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继发于睑板腺炎的慢性流泪(英文)

国际眼科杂志 2014年第3期14卷 386-389页

作者：马晓萍 john d.ng 复旦大学附属中山医院眼科中国上海市200032 俄勒冈健康与科学大学Casey眼科研究所美国俄勒冈州97239

目的:阐述慢性流泪与睑板腺炎的关系,探讨治疗睑板腺炎对改善慢性流泪症状的疗效。方法:对美国OHSU的Casey眼科研究所2000/2009年间1 000例流泪患者进行回顾性研究。其中206(20.6%)例患者通过裂隙灯检查被诊断为睑板腺炎,诊断标准包括:... 详细信息

目的:阐述慢性流泪与睑板腺炎的关系,探讨治疗睑板腺炎对改善慢性流泪症状的疗效。方法:对美国OHSU的Casey眼科研究所2000/2009年间1 000例流泪患者进行回顾性研究。其中206(20.6%)例患者通过裂隙灯检查被诊断为睑板腺炎,诊断标准包括:睑板腺功能障碍,睑缘炎,睑缘毛细血管扩张,浅层点状角膜病变。治疗包括保持眼睑清洁,使用人工泪液,睑缘按摩和热敷,全身口服抗生素和眼部抗生素点眼,皮质类固醇点眼,饮食中补充Omega-3等治疗。结果:所有患者中,206例(20.6%)患者被诊断为睑板腺炎(平均年龄65.8岁,平均流泪时间是2.78a)。其中196例(95%)是白人;女性106例(51.5%),男性100例(48.5%)。平均随访5.07mo。通过治疗睑板腺炎,症状得到改善152例(73.79%)。症状未改善43例(20.87%)。在43例患者中14例(6.81%)患者未找到治疗失败的原因,29例(14.08%)患者不愿做长期治疗而导致治疗失败。失去随访11例(5.34%)。结论:Casey眼科研究所流泪患者中20.6%患有睑板腺炎,通过治疗73.78%患者流泪症状改善。我们认为:流泪患者需注意其睑板腺情况,一旦诊断为睑板腺炎则应积极治疗;其次通过各种手术治疗仍然流泪的患者,眼科医生需注意其睑板腺的情况。

关键词：眼表溢泪流泪睑板腺炎睑缘炎

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前巩膜片技术预防多孔材料义眼座植入的暴露

眼外伤职业眼病杂志 2010年第5期32卷 356-359页

作者：马晓萍 john d.ng 复旦大学附属中山医院眼科上海200032 Ophthalmic Facial Plastic Surgery Casey Eye InstituteOregon Health and Sciences University Portland

目的探讨在眼球摘除后多孔材料义眼座前部增加一巩膜片植入眼眶后预防暴露的有效性。方法美国Ore-gon州OHSU医学院Casey Eye Institute眼科研究所眼面部整形外科从2000年1月至2009年1月,john d.ng医生的162例(170眼)眼球摘除合并眼眶内... 详细信息

目的探讨在眼球摘除后多孔材料义眼座前部增加一巩膜片植入眼眶后预防暴露的有效性。方法美国Ore-gon州OHSU医学院Casey Eye Institute眼科研究所眼面部整形外科从2000年1月至2009年1月,john d.ng医生的162例(170眼)眼球摘除合并眼眶内植入有孔材料,使用前巩膜片技术(在多孔义眼座的前部缝合一7.5 mm×7.5 mm的巩膜片,并将四条直肌缝在巩膜片上)。根据病例资料,眼疾诊断,手术操作技术,先前眼科手术史,植入物的大小,随访时间,植入后并发症等,观察统计义眼暴露率及并发症。结果植入暴露发生7例,7眼(4.12%,7/170)。其中一例发生在早期(6个月)。这7例中1例给于抗生素及结膜切除手术,暴露得到修复;另外6例结膜撕裂较大未能得到修复,遂取出义眼座植入一新的前部缝有巩膜片的义眼座。这7例经过1a以上的随访,未出现再次暴露。结论巩膜片在移植物的前表面可以作为一种屏障,在预防暴露方面具有一定的有效性。

关键词：义眼座巩膜片,前暴露

The High Throughput Protein to Structure Pipeline at SECSG

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The High Throughput Protein to Structure Pipeline at SECSG

Targeting TrkB–PSd-95 coupling to mitigate neurological disorders

10～(th) International Conference on the Crystallization of Biological Macromlecules

作者： Joseph d.ng john Rose Laboratory for Structural Biology University of Alabama in HuntsvilleHuntsvilleAL 35899 U.S.A Southeast Collaboratory for Structural Genomics Department of Biochemistry and Molecular BiologyUniversity of Georgia AthensGA 30602 U.S.A

＜正＞ The Southeast Collaboratory for Structural Genomics （SECSG） is a networked center with six partner institutions spanning three southeast states in the US. Our research focus is to develop and test experimental and computational strategies for high throughput structure determination of proteins by X-ray crystallography and NMR methods and to apply these strategies to scan the entire genome of an organism at a rapid pace. After 3.5 years of implementation and fine tuning, a complete protein to

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Crystal Quality Improvement by Reductive Methylation of Surface Lysines

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Crystal Quality Improvement by Reductive Methylation of Surf...

