted normal distribution of.SCAP-SREBP complex in HepG2 by enhancing translocation of.SCAP-SREBP f.om the ER to the Golgi despite a high concentration of.LDL in the culture medium. Conclusions IL-1β disrupts cho

关键词： low-density lipoprotein receptor cytokines sterol regulatory element binding protein-2 SREBP cleavage-activating protein cholesterol

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危影重重

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作者： (美)约翰 f. 博文齐(john f. Bovenzi)

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Characterizing drought in Calif.rnia:new drought indices and scenario-testing in support of.resource management

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Ecological Processes 2018年第1期7卷 1-13页

作者： Lorraine E.f.int Alan L.f.int john Mendoza Julie Kalansky f.M.Ralph U.S.Geological Survey 6000 J.StSacramentoCA 95819USA Sonoma County Water Agency 404 Aviation Dr.Santa RosaCA 95403USA Scripps Institution of.Oceanography 9500 Gilman Dr.La JollaCA 92093USA

Introduction:Calif.rnia’s recent drought(2012–2016)has implications throughout the state f.r natural resource management and adaptation planning and has generated many discussions about drought characterization and *** study characterizes drought conditions with two indices describing def.cits in natural water supply and increases in landscape stress developed on the basis of.water balance modeling,at a f.ne spatial scale to assess the variation in conditions across the entire state,and provides an in-depth evaluation f.r the Russian River basin in northern Calif.rnia to address local resource management by developing extreme drought scenarios f.r consideration in planning and ***:We employed the USGS Basin Characterization Model to characterize drought on the basis of.water supply(a measure of.recharge plus runof.)and landscape stress(climatic water def.cit).These were applied to the state and to the Russian River basin where antecedent soil moisture conditions were evaluated and extreme drought scenarios were developed and run through a water management and reservoir operations model to f.rther explore impacts on water ***:Drought indices indicated that as of.the end of.water year 2016 when reservoirs were f.ll,additional water supply and landscape replenishment of.up to three average years of.precipitation in some locations was needed to return to normal *** soil conditions in the Russian River were determined to contribute to very dif.erent water supply results f.r dif.erent years and were necessary to understand to anticipate proper watershed response to *** drought scenarios manif.sted very dif.erent kinds of.drought and recovery and characterization helps to guide the management response to ***:These scenarios and indices illustrate how droughts dif.er with regard to water supply and landscape stress and how long warm droughts recover much more slowly than short very dry dro

关键词： Calif.rnia drought Russian River Water supply Basin Characterization Model

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驾驭交易

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作者： (美)约翰·f. 卡特(john f. Carter)

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