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The assessment of.atrial f.nction by velocity-encoded magnetic resonance imaging

World Journal of.Cardiovascular Diseases 2013年第2期3卷 18-24页

作者： Charles C. Vu john f. heitner Igor Klem Peter J. Cawley Anna Lisa C. Crowley Manesh R. Patel Jonathan W. Weinsaf. Michele A. Parker Michael Elliott Robert M. Judd Raymond J. Kim Joseph C. Greenf.eld Jr. Division of.Cardiology New York Methodist Hospital Brooklyn USA Division of.Cardiology New York Presbyterian Hospital Weill Cornell Medical Center New York USA Division of.Cardiology University of Washington School of Medicine Seattle USA Duke Cardiovascular Magnetic Resonance Center Duke University Medical Center Durham USA Stony Brook School of.Medicine Stony Brook USA

Introduction: The purpose of.this study was to assess velocity-encoded cardiac magnetic resonance imaging (Ve-CMR) in a population of.patients ref.rred f.r cardiac magnetic resonance imaging (CMR), to determine the variability of.atrial f.nction, and to identif. clinical parameters associated with lef. atrial f.nction. Methods: This is a prospective study evaluating patients who were ref.rred to our CMR center f.r a clinical CMR. Lef. atrial f.nction was obtained via Ve-CMR thru-plane images across the mitral valve af.er acquiring 2 perpendicular in-plane images as “scouts”. The atrial f.nction and mitral inf.ow were quantif.ed by computer analysis (Argus, Siemens). Atrial f.nction was def.ned as atrial contraction (A-wave) volume divided by total inf.ow volume. Lef. atrial volumes were calculated via computer analysis. Mitral regurgitation and lef. ventricular ejection f.actions were assessed visually. Results: Thirty-nine patients, with mean age 56 +/- 10 years, were enrolled. The mean lef. atrial f.nction was 22.9% +/-14.5%;the range in lef. atrial f.nction was 0% - 57%. There was a signif.cant positive correlation between atrial f.nction and increased lef. ventricular ejection f.action (r = 0.44, P f.cant negative correlation between atrial f.nction and severity of.mitral regurgitation (r = -0.60, P f. atrial volume (r = -0.36, P = 0.02). Conclusion: Our results indicate a wide variability in lef. atrial f.nction and a signif.cant association between lef. atrial f.nction and lef. ventricular ejection f.action, lef. atrial volume and mitral regurgitation.

关键词： Atrial f.nction Velocity-Encoded Cardiovascular Magnetic Resonance

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Design of.Poiseuille f.ow Controllers Using the Method of.Inequalities

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International Journal of.Automation and computing 2009年第1期6卷 14-21页

作者： john McKernan James f. Whidborne George Papadakis Department of.Mechanical Engineering King s College London Strand Department of.Aerospace Sciences Cranfield University

This paper investigates the use of.the method of.inequalities （MoI） to design output-f.edback compensators f.r the problem of.the control of.instabilities in a laminar plane Poiseuille f.ow. In common with many f.ows, the dynamics of.streamwise vortices in plane Poiseuille f.ow are very non-normal. Consequently, small perturbations grow rapidly with a large transient that may trigger nonlinearities and lead to turbulence even though such perturbations would, in a linear f.ow model, eventually decay. Such a system can be described as a conditionally linear system. The sensitivity is measured using the maximum transient energy growth, which is widely used in the f.uid dynamics community. The paper considers two approaches. In the f.rst approach, the MoI is used to design low-order proportional and proportional-integral （PI） controllers. In the second one, the MoI is combined with Mcf.rlane and Glover＇s H∞ loop-shaping design procedure in a mixed-optimization approach.

关键词： Transient energy growth transient behaviour f.ow control Poiseuille f.ow method of.inequalities (MoI) mixed opti-mization H∞-optimization.

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Landscape of.the mind

Landscape of the mind

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作者： Hof.ecker john f.

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Calcium-mediated paired pulse depression in juvenile rat dorsal striatum

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Neural Regeneration Research 2012年第10期7卷 772-777页

作者： Yuf.ng Xie Michael f. Jackson john f. MacDonald Robarts Research Institute University of Western Ontario London Ontario Canada Department of.Physiology and Pharmacology University of Western Ontario London Ontario Canada Department of.Anatomy and Cell Biology University of Westem Ontario London Ontario Canada

As the major division of.the basal ganglia, neostriatum f.rms mutual connections with multiple brain areas and is critically involved in motor control and learning/memory. Long-term synaptic plasticity has been widely studied in dif.erent species recently. However, there are rare reports about the short-term synaptic plasticity in neostratium. In the present study, using f.eld excitatory postsynaptic potentials recording, we reported one f.rm of.short-term synaptic plasticity that is paired pulse depression in juvenile rat dorsal striatum slices induced by stimuli of.the white matter. The f.eld excitatory postsynaptic potentials could be abolished by α-amino-3-hydroxy-5-methylizoxazole-4-propionic acid receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione, but not by gamma-aminobutyric acid type A receptor antagonist bicuculline or dopamine D1 receptor antagonist SKf.81297. The paired pulse depression in the corticostratial pathway was dif.erent f.om paired pulse f.cilitation in the hippocampal CA1 synapse. In addition, the paired pulse depression was not af.ected by bath application of.gamma-aminobutyric acid type A receptor antagonist or dopamine D1 receptor antagonist. However, low calcium and high magnesium could attenuate the paired pulse depression. These f.ndings suggest a more complicated plasticity f.rm in the dorsal striatum of.juvenile rats that is dif.erent f.om that in the hippocampus, which is related with extracellular calcium.

