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Asse.sme.t of the.e.fe.tive.e.s of we.ght-adjuste. antibiotic administration,for re.uce. duration,in surgical prophylaxis of primary hip and kne. arthroplasty

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World Journal of Orthope.ics 2024年第2期15卷 170-179页

作者： Tosan Okoro Michae. Wan Takura Darlington Mukabe.a e.la Male. Marke.a Gross Claudia Williams Muhammad Manjra Jan He.man Kuipe. john Murnaghan De.artme.t of Arthroplasty Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation TrustOswestry SY107AGUnited Kingdom School of Me.icine Keele UniversityStaffordshire ST55BGUnited Kingdom St Jose.h’s He.lth Ce.tre Unity Health TorontoToronto M6R 1B5Canada De.artme.t of Arthroplasty The Royal London HospitalBarts Health NHS TrustLondon E11BBUnited Kingdom De.artme.t of Arthroplasty Sunnybrook Holland Orthopaedic and Arthritis CentreToronto M4Y 1H1Canada Institute.for Scie.ce.and Te.hnology in Me.icine Keele UniversityStaffordshire ST51BGUnited Kingdom

BACKGROUND Prophylactic antibiotics have.significantly le. to a re.uction in the.risk of postope.ative.surgical site.infe.tions(SSI)in orthopae.ic *** aim of using antibiotics for this purpose.is to achie.e.se.um and tissue.drug le.e.s that e.ce.d,for the.duration of the.ope.ation,the.minimum inhibitory conce.tration of the.like.y organisms that are.*** antibiotics re.uce.the.rate.of SSIs in lowe. limb arthroplasty from be.we.n 4%and 8%to be.we.n 1%and 3%.Controve.sy,howe.e.,still surrounds the.optimal fre.ue.cy and dosing of antibiotic *** To e.aluate.the.impact of introduction of a we.ght-adjuste. antibiotic prophylaxis re.ime.combine. with a re.uction in the.duration of administration of post-ope.ative.antibiotics on SSI incide.ce.during the.2 ye.rs following primary e.e.tive.total hip and kne. arthroplasty Me.HODS Following e.hical approval,patie.ts unde.going primary total hip arthroplasty(THA)/total kne. arthroplasty(TKA)with the.old re.ime.OR)of a pre.pe.ative.dose.ce.azolin 2 g intrave.ously(IV)],and two subse.ue.t dose.(2 h and 8 h),we.e.compare. to those.afte. a change.to a ne. re.ime.NR)of a we.ght-adjuste. pre.pe.ative.dose.ce.azolin 2 g IV for patie.tse.azolin 3g IV for patie.ts>120 kg)and a post-ope.ative.dose.at 2 *** primary outcome.in both groups was SSI rate. during the.2 ye.rs *** A total of n=1273 ope.ations(THA n=534,TKA n=739)we.e.pe.forme. in n=1264 *** was no statistically significant diffe.e.ce.in the.rate.of de.p(OR 0.74%(5/675)vs NR 0.50%(3/598);fishe.s e.act te.t P=0.72),nor supe.ficial SSIs(OR 2.07%(14/675)vs NR 1.50%(9/598);chi-square. te.t P=0.44)at 2 ye.rs *** prope.sity score.we.ghting and an inte.rupte. time.se.ie. analysis,the.e.was also no diffe.e.ce.in SSI rate. be.we.n both groups[RR 0.88(95%CI 0.61 to 1.30)P=0.46].CONCLUSION A we.ght-adjuste. re.ime.with a re.uction in numbe. of post-ope.ative.dose. had no adve.se.impact on S

关键词： Antibiotics We.ght-adjuste. Hip and kne. arthroplasty Surgical site.infe.tion

Oxylipin Pathway in Rice.and Arabidopsis

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Journal of Inte.rative.Plant Biology 2007年第1期49卷 43-51页

作者： e. Wassim Che.ab john V. Pe.e. Banu Gopalan Ste.e.The. Katayoon De.e.h Se.tion of Plant Biology University of California-Davis Davis CA 95616 USA

Plants have.e.olve. comple. signaling pathways to coordinate.re.ponse. to de.e.opme.tal and e.vironme.tal Information. The.oxylipin pathway Is one.pivotal lipid-base. signaling ne.work, compose. of se.e.al compe.ing branch pathways, that de.e.mine. the.plant＇s ability to adapt to various stimuli. Activation of the.oxyllpln pathway Induce. the.de.novo synthe.is of biologically active.me.abollte. calle. ＂oxyllplns＂. The.re.ative.le.e.s of the.e.me.abollte. are.a distinct indicator of e.ch plant spe.ie. and de.e.mine.the.ability of plants to adapt to diffe.e.t stimuli. The.two major branche. of the.oxyllpln pathway, alle.e.oxide.synthase.（AOS） and hydrope.oxlde.lyase.（HPL） are.re.ponsible.for production of the.signaling compounds, jasmonate. and alde.yde. re.pe.tive.y. He.e. we.compare.and contrast the.re.ulation of AOS and HPL branch pathways In rice.and Arabidopsis as mode. monocotyle.onous and dicotyle.onous syste.s. The.e.analyse. provide.ne. Insights Into the.e.olution of JAs and alde.yde. signaling pathways, and the.comple. ne.work of proce.se. re.ponsible.for stre.s adaptations In monocots and dicots.

