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Proteomic and metabolomic profiling underlines the stage- and time-dependent effects of high temperature on grape berry metabolism

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Journal of Integrative Plant Biology 2020年第8期62卷 1132-1158页

作者： David Lecourieux Christian Kappel Stéphane Claverol Philippe Pieri Regina Feil john e.lunn Marc Bonneu Lijun Wang eric Gomès Serge Delrot Fatma Lecourieux UMR1287 eGFV INRAEBordeaux Sciences AgroBordeaux UniversityISVV33140 Villenave d'OrnonFrance Institut of Biochemistry and Biology Potsdam UniversityD-14476 PotsdamGermany Proteome Platform Bordeaux Functional Genomic CenterBordeaux University33076 BordeauxFrance Max Planck Institute of Molecular Plant Physiology 14476 PotsdamGolmGermany Institute of Botany the Chinese Academy of SciencesBeijing 100093China UMR1287 eGFV CNRSINRAEBordeaux Sciences AgroBordeaux UniversityISVV33140 Villenave d'OrnonFrance

Climate change scenarios predict an increase in mean air temperatures and in the frequency,intensity,and length of extreme temperature events in many wine-growing regions *** elevated temperature has detrimental effects on berry growth and composition,it threatens the economic and environmental sustainability of wine *** Cabernet Sauvignon fruit-bearing cuttings,we investigated the effects of high temperature(HT)on grapevine berries through a label-free shotgun proteomic analysis coupled to a complementary metabolomic *** the 2,279 proteins identified,592 differentially abundant proteins were found in berries exposed to *** gene ontology categories“stress,”“protein,”“secondary metabolism,”and“cell wall”were predominantly altered under *** temperatures strongly impaired carbohydrate and energy metabolism,and the effects depended on the stage of development and duration of *** amounts correlated poorly with protein expression levels in HT berries,highlighting the value of proteomic studies in the context of heat ***,this work reveals that HT alters key proteins driving berry development and ***,we provide a list of differentially abundant proteins that can be considered as potential markers for developing or selecting grape varieties that are better adapted to warmer climates or extreme heat waves.

关键词： metabolism extreme high

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Carbon Supply and the Regulation of Cell Wa Synthesis

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Molecular Plant 2018年第1期11卷 75-94页

作者： Jana Verbancic john edward lunn Mark Stitt Staffan Persson Max Planck Institute of Molecular Plant Physiology Am Muhlenberg 1 14476 Potsdam-Golm Germany School of Biosciences University of Melbourne Parkville VIC 3010 Australia

All plant cells are surrounded by a cell wall that determines the directionality of cell growth and protects the cell against its environment. Plant cell walls are comprised primarily of polysaccharides and represent the largest sink for photosynthetically fixed carbon, both for individual plants and in the terrestrial biosphere as a whole. Cell wall synthesis is a highly sophisticated process, involving multiple enzymes and metabolic intermediates, intracellular trafficking of proteins and cell wall precursors, assembly of cell wall polymers into the extracellular matrix, remodeling of polymers and their interactions, and recycling of cell wall sugars. In this review we discuss how newly fixed carbon, in the form of UDP-glucose and other nucleotide sugars, contributes to the synthesis of cell wall polysaccharides, and how cell wall synthesis is influenced by the carbon status of the plant, with a focus on the model species Arabidopsis （Arabidopsis thaliana）.

关键词： carbon availability cell walls nucleotide sugars sucrose synthase

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Cronkhite-Canada Syndrome:an unusual finding of gastro-intestinal adenomatous polyps in a syndrome characterized by hamartomatous polyps

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Gastroenterology Report 2015年第3期3卷 254-257页

作者： Christopher M.Flannery john A.lunn Department of Gastroenterology Loma Linda University Medical CenterLoma LindaCAUSA Department of Gastroenterology Veterans Affairs Loma Linda Healthcare System Loma LindaCAUSA

Cronkhite-Canada syndrome is a rare,hamartomatous polyposis syndrome of unknown *** gastrointestinal polyps,alopecia,onychodystrophy,cutaneous hyperpigmentation,abdominal pain,diarrhea,and complications of weight loss are typical of the *** this report,we describe a pathological finding of colonic adenomatous polyposis as opposed to hamartomatous *** also describe our treatment,long-term therapeutic plan,and the need for further research.