关键词： paired pulses depression dorsal striatum calcium juvenile rats

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Synchronous f.rmation of.the‘f.rearc’Bay of.Islands ophiolite and its basal high-temperature metamorphic sole constrained by U-Pb zircon ages

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Geoscience f.ontiers 2023年第6期14卷 234-272页

作者： Weiyao Yan john f.Casey Department of.Earth and Atmospheric Sciences University of HoustonHoustonTXUSA

The welded metamorphic sole at the base of.the Bay of.Islands Ophiolite Complex(BOIC)in the Northern Appalachians of.Newf.undland shows a typical inverted pressure-temperature(P-T)metamorphic gradient f.om HT-MP granulite to LT-LP greenschist *** incorporates maf.c volcanic/plutonic protoliths mixed with pelagic,hemi-pelagic and coarser epiclastic sedimentary *** LA-ICP-MS U–Pb concordia ages,trace elements,and Ti-in-zircon geothermometry f.r -250 zircon analyses f.om three metabasites of.the upper HT sole amphibolites with N-MORB-like protoliths are *** samples collected within meters of.the ophiolite peridotite-sole contact of.the Blow Me Down Mountain and North Arm Mountain massif. yielded the oldest comparable concordia ages of.487.7±2.6 Ma and 489.1±3.1 Ma,respectively,that are both within error of.the igneous age of.488.3±1.5 Ma of.the directly overlying BOIC ophiolite,which f.rmed at a supra-subduction zone(SSZ)f.rearc spreading center.A third slightly younger age of.484.2±2.4 Ma was obtained f.r an upper HT amphibolite sample with similar phase assemblages but collected30 m below the peridotite contact of.the Table Mountain *** crystals analyzed have similar size and morphologies,subparallel rare earth element(REE)variation patterns,and steep heavy REE-enrichments((Lu/Gd)_(cn)>20),signif.cant positive Ce anomalies(dominantly>5)and slight positive to dominantly negative Eu anomalies(1.2–0.4).Zircon shows Th/U mean values of.0.37–0.48 with little to no rim to core *** Ti-in-zircon mean crystallization temperatures range f.om764–787℃.These neocrystallized zircon crystals appear to be derived f.om thin leucosomes within the three *** other samples also f.om the upper HT sole show evidence of.inherited detrital zircon with core dates spanning the Cambrian Notre Dame Arc through older Laurentian-like basement and rif. age *** of.the sole took place below a hot f.rearc asthenospheric wed

关键词： Ophiolite metamorphic sole U-Pb zircon ages Hot subduction interf.ce Supra-subduction f.rearc spreading center Arc-continent collision Taconic Orogeny

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Human development across the lif.span john S. Dacey, john f. Travers.

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2002年

作者： john S. Dacey john f. Travers.

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Xylose: absorption, f.rmentation, and post-absorptive metabolism in the pig

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Journal of.Animal Science and Biotechnology 2018年第1期9卷 1-9页

作者： Nichole f.Huntley john f.Patience Department of.Animal Science 213 Kildee HallIowa State University Department of.Animal Science 201B Kildee HallIowa State University

Xylose, as β-1,4-linked xylan, makes up much of.the hemicel ulose in cel wal s of.cereal carbohydrates f.d to pigs. As inclusion of.f.brous ingredients in swine diets continues to increase, supplementation of.carbohydrases, such as xylanase,is of.interest. However, much progress is warranted to achieve consistent enzyme ef.icacy, including an improved understanding of.the utilization and energetic contribution of.xylanase hydrolysis product（i.e. xylooligosaccharides or monomeric xylose）. This review examines reports on xylose absorption and metabolism in the pig and identif.es gaps in this knowledge that are essential to understanding the value of.carbohydrase hydrolysis products in the nutrition of.the pig. Xylose research in pigs was f.rst reported in 1954, with only sporadic contributions since. Theref.re, this review also discusses relevant xylose research in other monogastric species, including humans. In both pigs and poultry, increasing purif.ed D-xylose inclusion general y results in linear decreases in perf.rmance, ef.iciency, and diet digestibility. However,supplementation levels studied thus f.r have ranged f.om 5% to 40%, while theoretical xylose release due to xylanase supplementation would be less than 4%. More than 95% of.ingested D-xylose disappears bef.re the terminal ileum but mechanisms of.absorption have yet to be f.l y elucidated. Some data support the hypothesis that mechanisms exist to handle low xylose concentrations but become overwhelmed as luminal concentrations increase. Very little is known about xylose metabolic utilization in vertebrates but it is wel recognized that a large proportion of.dietary xylose appears in the urine and signif.cantly decreases the metabolizable energy available f.om the diet. Nevertheless, evidence of.labeled D-xylose-1-^（14）C appearing as expired^（14）CO_2 in both humans and guinea pigs suggests that there is potential,although small, f.r xylose oxidation. It is yet to be determined if.pigs develop increased xy