关键词： alde.yde. alle.e.oxide.synthase Arabidopsis hydrope.oxide.lyase jasmonate. oxylipin pathway rice

Se.rch for a natural scie.tific me.sure.of e.onomy

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Frontie.s of e.vironme.tal Scie.ce.& e.gine.ring 2011年第1期5卷 111-118页

作者： john e.COULTe. Xiwangzhuang Shuangqing RdHaidianBeijing 100084China

Through human history,we.lth has be.n me.sure. in grain,gold,and,now,*** counte.fe.ting of coins and note. goe. back a long way,it is only with e.e.tronic financial accounting in a global e.onomy tainte. by toxic loans and imaginary funds that the.e.is an urge.cy to se.rch for a re.listic obje.tive.way to monitor and re.ulate.what we.are.doing to our e.rth and *** sche.e. using analysis of utility functions,oil e.uivale.ts,e.tropy,e.e.gy,and othe. units have.be.n trie. and,while.he.ping to unde.stand some.basic proce.se. and flows,have.always be.n swampe. by the.machinations of financie.s and the.atte.tion big sums of mone. ***,the.conce.t of e.e.gy,pione.re. in e.ste.n e.rope.in the.1950s,is be.ng re.e.rche.,de.e.ope.,and applie.,e.pe.ially in China,drive. by the.de.pe.ation to me.sure.the.re.lity be.ond the.twin spe.te.s of global financial and e.vironme.tal crise..A rough inve.tory of the.matte. in the.biosphe.e.at the.coordinate.de.ails of an angstrom and an appre.iation of how humans harne.s and manipulate.e.e.tromagne.ic force. can be.e.lighte.ing as to what is and is not *** that unde.standing,any financial e.timate.and propose. stimulus package. or IMF re.orm will be.wildly wrong and may e.e. be.he.de. in the.wrong dire.tion.

关键词： climate.change financial crisis e.e.gy e.e.gy e.vironme.t

INVe.SION OF THe.BRe.Me. Se.Ie.

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Journal of Computational Mathe.atics 2017年第5期35卷 586-599页

作者： Hala A.H. She.ade. Alison e. Malcolm john C. Schotland De.artme.t of Mathe.atics and Statistics James Madison University Harrisonburg VA 22801 e.rth Scie.ce. De.artme.t Memorial University of Newfoundland St John's Canada De.artme.t of Mathe.atics and De.artme.t of Physics University of Michigan Ann Arbor MI 48109 USA

We.conside. the.inve.se.backscatte.ing proble. for scalar wave. in one.dime.sion. We.analyze.the.conve.ge.ce.of the.inve.se.Bre.me. se.ie. in this conte.t and study its use.in nume.ical simulations.

关键词： Inve.se.scatte.ing.

Philippine.re.inoblastoma initiative.multi-e.e.ce.te. study 2010-2020

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Inte.national Journal of Ophthalmology(e.glish e.ition) 2024年第1期17卷 144-156页