关键词： Cronkhite-Canada syndrome gastro-intestinal adenomatous polyps hamartomatous polyps

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Arabidopsis Coordinates the Diurnal Regulation of Carbon Allocation and Growth across a Wide Range of Photoperiods

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Molecular Plant 2014年第1期7卷 137-155页

作者： Ronan Sulpice Anna Flis Alexander A. Ivakov Federico Apelt Nicole Krohn Beatrice encke Christin Abel Regina Feil john e. lunn Mark Stitt Max Planck Institute of Molecular Plant Physiology Am Muehlenberg 1 14476 Potsdam-Golm Germany National University of Galway Plant Systems Biology Lab Plant and AgriBiosciences Research Centre Botany and Plant Science Galway Ireland

In short photoperiods, plants accumulate starch more rapidly in the light and degrade it more slowly at night, ensuring that their starch reserves last until dawn. To investigate the accompanying changes in the timing of growth, Arabidopsis was grown in a range of photoperiods and analyzed for rosette biomass, photosynthesis, respiration, ribosome abundance, polysome loading, starch, and over 40 metabolites at dawn and dusk. The data set was used to model growth rates in the daytime and night, and to identify metabolites that correlate with growth. Modeled growth rates and polysome loading were high in the daytime and at night in long photoperiods, but decreased at night in short photoperiods. Ribosome abundance was similar in all photoperiods. It is discussed how the amount of starch accumulated in the light period, the length of the night, and maintenance costs interact to constrain growth at night in short photoperiods, and alter the strategy for optimizing ribosome use. Significant correlations were found in the day- time and the night between growth rates and the levels of the sugar-signal trehalose 6-phosphate and the amino acid biosynthesis intermediate shikimate, identifying these metabolites as hubs in a network that coordinates growth with diurnal changes in the carbon supply.

关键词： Arabidopsis diurnal growth photoperiod ribosomes trehalose-6-phosphate starch

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COMBINeD eFFeCTS OF SeLeCTIVe PHOTOTHeRMAL THeRAPY AND IMMUNOADJUVANT AGAINST STAGe IV BReAST CANCeR

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Journal of Innovative Optical Health Sciences 2010年第4期3卷 279-284页

作者： XIAOSONG LI TOMAS HODe MARIA C.GUeRRA GABRIeLA L.FeRReL john A.lunn ORN ADALSTeINSSON ROBeRT e.NORDQUIST WeI R.CHeN Department of Oncology the First Affiliated Hospital of Chinese PLA General Hospital Beijing 100048 China Department of Laser Medicine Chinese PLA General Hospital Beijing 100853 China Department of engineering and Physics University of Central Oklahoma 100 N.University Drive Edmond Oklahoma 73034USA ImmunoPhotonics Inc. 1601 South Providence Road ColumbiaMissouri 65211USA Hospital Nacional edgardo Rebagliati Martins Av.edgardo Rebagliati#490—Jesus Maria LimaPeru Collins Ave. P.O.Box N-215 NassauThe Bahamas International Strategic Cancer Alliance 873 e.Baltimore Pike#333 Kennett Square Philadelphia 19348USA

Metastasis to distant sites is a severe treatment challenge and a major cause of death for breast cancer *** immunotherapy(LIT)is a novel technique,combining a selective photothermal therapy with local application of glycated chitosan,a potent *** pre-clinical studies of LIT have shown its unique characteristics in generating specific antitumor *** clinical application of LIT in the treatment of melanoma patients has achieved preliminary ***,LIT has been used to treat late-stage breast cancer *** we report for the first time the clinical results of this combination therapy in breast cancer *** LIT treatment procedures are presented and the medical history of two stage Ⅳ breast cancer patients is *** of the breast cancer lesions and the metastasis of lung and brain disappeared after repeated treatments of *** patient achieved complete response;the other achieved partial response at the time of this *** there is still a long way for LIT to become a standard modality for breast cancer treatment,the results of this study indicated its promising future.

关键词： Laser immunotherapy near-infrared laser glycated chitosan indocyanine green metastasis cancer stage IV breast cancer patients clinical trials

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Search for a natural scientific measure of economy

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Frontiers of environmental Science & engineering 2011年第1期5卷 111-118页

作者： john e COULTeR Xiwangzhuang Shuangqing RdHaidianBeijing 100084China

Through human history,wealth has been measured in grain,gold,and,now,*** counterfeiting of coins and notes goes back a long way,it is only with electronic financial accounting in a global economy tainted by toxic loans and imaginary funds that there is an urgency to search for a realistic objective way to monitor and regulate what we are doing to our earth and *** schemes using analysis of utility functions,oil equivalents,entropy,energy,and other units have been tried and,while helping to understand some basic processes and flows,have always been swamped by the machinations of financiers and the attention big sums of money ***,the concept of exergy,pioneered in eastern europe in the 1950s,is being researched,developed,and applied,especially in China,driven by the desperation to measure the reality beyond the twin specters of global financial and environmental crises.A rough inventory of the matter in the biosphere at the coordinate details of an angstrom and an appreciation of how humans harness and manipulate electromagnetic forces can be enlightening as to what is and is not *** that understanding,any financial estimate and proposed stimulus packages or IMF reform will be wildly wrong and may even be headed in the wrong direction.