关键词： Pentose utilization Swine Threitol Xylose absorption Xylose metabolism

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Cloning, Expression, and Homology Modeling of.GroEL Protein f.om Leptospira interrogans Serovar Autumnalis Strain N2

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Genomics, Proteomics & Bioinf.rmatics 2011年第4期9卷 151-157页

作者： Kalimuthusamy Natarajaseenivasan Santhanam Shanmughapriya Sridhar Velineni Sergey C. Artiushin john f. Timoney Medical Microbiology Laboratory Department of Microbiology School of Life Sciences Bharathidasan University Gluck Equine Research Center University of Kentucky

Leptospirosis is an inf.ctious bacterial disease caused by Leptospira species. In this study, we cloned and se- quenced the gene encoding the immunodominant protein GroEL f.om L. interrogans serovar Autumnalis strain N2, which was isolated f.om the urine of.a patient during an outbreak of.leptospirosis in Chennai, India. This groEL gene encodes a protein of.60 kDa with a high degree of.homology （99% similarity） to those of.other leptospiral serovars. Recombinant GroEL was overexpressed in Escherichia coli. lmmunoblot analysis indi- cated that the sera f.om conf.rmed leptospirosis patients showed strong reactivity with the recombinant GroEL while no reactivity was observed with the sera f.om seronegative control patient. In addition, the 3D structure of.GroEL was constructed using chaperonin complex cpn60 f.om Thermus thermophilus as template and vali- dated. The results indicated a Z-score of.-8.35, which is in good agreement with the expected value f.r a pro- tein. The superposition of.the Ca traces of.cpn60 structure and predicted structure of.leptospiral GroEL indicates good agreement of.secondary structure elements with an RMSD value of.1.5A. f.rther study is necessary to evaluate GroEL f.r serological diagnosis of.leptospirosis and f.r its potential as a vaccine component.

关键词： GroEL expression homology modeling leptospirosis serodiagnosis

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Analysis of.Staf.ing and Training Needs f.r Ef.ective Delivery of.Extension Service in Sustainable Land Management in Kilimanjaro Region, Tanzania

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Open Journal of.Soil Science 2014年第13期4卷 459-468页

作者： john f. Kessy Department of.f.rest Economics Sokoine University of Agriculture Morogoro Tanzania

An assessment of.staf.ing and training needs f.r ef.ective delivery of.extension services in mainstreaming sustainable land management (SLM) practices in Kilimanjaro Region was conducted in June/July 2013. Data collection methods included discussions with key inf.rmants at the regional and district levels, consultations with village level stakeholders and potential collaborators, review of.human resources data both at regional, district and ward levels and collection of.individual staf. bio-data including capacity def.ciencies. The staf.ing situation at the regional and district levels was considered to be adequate f.r ef.ective mainstreaming of.SLM interventions in the region. Staf.ing at ward and village levels was very poor and largely inadequate f.r sustainable execution of.extension services. It is optimistically estimated that on average the staf.ing at ward level needs to be increased by at least 50%. In some districts the def.ciency of.extension staf. at ward level was as high as 80%. Training needs exist at all levels f.om the region down to community level. At the regional and district levels both long and short term training programs were required. At the community level required training is more practical and purely f.cused in mainstreaming SLM interventions at individual households and community lands. Potential collaborators with local government were identif.ed in f.ur main categories namely, NGOs/CBOs, private sector, government departments and f.ith-based organizations. The study recommends a capacity building program on specif.c knowledge gaps identif.ed at regional, district, ward and village levels. The study f.rther recommends that immediate measures need to be taken by the district authorities to address the staf.ing problem at ward level including recruitment of.volunteers and developing collaboration f.amework with identif.ed potential partners.

关键词： Staf.ing Training Extension Services Sustainable Land Management

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A Theoretical Examination of.Untaxed Entities and Taxed Entities in the Market f.r Commercial Real Estate

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Journal of.Modern Accounting and Auditing 2012年第2期8卷 267-280页

作者： john f. McDonald Roosevelt University Chicago USA

This paper is a theoretical examination of.untaxed and taxed entities that invest in real estate. The standard advice to real estate investors is to avoid using entities that are subject to taxation （such as C corporations） and employ entities that are not subject to taxation （such as limited liability companies, S corporations, and real estate investment trusts） in order to avoid double taxation of.income. This paper shows that, in most situations, untaxed entities place a greater value on a given real estate property than a taxed entity does, which implies that taxed entities are at a distinct disadvantage at competing in the market f.r property. However, this conclusion is reversed if.untaxed entities use a large amount of.f.nancial leverage compared to taxed entities and the borrowing rate f.r both is greater than the risk-f.ee rate.

关键词： f.nancial leverage capital asset pricing model taxation

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