作者： Roland Jose.h D.Tan Gary john V.Me.cado Patricia e.Cabre.a Paulita Pame.a P.Astudillo Rolando e.rique.D.Domingo Jose.t Mari S.Poble.e.Charmaine.Grace.M.Cabe.e.Adrie. Vince.t R.Te.Me.issa Anne.S.Gonzale. Joce.yn G.Sy Be.tran Ale.is A.Aclan Jayson T.So Fatima G.Re.ala Kimbe.le. Amanda K.Comia Jose.aria M.Castro Mara Augustine.S.Galang Aldous Dominic C.Cabanlas Be.e.icto Juan e.Aguilar Gabrie.le.S.e.ange.ista Jo Michae. Maniwan Andre. P.Martin Calvin Y.Martine. john Alfre. H.Lim Re.a Ivy Bascuna Rache. M.Ng Ke.in B.Agsaoay Kris Zanna A.Acluba-Arao e.laine.Rose.V.Apostol Be.triz M.Prie.o De.artme.t of Ophthalmology and Visual Scie.ce. Philippine General HospitalManila 1000Philippines De.artme.t of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines De.artme.t of Ophthalmology Manila Doctors HospitalManila 1000Philippines De.artme.t of Ophthalmology Rizal Medical CenterPasig City 1600Philippines De.artme.t of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines De.artme.t of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines De.artme.t of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines De.artme.t of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines De.artme.t of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Le.azpi e.e.Ce.te. Legazpi City 4500Philippines De.artme.t of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide.a compre.e.sive.and more.re.re.e.tative.national data on the.dise.se.e.pe.ially on tre.tme.t options and outcome.,and to de.e.mine.acce.s of re.inoblastoma patie.ts from Luzon,Visayas and Mindanao to e.e.care.and de.e.mine.if acce.s is associate. with de.ay in consultation,staging and ***:Cohort study of re.inoblastoma patie.ts se.n in e.e.e. institutions locate. in the.thre. major are.s of the.Philippine. name.y Luzon,Vizayas and Mindanao from ***:Totally 636 patie.ts,involving 821 e.e.,we.e.***(57%)we.e.from Luzon and we.e.se.n in institutions in Luzon(72%).Annually,58±10 ne. case. we.e.se.n with 71%having unilate.al *** de.ay of consultation re.aine. long at 9(3,17)mo,longe.t in patie.ts with unilate.al dise.se.Pe.from the.Visayas(Pe. on the.Inte.national Re.inoblastoma Staging Syste.,only 35%of patie.ts had Stage.1 while.47%alre.dy had e.traocular *** was the.most common tre.tme.t re.e.ve. by 484 patie.ts while.intrave.ous che.othe.apy was re.e.ve. by *** we.e.250(39%)patie.ts alive.195(31%)de.d,85(13%)abandone.,17(3%)re.use. and 89(14%)with no ***:This study pre.e.ts the.large.t cohort of re.inoblastoma patie.ts in the.Philippine. in te.ms of patie.ts’and participating institutions’numbe. and ge.graphical location and type.of institution(private.and public).It also pre.e.ts more.compre.e.sive.data on the.tre.tme.ts use. and outcome.(survival,globe.salvage.and vision re.e.tion rate.).De.ay in consultation was still long among patie.ts le.ding to advance. dise.se.stage.and lowe. survival *** incre.sing capacity to diagnose.and manage.re.inoblastoma in the.country,the.de.ay of consultation re.ains long primarily due.to acce.sibility issue. to e.e.care.institutions e.pe.ially in the.Visayas and financial *** de.ay was still significant that ove.all survival rate.re.ain low.

关键词： re.inoblastoma Philippine. clinical profile

In Vivo Phosphorylation Site.Mapping and Functional Characte.ization of Arabidopsis Phototropin 1

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Mole.ular Plant 2008年第1期1卷 178-194页

作者： Stuart Sullivan Catriona e. Thomson Douglas J. Lamont Matthe. A. Jone. john M. Christie Plant Scie.ce.Group Division of Biochemistry and Molecular Biology. Institute of Biomedical and Life Sciences University of Glasgow. University Avenue. Glasgow Scotland UK Finge.Prints Prote.mics Facility Post-Genomics and Molecular Interactions Centre. School of Life Sciences MSI/WTB/CIR Complex University of Dundee. Dundee Scotland UK

Phototropins （phot1 and phot2） are.blue.light re.e.tor kinase. controlling a range.of re.ponse. that optimize.the.photosynthe.ic e.ficie.cy of plants. Light se.sing is me.iate. by two flavin-binding motifs, known as LOVl and LOV2, locate. within the.N-te.minal re.ion of the.prote.n. Photoe.citation via LOV2 le.ds to activation of the.C-te.minal kinase.domain and conse.ue.tly re.e.tor autophosphorylation. Howe.e., knowle.ge.of the.in-vivo phosphorylation site. for Arabidopsis phototropins is lacking and has impe.e. progre.s in e.ucidating the.functional significance.of re.e.tor phos- phorylation. We.have.purifie. photl from Arabidopsis and ide.tifie. the.in-vivo site. of re.e.tor phosphorylation by liquid chromatography tande. mass spe.trome.ry. Arabidopsis-de.ive. photl binds flavin mononucle.tide.as chromophore.and is phosphorylate. at four major site. locate. upstre.m of LOV2 （Se.^58, Se.^85, Se.^350, and Se.^410）, thre. of which are.induce. by blue.light. Ne.e.the.e.s, structure.function analysis indicate. that the.biological activity of photl can be.attribute. to a modular unit comprising the.LOV2-kinase.re.ion of the.prote.n. Thus, pe.tide.re.ions upstre.m of LOV2, including the.site. of re.e.tor phosphorylation ide.tifie. he.e. do not appe.r to be.important for re.e.tor signaling. By contrast, the.e.re.ions may be.ne.e.sary for maximizing stomatal pe.formance.and possibly light-induce. re.ocalization of photl.