关键词： climate change financial crisis energy exergy environment

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Development of Light Weight Structures to Provide Blast-Resistant Designs

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Transactions of Tianjin University 2006年第B9期12卷 16-21页

作者： CRAWFORD john e Karagozian & Case 2550 N.Hollywood Way #500BurbankCA 91505USA

In the past, blast-resistant designs for structures were often constructed with massive type structural systems, which relied more on brute strength than on finesse to achieve the required blast resistance. However, structures composed of COLD-FORMeD steel components, such as sheet metal and metal studs, have shown great promise in providing blast resistance with the added benefits of low cost and ease of construction. Some examples of using such structures to provide containment for package handling facilities (PHF) are described in the paper for situations where blast containment is needed, such as a potential package bomb being discovered during the package vetting process. Results from tests and analytic data are used to illustrate aspects of design peculiar to such types of applications. Designs for specific capacities of PHF are described.

关键词： blast containment package handling facility hardened design light weight structures COLD-FORMeD steel structures

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Simulation of Fragment Impact on Multi-Layer Targets Using Contact Method

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Transactions of Tianjin University 2006年第B9期12卷 152-157页

作者： CRAWFORD john e Karagozian & Case 2550 N.Hollywood WaySuite 500BurbankCA 91505USA

Cased explosives generate highly energetic fragments as their casing breaks up. Due to the complexity of casing fragment related behavior such as embedment, perforation and ricochet, it may be insufficient to use equivalent triangular pressure loading in fragment impact simulations. This simplified method may over- or under-predict the target response. Recently, a procedure using contact techniques has been proposed to overcome such difficulties. It has been shown that the new method has the inherent capability in modeling the multi-piece and multi-hit fragment impact problems in a more realistic way. To investigate the applicability of the proposed method to simulations involving multi-layer penetration, the selected problems of fragment impact on multi-layer targets are described in this paper. It is demonstrated that this method is capable of predicting the complicated multi-layer structural response caused by fragment impact and penetration. Modeling procedures and some technical issues are also discussed.

关键词： contact finite element fragment impact multi-layer penetration simulation

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SWITCHING AND SeQUeNCING AVAILABLe THeRAPIeS SO AS TO MAXIMIZe A PATIeNT＇S eXPeCTeD TOTAL LIFeTIMe

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International Journal of Biomathematics 2012年第4期5卷 113-125页

作者： john e. GOULIONIS Department of Statistics and Insurance Science University of Piraeus 80 Karaoli a Dimitriou Street 18534 Piraeus Greece

This paper has focused on applying mathematical techniques to address fundamental question in therapy planning when to switch, and how to sequence therapies. We consider switching and sequencing available therapies so as to maximize a patient＇s expected total lifetime. We assume knowledge only about the lifetime distributions induced by the therapies. We discuss a specialization of this model that is tailored to a frequently reoccurring type of management problem, where our goal is to determine the best timing for testing and treatment decisions for patients with ischemic heart disease. Typically, decisions are made with an overall, goal of maximizing the patient＇s expected lifetime or quality-adjusted lifetime.

关键词： expected total lifetime maintenance ischemic heart disease stochasticordering relationships statistical distributions.

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New technologies in the gastrointestinal clinic and research: Impedance and high-resolution manometry

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World Journal of Gastroenterology 2009年第2期15卷 131-138页

作者： john e Pandolfino Peter J Kahrilas Division of Gastroenterology Department of Medicine Northwestern University Feinberg School of Medicine Suite 1400 Chicago Illinois 60611 United States

The last five years have been an exciting time in the study of esophageal motor disorders due to the recent advances in esophageal function testing. New technologies have emerged, such as intraluminal impedance, while conventional techniques, such as manometry, have enjoyed many improvements due to advances in transducer technology, computerization and graphic data presentation. While these techniques provide more detailed information regarding esophageal function, our understanding of whether they can improve our ability to diagnose and treat patients more effectively is evolving. These techniques are also excellent research tools and they have added substantially to our understanding of esophageal motor function in dysphagia. This review describes the potential benefits that these new technologies may have over conventional techniques for the evaluation of dysphagia.

关键词： Dysphagia, Multichannel intraluminal Impedance Bolus transit High-resolution manometry esophagogastric junction Achalasia

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