Modelling the impacts of structural conservation measures on sediment and water yield in Thika-Chania catchment, Kenya

10～(th) International Conference on the Crystallization of Biological Macromlecules

作者： Ashit K.Shah Jessie Chang Joseph d.ng john P.Rose A2-1003 Gangan Vihar Bibewadi-Kondhwa RoadPune-4111 037INDIA Southeast Collaboratory for Structural Genomics Department of Biochemistry and Molecular BiologyUniversity of Georgia AthensGA 30602U.S.A Laboratory for Structural Biology University of Alabama in HuntsvilleHuntsvilleAL 35899U.S.A Southeast Collaboratory for Structural Genomics Department of Biochemistry and Molecular BiologyUniversity of Georgia AthensGA 30602U.S.A

＜正＞ Structural genomics project requires high throughput protein production, crystallization and structure determination. Obtaining high quality crystals, however, still remains a challenge and is a major bottleneck for rapid crystal production. Reductive methylation of surface lysines, as one of the crystal salvaging pathways in SECSG （Southeast Collaboratory for Structural Genomics）,

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International Soil and Water Conservation Research 2018年第2期6卷 165-174页

作者： john ng'ang'a Gathagu Joseph KSang Caroline WMaina Water Engineering Pan African University Institute of Water and Energy SciencesTlemcenAlgeria department of Soil Water and Environmental EngineeringJomo Kenyatta University of Agriculture and TechnologyNairobiKenya department of Agricultural Engineering Egerton UniversityKenya

Recently, there has been a growing need to implement soil and water conservation measures in order to control sediment and water yield from agricultural areas. The objective of this study was to use a modeling approach to evaluate the impacts of structural conservation measures on water and sediment yield from Thika Chania catchment in Central Kenya. The SWAT model was calibrated and validated for stream flow and sediment yield at a gauging station in the catchment. The calibrated model was run to create a base scenario for the simulation of structural conservation methods, i.e. terraces and grassed waterways. Model simulation results indicated that terraces and grassed waterways would significantly impact water and sediment yield at the catchment outlet. Terraces were found to provide the greatest reduction in sediment yield, by 81% from the baseline scenario, while grassed waterways reduced se-diment yield by 54%. Terraces indicated a reduction in surface runoff by 30% from the base annual average value of 202 mm. This was attributed to the increased infiltration that was indicated by increase in base flow by 8%. However, grassed waterways did not indicate any significant reduction in water yield. The results of this study show that structural conservation measures could reduce sediment yield from cultivated areas by more than 50% at the sub catchment level. Results also indicated that the effective-ness of structural conservation measures can be increased by implementing more than one method. Structural conservation measures studied in the current study were found to have a positive impact in controlling water and sediment yield in the catchment. However, further studies need to be conducted to evaluate the costs and benefits of implementing them at a small scale.

关键词： Terraces Grassed waterways SWAT Conservation measures Sediment yield

Mg/MgO interfaces as efficient hydrogen evolution cathodes causing accelerated corrosion of additive manufactured Mg alloys:A dFT analysis

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Journal of Magnesium and Alloys 2024年第1期12卷 110-119页

作者： Man-Fai ng Kai Xiang Kuah Teck Leong Tan daniel john Blackwood department of Materials Science&Engineering National University of Singapore9 Engineering Drive 1Singapore 117575Republic of Singapore Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A∗STAR)1 Fusionopolis Way#16-16 ConnexisSingapore 138632Republic of Singapore

The corrosion rates of additive-manufactured Mg alloys are higher than their as-cast counterparts,possibly due to increased kinetics for the hydrogen evolution reaction on secondary phases,which may include oxide *** Kelvin Probe Force Microscopy demonstrated that MgO inclusions could act as cathodes for Mg corrosion,but their low conductivity likely precludes ***,the density of state calculations through density functional theory using hybrid HSE06 functional revealed overlapping electronic states at the Mg/MgO interface,which facilitates electron transfers and participates in redox *** determination of the hydrogen absorption energy at the Mg/MgO interface reveals it to be an excellent catalytic site,with HER being found to be a factor of 23x more efficient at the interface than on metallic *** results not only support the plausibility of the Mg/MgO interface being an effective cathode to the adjacent anodic Mg matrix during corrosion but also contribute to the understand.ng of the enhanced cathodic activities observed during the anodic dissolution of magnesium.

关键词： Magnesium Magnesium oxide Interface Hydrogen evolution dFT

A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： john Mitrofanis Jonathan Stone Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,lead.ng often to their death.A range of pathological conditions,includ.ng stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

(Super)paramagnetic nanoparticles as platform materials for environmental applications: From synthesis to demonstration

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Frontiers of Environmental Science & Engineering 2020年第5期14卷 15-23页

作者： Wenlu Li john d.Fortner department of Chemical and Environmental Engineering Yale UniversityNew HavenCT 06520USA

Over the past few decades,engineered,(super)paramagnetic nanoparticles have drawn extensive research attention for a broad range of applications based on their tunable size and shape,surface chemistries,and magnetic *** review summaries our recent work on the synthesis,surface modification,and environmental application of(super)paramagnetic *** utilizing high-temperature thermo-decomposition methods,first,we have broadly demonstrated the synthesis of highly monodispersed,(super)paramagnetic nanoparticles,via the pyrolysis of metal carboxylate salts in an organic *** uniform magnetic nanoparticles with various size,composition,and shape can be precisely tuned by controlled reaction parameters,such as the initial precursors,heating rate,final reaction temperature,reaction time,and the *** materials can be further rendered water stable via functionalization with surface mono/bi-layer coating structure using a series of tunable ionic/non-ionic ***,we have demonstrated platform potential of these materials for heavy metal ions sensing,sorption,and separation from the aqueous phase.

关键词： Superparamagnetic nanoparticles Surface functionalization Environmental sensing Heavy metal ion sorption