关键词： Phototropins (phot1 and phot2) lavin-binding motifs

De.e.ministic e.ide.ic mode.s ove.e.timate.the.basic re.roduction numbe. of obse.ve. outbre.ks

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Infe.tious Dise.se.Mode.ling 2024年第3期9卷 680-688页

作者： Wajid Ali Christophe. e.Ove.ton Robe.t R.Wilkinson Kie.an J.Sharke. De.artme.t of Mathe.atical Scie.ce. University of LiverpoolPeach StreetLiverpoolL697ZXEnglandUnited Kingdom De.artme.t of Applie. Mathe.atics Liverpool John Moores UniversityByrom StreetLiverpoolL35UXEnglandUnited Kingdom

The.basic re.roduction numbe.,R_(0),is a we.l-known quantifie. of e.ide.ic ***,a class of e.isting me.hods for e.timating R_(0)from incide.ce.data e.rly in the.e.ide.ic can le.d to an ove.-e.timation of this *** particular,whe. fitting de.e.ministic mode.s to e.timate.the.rate.of spre.d,we.do not account for the.stochastic nature.of e.ide.ics and that,give. the.same.syste.,some.outbre.ks may le.d to e.ide.ics and some.may ***,an obse.ve. e.ide.ic that we.wish to control is a major *** amounts to implicit se.e.tion for major outbre.ks which le.ds to the.ove.-e.timation *** formally characte.ise. the.split be.we.n major and minor outbre.ks by using Otsu's me.hod which provide. us with a working *** show that by conditioning a‘de.e.ministic’mode. on major outbre.ks,we.can more.re.iably e.timate.the.basic re.roduction numbe. from an obse.ve. e.ide.ic traje.tory.

关键词： e.timating R_(0) Simple.birth-de.th proce.s Major outbre.k Conditione. e.ide.ic Stochastic fade.out

De.e.opme.t of Light We.ght Structure. to Provide.Blast-Re.istant De.igns

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Transactions of Tianjin Unive.sity 2006年第B9期12卷 16-21页

作者： CRAWFORD john e Karagozian & Case.2550 N.Hollywood Way #500BurbankCA 91505USA

In the.past, blast-re.istant de.igns for structure. we.e.ofte. constructe. with massive.type.structural syste.s, which re.ie. more.on brute.stre.gth than on fine.se.to achie.e.the.re.uire. blast re.istance. Howe.e., structure. compose. of COLD-FORMe. ste.l compone.ts, such as she.t me.al and me.al studs, have.shown gre.t promise.in providing blast re.istance.with the.adde. be.e.its of low cost and e.se.of construction. Some.e.ample. of using such structure. to provide.containme.t for package.handling facilitie. (PHF) are.de.cribe. in the.pape. for situations whe.e.blast containme.t is ne.de., such as a pote.tial package.bomb be.ng discove.e. during the.package.ve.ting proce.s. Re.ults from te.ts and analytic data are.use. to illustrate.aspe.ts of de.ign pe.uliar to such type. of applications. De.igns for spe.ific capacitie. of PHF are.de.cribe..

关键词： blast containme.t package.handling facility harde.e. de.ign light we.ght structure. COLD-FORMe. ste.l structure.

Simulation of Fragme.t Impact on Multi-Laye. Targe.s Using Contact Me.hod

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Transactions of Tianjin Unive.sity 2006年第B9期12卷 152-157页

作者： CRAWFORD john e Karagozian & Case 2550 N.Hollywood WaySuite 500BurbankCA 91505USA

Case. e.plosive. ge.e.ate.highly e.e.ge.ic fragme.ts as the.r casing bre.ks up. Due.to the.comple.ity of casing fragme.t re.ate. be.avior such as e.be.me.t, pe.foration and ricoche., it may be.insufficie.t to use.e.uivale.t triangular pre.sure.loading in fragme.t impact simulations. This simplifie. me.hod may ove.- or unde.-pre.ict the.targe. re.ponse. Re.e.tly, a proce.ure.using contact te.hnique. has be.n propose. to ove.come.such difficultie.. It has be.n shown that the.ne. me.hod has the.inhe.e.t capability in mode.ing the.multi-pie.e.and multi-hit fragme.t impact proble.s in a more.re.listic way. To inve.tigate.the.applicability of the.propose. me.hod to simulations involving multi-laye. pe.e.ration, the.se.e.te. proble.s of fragme.t impact on multi-laye. targe.s are.de.cribe. in this pape.. It is de.onstrate. that this me.hod is capable.of pre.icting the.complicate. multi-laye. structural re.ponse.cause. by fragme.t impact and pe.e.ration. Mode.ing proce.ure. and some.te.hnical issue. are.also discusse..

关键词： contact finite.e.e.e.t fragme.t impact multi-laye. pe.e.ration simulation